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Volumn 144, Issue 1-3, 2011, Pages 1095-1111

Methoxy VO-salen stimulates pancreatic β cell survival by upregulation of eNOS and downregulation of apoptosis in STZ-induced diabetic rats

Author keywords

Apoptosis; Endothelial nitric oxide synthase; MetVO salen; Rat pancreas; Streptozotocin

Indexed keywords

ANTIDIABETIC AGENT; CATALASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; METHOXY VANADIUM OXIDE SALEN COMPLEX; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84155167815     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-011-9139-1     Document Type: Article
Times cited : (14)

References (57)
  • 1
    • 2342466734 scopus 로고    scopus 로고
    • Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
    • DOI 10.2337/diacare.27.5.1047
    • Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes; estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047-1053 (Pubitemid 38579764)
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 2
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • DOI 10.1038/414813a
    • Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820 (Pubitemid 34000785)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 813-820
    • Brownlee, M.1
  • 3
    • 0023090431 scopus 로고
    • Diabetes and atherosclerosis an epidemiologic view
    • Pyorala K, Laakso M, Unsitupa M (1987) Diabetes and atherosclerosis an epidemiologic view. Diabetes Metab 3:463-524
    • (1987) Diabetes Metab , vol.3 , pp. 463-524
    • Pyorala, K.1    Laakso, M.2    Unsitupa, M.3
  • 5
    • 0026025852 scopus 로고
    • The antioxidant, nutrients and disease prevention: What do we know and what do we need to find out
    • Pryor WA (1991) The antioxidant, nutrients and disease prevention: what do we know and what do we need to find out. Am J Clin Nutr 53:391-393
    • (1991) Am J Clin Nutr , vol.53 , pp. 391-393
    • Pryor, W.A.1
  • 6
    • 0035115147 scopus 로고    scopus 로고
    • Studies on the antioxidative activities of Hsian-tsao (Mesona procumbens Hemsl) Leaf Gum
    • Lai LS, Chou ST, Chao WW (2001) Studies on the antioxidative activities of Hsian-tsao (Mesona procumbens Hemsl) Leaf Gum. J Agric Food Chem 49:963-968
    • (2001) J Agric Food Chem , vol.49 , pp. 963-968
    • Lai, L.S.1    Chou, S.T.2    Chao, W.W.3
  • 7
    • 0001692230 scopus 로고    scopus 로고
    • Functional mimics of superoxide dismutase enzymes as therapeutic agents
    • Riley DP
    • Riley DP (1999) Functional mimics of superoxide dismutase enzymes as therapeutic agents. Chem Rev 99:2573-2588
    • (1999) Chem Rev , vol.99 , pp. 2573-2588
  • 8
    • 0037391621 scopus 로고    scopus 로고
    • Studies of pyridinyl containing 14 membered macrocyclic copper (II) complexes
    • Autzen S, Korth HG, Boese R, Groot H,Sustmann R (2003) Studies of pyridinyl containing 14 membered macrocyclic copper (II) complexes. Eur J Inorg Chem 1401-1410
    • (2003) Eur J Inorg Chem , pp. 1401-1410
    • Autzen, S.1    Korth, H.G.2    Boese, R.3    Groot Hsustmann, R.4
  • 9
    • 0029053449 scopus 로고
    • Time course effects of vanadium supplementation on cytosolic reduced glutathione S-transferase activity
    • Bishayee A, Chatterjee M (1995) Time course effects of vanadium supplementation on cytosolic reduced glutathione S-transferase activity. Biol Trace Element Res 48:275-285
    • (1995) Biol Trace Element Res , vol.48 , pp. 275-285
    • Bishayee, A.1    Chatterjee, M.2
  • 10
    • 0020824392 scopus 로고
    • Detergent induced distinction between fluoride and vanadate stimulated adenylate cyclases and their responses to guanine nucleotides
    • Combest WL, Jhonson R (1993) Detergent induced distinction between fluoride and vanadate stimulated adenylate cyclases and their responses to guanine nucleotides. Arch Biochem Biophys 225:916-927
    • (1993) Arch Biochem Biophys , vol.225 , pp. 916-927
    • Combest, W.L.1    Jhonson, R.2
  • 11
    • 0025366163 scopus 로고
    • Glutathione reductase functions as vanadate(V) reductase
    • Shi X, Dalat NS (1990) Glutathione reductase functions as vanadate(V) reductase. Arch Biochem Biophys 278:228-290
    • (1990) Arch Biochem Biophys , vol.278 , pp. 228-290
    • Shi, X.1    Dalat, N.S.2
  • 12
    • 0029633865 scopus 로고
    • Solid state defect mechanism in vanadyl pyrophosphate catalyst implications for selective oxidation
    • Gai PL, Kourtakis K (1995) Solid state defect mechanism in vanadyl pyrophosphate catalyst implications for selective oxidation. Science 267:661-663
    • (1995) Science , vol.267 , pp. 661-663
    • Gai, P.L.1    Kourtakis, K.2
  • 13
    • 3042737491 scopus 로고    scopus 로고
    • Vanadium compounds in the treatment of diabetes
    • Thompson KH, Orvig C (2004) Vanadium compounds in the treatment of diabetes. Met Ions Biol Syst 41:221-225
    • (2004) Met Ions Biol Syst , vol.41 , pp. 221-225
    • Thompson, K.H.1    Orvig, C.2
  • 14
    • 17844382172 scopus 로고    scopus 로고
    • Therapeutic potential of vanadium in treating diabetes mellitus
    • Sakurai H (2005) Therapeutic potential of vanadium in treating diabetes mellitus. Clin Calcium 15:49-57
    • (2005) Clin Calcium , vol.15 , pp. 49-57
    • Sakurai, H.1
  • 16
    • 33748374269 scopus 로고    scopus 로고
    • Biological activity of vanadium compounds
    • DOI 10.2478/s11535-006-0029-z
    • Goc A (2006) Biological activity of vanadium compounds. Cent Eur Biol 1:314-332 (Pubitemid 44334815)
    • (2006) Central European Journal of Biology , vol.1 , Issue.3 , pp. 314-332
    • Goc, A.1
  • 18
    • 0035691617 scopus 로고    scopus 로고
    • The mechanism of alloxan and streptozotocin in action in beta cells of rat pancreas
    • Szkudelski T (2001) The mechanism of alloxan and streptozotocin in action in beta cells of rat pancreas. Physiol Res 50:536-546
    • (2001) Physiol Res , vol.50 , pp. 536-546
    • Szkudelski, T.1
  • 19
    • 2542623001 scopus 로고    scopus 로고
    • Effect of Streptozotocin on the ultrastructure of rat pancreatic islets
    • DOI 10.1002/jemt.20039
    • Mythili MD, Vyas R, Akila G, Gunasekaran S (2004) Effect of streptozotocin on the ultra structure of rat pancreatic islets. Microsc Res Tech 63:274-281 (Pubitemid 38702356)
    • (2004) Microscopy Research and Technique , vol.63 , Issue.5 , pp. 274-281
    • Mythili, M.D.1    Vyas, R.2    Akila, G.3    Gunasekaran, S.4
  • 20
    • 0026531834 scopus 로고
    • Biological roles of nitric oxide
    • Bredt DS, Snyder SH (1992) Biological roles of nitric oxide. Sci Am 68-77
    • (1992) Sci Am , pp. 68-77
    • Bredt, D.S.1    Snyder, S.H.2
  • 21
    • 0039558662 scopus 로고    scopus 로고
    • Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III)
    • Forstermann U, Boissel JP, Kleinet H (1998) Expressional control of the constitutive isoforms of nitric oxide synthase (NOS I and NOS III). Fed Am Soc Exp Biol 12:773-790 (Pubitemid 28294668)
    • (1998) FASEB Journal , vol.12 , Issue.10 , pp. 773-790
    • Forstermann, U.1    Boissel, J.-P.2    Kleinert, H.3
  • 22
    • 33746005647 scopus 로고    scopus 로고
    • A central role of eNOS in the protective effect of wine against metabolic syndrome
    • DOI 10.1002/cbf.1269
    • Leighton F, Miranda-Rottmann S, Urquiaga I (2006) A central role of eNOS in the protective effect of wine against metabolic syndrome. Cell Biochem Funct 24:291-298 (Pubitemid 44065231)
    • (2006) Cell Biochemistry and Function , vol.24 , Issue.4 , pp. 291-298
    • Leighton, F.1    Miranda-Rottmann, S.2    Urquiaga, I.3
  • 24
    • 0031026488 scopus 로고    scopus 로고
    • Evidence that nitric oxide increases glucose transport in skeletal muscle
    • Balon TW, Nadler JL (1997) Evidence that nitric oxide increases glucose transport in skeletal muscle. J Appl Physiol 82:359-363 (Pubitemid 27052084)
    • (1997) Journal of Applied Physiology , vol.82 , Issue.1 , pp. 359-363
    • Balon, T.W.1    Nadler, J.L.2
  • 26
    • 16844382827 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling
    • Das A, Xi L, Kukreja RC (2005) Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. J Biol Chem 280:12944-12955
    • (2005) J Biol Chem , vol.280 , pp. 12944-12955
    • Das, A.1    Xi, L.2    Kukreja, R.C.3
  • 27
    • 5644304230 scopus 로고    scopus 로고
    • Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy
    • DOI 10.1159/000080104
    • Patil CS, Singh VP, Singh S (2004) Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy. Pharmacology 72:190-195 (Pubitemid 39370248)
    • (2004) Pharmacology , vol.72 , Issue.3 , pp. 190-195
    • Patil, C.S.1    Singh, V.P.2    Singh, S.3    Kulkarni, S.K.4
  • 28
    • 34547894200 scopus 로고    scopus 로고
    • Protective effect of endothelial nitric oxide synthase against induction of chemically-induced diabetes in mice
    • DOI 10.1016/j.niox.2007.06.001, PII S1089860307000602
    • Zhang J, Kawashima S, Yokoyama M, Huang P, Hill CE (2007) Protective effect of endothelial nitric oxide synthase against induction of chemically-induced diabetes in mice. Nitric oxide 17:69-74 (Pubitemid 47259728)
    • (2007) Nitric Oxide - Biology and Chemistry , vol.17 , Issue.2 , pp. 69-74
    • Zhang, J.1    Kawashima, S.2    Yokoyama, M.3    Huang, P.4    Hill, C.E.5
  • 29
    • 0031946009 scopus 로고    scopus 로고
    • Deciphering the apoptotic pathway: All roads lead to death
    • DOI 10.1046/j.1440-1711.1998.00712.x
    • Lincz LF (1998) Desiphering the apoptotic pathway: all roads lead to death. Immunol Cell Biol 76:1-19 (Pubitemid 28194692)
    • (1998) Immunology and Cell Biology , vol.76 , Issue.1 , pp. 1-19
    • Lincz, L.F.1
  • 30
    • 0028987251 scopus 로고
    • Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model
    • Finegood DT, Scaglia L, Bonner-Weir S (1995) Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44:249-256
    • (1995) Diabetes , vol.44 , pp. 249-256
    • Finegood, D.T.1    Scaglia, L.2    Bonner-Weir, S.3
  • 32
    • 24144490962 scopus 로고    scopus 로고
    • Exposure to chronic high glucose induces β-cell apoptosis through decreased interaction of glucokinase with mitochondria: Downregulation of glucokinase in pancreatic β-cells
    • DOI 10.2337/diabetes.54.9.2602
    • Kim WH, Lee JW, Suh YH, Hong SH, Choi JS, Lim JH, Song JH, Gao B, Jung MH (2005) Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells. Diabetes 54:2602-2611 (Pubitemid 41233581)
    • (2005) Diabetes , vol.54 , Issue.9 , pp. 2602-2611
    • Kim, W.-H.1    Lee, J.W.2    Suh, Y.H.3    Hong, S.H.4    Choi, J.S.5    Lim, J.H.6    Song, J.H.7    Gao, B.8    Jung, M.H.9
  • 33
    • 34249940271 scopus 로고    scopus 로고
    • Synthesis and electrochemistry of vanadium (IV) Schiff base complexes
    • Kianfar AH, Mohebbi S (2007) Synthesis and electrochemistry of vanadium (IV) Schiff base complexes. J Iran Chem Soc 4:215-220
    • (2007) J Iran Chem Soc , vol.4 , pp. 215-220
    • Kianfar, A.H.1    Mohebbi, S.2
  • 34
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • DOI 10.1016/0003-2697(79)90738-3
    • Okhawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissue by thiobarbituric reaction. Anal Biochem 95:351-358 (Pubitemid 9194347)
    • (1979) Analytical Biochemistry , vol.95 , Issue.2 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 35
    • 0031808543 scopus 로고    scopus 로고
    • Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes
    • Kakkar R, Mantha VS, Radhi J, Prasad K, Kalra J (1998) Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes. Clin Sci 94:623-632 (Pubitemid 28269062)
    • (1998) Clinical Science , vol.94 , Issue.6 , pp. 623-632
    • Kakkar, R.1    Mantha, S.V.2    Radhi, J.3    Prasad, K.4    Kalra, J.5
  • 36
    • 0028858064 scopus 로고
    • Lipid peroxidation and antioxidant enzyme activity in streptozotocin-induced Fischer rats
    • Kakkar R, Kalra J, Mantha SV, Prasad K (1995) Lipid peroxidation and antioxidant enzyme activity in streptozotocin-induced Fischer rats. Mol Cell Biochem 151:113-119
    • (1995) Mol Cell Biochem , vol.151 , pp. 113-119
    • Kakkar, R.1    Kalra, J.2    Mantha, S.V.3    Prasad, K.4
  • 37
    • 3242690674 scopus 로고    scopus 로고
    • Antioxidant activity of DHC-1 - A herbal formulation
    • DOI 10.1016/j.jep.2004.05.008, PII S0378874104002351
    • Balaraman R, Bafna PA, Kolhapure SA (2004) Antioxidant activity of DHC-1 - A herbal formulation. J Ethnopharmacol 94:135-141 (Pubitemid 38942845)
    • (2004) Journal of Ethnopharmacology , vol.94 , Issue.1 , pp. 135-141
    • Balaraman, R.1    Bafna, P.A.2    Kolhapure, S.A.3
  • 38
    • 0036200075 scopus 로고    scopus 로고
    • Metallothionein 2A expression is associated with cell proliferation in breast cancer
    • Jin R, Chow VT, Tan PH, Dheen ST, Duan W, Bay BH (2002) Metallothionein 2A expression is associated with cell proliferation in breast cancer. Carcinogenesis 23:81-86 (Pubitemid 34213555)
    • (2002) Carcinogenesis , vol.23 , Issue.1 , pp. 81-86
    • Jin, R.1    Chow, V.T.-K.2    Tan, P.-H.3    Thameem Dheen, S.4    Duan, W.5    Bay, B.-H.6
  • 39
    • 0001047585 scopus 로고    scopus 로고
    • Reactive oxygen species: Oxidative damage and pathogenesis
    • Bandyopadhyay U, Das D, Banerjee RK (1999) Reactive oxygen species: Oxidative damage and pathogenesis. Curr Sci 77:658-666 (Pubitemid 129558409)
    • (1999) Current Science , vol.77 , Issue.5 , pp. 658-666
    • Bandyopadhyay, U.1    Das, D.2    Banerjee, R.K.3
  • 40
    • 0034981339 scopus 로고    scopus 로고
    • Effects of isoeugenol on oxidative stress pathways in normal and streptozotocin-induced diabetic rats
    • DOI 10.1002/jbt.13
    • Rauscher FM, Ruth A, Watkins JB (2001) Effects of isoeugenol on oxidative stress pathways in normal and streptozotocin induced diabetic rats. J Biochem Mol Toxicol 15:159-164 (Pubitemid 32514750)
    • (2001) Journal of Biochemical and Molecular Toxicology , vol.15 , Issue.3 , pp. 159-164
    • Rauscher, F.M.1    Sanders, R.A.2    Watkins III, J.B.3
  • 41
    • 0025060803 scopus 로고
    • Insulin-mimetic effects of vanadate Possible implications for future treatment of diabetes
    • Schechter Y, Perspectives in diabetes (1990) Insulin-mimetic effects of vanadate Possible implications for future treatment of diabetes. Diabetes 39:5
    • (1990) Diabetes , vol.39 , pp. 5
    • Schechter, Y.1    In Diabetes, P.2
  • 43
    • 0034434893 scopus 로고    scopus 로고
    • Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin
    • DOI 10.1007/s001250051564
    • Eslnar M, Guldbakke B, Tiedge M, Munday R, Lenzen S (2000) Relative importance of transport and alkylation for pancreatic betacells toxicity of streptozotocin. Diabetologia 43:1528-1533 (Pubitemid 32734859)
    • (2000) Diabetologia , vol.43 , Issue.12 , pp. 1528-1533
    • Elsner, M.1    Guldbakke, B.2    Tiedge, M.3    Munday, R.4    Lenzen, S.5
  • 44
    • 0030755933 scopus 로고    scopus 로고
    • Partial preservation of pancreatic β-cells by vanadium: Evidence for long-term amelioration of diabetes
    • DOI 10.1016/S0026-0495(97)90121-9
    • Cam MC, Li WM, McNeill JH (1997) Partial preservation of pancreatic b-cells by vanadium: evidence for long-term amelioration of diabetes. Metabolism 46:769-778 (Pubitemid 27300619)
    • (1997) Metabolism: Clinical and Experimental , vol.46 , Issue.7 , pp. 769-778
    • Cam, M.C.1    Li, W.M.2    McNeill, J.H.3
  • 45
    • 0032699589 scopus 로고    scopus 로고
    • Distinct glucose lowering and beta cell protective effects of vanadium and food restriction in streptozotocin-diabetes
    • Cam MC, Rodrigues B, McNeill JH (1999) Distinct glucose lowering and beta cell protective effects of vanadium and food restriction in streptozotocin-diabetes. Eur J Endocrinol 141:546-554
    • (1999) Eur J Endocrinol , vol.141 , pp. 546-554
    • Cam, M.C.1    Rodrigues, B.2    McNeill, J.H.3
  • 46
    • 0029591908 scopus 로고
    • Hypolipidemic effect of water extract of Ficus bengalensis in alloxan induced diabetes mellitus in rabbits
    • Shukla R, Anand K, Prabhu KM, Murthy PS (1995) Hypolipidemic effect of water extract of Ficus bengalensis in alloxan induced diabetes mellitus in rabbits. Indian J Clin Biochem 10:119-121 (Pubitemid 26038409)
    • (1995) Indian Journal of Clinical Biochemistry , vol.10 , Issue.2 , pp. 119-121
    • Shukla, R.1    Anand, K.2    Prabhu, K.M.3    Murthy, P.S.4
  • 47
    • 0030832566 scopus 로고    scopus 로고
    • Antidiabetic and antihyperlipaemic effects of neem seed kernel powder on alloxan diabetic rabbits
    • Bopanna KN, Kannan J, Sushma G, Balaraman R, Rathod SP (1997) Antidiabetic and antihyperlipidemic effects of neem seed kernel powder on alloxan diabetic rabbits. Indian J Pharmacol 29:162-167 (Pubitemid 27296934)
    • (1997) Indian Journal of Pharmacology , vol.29 , Issue.3 , pp. 162-167
    • Bopanna, K.N.1    Kannan, J.2    Gadgil, S.3    Balaraman, R.4    Rathod, S.P.5
  • 48
    • 34247245847 scopus 로고    scopus 로고
    • Lipid disorders in diabetes mellitus and current management
    • DOI 10.2174/157341207779802386
    • Shen GX (2007) Lipid Disorders in Diabetes Mellitus and Current Management. Curr Pharm Anal 3:17-24 (Pubitemid 46605114)
    • (2007) Current Pharmaceutical Analysis , vol.3 , Issue.1 , pp. 17-24
    • Shen, G.X.1
  • 51
    • 0029559764 scopus 로고
    • Protective effect of vanadate on oxyradical-induced changes in isolated perfused heart
    • DOI 10.1007/BF01075921
    • Matsubara T, Marcu SM, Misra PH, Dhalla NS (1995) Protective effect of vanadate on oxyradicleinduced changes in isolated perfused heart. Mol Cell Biochem 153:79-85 (Pubitemid 26003369)
    • (1995) Molecular and Cellular Biochemistry , vol.153 , Issue.1-2 , pp. 79-85
    • Matsubara, T.1    Musat-Marcu, S.2    Misra, H.P.3    Dhalla, N.S.4
  • 52
    • 0031808543 scopus 로고    scopus 로고
    • Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes
    • Kakkar R, Mantha SV, Radhi J, Prasad K, Karla J (1998) Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes. Clin Sci 94:623-632 (Pubitemid 28269062)
    • (1998) Clinical Science , vol.94 , Issue.6 , pp. 623-632
    • Kakkar, R.1    Mantha, S.V.2    Radhi, J.3    Prasad, K.4    Kalra, J.5
  • 54
    • 0023576328 scopus 로고
    • Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment
    • Wohaieb AS, Godin DV (1987) Alterations in free radical tissue defence mechanism in streptozocin induced diabetes in rat. Diabetes 36:1014-1018 (Pubitemid 18088387)
    • (1987) Diabetes , vol.36 , Issue.9 , pp. 1014-1018
    • Wohaieb, S.A.1    Godin, D.V.2
  • 56
    • 0037341238 scopus 로고    scopus 로고
    • Glucose toxicity in β-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection
    • DOI 10.2337/diabetes.52.3.581
    • Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahasi H (2003) Glucose toxicity in β cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52:581-587 (Pubitemid 36323562)
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 581-587
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Tanaka, Y.4    Takahashi, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.