메뉴 건너뛰기




Volumn 340, Issue 1, 2012, Pages 11-18

Differential modulation of brainstem phosphatidylinositol 3-kinase/akt and extracellular signal-regulated kinase 1/2 signaling underlies WIN55,212-2 centrally mediated pressor response in conscious rats

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; WORTMANNIN;

EID: 84055223452     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.186858     Document Type: Article
Times cited : (20)

References (37)
  • 2
    • 60649109058 scopus 로고    scopus 로고
    • α2A-adrenergic receptor signaling underlies synergistic enhancement of ethanol-induced behavioral impairment by clonidine
    • Bender TS and Abdel-Rahman AA (2009) α2A-adrenergic receptor signaling underlies synergistic enhancement of ethanol-induced behavioral impairment by clonidine. Alcohol Clin Exp Res 33:408-418.
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 408-418
    • Bender, T.S.1    Abdel-Rahman, A.A.2
  • 3
    • 26844527851 scopus 로고    scopus 로고
    • Uptake blockade of endocannabinoids in the NTS modulates baroreflex-evoked sympathoinhibition
    • DOI 10.1016/j.brainres.2005.08.030, PII S0006899305012102
    • Brozoski DT, Dean C, Hopp FA, and Seagard JL (2005) Uptake blockade of endocannabinoids in the NTS modulates baroreflex-evoked sympathoinhibition. Brain Research 1059:197-202. (Pubitemid 41457318)
    • (2005) Brain Research , vol.1059 , Issue.2 , pp. 197-202
    • Brozoski, D.T.1    Dean, C.2    Hopp, F.A.3    Seagard, J.L.4
  • 4
    • 26844522807 scopus 로고    scopus 로고
    • NADPH oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla
    • DOI 10.1161/01.RES.0000185804.79157.C0
    • Chan SH, Hsu KS, Huang CC, Wang LL, Ou CC, and Chan JY (2005) NADPH oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla. Circ Res 97:772-780. (Pubitemid 41447127)
    • (2005) Circulation Research , vol.97 , Issue.8 , pp. 772-780
    • Chan, S.H.H.1    Hsu, K.-S.2    Huang, C.-C.3    Wang, L.-L.4    Ou, C.-C.5    Chan, J.Y.H.6
  • 5
    • 34548437629 scopus 로고    scopus 로고
    • Upregulation of AT1 receptor gene on activation of protein kinase C/nicotinamide adenine dinucleotide diphosphate oxidase/ERK1/2/c-fos signaling cascade mediates long-term pressor effect of angiotensin II in rostral ventrolateral medulla
    • DOI 10.1097/HJH.0b013e328217b286, PII 0000487220070900000015
    • Chan SH, Wang LL, Tseng HL, and Chan JY (2007) Up-regulation of AT1 receptor gene on activation of protein kinase C/nicotinamide adenine dinucleotide diphosphate oxidase/ERK1/2/c-fos signaling cascade mediates long-term pressor effect of angiotensin II in rostral ventrolateral medulla. J Hypertens 25:1845-1861. (Pubitemid 47356625)
    • (2007) Journal of Hypertension , vol.25 , Issue.9 , pp. 1845-1861
    • Chan, S.H.H.1    Wang, L.-L.2    Tseng, H.-L.3    Chan, J.Y.H.4
  • 6
    • 84859057169 scopus 로고    scopus 로고
    • CB1 cannabinoid receptors transactivate multiple receptor tyrosine kinases and regulate multiple serine/threonine kinases to achieve ERK activation in neuronal cells
    • Dalton GD and Howlett AC (2011) CB1 cannabinoid receptors transactivate multiple receptor tyrosine kinases and regulate multiple serine/threonine kinases to achieve ERK activation in neuronal cells. Br J Pharmacol http://dx.doi.org/10.1111/j.1476- 5381.2011.01455.x.
    • (2011) Br J Pharmacol
    • Dalton, G.D.1    Howlett, A.C.2
  • 8
    • 4644226099 scopus 로고    scopus 로고
    • Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein
    • DOI 10.1016/j.cellsig.2004.05.011, PII S0898656804001007
    • Ellert-Miklaszewska A, Kaminska B, and Konarska L (2005) Cannabinoids downregulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein. Cell Signal 17:25-37. (Pubitemid 39286777)
    • (2005) Cellular Signalling , vol.17 , Issue.1 , pp. 25-37
    • Ellert-Miklaszewska, A.1    Kaminska, B.2    Konarska, L.3
  • 9
    • 33846030175 scopus 로고    scopus 로고
    • Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function
    • DOI 10.1074/jbc.M602494200
    • Ellis J, Pediani JD, Canals M, Milasta S, and Milligan G (2006) Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. J Biol Chem 281:38812-38824. (Pubitemid 46042008)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.50 , pp. 38812-38824
    • Ellis, J.1    Pediani, J.D.2    Canals, M.3    Milasta, S.4    Milligan, G.5
  • 10
    • 0036893729 scopus 로고    scopus 로고
    • 1 cannabinoid receptor
    • DOI 10.1124/mol.62.6.1385
    • Galve-Roperh I, Rueda D, Gómez del Pulgar T, Velasco G, and Guzmán M (2002) Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor. Mol Pharmacol 62:1385-1392. (Pubitemid 35403833)
    • (2002) Molecular Pharmacology , vol.62 , Issue.6 , pp. 1385-1392
    • Galve-Roperh, I.1    Rueda, D.2    Del, P.T.G.3    Velasco, G.4    Guzman, M.5
  • 11
    • 35348910284 scopus 로고    scopus 로고
    • The cannabinoid &Delta9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells
    • Greenhough A, Patsos HA, Williams AC, and Paraskeva C (2007) The cannabinoid &Delta9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. Int J Cancer 121:2172-2180.
    • (2007) Int J Cancer , vol.121 , pp. 2172-2180
    • Greenhough, A.1    Patsos, H.A.2    Williams, A.C.3    Paraskeva, C.4
  • 12
    • 0038606535 scopus 로고    scopus 로고
    • Hypersensitization of the Orexin 1 receptor by the CB1 receptor: Evidence for cross-talk blocked by the specific CB1 antagonist, SR141716
    • Hilairet S, Bouaboula M, Carrière D, Le Fur G, and Casellas P (2003) Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716. J Biol Chem 278:23731-23737.
    • (2003) J Biol Chem , vol.278 , pp. 23731-23737
    • Hilairet, S.1    Bouaboula, M.2    Carrière, D.3    Le Fur, G.4    Casellas, P.5
  • 13
    • 6444220103 scopus 로고    scopus 로고
    • In situ Akt phosphorylation in the nucleus tractus solitarii is involved in central control of blood pressure and heart rate
    • DOI 10.1161/01.CIR.0000145116.75657.2D
    • Huang HN, Lu PJ, Lo WC, Lin CH, Hsiao M, and Tseng CJ (2004) In situ Akt phosphorylation in the nucleus tractus solitarii is involved in central control of blood pressure and heart rate. Circulation 110:2476-2483. (Pubitemid 39407356)
    • (2004) Circulation , vol.110 , Issue.16 , pp. 2476-2483
    • Huang, H.-N.1    Lu, P.-J.2    Lo, W.-C.3    Lin, C.-H.4    Hsiao, M.5    Tseng, C.-J.6
  • 14
    • 80052937941 scopus 로고    scopus 로고
    • Role of brainstem GABAergic signaling in central cannabinoid receptor evoked sympathoexcitation and pressor response in conscious rats
    • Ibrahim BM and Abdel-Rahman AA (2011) Role of brainstem GABAergic signaling in central cannabinoid receptor evoked sympathoexcitation and pressor response in conscious rats. Brain Res 1414:1-9.
    • (2011) Brain Res , vol.1414 , pp. 1-9
    • Ibrahim, B.M.1    Abdel-Rahman, A.A.2
  • 15
    • 0003633755 scopus 로고    scopus 로고
    • Institute of Laboratory Animal Resources 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC
    • Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
    • (1996) Guide for the Care and Use of Laboratory Animals
  • 16
    • 2542449375 scopus 로고    scopus 로고
    • Role of ERK and Rho kinase pathways in central pressor action of urotensin II
    • DOI 10.1097/00004872-200405000-00021
    • Lin Y, Matsumura K, Tsuchihashi T, Fukuhara M, Fujii K, and Iida M (2004) Role of ERK and Rho kinase pathways in central pressor action of urotensin II. J Hypertens 22:983-988. (Pubitemid 38680474)
    • (2004) Journal of Hypertension , vol.22 , Issue.5 , pp. 983-988
    • Lin, Y.1    Matsumura, K.2    Tsuchihashi, T.3    Fukuhara, M.4    Fujii, K.5    Iida, M.6
  • 17
    • 0037008883 scopus 로고    scopus 로고
    • Implications of phosphoinositide 3-kinase in the μ- and δ-opioid receptor-mediated supraspinal antinociception in the mouse
    • DOI 10.1016/S0306-4522(02)00197-5, PII S0306452202001975
    • Narita M, Ohnishi O, Nemoto M, Yajima Y, and Suzuki T (2002) Implications of phosphoinositide 3-kinase in the μ- and δ-opioid receptor-mediated supraspinal antinociception in the mouse. Neuroscience 113:647-652. (Pubitemid 34874688)
    • (2002) Neuroscience , vol.113 , Issue.3 , pp. 647-652
    • Narita, M.1    Ohnishi, O.2    Nemoto, M.3    Yajima, Y.4    Suzuki, T.5
  • 18
    • 33745266157 scopus 로고    scopus 로고
    • Central adenosine signaling plays a key role in centrally mediated hypotension in conscious aortic barodenervated rats
    • Nassar N and Abdel-Rahman AA (2006) Central adenosine signaling plays a key role in centrally mediated hypotension in conscious aortic barodenervated rats. J Pharmacol Exp Ther 318:255-261.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 255-261
    • Nassar, N.1    Abdel-Rahman, A.A.2
  • 19
    • 37349077519 scopus 로고    scopus 로고
    • 2A- dependent hypotensive action of clonidine in conscious aortic barodenervated rats
    • DOI 10.1124/jpet.107.129692
    • Nassar N and Abdel-Rahman AA (2008) Brainstem phosphorylated extracellular signal-regulated kinase 1/2-nitric-oxide synthase signaling mediates the adenosine A2A-dependent hypotensive action of clonidine in conscious aortic barodenervated rats. J Pharmacol Exp Ther 324:79-85. (Pubitemid 350294148)
    • (2008) Journal of Pharmacology and Experimental Therapeutics , vol.324 , Issue.1 , pp. 79-85
    • Nassar, N.1    Abdel-Rahman, A.A.2
  • 20
    • 80053143964 scopus 로고    scopus 로고
    • Enhanced hemeoxygenase activity in the rostral ventrolateral medulla mediates exaggerated hemin-evoked hypotension in the spontaneously hypertensive rat
    • Nassar NN, Li G, Strat AL, and Abdel-Rahman AA (2011) Enhanced hemeoxygenase activity in the rostral ventrolateral medulla mediates exaggerated hemin-evoked hypotension in the spontaneously hypertensive rat. J Pharmacol Exp Ther 339: 267-274.
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 267-274
    • Nassar, N.N.1    Li, G.2    Strat, A.L.3    Abdel-Rahman, A.A.4
  • 21
    • 0032929957 scopus 로고    scopus 로고
    • Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation
    • Niederhoffer N and Szabo B (1999) Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation. Br J Pharmacol 126:457-466.
    • (1999) Br J Pharmacol , vol.126 , pp. 457-466
    • Niederhoffer, N.1    Szabo, B.2
  • 22
    • 0033928782 scopus 로고    scopus 로고
    • Cannabinoids cause central sympathoexcitation and bradycardia in rabbits
    • Niederhoffer N and Szabo B (2000) Cannabinoids cause central sympathoexcitation and bradycardia in rabbits. J Pharmacol Exp Ther 294:707-713.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 707-713
    • Niederhoffer, N.1    Szabo, B.2
  • 23
    • 34547484379 scopus 로고    scopus 로고
    • Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain
    • DOI 10.1111/j.1471-4159.2007.04642.x
    • Ozaita A, Puighermanal E, and Maldonado R (2007) Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain. J Neurochem 102:1105-1114. (Pubitemid 47174245)
    • (2007) Journal of Neurochemistry , vol.102 , Issue.4 , pp. 1105-1114
    • Ozaita, A.1    Puighermanal, E.2    Maldonado, R.3
  • 24
    • 0141923030 scopus 로고    scopus 로고
    • Cannabinoid receptor activation in the rostral ventrolateral medulla oblongata evokes cardiorespiratory effects in anaesthetised rats
    • DOI 10.1038/sj.bjp.0705422
    • Padley JR, Li Q, Pilowsky PM, and Goodchild AK (2003) Cannabinoid receptor activation in the rostral ventrolateral medulla oblongata evokes cardiorespiratory effects in anaesthetised rats. Br J Pharmacol 140:384-394. (Pubitemid 37249199)
    • (2003) British Journal of Pharmacology , vol.140 , Issue.2 , pp. 384-394
    • Padley, J.R.1    Li, Q.2    Pilowsky, P.M.3    Goodchild, A.K.4
  • 26
    • 3843077611 scopus 로고    scopus 로고
    • Central effects of the cannabinoid receptor agonist WIN55212-2 on respiratory and cardiovascular regulation in anaesthetised rats
    • DOI 10.1038/sj.bjp.0705874
    • Pfitzer T, Niederhoffer N, and Szabo B (2004) Central effects of the cannabinoid receptor agonist WIN55212-2 on respiratory and cardiovascular regulation in anaesthetised rats. Br J Pharmacol 142:943-952. (Pubitemid 39037044)
    • (2004) British Journal of Pharmacology , vol.142 , Issue.6 , pp. 943-952
    • Pfitzer, T.1    Niederhoffer, N.2    Szabo, B.3
  • 28
    • 79958865842 scopus 로고    scopus 로고
    • AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II
    • Rozenfeld R, Gupta A, Gagnidze K, Lim MP, Gomes I, Lee-Ramos D, Nieto N, and Devi LA (2011) AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J 30:2350-2363.
    • (2011) EMBO J , vol.30 , pp. 2350-2363
    • Rozenfeld, R.1    Gupta, A.2    Gagnidze, K.3    Lim, M.P.4    Gomes, I.5    Lee-Ramos, D.6    Nieto, N.7    Devi, L.A.8
  • 29
    • 17144470224 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-kinase/PKB pathway by CB1 and CB2 cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction
    • Sánchez MG, Ruiz-Llorente L, Sánchez AM, and Díaz-Laviada I (2003) Activation of phosphoinositide 3-kinase/PKB pathway by CB1 and CB2 cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cell Signal 15:851-859.
    • (2003) Cell Signal , vol.15 , pp. 851-859
    • Sánchez, M.G.1    Ruiz-Llorente, L.2    Sánchez, A.M.3    Díaz-Laviada, I.4
  • 31
    • 19344369593 scopus 로고    scopus 로고
    • Effects of endocannabinoids on discharge of baroreceptive NTS neurons
    • DOI 10.1016/j.neulet.2005.02.044, PII S0304394005002260
    • Seagard JL, Hopp FA, Hillard CJ, and Dean C (2005) Effects of endocannabinoids on discharge of baroreceptive NTS neurons. Neurosci Lett 381:334-339. (Pubitemid 40719182)
    • (2005) Neuroscience Letters , vol.381 , Issue.3 , pp. 334-339
    • Seagard, J.L.1    Hopp, F.A.2    Hillard, C.J.3    Dean, C.4
  • 32
    • 0035726046 scopus 로고    scopus 로고
    • Differential role of kinases in brain stem of hypertensive and normotensive rats
    • Seyedabadi M, Goodchild AK, and Pilowsky PM (2001) Differential role of kinases in brain stem of hypertensive and normotensive rats. Hypertension 38:1087-1092. (Pubitemid 34252810)
    • (2001) Hypertension , vol.38 , Issue.5 , pp. 1087-1092
    • Seyedabadi, M.1    Goodchild, A.K.2    Pilowsky, P.M.3
  • 33
    • 0034889428 scopus 로고    scopus 로고
    • Δ9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission
    • DOI 10.1046/j.0953-816X.2001.01652.x
    • Valjent E, Pagès C, Rogard M, Besson MJ, Maldonado R, and Caboche J (2001) Δ9-Tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission. Eur J Neurosci 14:342-352. (Pubitemid 32777639)
    • (2001) European Journal of Neuroscience , vol.14 , Issue.2 , pp. 342-352
    • Valjent, E.1    Pages, C.2    Rogard, M.3    Besson, M.-J.4    Maldonado, R.5    Caboche, J.6
  • 34
    • 14044262910 scopus 로고    scopus 로고
    • Increased PI3-kinase in presympathetic brain areas of the spontaneously hypertensive rat
    • DOI 10.1161/01.RES.0000156275.06641.b2
    • Veerasingham SJ, Yamazato M, Berecek KH, Wyss JM, and Raizada MK (2005) Increased PI3-kinase in presympathetic brain areas of the spontaneously hypertensive rat. Circ Res 96:277-279. (Pubitemid 40279901)
    • (2005) Circulation Research , vol.96 , Issue.3 , pp. 277-279
    • Veerasingham, S.J.1    Yamazato, M.2    Berecek, K.H.3    Wyss, J.M.4    Raizada, M.K.5
  • 35
    • 0037523369 scopus 로고    scopus 로고
    • Control of synaptic strength, a novel function of Akt
    • DOI 10.1016/S0896-6273(03)00356-8
    • Wang Q, Liu L, Pei L, Ju W, Ahmadian G, Lu J, Wang Y, Liu F, and Wang YT (2003) Control of synaptic strength, a novel function of Akt. Neuron 38:915-928. (Pubitemid 36782383)
    • (2003) Neuron , vol.38 , Issue.6 , pp. 915-928
    • Wang, Q.1    Liu, L.2    Pei, L.3    Ju, W.4    Ahmadian, G.5    Lu, J.6    Wang, Y.7    Liu, F.8    Wang, Y.T.9
  • 36
    • 23944442034 scopus 로고    scopus 로고
    • 1)-receptor- mediated hypotension
    • DOI 10.1124/jpet.105.087510
    • Zhang J and Abdel-Rahman AA (2005) Mitogen-activated protein kinase phosphorylation in the rostral ventrolateral medulla plays a key role in imidazoline (i1)- receptor-mediated hypotension. J Pharmacol Exp Ther 314:945-952. (Pubitemid 41205956)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.314 , Issue.3 , pp. 945-952
    • Zhang, J.1    Abdel-Rahman, A.A.2
  • 37
    • 58149390142 scopus 로고    scopus 로고
    • Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat
    • Zubcevic J, Waki H, Diez-Freire C, Gampel A, Raizada MK, and Paton JF (2009) Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat. Hypertension 53:97-103.
    • (2009) Hypertension , vol.53 , pp. 97-103
    • Zubcevic, J.1    Waki, H.2    Diez-Freire, C.3    Gampel, A.4    Raizada, M.K.5    Paton, J.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.