Brainstem phosphorylated extracellular signal-regulated kinase 1/2-nitric-oxide synthase signaling mediates the adenosine A2A- dependent hypotensive action of clonidine in conscious aortic barodenervated rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 1, 2008, Pages 79-85

  Nassar, Noha ^a   Abdel Rahman, Abdel A ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A2A RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; CLONIDINE; IMIDAZOLINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DENERVATION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; HYPOTENSION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA, ABDOMINAL; CLONIDINE; DENERVATION; HYPOTENSION; IMIDAZOLINE RECEPTORS; MALE; MEDULLA OBLONGATA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A2A; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 37349077519     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.129692     Document Type: Article

References (24)

1. Abdel-Rahman AA (1992) Aortic baroreceptors exert a tonically active restraining influence on centrally mediated depressor responses. J Cardiovasc Pharmacol 19:233-245.
2. Chan SH, Wang LL, Wang SH, and Chan JY (2001) Differential cardiovascular responses to blockade of nNOS or iNOS in rostral ventrolateral medulla of the rat. Br J Pharmacol 133:606-614.
3. el-Mas MM and Abdel-Rahman AA (1995) Upregulation of imidazoline receptors in the medulla oblongata accounts for the enhanced hypotensive effect of clonidine in aortic barodenervated rats. Brain Res 691:195-204.
4. El-Mas MM and Abdel-Rahman AA (1997) Aortic barodenervation up-regulates alpha2-adrenoceptors in the nucleus tractus solitarius and rostral ventrolateral medulla: an autoradiographic study. Neuroscience 79:581-590.
5. Gerfen CR (1997) Basic neuroanatomical methods, in Current Protocols in Neuroscience (Crawely JN, Grefen CR, Rogawski MA, Sibley DR, Skolnick P, and Wray S eds) pp 1.1.1-1.1.11, John Wiley & Sons, Inc., New York.
6. Granata AR, Ruggiero DA, Park DH, Joh TH, and Reis DJ (1985) Brain stem area with C1 epinephrine neurons mediates baroreflex vasodepressor responses. Am J Physiol Heart Circ Physiol 248:H547-H567.
7. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
8. Moreira TS, Takakura AC, Menani JV, Sato MA, and Colombari E (2004) Central blockade of nitric oxide synthesis reduces moxonidine-induced hypotension. Br J Pharmacol 142:765-771.
9. Nassar N and Abdel-Rahman AA (2005) Central A1 receptor blockade unmasks clonidine hypotension. Experimental Biology and XXXV International Congress of Physiological Sciences. 2005 Mar 31-Apr 5. Abstract 87.3, FASEB, Bethesda, MD.
10. Nassar N and Abdel-Rahman AA (2006a) Central adenosine signaling plays a key role in centrally mediated hypotension in conscious aortic-barodenervated rats. J Pharmacol Exp Ther 318:255-261.
11. Nassar N and Abdel-Rahman AA (2006b) Enhanced A2A and reduced A1 adenosine receptor signaling in the aortic barodenervated rat, in Society for Neuroscience 36th Annual Meeting; 2006 Oct 14-18; Atlanta, GA.
12. Osborn JW and England SK (1990) Normalization of arterial pressure after barodenervation: role of pressure natriuresis. Am J Physiol Regul Integr Comp Physiol 259:R1172-R1180.
13. Paxions G and Watson C (1982) The Rat Brain in Stereotaxic Coordinates, Academic Press, New York.
14. Schulte G, and Fredholm BB (2003) Signalling from adenosine receptors to mitogenactivated protein kinases. Cell Signal 195:813-827.
15. Scislo TJ and O'Leary DS (2005) Purinergic mechanisms of the nucleus of the solitary tract and neural cardiovascular control. Neurol Res 27:182-194.
16. Seyedabadi M, Goodchild AK, and Pilowsky PM (2001) Differential role of kinases in brain stem of hypertensive and normotensive rats. Hypertension 38:1087-1092.
17. Springell DA, Costin NS, Pilowsky PM, and Goodchild AK (2005) Hypotension and short-term anaesthesia induce ERK1/2 phosphorylation in autonomic nuclei of the brainstem. Eur J Neurosci 22:2257-2270.
18. Szabo B (2002) Imidazoline antihypertensive drugs: a critical review on their mechanism of action. Pharmacol Ther 93:1-35.
19. Szabo B, Bock C, Nordheim U, and Niederhoffer N (1999) Mechanism of the sympathoinhibition produced by the clonidine-like drugs rilmenidine and moxonidine. Ann N Y Acad Sci 881:253-264.
20. Thomas T, St Lambert JH, Dashwood MR, and Spyer KM (2000) Localization and action of adenosine A2a receptors in regions of the brainstem important in cardiovascular control. Neuroscience 95:513-518.
21. Vásquez G, Sanhueza F, Vasquez R, Gonzalez M, San Martin R, Casanello P, and Sobrevia L (2004) Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium. J Physiol 560:111-122.
22. Wyatt AW, Steinert JR, Wheeler-Jones CP, Morgan AJ, Sugden D, Pearson JD, Sobrevia L, and Mann GE (2002) Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism. FASEB J 16:1584-1594.
23. Zhang J and Abdel-Rahman AA (2005) Mitogen-activated protein kinase phosphorylation in the rostral ventrolateral medulla plays a key role in imidazoline (i1)-receptor-mediated hypotension. J Pharmacol Exp Ther 314:945-952.
24. Zhang J, El-Mas MM, and Abdel-Rahman AA (2001) Imidazoline I(1) receptorinduced activation of phosphatidylcholine-specific phospholipase C elicits mitogenactivated protein kinase phosphorylation in PC12 cells. Eur J Pharmacol 415:117-125.