ERK/MAPK pathway regulates GABAA receptors

Journal of Neurobiology

Volumn 66, Issue 13, 2006, Pages 1467-1474

  Bell Horner, Cathy L ^a   Dohi, Akiko ^a   Nguyen, Quynh ^a   Dillon, Glenn H ^a   Singh, Meharvan ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

ERK; GABA; GABAA receptor; MAPK; Phosphorylation

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ION CHANNEL; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEIN KINASE; RECEPTOR SUBUNIT; UO 126;

ALPHA CHAIN; ARTICLE; BETA CHAIN; CELL STRAIN HEK293; CHANNEL GATING; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; ENZYME INHIBITORS; HUMANS; MEMBRANE POTENTIALS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTAGENESIS; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 33750803944     PISSN: 00223034     EISSN: 10974695     Source Type: Journal    
DOI: 10.1002/neu.20327     Document Type: Article

References (46)

1. Adams JP, Sweatt JD. 2002. Molecular psychology: Roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol 42:135-163.
2. Alsbo CW, Kristiansen U, Moller F, Hansen SL, Johansen FF. 2001. GABAA receptor subunit interactions important for benzodiazepine and zinc modulation: A patch-clamp and single cell RT-PCR study. Eur J Neurosci 13:1673-1682.
3. Brandon N, Jovanovic J, Moss S. 2002. Multiple roles of protein kinases in the modulation of γ-aminobutyric acid(A) receptor function and cell surface expression. Pharmacol Ther 94:113-122.
4. Browning MD, Bureau M, Dudek EM, Olsen RW. 1990. Protein kinase C and cAMP-dependent protein kinase phosphorylate the γ subunit of the purified γ-aminobutyric acid A receptor. Proc Natl Acad Sci USA 87:1315-1318.
5. Chang Y, Wang R, Barot S, Weiss DS. 1996. Stoichiometry of a recombinant GABAA receptor. J Neurosci 16:5415-5424.
6. Chen C, Okayama H. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752.
7. Churn SB, DeLorenzo RJ. 1998. Modulation of GABAergic receptor binding by activation of calcium and calmodulin-dependent kinase II membrane phosphorylation. Brain Res 809:68-76.
8. Churn SB, Rana A, Lee K, Parsons JT, De Bias A, Delorenzo RJ. 2002. Calcium/calmodulin-dependent kinase II phosphorylation of the GABAA receptor α1 subunit modulates benzodiazepine binding. J Neurochem 82: 1065-1076.
9. Creedon DJ, Johnson EM, Lawrence JC. 1996. Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival. J Biol Chem 271:20713-20718.
10. Davis RJ. 1995. Transcriptional regulation by MAP kinases. Mol Reprod Dev 42:459-467.
11. Dunne EL, Moss SJ, Smart TG. 1998. Inhibition of GABAA receptor function by tyrosine kinase inhibitors and their inactive analogues. Mol Cell Neurosci 12:300-310.
12. Hamilton BJ, Lennon DJ, Im HK, Im WB, Seeburg PH, Carter DB. 1993. Stable expression of cloned rat GABAA receptor subunits in a human kidney cell line. Neurosci Lett 153:206-209.
13. Herring D, Huang R, Singh M, Dillon GH, Leidenheimer NJ. 2005. PKC modulation of GABAA receptor endocytosis and function is inhibited by mutation of a dileucine motif within the receptor β 2 subunit. Neuropharmacology 48:181-194.
14. Herring D, Huang R, Singh M, Robinson LC, Dillon GH, Leidenheimer NJ. 2003. Constitutive GABAA receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the β 2 subunit of the receptor. J Biol Chem 278:24046-24052.
15. A receptors: Mechanism and site of action. J Pharmacol Exp Ther 298:986-995.
16. Huang RQ, Dillon GH. 1998. Maintenance of recombinant type A γ-aminobutyric acid receptor function: Role of protein tyrosine phosphorylation and calcineurin. J Pharmacol Exp Ther 286:243-255.
17. Huang RQ, Dillon GH. 1999. Effect of extracellular pH on GABA-activated current in rat recombinant receptors and thin hypothalamic slices. J Neurophysiol 82:1233-1243.
18. Huang RQ, Fang MJ, Dillon GH. 1999. The tyrosine kinase inhibitor genistein directly inhibits GABAA receptors. Brain Res Mol Brain Res 67:177-183.
19. Kapur J, Macdonald RL. 1996. Cyclic AMP-dependent protein kinase enhances hippocampal dentate granule cell GABAA receptor currents. J Neurophysiol 76:2626-2634.
20. Kirkness EF, Bovenkerk CF, Ueda T, Turner AJ. 1989. Phosphorylation of γ-aminobutyrate (GABA)/benzodiazepine receptors by cyclic AMP-dependent protein kinase. Biochem J 259:613-616.
21. Klesse LJ, Meyers KA, Marshall CJ, Parada LF. 1999. Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. Oncogene 18:2055-2068.
22. Lin YF, Angelotti TP, Dudek EM, Browning MD, Macdonald RL. 1996. Enhancement of recombinant α 1 β 1 γ 2L γ-aminobutyric acid A receptor whole-cell currents by protein kinase C is mediated through phosphorylation of both β 1 and γ 2L subunits. Mol Pharmacol 50:185-195.
23. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
24. Marshall CJ. 1994. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr Opin Genet Dev 4:82-89.
25. McDonald BJ, Amato A, Connolly CN, Benke D, Moss SJ, Smart TG. 1998. Adjacent phosphorylation sites on GABAA receptor β subunits determine regulation by cAMP-dependent protein kinase. Nat Neurosci 1:23-28.
26. McDonald BJ, Moss SJ. 1994. Differential phosphorylation of intracellular domains of γ-aminobutyric acid type A receptor subunits by calcium/calmodulin type 2-dependent protein kinase and cGMP-dependent protein kinase. J Biol Chem 269:18111-18117.
27. McDonald BJ, Moss SJ. 1997. Conserved phosphorylation of the intracellular domains of GABA(A) receptor β2 and β3 subunits by cAMP-dependent protein kinase, cGMP-dependent protein kinase protein kinase C and Ca2+/calmodulin type II-dependent protein kinase. Neuropharmacology 36:1377-1385.
28. Moss SJ, Doherty CA, Huganir RL. 1992. Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the β 1, γ 2S, and γ 2L subunits of the γ-aminobutyric acid type A receptor. J Biol Chem 267:14470-14476.
29. Moss SJ, Gorrie GH, Amato A, Smart TG. 1995. Modulation of GABAA receptors by tyrosine phosphorylation. Nature 377:344-348.
30. Moss SJ, Smart TG. 1996. Modulation of amino acid-gated ion channels by protein phosphorylation. Int Rev Neurobiol 39:1-52.
31. Rane SG. 1999. Ion channels as physiological effectors for growth factor receptor and Ras/ERK signaling pathways. Adv Second Messenger Phosphoprotein Res 33:107-127.
32. Schrader LA, Birnbaum SG, Nadin BM, Ren Y, Bui D, Anderson AE, Sweatt JD. 2006. ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit. Am J Physiol Cell Physiol 290:C852-C861.
33. Seger R, Krebs EG. 1995. The MAPK signaling cascade. FASEB J 9:726-735.
34. Sgambato V, Pages C, Rogard M, Besson MJ, Caboche J. 1998. Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation. J Neurosci 18:8814-8825.
35. Singer CA, Rogers KL, Strickland TM, Dorsa DM. 1996. Estrogen protects primary cortical neurons from glutamate toxicity. Neurosci Lett 212:13-16.
36. Singh M, Setalo G Jr, Guan X, Warren M, Toran-Allerand C. 1999. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: Convergence of estrogen and neurotrophin signaling pathways. J Neurosci 19:1179-1188.
37. Szeberenyi J. 1996. Gene activation pathways of nerve growth factor signaling: A minireview. Neurobiology (Bp) 4:1-11.
38. Szeberenyi J, Erhardt P. 1994. Cellular components of nerve growth factor signaling. Biochim Biophys Acta 1222:187-202.
39. Thiels E, Klann E. 2001. Extracellular signal-regulated kinase, synaptic plasticity, and memory. Rev Neurosci 12:327-345.
40. Valenzuela CF, Machu TK, McKernan RM, Whiting P, VanRenterghem BB, McManaman JL, Brozowski SJ, et al. 1995. Tyrosine kinase phosphorylation of GABAA receptors. Brain Res Mol Brain Res 31:165-172.
41. Vanhoutte P, Barnier JV, Guibert B, Pages C, Besson MJ, Hipskind RA, Caboche J. 1999. Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices. Mol Cell Biol 19:136-146.
42. Wexler EM, Stanton PK, Nawy S. 1998. Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase. J Neurosci 18:2342-2349.
43. Whitmarsh AJ, Shore P, Sharrocks AD, Davis RJ. 1995. Integration of MAP kinase signal transduction pathways at the serum response element. Science 269:403-407.
44. Wisden W, Seeburg PH. 1992. GABAA receptor channels: From subunits to functional entities. Curr Opin Neurobiol 2:263-269.
45. Xing J, Kornhauser JM, Xia Z, Thiele EA, Greenberg ME. 1998. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol Cell Biol 18:1946-1955.
46. Yan CYI, Greene LA. 1998. Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. J Neurosci 18:4042-4049.