메뉴 건너뛰기




Volumn 13, Issue 1, 2012, Pages 27-42

Platelet activation in obesity and metabolic syndrome

Author keywords

Atherothrombosis; Metabolic syndrome; Obesity; Platelets

Indexed keywords

ACETYLSALICYLIC ACID; ADIPONECTIN; AMYLOID PRECURSOR PROTEIN; ANTIOBESITY AGENT; ARACHIDONATE 5 LIPOXYGENASE; CD36 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR2; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; LEPTIN; MYELOPEROXIDASE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PADGEM PROTEIN; SCAVENGER RECEPTOR BI; STROMAL CELL DERIVED FACTOR 1; THROMBOXANE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 83855165740     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/j.1467-789X.2011.00930.x     Document Type: Review
Times cited : (197)

References (157)
  • 1
    • 74549140993 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2008
    • Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010; 303: 235-241.
    • (2010) JAMA , vol.303 , pp. 235-241
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Curtin, L.R.4
  • 3
    • 79751531393 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2011 update: a report from the American Heart Association
    • Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM etal. Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation 2011; 123: e18-e209.
    • (2011) Circulation , vol.123
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3    Adams, R.J.4    Berry, J.D.5    Brown, T.M.6
  • 4
    • 74949084667 scopus 로고    scopus 로고
    • Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men
    • Arnlov J, Ingelsson E, Sundstrom J, Lind L. Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation 2010; 121: 230-236.
    • (2010) Circulation , vol.121 , pp. 230-236
    • Arnlov, J.1    Ingelsson, E.2    Sundstrom, J.3    Lind, L.4
  • 6
    • 33845914986 scopus 로고    scopus 로고
    • Mechanisms linking obesity with cardiovascular disease
    • Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006; 444: 875-880.
    • (2006) Nature , vol.444 , pp. 875-880
    • Van Gaal, L.F.1    Mertens, I.L.2    De Block, C.E.3
  • 7
    • 33947430960 scopus 로고    scopus 로고
    • Endocrine functions of adipose tissue
    • Waki H, Tontonoz P. Endocrine functions of adipose tissue. Annu Rev Pathol 2007; 2: 31-56.
    • (2007) Annu Rev Pathol , vol.2 , pp. 31-56
    • Waki, H.1    Tontonoz, P.2
  • 9
    • 0036322988 scopus 로고    scopus 로고
    • Obesity, haemostasis and the fibrinolytic system
    • Mertens I, Van Gaal LF. Obesity, haemostasis and the fibrinolytic system. Obes Rev 2002; 3: 85-101.
    • (2002) Obes Rev , vol.3 , pp. 85-101
    • Mertens, I.1    Van Gaal, L.F.2
  • 11
    • 0029888976 scopus 로고    scopus 로고
    • Platelet size: measurement, physiology and vascular disease
    • Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157-161.
    • (1996) Blood Coagul Fibrinolysis , vol.7 , pp. 157-161
    • Bath, P.M.1    Butterworth, R.J.2
  • 12
    • 70349260634 scopus 로고    scopus 로고
    • The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases
    • Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2009; 63: 1509-1515.
    • (2009) Int J Clin Pract , vol.63 , pp. 1509-1515
    • Vizioli, L.1    Muscari, S.2    Muscari, A.3
  • 14
    • 34248379443 scopus 로고    scopus 로고
    • The effect of weight loss on the mean platelet volume in obese patients
    • Coban E, Yilmaz A, Sari R. The effect of weight loss on the mean platelet volume in obese patients. Platelets 2007; 18: 212-216.
    • (2007) Platelets , vol.18 , pp. 212-216
    • Coban, E.1    Yilmaz, A.2    Sari, R.3
  • 15
    • 34248571463 scopus 로고    scopus 로고
    • Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease
    • Tavil Y, Sen N, Yazici HU, Hizal F, Abaci A, Cengel A. Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thromb Res 2007; 120: 245-250.
    • (2007) Thromb Res , vol.120 , pp. 245-250
    • Tavil, Y.1    Sen, N.2    Yazici, H.U.3    Hizal, F.4    Abaci, A.5    Cengel, A.6
  • 16
    • 77958526376 scopus 로고    scopus 로고
    • Mean platelet volume in obese adolescents with nonalcoholic fatty liver disease
    • Arslan N, Makay B. Mean platelet volume in obese adolescents with nonalcoholic fatty liver disease. J Pediatr Endocrinol Metab 2010; 23: 807-813.
    • (2010) J Pediatr Endocrinol Metab , vol.23 , pp. 807-813
    • Arslan, N.1    Makay, B.2
  • 17
    • 75449101587 scopus 로고    scopus 로고
    • Mean platelet volume in patients with non-alcoholic fatty liver disease
    • Ozhan H, Aydin M, Yazici M, Yazgan O, Basar C, Gungor A etal. Mean platelet volume in patients with non-alcoholic fatty liver disease. Platelets 2010; 21: 29-32.
    • (2010) Platelets , vol.21 , pp. 29-32
    • Ozhan, H.1    Aydin, M.2    Yazici, M.3    Yazgan, O.4    Basar, C.5    Gungor, A.6
  • 18
    • 0025647249 scopus 로고
    • Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: possible implication of IL-6
    • Kimura H, Ishibashi T, Shikama Y, Okano A, Akiyama Y, Uchida T etal. Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: possible implication of IL-6. Blood 1990; 76: 2493-2500.
    • (1990) Blood , vol.76 , pp. 2493-2500
    • Kimura, H.1    Ishibashi, T.2    Shikama, Y.3    Okano, A.4    Akiyama, Y.5    Uchida, T.6
  • 20
    • 34247574729 scopus 로고    scopus 로고
    • Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin
    • Guthikonda S, Lev EI, Patel R, DeLao T, Bergeron AL, Dong JF etal. Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin. J Thromb Haemost 2007; 5: 490-496.
    • (2007) J Thromb Haemost , vol.5 , pp. 490-496
    • Guthikonda, S.1    Lev, E.I.2    Patel, R.3    DeLao, T.4    Bergeron, A.L.5    Dong, J.F.6
  • 22
    • 78751500186 scopus 로고    scopus 로고
    • P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance
    • Sato C, Shikata K, Hirota D, Sasaki M, Nishishita S, Miyamoto S etal. P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance. Diabetes 2011; 60: 189-199.
    • (2011) Diabetes , vol.60 , pp. 189-199
    • Sato, C.1    Shikata, K.2    Hirota, D.3    Sasaki, M.4    Nishishita, S.5    Miyamoto, S.6
  • 24
    • 33646496156 scopus 로고    scopus 로고
    • Enhanced soluble CD40L in patients with the metabolic syndrome: relationship with in vivo thrombin generation
    • Angelico F, Alessandri C, Ferro D, Pignatelli P, Del Ben M, Fiorello S etal. Enhanced soluble CD40L in patients with the metabolic syndrome: relationship with in vivo thrombin generation. Diabetologia 2006; 49: 1169-1174.
    • (2006) Diabetologia , vol.49 , pp. 1169-1174
    • Angelico, F.1    Alessandri, C.2    Ferro, D.3    Pignatelli, P.4    Del Ben, M.5    Fiorello, S.6
  • 25
    • 0035883087 scopus 로고    scopus 로고
    • The inflammatory action of CD40 ligand (CD154) expressed on activated human platelets is temporally limited by coexpressed CD40
    • Henn V, Steinbach S, Buchner K, Presek P, Kroczek RA. The inflammatory action of CD40 ligand (CD154) expressed on activated human platelets is temporally limited by coexpressed CD40. Blood 2001; 98: 1047-1054.
    • (2001) Blood , vol.98 , pp. 1047-1054
    • Henn, V.1    Steinbach, S.2    Buchner, K.3    Presek, P.4    Kroczek, R.A.5
  • 27
    • 67349103904 scopus 로고    scopus 로고
    • The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes
    • Poggi M, Jager J, Paulmyer-Lacroix O, Peiretti F, Gremeaux T, Verdier M etal. The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes. Diabetologia 2009; 52: 1152-1163.
    • (2009) Diabetologia , vol.52 , pp. 1152-1163
    • Poggi, M.1    Jager, J.2    Paulmyer-Lacroix, O.3    Peiretti, F.4    Gremeaux, T.5    Verdier, M.6
  • 28
    • 77952013973 scopus 로고    scopus 로고
    • CD40L induces inflammation and adipogenesis in adipose cells - a potential link between metabolic and cardiovascular disease
    • Missiou A, Wolf D, Platzer I, Ernst S, Walter C, Rudolf P etal. CD40L induces inflammation and adipogenesis in adipose cells - a potential link between metabolic and cardiovascular disease. Thromb Haemost 2010; 103: 788-796.
    • (2010) Thromb Haemost , vol.103 , pp. 788-796
    • Missiou, A.1    Wolf, D.2    Platzer, I.3    Ernst, S.4    Walter, C.5    Rudolf, P.6
  • 29
    • 0032128299 scopus 로고    scopus 로고
    • Modulation of monocyte-endothelial cell interactions by platelet microparticles
    • Barry OP, Pratico D, Savani RC, FitzGerald GA. Modulation of monocyte-endothelial cell interactions by platelet microparticles. J Clin Invest 1998; 102: 136-144.
    • (1998) J Clin Invest , vol.102 , pp. 136-144
    • Barry, O.P.1    Pratico, D.2    Savani, R.C.3    FitzGerald, G.A.4
  • 30
    • 42649132508 scopus 로고    scopus 로고
    • Patients with metabolic syndrome exhibit higher platelet activity than those with conventional risk factors for vascular disease
    • Serebruany VL, Malinin A, Ong S, Atar D. Patients with metabolic syndrome exhibit higher platelet activity than those with conventional risk factors for vascular disease. J Thromb Thrombolysis 2008; 25: 207-213.
    • (2008) J Thromb Thrombolysis , vol.25 , pp. 207-213
    • Serebruany, V.L.1    Malinin, A.2    Ong, S.3    Atar, D.4
  • 31
    • 33750842744 scopus 로고    scopus 로고
    • Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity
    • Murakami T, Horigome H, Tanaka K, Nakata Y, Ohkawara K, Katayama Y etal. Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity. Thromb Res 2007; 119: 45-53.
    • (2007) Thromb Res , vol.119 , pp. 45-53
    • Murakami, T.1    Horigome, H.2    Tanaka, K.3    Nakata, Y.4    Ohkawara, K.5    Katayama, Y.6
  • 32
  • 34
    • 15044352193 scopus 로고    scopus 로고
    • Isoprostane formation and inhibition in atherothrombosis
    • Patrono C, Falco A, Davì G. Isoprostane formation and inhibition in atherothrombosis. Curr Opin Pharmacol 2005; 5: 198-203.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 198-203
    • Patrono, C.1    Falco, A.2    Davì, G.3
  • 36
    • 0033505398 scopus 로고    scopus 로고
    • Determinants of enhanced thromboxane biosynthesis in patients with systemic lupus erythematosus
    • Ferro D, Basili S, Roccaforte S, Di Franco M, Cipollone F, Ciabattoni G etal. Determinants of enhanced thromboxane biosynthesis in patients with systemic lupus erythematosus. Arthritis Rheum 1999; 42: 2689-2697.
    • (1999) Arthritis Rheum , vol.42 , pp. 2689-2697
    • Ferro, D.1    Basili, S.2    Roccaforte, S.3    Di Franco, M.4    Cipollone, F.5    Ciabattoni, G.6
  • 37
    • 37249068049 scopus 로고    scopus 로고
    • Platelet activation and atherothrombosis
    • Davì G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357: 2482-2494.
    • (2007) N Engl J Med , vol.357 , pp. 2482-2494
    • Davì, G.1    Patrono, C.2
  • 39
    • 33846118743 scopus 로고    scopus 로고
    • Platelets as immune cells: bridging inflammation and cardiovascular disease
    • von Hundelshausen P, Weber C. Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res 2007; 100: 27-40.
    • (2007) Circ Res , vol.100 , pp. 27-40
    • von Hundelshausen, P.1    Weber, C.2
  • 40
    • 77952673125 scopus 로고    scopus 로고
    • Correlation and association of plasma interleukin-6 and plasma platelet-derived microparticles, markers of activated platelets, in healthy individuals
    • Ueba T, Nomura S, Inami N, Nishikawa T, Kajiwara M, Iwata R etal. Correlation and association of plasma interleukin-6 and plasma platelet-derived microparticles, markers of activated platelets, in healthy individuals. Thromb Res 2010; 125: e329-e334.
    • (2010) Thromb Res , vol.125
    • Ueba, T.1    Nomura, S.2    Inami, N.3    Nishikawa, T.4    Kajiwara, M.5    Iwata, R.6
  • 41
    • 68949149210 scopus 로고    scopus 로고
    • Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study
    • Jylhava J, Haarala A, Eklund C, Pertovaara M, Kahonen M, Hutri-Kahonen N etal. Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study. J Intern Med 2009; 266: 286-295.
    • (2009) J Intern Med , vol.266 , pp. 286-295
    • Jylhava, J.1    Haarala, A.2    Eklund, C.3    Pertovaara, M.4    Kahonen, M.5    Hutri-Kahonen, N.6
  • 43
    • 58049219012 scopus 로고    scopus 로고
    • Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
    • Hajer GR, van Haeften TW, Visseren FL. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 2008; 29: 2959-2971.
    • (2008) Eur Heart J , vol.29 , pp. 2959-2971
    • Hajer, G.R.1    van Haeften, T.W.2    Visseren, F.L.3
  • 44
    • 24744432090 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha as trigger of platelet activation in patients with heart failure
    • Pignatelli P, De Biase L, Lenti L, Tocci G, Brunelli A, Cangemi R etal. Tumor necrosis factor-alpha as trigger of platelet activation in patients with heart failure. Blood 2005; 106: 1992-1994.
    • (2005) Blood , vol.106 , pp. 1992-1994
    • Pignatelli, P.1    De Biase, L.2    Lenti, L.3    Tocci, G.4    Brunelli, A.5    Cangemi, R.6
  • 45
    • 68049112204 scopus 로고    scopus 로고
    • Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques
    • Eisenhardt SU, Habersberger J, Murphy A, Chen YC, Woollard KJ, Bassler N etal. Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques. Circ Res 2009; 105: 128-137.
    • (2009) Circ Res , vol.105 , pp. 128-137
    • Eisenhardt, S.U.1    Habersberger, J.2    Murphy, A.3    Chen, Y.C.4    Woollard, K.J.5    Bassler, N.6
  • 47
    • 10744233017 scopus 로고    scopus 로고
    • Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome
    • Troseid M, Lappegard KT, Claudi T, Damas JK, Morkrid L, Brendberg R etal. Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome. Eur Heart J 2004; 25: 349-355.
    • (2004) Eur Heart J , vol.25 , pp. 349-355
    • Troseid, M.1    Lappegard, K.T.2    Claudi, T.3    Damas, J.K.4    Morkrid, L.5    Brendberg, R.6
  • 48
    • 76649125265 scopus 로고    scopus 로고
    • Enhanced levels of soluble CD40 ligand and C-reactive protein in a total of 312 patients with metabolic syndrome
    • Unek IT, Bayraktar F, Solmaz D, Ellidokuz H, Yuksel F, Sisman AR etal. Enhanced levels of soluble CD40 ligand and C-reactive protein in a total of 312 patients with metabolic syndrome. Metabolism 2010; 59: 305-313.
    • (2010) Metabolism , vol.59 , pp. 305-313
    • Unek, I.T.1    Bayraktar, F.2    Solmaz, D.3    Ellidokuz, H.4    Yuksel, F.5    Sisman, A.R.6
  • 49
    • 0141988868 scopus 로고    scopus 로고
    • Enhanced interleukin-1beta in hypercholesterolemia: effects of simvastatin and low-dose aspirin
    • Ferroni P, Martini F, Cardarello CM, Gazzaniga PP, Davì G, Basili S. Enhanced interleukin-1beta in hypercholesterolemia: effects of simvastatin and low-dose aspirin. Circulation 2003; 108: 1673-1675.
    • (2003) Circulation , vol.108 , pp. 1673-1675
    • Ferroni, P.1    Martini, F.2    Cardarello, C.M.3    Gazzaniga, P.P.4    Davì, G.5    Basili, S.6
  • 50
    • 20144375193 scopus 로고    scopus 로고
    • Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type 2
    • Fateh-Moghadam S, Li Z, Ersel S, Reuter T, Htun P, Plockinger U etal. Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type 2. Arterioscler Thromb Vasc Biol 2005; 25: 1299-1303.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1299-1303
    • Fateh-Moghadam, S.1    Li, Z.2    Ersel, S.3    Reuter, T.4    Htun, P.5    Plockinger, U.6
  • 51
    • 40749114795 scopus 로고    scopus 로고
    • Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function
    • Zimmerman GA, Weyrich AS. Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function. Arterioscler Thromb Vasc Biol 2008; 28: s17-s24.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28
    • Zimmerman, G.A.1    Weyrich, A.S.2
  • 52
    • 77954763055 scopus 로고    scopus 로고
    • Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study
    • Freedman JE, Larson MG, Tanriverdi K, O'Donnell CJ, Morin K, Hakanson AS etal. Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study. Circulation 2010; 122: 119-129.
    • (2010) Circulation , vol.122 , pp. 119-129
    • Freedman, J.E.1    Larson, M.G.2    Tanriverdi, K.3    O'Donnell, C.J.4    Morin, K.5    Hakanson, A.S.6
  • 54
    • 0024202215 scopus 로고
    • The platelet insulin receptor: detection, partial characterization, and search for a function
    • Falcon C, Pfliegler G, Deckmyn H, Vermylen J. The platelet insulin receptor: detection, partial characterization, and search for a function. Biochem Biophys Res Commun 1988; 157: 1190-1196.
    • (1988) Biochem Biophys Res Commun , vol.157 , pp. 1190-1196
    • Falcon, C.1    Pfliegler, G.2    Deckmyn, H.3    Vermylen, J.4
  • 55
    • 0024213166 scopus 로고
    • Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo
    • Trovati M, Anfossi G, Cavalot F, Massucco P, Mularoni E, Emanuelli G. Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo. Diabetes 1988; 37: 780-786.
    • (1988) Diabetes , vol.37 , pp. 780-786
    • Trovati, M.1    Anfossi, G.2    Cavalot, F.3    Massucco, P.4    Mularoni, E.5    Emanuelli, G.6
  • 56
    • 15444357865 scopus 로고    scopus 로고
    • Insulin stimulates nitric oxide synthesis in human platelets and, through nitric oxide, increases platelet concentrations of both guanosine-3′, 5′-cyclic monophosphate and adenosine-3′, 5′-cyclic monophosphate
    • Trovati M, Anfossi G, Massucco P, Mattiello L, Costamagna C, Piretto V etal. Insulin stimulates nitric oxide synthesis in human platelets and, through nitric oxide, increases platelet concentrations of both guanosine-3′, 5′-cyclic monophosphate and adenosine-3′, 5′-cyclic monophosphate. Diabetes 1997; 46: 742-749.
    • (1997) Diabetes , vol.46 , pp. 742-749
    • Trovati, M.1    Anfossi, G.2    Massucco, P.3    Mattiello, L.4    Costamagna, C.5    Piretto, V.6
  • 57
    • 0018765188 scopus 로고
    • Demonstration and partial characterization of insulin receptors in human platelets
    • Hajek AS, Joist JH, Baker RK, Jarett L, Daughaday WH. Demonstration and partial characterization of insulin receptors in human platelets. J Clin Invest 1979; 63: 1060-1065.
    • (1979) J Clin Invest , vol.63 , pp. 1060-1065
    • Hajek, A.S.1    Joist, J.H.2    Baker, R.K.3    Jarett, L.4    Daughaday, W.H.5
  • 58
    • 0027948944 scopus 로고
    • Blunted inhibition by insulin of agonist-stimulated calcium, pH and aggregatory responses in platelets from hypertensive patients
    • Touyz RM, Schiffrin EL. Blunted inhibition by insulin of agonist-stimulated calcium, pH and aggregatory responses in platelets from hypertensive patients. J Hypertens 1994; 12: 1255-1263.
    • (1994) J Hypertens , vol.12 , pp. 1255-1263
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 59
    • 33750955991 scopus 로고    scopus 로고
    • Platelet resistance to the anti-aggregating agents in the insulin resistant states
    • Anfossi G, Russo I, Trovati M. Platelet resistance to the anti-aggregating agents in the insulin resistant states. Curr Diabetes Rev 2006; 2: 409-430.
    • (2006) Curr Diabetes Rev , vol.2 , pp. 409-430
    • Anfossi, G.1    Russo, I.2    Trovati, M.3
  • 60
    • 0028848187 scopus 로고
    • Impaired insulin-induced platelet antiaggregating effect in obesity and in obese NIDDM patients
    • Trovati M, Mularoni EM, Burzacca S, Ponziani MC, Massucco P, Mattiello L etal. Impaired insulin-induced platelet antiaggregating effect in obesity and in obese NIDDM patients. Diabetes 1995; 44: 1318-1322.
    • (1995) Diabetes , vol.44 , pp. 1318-1322
    • Trovati, M.1    Mularoni, E.M.2    Burzacca, S.3    Ponziani, M.C.4    Massucco, P.5    Mattiello, L.6
  • 61
    • 3943106073 scopus 로고    scopus 로고
    • Impaired synthesis and action of antiaggregating cyclic nucleotides in platelets from obese subjects: possible role in platelet hyperactivation in obesity
    • Anfossi G, Russo I, Massucco P, Mattiello L, Doronzo G, De Salve A etal. Impaired synthesis and action of antiaggregating cyclic nucleotides in platelets from obese subjects: possible role in platelet hyperactivation in obesity. Eur J Clin Invest 2004; 34: 482-489.
    • (2004) Eur J Clin Invest , vol.34 , pp. 482-489
    • Anfossi, G.1    Russo, I.2    Massucco, P.3    Mattiello, L.4    Doronzo, G.5    De Salve, A.6
  • 62
    • 77955402723 scopus 로고    scopus 로고
    • Adipocytokines in atherothrombosis: focus on platelets and vascular smooth muscle cells
    • Anfossi G, Russo I, Doronzo G, Pomero A, Trovati M. Adipocytokines in atherothrombosis: focus on platelets and vascular smooth muscle cells. Mediators Inflamm 2010; 2010: 174341.
    • (2010) Mediators Inflamm , vol.2010 , pp. 174341
    • Anfossi, G.1    Russo, I.2    Doronzo, G.3    Pomero, A.4    Trovati, M.5
  • 63
    • 77950189188 scopus 로고    scopus 로고
    • In central obesity, weight loss restores platelet sensitivity to nitric oxide and prostacyclin
    • Russo I, Traversa M, Bonomo K, De Salve A, Mattiello L, Del Mese P etal. In central obesity, weight loss restores platelet sensitivity to nitric oxide and prostacyclin. Obesity 2010; 18: 788-797.
    • (2010) Obesity , vol.18 , pp. 788-797
    • Russo, I.1    Traversa, M.2    Bonomo, K.3    De Salve, A.4    Mattiello, L.5    Del Mese, P.6
  • 64
    • 0035179087 scopus 로고    scopus 로고
    • Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity
    • Konstantinides S, Schafer K, Koschnick S, Loskutoff DJ. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 2001; 108: 1533-1540.
    • (2001) J Clin Invest , vol.108 , pp. 1533-1540
    • Konstantinides, S.1    Schafer, K.2    Koschnick, S.3    Loskutoff, D.J.4
  • 66
    • 0032971218 scopus 로고    scopus 로고
    • Leptin promotes aggregation of human platelets via the long form of its receptor
    • Nakata M, Yada T, Soejima N, Maruyama I. Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes 1999; 48: 426-429.
    • (1999) Diabetes , vol.48 , pp. 426-429
    • Nakata, M.1    Yada, T.2    Soejima, N.3    Maruyama, I.4
  • 68
    • 33847335031 scopus 로고    scopus 로고
    • Adiponectin, ghrelin, and leptin differentially influence human platelet and human vascular endothelial cell functions: implication in obesity-associated cardiovascular diseases
    • Elbatarny HS, Netherton SJ, Ovens JD, Ferguson AV, Maurice DH. Adiponectin, ghrelin, and leptin differentially influence human platelet and human vascular endothelial cell functions: implication in obesity-associated cardiovascular diseases. Eur J Pharmacol 2007; 558: 7-13.
    • (2007) Eur J Pharmacol , vol.558 , pp. 7-13
    • Elbatarny, H.S.1    Netherton, S.J.2    Ovens, J.D.3    Ferguson, A.V.4    Maurice, D.H.5
  • 69
    • 77950817472 scopus 로고    scopus 로고
    • Adiponectin diminishes platelet aggregation and sCD40L release. Potential role in the metabolic syndrome
    • Restituto P, Colina I, Varo JJ, Varo N. Adiponectin diminishes platelet aggregation and sCD40L release. Potential role in the metabolic syndrome. Am J Physiol Endocrinol Metab 2010; 298: E1072-E1077.
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Restituto, P.1    Colina, I.2    Varo, J.J.3    Varo, N.4
  • 71
    • 2442464884 scopus 로고    scopus 로고
    • Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages
    • Kumada M, Kihara S, Ouchi N, Kobayashi H, Okamoto Y, Ohashi K etal. Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation 2004; 109: 2046-2049.
    • (2004) Circulation , vol.109 , pp. 2046-2049
    • Kumada, M.1    Kihara, S.2    Ouchi, N.3    Kobayashi, H.4    Okamoto, Y.5    Ohashi, K.6
  • 72
    • 67349091737 scopus 로고    scopus 로고
    • Oxidative stress and metabolic syndrome
    • Roberts CK, Sindhu KK. Oxidative stress and metabolic syndrome. Life Sci 2009; 84: 705-712.
    • (2009) Life Sci , vol.84 , pp. 705-712
    • Roberts, C.K.1    Sindhu, K.K.2
  • 74
    • 0036796875 scopus 로고    scopus 로고
    • Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes
    • Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002; 23: 599-622.
    • (2002) Endocr Rev , vol.23 , pp. 599-622
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 75
    • 2942698938 scopus 로고    scopus 로고
    • A novel pathway to the manifestations of metabolic syndrome
    • Sonnenberg GE, Krakower GR, Kissebah AH. A novel pathway to the manifestations of metabolic syndrome. Obes Res 2004; 12: 180-186.
    • (2004) Obes Res , vol.12 , pp. 180-186
    • Sonnenberg, G.E.1    Krakower, G.R.2    Kissebah, A.H.3
  • 76
    • 80051993151 scopus 로고    scopus 로고
    • Oxidative stress as pathogenesis of cardiovascular risk associated with metabolic syndrome
    • Otani H. Oxidative stress as pathogenesis of cardiovascular risk associated with metabolic syndrome. Antioxid Redox Signal 2011; 15: 1911-1926.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1911-1926
    • Otani, H.1
  • 77
    • 44449162751 scopus 로고    scopus 로고
    • Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies
    • Forstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 2008; 5: 338-349.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 338-349
    • Forstermann, U.1
  • 80
    • 0034691261 scopus 로고    scopus 로고
    • Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo
    • Audoly LP, Rocca B, Fabre JE, Koller BH, Thomas D, Loeb AL etal. Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo. Circulation 2000; 101: 2833-2840.
    • (2000) Circulation , vol.101 , pp. 2833-2840
    • Audoly, L.P.1    Rocca, B.2    Fabre, J.E.3    Koller, B.H.4    Thomas, D.5    Loeb, A.L.6
  • 83
    • 0032905015 scopus 로고    scopus 로고
    • In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation
    • Davì G, Ciabattoni G, Consoli A, Mezzetti A, Falco A, Santarone S etal. In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation 1999; 99: 224-229.
    • (1999) Circulation , vol.99 , pp. 224-229
    • Davì, G.1    Ciabattoni, G.2    Consoli, A.3    Mezzetti, A.4    Falco, A.5    Santarone, S.6
  • 85
    • 78649662472 scopus 로고    scopus 로고
    • Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome: relationship with oxidative stress
    • Apr 14. [Epub ahead of print]
    • Helal O, Defoort C, Robert S, Marin C, Lesavre N, Lopez-Miranda J etal. Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome: relationship with oxidative stress. Nutr Metab Cardiovasc Dis 2010 Apr 14. [Epub ahead of print].
    • (2010) Nutr Metab Cardiovasc Dis
    • Helal, O.1    Defoort, C.2    Robert, S.3    Marin, C.4    Lesavre, N.5    Lopez-Miranda, J.6
  • 88
    • 27144548487 scopus 로고    scopus 로고
    • Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway
    • Begonja AJ, Gambaryan S, Geiger J, Aktas B, Pozgajova M, Nieswandt B etal. Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway. Blood 2005; 106: 2757-2760.
    • (2005) Blood , vol.106 , pp. 2757-2760
    • Begonja, A.J.1    Gambaryan, S.2    Geiger, J.3    Aktas, B.4    Pozgajova, M.5    Nieswandt, B.6
  • 89
    • 0036924462 scopus 로고    scopus 로고
    • Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase
    • Krotz F, Sohn HY, Keller M, Gloe T, Bolz SS, Becker BF etal. Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase. Arterioscler Thromb Vasc Biol 2002; 22: 2003-2009.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 2003-2009
    • Krotz, F.1    Sohn, H.Y.2    Keller, M.3    Gloe, T.4    Bolz, S.S.5    Becker, B.F.6
  • 90
    • 0141450395 scopus 로고    scopus 로고
    • Lipid and protein oxidation contribute to a prothrombotic state in patients with type 2 diabetes mellitus
    • De Cristofaro R, Rocca B, Vitacolonna E, Falco A, Marchesani P, Ciabattoni G etal. Lipid and protein oxidation contribute to a prothrombotic state in patients with type 2 diabetes mellitus. J Thromb Haemost 2003; 1: 250-256.
    • (2003) J Thromb Haemost , vol.1 , pp. 250-256
    • De Cristofaro, R.1    Rocca, B.2    Vitacolonna, E.3    Falco, A.4    Marchesani, P.5    Ciabattoni, G.6
  • 91
    • 65649127808 scopus 로고    scopus 로고
    • Soluble forms of RAGE in human diseases: clinical and therapeutical implications
    • Santilli F, Vazzana N, Bucciarelli LG, Davì G. Soluble forms of RAGE in human diseases: clinical and therapeutical implications. Curr Med Chem 2009; 16: 940-952.
    • (2009) Curr Med Chem , vol.16 , pp. 940-952
    • Santilli, F.1    Vazzana, N.2    Bucciarelli, L.G.3    Davì, G.4
  • 93
    • 20444490454 scopus 로고    scopus 로고
    • Elevated release of sCD40L from platelets of diabetic patients by thrombin, glucose and advanced glycation end products
    • Varo N, Libby P, Nuzzo R, Italiano J, Doria A, Schonbeck U. Elevated release of sCD40L from platelets of diabetic patients by thrombin, glucose and advanced glycation end products. Diab Vasc Dis Res 2005; 2: 81-87.
    • (2005) Diab Vasc Dis Res , vol.2 , pp. 81-87
    • Varo, N.1    Libby, P.2    Nuzzo, R.3    Italiano, J.4    Doria, A.5    Schonbeck, U.6
  • 94
    • 73649104748 scopus 로고    scopus 로고
    • Formation of methionine sulfoxide by peroxynitrite at position 1606 of von Willebrand factor inhibits its cleavage by ADAMTS-13: a new prothrombotic mechanism in diseases associated with oxidative stress
    • Lancellotti S, De Filippis V, Pozzi N, Peyvandi F, Palla R, Rocca B etal. Formation of methionine sulfoxide by peroxynitrite at position 1606 of von Willebrand factor inhibits its cleavage by ADAMTS-13: a new prothrombotic mechanism in diseases associated with oxidative stress. Free Radic Biol Med 2010; 48: 446-456.
    • (2010) Free Radic Biol Med , vol.48 , pp. 446-456
    • Lancellotti, S.1    De Filippis, V.2    Pozzi, N.3    Peyvandi, F.4    Palla, R.5    Rocca, B.6
  • 97
    • 0037197722 scopus 로고    scopus 로고
    • Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis?
    • Steinberg D, Witztum JL. Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis? Circulation 2002; 105: 2107-2111.
    • (2002) Circulation , vol.105 , pp. 2107-2111
    • Steinberg, D.1    Witztum, J.L.2
  • 98
    • 1842475780 scopus 로고    scopus 로고
    • Deleterious impact of 'high normal' glucose levels and other metabolic syndrome components on arterial endothelial function and intima-media thickness in apparently healthy Chinese subjects: the CATHAY study
    • Thomas GN, Chook P, Qiao M, Huang XS, Leong HC, Celermajer DS etal. Deleterious impact of 'high normal' glucose levels and other metabolic syndrome components on arterial endothelial function and intima-media thickness in apparently healthy Chinese subjects: the CATHAY study. Arterioscler Thromb Vasc Biol 2004; 24: 739-743.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 739-743
    • Thomas, G.N.1    Chook, P.2    Qiao, M.3    Huang, X.S.4    Leong, H.C.5    Celermajer, D.S.6
  • 99
    • 34247134019 scopus 로고    scopus 로고
    • Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice
    • Bendall JK, Rinze R, Adlam D, Tatham AL, de Bono J, Wilson N etal. Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice. Circ Res 2007; 100: 1016-1025.
    • (2007) Circ Res , vol.100 , pp. 1016-1025
    • Bendall, J.K.1    Rinze, R.2    Adlam, D.3    Tatham, A.L.4    de Bono, J.5    Wilson, N.6
  • 100
    • 37349031781 scopus 로고    scopus 로고
    • Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease
    • Hamburg NM, Larson MG, Vita JA, Vasan RS, Keyes MJ, Widlansky ME etal. Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease. Am J Cardiol 2008; 101: 82-88.
    • (2008) Am J Cardiol , vol.101 , pp. 82-88
    • Hamburg, N.M.1    Larson, M.G.2    Vita, J.A.3    Vasan, R.S.4    Keyes, M.J.5    Widlansky, M.E.6
  • 102
    • 52249099513 scopus 로고    scopus 로고
    • Platelets, petechiae, and preservation of the vascular wall
    • Nachman RL, Rafii S. Platelets, petechiae, and preservation of the vascular wall. N Engl J Med 2008; 359: 1261-1270.
    • (2008) N Engl J Med , vol.359 , pp. 1261-1270
    • Nachman, R.L.1    Rafii, S.2
  • 103
    • 53949124123 scopus 로고    scopus 로고
    • Impaired interaction of platelets with endothelial progenitor cells in patients with cardiovascular risk factors
    • Dernbach E, Randriamboavonjy V, Fleming I, Zeiher AM, Dimmeler S, Urbich C. Impaired interaction of platelets with endothelial progenitor cells in patients with cardiovascular risk factors. Basic Res Cardiol 2008; 103: 572-581.
    • (2008) Basic Res Cardiol , vol.103 , pp. 572-581
    • Dernbach, E.1    Randriamboavonjy, V.2    Fleming, I.3    Zeiher, A.M.4    Dimmeler, S.5    Urbich, C.6
  • 104
    • 51649130509 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients
    • Santilli F, Romano M, Recchiuti A, Dragani A, Falco A, Lessiani G etal. Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients. Blood 2008; 112: 1085-1090.
    • (2008) Blood , vol.112 , pp. 1085-1090
    • Santilli, F.1    Romano, M.2    Recchiuti, A.3    Dragani, A.4    Falco, A.5    Lessiani, G.6
  • 105
    • 70350238803 scopus 로고    scopus 로고
    • Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study
    • Violi F, Sanguigni V, Carnevale R, Plebani A, Rossi P, Finocchi A etal. Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study. Circulation 2009; 120: 1616-1622.
    • (2009) Circulation , vol.120 , pp. 1616-1622
    • Violi, F.1    Sanguigni, V.2    Carnevale, R.3    Plebani, A.4    Rossi, P.5    Finocchi, A.6
  • 107
    • 84862214269 scopus 로고    scopus 로고
    • Weight loss is associated with improved endothelial dysfunction via NOX2-generated oxidative stress down-regulation in patients with the metabolic syndrome
    • Apr 22. [Epub ahead of print]
    • Angelico F, Loffredo L, Pignatelli P, Augelletti T, Carnevale R, Pacella A etal. Weight loss is associated with improved endothelial dysfunction via NOX2-generated oxidative stress down-regulation in patients with the metabolic syndrome. Intern Emerg Med 2011 Apr 22. [Epub ahead of print].
    • (2011) Intern Emerg Med
    • Angelico, F.1    Loffredo, L.2    Pignatelli, P.3    Augelletti, T.4    Carnevale, R.5    Pacella, A.6
  • 108
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    • Alberti KGMM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA etal. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009; 120: 1640-1645.
    • (2009) Circulation , vol.120 , pp. 1640-1645
    • Alberti, K.G.M.M.1    Eckel, R.H.2    Grundy, S.M.3    Zimmet, P.Z.4    Cleeman, J.I.5    Donato, K.A.6
  • 112
    • 0037840403 scopus 로고    scopus 로고
    • Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial
    • Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R etal. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 2003; 289: 1799-1804.
    • (2003) JAMA , vol.289 , pp. 1799-1804
    • Esposito, K.1    Pontillo, A.2    Di Palo, C.3    Giugliano, G.4    Masella, M.5    Marfella, R.6
  • 113
    • 1942440882 scopus 로고    scopus 로고
    • Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women
    • You T, Berman DM, Ryan AS, Nicklas BJ. Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women. J Clin Endocrinol Metab 2004; 89: 1739-1746.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1739-1746
    • You, T.1    Berman, D.M.2    Ryan, A.S.3    Nicklas, B.J.4
  • 114
    • 33646481040 scopus 로고    scopus 로고
    • Rimonabant: a cannabinoid receptor type 1 blocker for management of multiple cardiometabolic risk factors
    • Gelfand EV, Cannon CP. Rimonabant: a cannabinoid receptor type 1 blocker for management of multiple cardiometabolic risk factors. J Am Coll Cardiol 2006; 47: 1919-1926.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 1919-1926
    • Gelfand, E.V.1    Cannon, C.P.2
  • 115
    • 79952008057 scopus 로고    scopus 로고
    • Effect of the cannabinoid receptor-1 antagonist rimonabant on inflammation in mice with diet-induced obesity
    • Wang Q, Perrard XD, Perrard JL, Mansoori A, Smith CW, Ballantyne CM etal. Effect of the cannabinoid receptor-1 antagonist rimonabant on inflammation in mice with diet-induced obesity. Obesity 2010; 19: 505-513.
    • (2010) Obesity , vol.19 , pp. 505-513
    • Wang, Q.1    Perrard, X.D.2    Perrard, J.L.3    Mansoori, A.4    Smith, C.W.5    Ballantyne, C.M.6
  • 116
    • 0033585499 scopus 로고    scopus 로고
    • Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial
    • Davidson MH, Hauptman J, DiGirolamo M, Foreyt JP, Halsted CH, Heber D etal. Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial. JAMA 1999; 281: 235-242.
    • (1999) JAMA , vol.281 , pp. 235-242
    • Davidson, M.H.1    Hauptman, J.2    DiGirolamo, M.3    Foreyt, J.P.4    Halsted, C.H.5    Heber, D.6
  • 117
    • 34548088328 scopus 로고    scopus 로고
    • Effect of weight loss with or without orlistat treatment on adipocytokines, inflammation, and oxidative markers in obese women
    • Bougoulia M, Triantos A, Koliakos G. Effect of weight loss with or without orlistat treatment on adipocytokines, inflammation, and oxidative markers in obese women. Hormones (Athens) 2006; 5: 259-269.
    • (2006) Hormones (Athens) , vol.5 , pp. 259-269
    • Bougoulia, M.1    Triantos, A.2    Koliakos, G.3
  • 118
    • 0037407279 scopus 로고    scopus 로고
    • Decreasing levels of tumour necrosis factor alpha and interleukin 6 during lowering of body mass index with orlistat or placebo in obese subjects with cardiovascular risk factors
    • Samuelsson L, Gottsater A, Lindgarde F. Decreasing levels of tumour necrosis factor alpha and interleukin 6 during lowering of body mass index with orlistat or placebo in obese subjects with cardiovascular risk factors. Diabetes Obes Metab 2003; 5: 195-201.
    • (2003) Diabetes Obes Metab , vol.5 , pp. 195-201
    • Samuelsson, L.1    Gottsater, A.2    Lindgarde, F.3
  • 119
    • 44649106470 scopus 로고    scopus 로고
    • Role of metformin for weight management in patients without type 2 diabetes
    • Desilets AR, Dhakal-Karki S, Dunican KC. Role of metformin for weight management in patients without type 2 diabetes. Ann Pharmacother 2008; 42: 817-826.
    • (2008) Ann Pharmacother , vol.42 , pp. 817-826
    • Desilets, A.R.1    Dhakal-Karki, S.2    Dunican, K.C.3
  • 120
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352: 854-865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 121
    • 46749120271 scopus 로고    scopus 로고
    • Metformin, arterial function, intima-media thickness and nitroxidation in metabolic syndrome: the mefisto study
    • Meaney E, Vela A, Samaniego V, Meaney A, Asbun J, Zempoalteca J-C etal. Metformin, arterial function, intima-media thickness and nitroxidation in metabolic syndrome: the mefisto study. Clin Exp Pharmacol Physiol 2008; 35: 895-903.
    • (2008) Clin Exp Pharmacol Physiol , vol.35 , pp. 895-903
    • Meaney, E.1    Vela, A.2    Samaniego, V.3    Meaney, A.4    Asbun, J.5    Zempoalteca, J.-C.6
  • 124
    • 40749143091 scopus 로고    scopus 로고
    • Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects
    • Formoso G, De Filippis EA, Michetti N, Di Fulvio P, Pandolfi A, Bucciarelli T etal. Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects. Diabetes Metab Res Rev 2008; 24: 231-237.
    • (2008) Diabetes Metab Res Rev , vol.24 , pp. 231-237
    • Formoso, G.1    De Filippis, E.A.2    Michetti, N.3    Di Fulvio, P.4    Pandolfi, A.5    Bucciarelli, T.6
  • 125
    • 77952287163 scopus 로고    scopus 로고
    • Postprandial hyperglycemia is a determinant of platelet activation in early type 2 diabetes mellitus
    • Santilli F, Formoso G, Sbraccia P, Averna M, Miccoli R, Di Fulvio P etal. Postprandial hyperglycemia is a determinant of platelet activation in early type 2 diabetes mellitus. J Thromb Haemost 2010; 8: 828-837.
    • (2010) J Thromb Haemost , vol.8 , pp. 828-837
    • Santilli, F.1    Formoso, G.2    Sbraccia, P.3    Averna, M.4    Miccoli, R.5    Di Fulvio, P.6
  • 126
    • 34249657825 scopus 로고    scopus 로고
    • Bariatric surgery for morbid obesity
    • DeMaria EJ. Bariatric surgery for morbid obesity. N Engl J Med 2007; 356: 2176-2183.
    • (2007) N Engl J Med , vol.356 , pp. 2176-2183
    • DeMaria, E.J.1
  • 130
    • 0038120873 scopus 로고    scopus 로고
    • Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patients
    • Kopp HP, Kopp CW, Festa A, Krzyzanowska K, Kriwanek S, Minar E etal. Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patients. Arterioscler Thromb Vasc Biol 2003; 23: 1042-1047.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1042-1047
    • Kopp, H.P.1    Kopp, C.W.2    Festa, A.3    Krzyzanowska, K.4    Kriwanek, S.5    Minar, E.6
  • 131
    • 33646674384 scopus 로고    scopus 로고
    • Effect of massive weight loss induced by bariatric surgery on serum levels of interleukin-18 and monocyte-chemoattractant-protein-1 in morbid obesity
    • Schernthaner GH, Kopp HP, Kriwanek S, Krzyzanowska K, Satler M, Koppensteiner R etal. Effect of massive weight loss induced by bariatric surgery on serum levels of interleukin-18 and monocyte-chemoattractant-protein-1 in morbid obesity. Obes Surg 2006; 16: 709-715.
    • (2006) Obes Surg , vol.16 , pp. 709-715
    • Schernthaner, G.H.1    Kopp, H.P.2    Kriwanek, S.3    Krzyzanowska, K.4    Satler, M.5    Koppensteiner, R.6
  • 132
    • 71749097050 scopus 로고    scopus 로고
    • Effects of bariatric surgery on inflammatory, functional and structural markers of coronary atherosclerosis
    • Habib P, Scrocco JD, Terek M, Vanek V, Mikolich JR. Effects of bariatric surgery on inflammatory, functional and structural markers of coronary atherosclerosis. Am J Cardiol 2009; 104: 1251-1255.
    • (2009) Am J Cardiol , vol.104 , pp. 1251-1255
    • Habib, P.1    Scrocco, J.D.2    Terek, M.3    Vanek, V.4    Mikolich, J.R.5
  • 134
    • 55449132867 scopus 로고    scopus 로고
    • Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk
    • Eikelboom JW, Hankey GJ, Thom J, Bhatt DL, Steg PG, Montalescot G etal. Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk. Circulation 2008; 118: 1705-1712.
    • (2008) Circulation , vol.118 , pp. 1705-1712
    • Eikelboom, J.W.1    Hankey, G.J.2    Thom, J.3    Bhatt, D.L.4    Steg, P.G.5    Montalescot, G.6
  • 135
  • 136
    • 60049093774 scopus 로고    scopus 로고
    • Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: implications for aspirin 'resistance'
    • Santilli F, Rocca B, De Cristofaro R, Lattanzio S, Pietrangelo L, Habib A etal. Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: implications for aspirin 'resistance'. J Am Coll Cardiol 2009; 53: 667-677.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 667-677
    • Santilli, F.1    Rocca, B.2    De Cristofaro, R.3    Lattanzio, S.4    Pietrangelo, L.5    Habib, A.6
  • 137
    • 28244447830 scopus 로고    scopus 로고
    • Determinants of the interindividual variability in response to antiplatelet drugs
    • Rocca B, Patrono C. Determinants of the interindividual variability in response to antiplatelet drugs. J Thromb Haemost 2005; 3: 1597-1602.
    • (2005) J Thromb Haemost , vol.3 , pp. 1597-1602
    • Rocca, B.1    Patrono, C.2
  • 138
    • 33747168513 scopus 로고    scopus 로고
    • Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers
    • Cox D, Maree AO, Dooley M, Conroy R, Byrne MF, Fitzgerald DJ. Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers. Stroke 2006; 37: 2153-2158.
    • (2006) Stroke , vol.37 , pp. 2153-2158
    • Cox, D.1    Maree, A.O.2    Dooley, M.3    Conroy, R.4    Byrne, M.F.5    Fitzgerald, D.J.6
  • 139
    • 27744581956 scopus 로고    scopus 로고
    • Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease
    • Maree AO, Curtin RJ, Dooley M, Conroy RM, Crean P, Cox D etal. Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease. J Am Coll Cardiol 2005; 46: 1258-1263.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1258-1263
    • Maree, A.O.1    Curtin, R.J.2    Dooley, M.3    Conroy, R.M.4    Crean, P.5    Cox, D.6
  • 140
    • 0023137593 scopus 로고
    • Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs
    • Reilly IA, FitzGerald GA. Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs. Blood 1987; 69: 180-186.
    • (1987) Blood , vol.69 , pp. 180-186
    • Reilly, I.A.1    FitzGerald, G.A.2
  • 142
    • 18444377050 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets
    • Rocca B, Secchiero P, Ciabattoni G, Ranelletti FO, Catani L, Guidotti L etal. Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets. Proc Natl Acad Sci U S A 2002; 99: 7634-7639.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 7634-7639
    • Rocca, B.1    Secchiero, P.2    Ciabattoni, G.3    Ranelletti, F.O.4    Catani, L.5    Guidotti, L.6
  • 143
    • 77649228280 scopus 로고    scopus 로고
    • The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy
    • Dragani A, Pascale S, Recchiuti A, Mattoscio D, Lattanzio S, Petrucci G etal. The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy. Blood 2010; 115: 1054-1061.
    • (2010) Blood , vol.115 , pp. 1054-1061
    • Dragani, A.1    Pascale, S.2    Recchiuti, A.3    Mattoscio, D.4    Lattanzio, S.5    Petrucci, G.6
  • 144
    • 23744515307 scopus 로고    scopus 로고
    • Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets
    • Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S etal. Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 2005; 122: 379-391.
    • (2005) Cell , vol.122 , pp. 379-391
    • Denis, M.M.1    Tolley, N.D.2    Bunting, M.3    Schwertz, H.4    Jiang, H.5    Lindemann, S.6
  • 145
    • 33645294424 scopus 로고    scopus 로고
    • De novo synthesis of cyclooxygenase-1 counteracts the suppression of platelet thromboxane biosynthesis by aspirin
    • Evangelista V, Manarini S, Di Santo A, Capone ML, Ricciotti E, Di Francesco L etal. De novo synthesis of cyclooxygenase-1 counteracts the suppression of platelet thromboxane biosynthesis by aspirin. Circ Res 2006; 98: 593-595.
    • (2006) Circ Res , vol.98 , pp. 593-595
    • Evangelista, V.1    Manarini, S.2    Di Santo, A.3    Capone, M.L.4    Ricciotti, E.5    Di Francesco, L.6
  • 146
    • 77952290056 scopus 로고    scopus 로고
    • Aspirin as antiplatelet agent in diabetes. PROS
    • Davì G, Santilli F. Aspirin as antiplatelet agent in diabetes. PROS. Eur J Intern Med 2010; 21: 149-153.
    • (2010) Eur J Intern Med , vol.21 , pp. 149-153
    • Davì, G.1    Santilli, F.2
  • 147
    • 34247554956 scopus 로고    scopus 로고
    • Platelet aggregation and aspirin non-responsiveness increase when an acute coronary syndrome is complicated by an infection
    • Modica A, Karlsson F, Mooe T. Platelet aggregation and aspirin non-responsiveness increase when an acute coronary syndrome is complicated by an infection. J Thromb Haemost 2007; 5: 507-511.
    • (2007) J Thromb Haemost , vol.5 , pp. 507-511
    • Modica, A.1    Karlsson, F.2    Mooe, T.3
  • 148
    • 79956302853 scopus 로고    scopus 로고
    • TP receptor activation and inhibition in atherothrombosis: the paradigm of diabetes mellitus
    • Santilli F, Mucci L, Davì G. TP receptor activation and inhibition in atherothrombosis: the paradigm of diabetes mellitus. Intern Emerg Med 2011; 6: 203-212.
    • (2011) Intern Emerg Med , vol.6 , pp. 203-212
    • Santilli, F.1    Mucci, L.2    Davì, G.3
  • 149
    • 0347933042 scopus 로고    scopus 로고
    • Inhibition of human blood platelet aggregation and the stimulation of nitric oxide synthesis by aspirin
    • Chakraborty K, Khan GA, Banerjee P, Ray U, Sinha AK. Inhibition of human blood platelet aggregation and the stimulation of nitric oxide synthesis by aspirin. Platelets 2003; 14: 421-427.
    • (2003) Platelets , vol.14 , pp. 421-427
    • Chakraborty, K.1    Khan, G.A.2    Banerjee, P.3    Ray, U.4    Sinha, A.K.5
  • 150
    • 27144481618 scopus 로고    scopus 로고
    • In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets
    • Williams PC, Coffey MJ, Coles B, Sanchez S, Morrow JD, Cockcroft JR etal. In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets. Blood 2005; 106: 2737-2743.
    • (2005) Blood , vol.106 , pp. 2737-2743
    • Williams, P.C.1    Coffey, M.J.2    Coles, B.3    Sanchez, S.4    Morrow, J.D.5    Cockcroft, J.R.6
  • 151
    • 78049354802 scopus 로고    scopus 로고
    • Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes
    • Boutaud O, Oates JA. Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes. Methods Mol Biol 2010; 644: 67-90.
    • (2010) Methods Mol Biol , vol.644 , pp. 67-90
    • Boutaud, O.1    Oates, J.A.2
  • 152
    • 0037980424 scopus 로고    scopus 로고
    • Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes
    • Aronoff DM, Boutaud O, Marnett LJ, Oates JA. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. Adv Exp Med Biol 2003; 525: 125-128.
    • (2003) Adv Exp Med Biol , vol.525 , pp. 125-128
    • Aronoff, D.M.1    Boutaud, O.2    Marnett, L.J.3    Oates, J.A.4
  • 154
    • 0029880924 scopus 로고    scopus 로고
    • A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease
    • Antonipillai I, Nadler J, Vu EJ, Bughi S, Natarajan R, Horton R. A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease. J Clin Endocrinol Metab 1996; 81: 1940-1945.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1940-1945
    • Antonipillai, I.1    Nadler, J.2    Vu, E.J.3    Bughi, S.4    Natarajan, R.5    Horton, R.6
  • 155
    • 80053051845 scopus 로고    scopus 로고
    • Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young men
    • Epub ahead of print]
    • Karaouzene N, Merzouk H, Aribi M, Merzouk SA, Yahia Berrouiguet A, Tessier C etal. Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young men. Nutr Metab Cardiovasc Dis 2010. [Epub ahead of print].
    • (2010) Nutr Metab Cardiovasc Dis
    • Karaouzene, N.1    Merzouk, H.2    Aribi, M.3    Merzouk, S.A.4    Yahia Berrouiguet, A.5    Tessier, C.6
  • 157
    • 40649109492 scopus 로고    scopus 로고
    • Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase
    • Bala M, Chin CN, Logan AT, Amin T, Marnett LJ, Boutaud O etal. Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase. Biochem Pharmacol 2008; 75: 1472-1481.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1472-1481
    • Bala, M.1    Chin, C.N.2    Logan, A.T.3    Amin, T.4    Marnett, L.J.5    Boutaud, O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.