Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin

Journal of Thrombosis and Haemostasis

Volumn 5, Issue 3, 2007, Pages 490-496

  Guthikonda, S ^a   Lev, E I ^b   Patel, R ^c   Delao, T ^b   Bergeron, A L ^c   Dong, J F ^c   Kleiman, Neal S ^b  

^a EMORY UNIVERSITY   (United States)

^b HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Aspirin; COX 2; Reticulated platelets; Thromboxane

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; COLLAGEN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INTEGRIN; INTEGRIN ALPHA2B BETA3; PADGEM PROTEIN; THROMBOXANE B2; UNCLASSIFIED DRUG; ANTITHROMBOCYTIC AGENT; FIBRINOGEN RECEPTOR; MEMBRANE PROTEIN; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS2 PROTEIN, HUMAN;

ADULT; ARTICLE; BLOOD SAMPLING; CORRELATION ANALYSIS; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INCIDENCE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SINGLE DRUG DOSE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; TURBIDIMETRY; BIOSYNTHESIS; BLOOD; BLOOD CLOTTING PARAMETERS; CLINICAL TRIAL; DRUG EFFECT; DRUG RESISTANCE; ENTERIC COATED TABLET; ENZYMOLOGY; METABOLISM; ORAL DRUG ADMINISTRATION; REFERENCE VALUE; THROMBOCYTE; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ADMINISTRATION, ORAL; ADULT; ASPIRIN; BLOOD PLATELETS; COLLAGEN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DRUG RESISTANCE; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MEMBRANE PROTEINS; P-SELECTIN; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; REFERENCE VALUES; TABLETS, ENTERIC-COATED; THROMBOXANE B2;

EID: 34247574729     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2007.02387.x     Document Type: Article

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