-
1
-
-
4544267059
-
Coenzyme Q10 serum levels in Huntington's disease
-
Andrich J., Saft C., Gerlach M., Schneider B., Arz A., Kuhn W., Muller T. Coenzyme Q10 serum levels in Huntington's disease. J. Neural Transm. Suppl. 2004, 111-116.
-
(2004)
J. Neural Transm. Suppl.
, pp. 111-116
-
-
Andrich, J.1
Saft, C.2
Gerlach, M.3
Schneider, B.4
Arz, A.5
Kuhn, W.6
Muller, T.7
-
2
-
-
7244236320
-
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
-
Arrasate M., Mitra S., Schweitzer E.S., Segal M.R., Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 2004, 431:805-810.
-
(2004)
Nature
, vol.431
, pp. 805-810
-
-
Arrasate, M.1
Mitra, S.2
Schweitzer, E.S.3
Segal, M.R.4
Finkbeiner, S.5
-
3
-
-
33847607138
-
Change in MRI striatal volumes as a biomarker in preclinical Huntington's disease
-
Aylward E.H. Change in MRI striatal volumes as a biomarker in preclinical Huntington's disease. Brain Res. Bull. 2007, 72:152-158.
-
(2007)
Brain Res. Bull.
, vol.72
, pp. 152-158
-
-
Aylward, E.H.1
-
4
-
-
79952740327
-
Longitudinal change in regional brain volumes in prodromal Huntington disease
-
Aylward E.H., Nopoulos P.C., Ross C.A., Langbehn D.R., Pierson R.K., Mills J.A., Johnson H.J., Magnotta V.A., Juhl A.R., Paulsen J.S. Longitudinal change in regional brain volumes in prodromal Huntington disease. J. Neurol. Neurosurg. Psychiatry 2011, 82:405-410.
-
(2011)
J. Neurol. Neurosurg. Psychiatry
, vol.82
, pp. 405-410
-
-
Aylward, E.H.1
Nopoulos, P.C.2
Ross, C.A.3
Langbehn, D.R.4
Pierson, R.K.5
Mills, J.A.6
Johnson, H.J.7
Magnotta, V.A.8
Juhl, A.R.9
Paulsen, J.S.10
-
5
-
-
56549119132
-
Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease
-
Benn C.L., Fox H., Bates G. Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease. BMC Mol. Neurodegeneration 2008, 3:1-17.
-
(2008)
BMC Mol. Neurodegeneration
, vol.3
, pp. 1-17
-
-
Benn, C.L.1
Fox, H.2
Bates, G.3
-
6
-
-
33645099245
-
Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics
-
Bhagavan H.N., Chopra R.K. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic. Res. 2006, 40:445-453.
-
(2006)
Free Radic. Res.
, vol.40
, pp. 445-453
-
-
Bhagavan, H.N.1
Chopra, R.K.2
-
7
-
-
78650694548
-
Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease
-
Blazquez C., Chiarlone A., Sagredo O., Aguado T., Pazos M.R., Resel E., Palazuelos J., Julien B., Salazar M., Borner C., Benito C., Carrasco C., Diez-Zaera M., Paoletti P., Diaz-Hernandez M., Ruiz C., Sendtner M., Lucas J.J., de Yebenes J.G., Marsicano G., Monory K., Lutz B., Romero J., Alberch J., Gines S., Kraus J., Fernandez-Ruiz J., Galve-Roperh I., Guzman M. Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease. Brain 2011, 134:119-136.
-
(2011)
Brain
, vol.134
, pp. 119-136
-
-
Blazquez, C.1
Chiarlone, A.2
Sagredo, O.3
Aguado, T.4
Pazos, M.R.5
Resel, E.6
Palazuelos, J.7
Julien, B.8
Salazar, M.9
Borner, C.10
Benito, C.11
Carrasco, C.12
Diez-Zaera, M.13
Paoletti, P.14
Diaz-Hernandez, M.15
Ruiz, C.16
Sendtner, M.17
Lucas, J.J.18
de Yebenes, J.G.19
Marsicano, G.20
Monory, K.21
Lutz, B.22
Romero, J.23
Alberch, J.24
Gines, S.25
Kraus, J.26
Fernandez-Ruiz, J.27
Galve-Roperh, I.28
Guzman, M.29
more..
-
8
-
-
28644433087
-
Normal huntingtin function: an alternative approach to Huntington's disease
-
Cattaneo E., Zuccato C., Tartari M. Normal huntingtin function: an alternative approach to Huntington's disease. Nat. Rev. Neurosci. 2005, 6:919-930.
-
(2005)
Nat. Rev. Neurosci.
, vol.6
, pp. 919-930
-
-
Cattaneo, E.1
Zuccato, C.2
Tartari, M.3
-
9
-
-
57649171115
-
Mitochondrial approaches for neuroprotection
-
Chaturvedi R.K., Beal M.F. Mitochondrial approaches for neuroprotection. Ann. N. Y. Acad. Sci. 2008, 1147:395-412.
-
(2008)
Ann. N. Y. Acad. Sci.
, vol.1147
, pp. 395-412
-
-
Chaturvedi, R.K.1
Beal, M.F.2
-
10
-
-
33749042331
-
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochonrial dysfunction and neurodegeneration
-
Cui L., Jeong H., Borovecki F., Parkhurst C.N., Tanese N., Krainc D. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochonrial dysfunction and neurodegeneration. Cell 2006, 127:59-69.
-
(2006)
Cell
, vol.127
, pp. 59-69
-
-
Cui, L.1
Jeong, H.2
Borovecki, F.3
Parkhurst, C.N.4
Tanese, N.5
Krainc, D.6
-
11
-
-
69049091946
-
Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease
-
Cummings D.M., Andre V.M., Uzgil B.O., Gee S.M., Fisher Y.E., Cepeda C., Levine M.S. Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease. J. Neurosci. 2009, 29:10371-10386.
-
(2009)
J. Neurosci.
, vol.29
, pp. 10371-10386
-
-
Cummings, D.M.1
Andre, V.M.2
Uzgil, B.O.3
Gee, S.M.4
Fisher, Y.E.5
Cepeda, C.6
Levine, M.S.7
-
12
-
-
77956240426
-
Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease
-
Cummings D.M., Cepeda C., Levine M.S. Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease. ASN Neuro 2010, 2:e00036.
-
(2010)
ASN Neuro
, vol.2
-
-
Cummings, D.M.1
Cepeda, C.2
Levine, M.S.3
-
13
-
-
0023791488
-
Regional distribution of ubiquinones and tocopherols in the mouse brain: lowest content of ubiquinols in the substantia nigra
-
Fariello R.G., Ghilardi O., Peschechera A., Ramacci M.T., Angelucci L. Regional distribution of ubiquinones and tocopherols in the mouse brain: lowest content of ubiquinols in the substantia nigra. Neuropharmacology 1988, 27:1077-1080.
-
(1988)
Neuropharmacology
, vol.27
, pp. 1077-1080
-
-
Fariello, R.G.1
Ghilardi, O.2
Peschechera, A.3
Ramacci, M.T.4
Angelucci, L.5
-
14
-
-
0029988363
-
Assessment of coenzyme Q10 tolerability in Huntington's disease
-
Feigin A., Kieburtz K., Como P., Hickey C., Claude K., Abwender D., Zimmerman C., Steinberg K., Shoulson I. Assessment of coenzyme Q10 tolerability in Huntington's disease. Mov. Disord. 1996, 11:321-323.
-
(1996)
Mov. Disord.
, vol.11
, pp. 321-323
-
-
Feigin, A.1
Kieburtz, K.2
Como, P.3
Hickey, C.4
Claude, K.5
Abwender, D.6
Zimmerman, C.7
Steinberg, K.8
Shoulson, I.9
-
15
-
-
0036523110
-
Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease
-
Ferrante R.J., Andreassen O.A., Dedeoglu A., Ferrante K.L., Jenkins B.G., Hersch S.M., Beal M.F. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J. Neurosci. 2002, 22:1592-1599.
-
(2002)
J. Neurosci.
, vol.22
, pp. 1592-1599
-
-
Ferrante, R.J.1
Andreassen, O.A.2
Dedeoglu, A.3
Ferrante, K.L.4
Jenkins, B.G.5
Hersch, S.M.6
Beal, M.F.7
-
16
-
-
33645068499
-
Tolerance of high-dose (3,000mg/day) coenzyme Q10 in ALS
-
Ferrante K.L., Shefner J., Zhang H., Betensky R., O'Brien M., Yu H., Fantasia M., Taft J., Beal M.F., Traynor B., Newhall K., Donofrio P., Caress J., Ashburn C., Freiberg B., O'Neill C., Paladenech C., Walker T., Pestronk A., Abrams B., Florence J., Renna R., Schierbecker J., Malkus B., Cudkowicz M. Tolerance of high-dose (3,000mg/day) coenzyme Q10 in ALS. Neurology 2005, 65:1834-1836.
-
(2005)
Neurology
, vol.65
, pp. 1834-1836
-
-
Ferrante, K.L.1
Shefner, J.2
Zhang, H.3
Betensky, R.4
O'Brien, M.5
Yu, H.6
Fantasia, M.7
Taft, J.8
Beal, M.F.9
Traynor, B.10
Newhall, K.11
Donofrio, P.12
Caress, J.13
Ashburn, C.14
Freiberg, B.15
O'Neill, C.16
Paladenech, C.17
Walker, T.18
Pestronk, A.19
Abrams, B.20
Florence, J.21
Renna, R.22
Schierbecker, J.23
Malkus, B.24
Cudkowicz, M.25
more..
-
17
-
-
0034081681
-
The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease
-
Glass M., Dragunow M., Faull R.L. The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease. Neuroscience 2000, 97:505-519.
-
(2000)
Neuroscience
, vol.97
, pp. 505-519
-
-
Glass, M.1
Dragunow, M.2
Faull, R.L.3
-
18
-
-
24044442568
-
Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing
-
Hickey M.A., Gallant K., Gross G.G., Levine M.S., Chesselet M.F. Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing. Neurobiol. Dis. 2005, 20:1-11.
-
(2005)
Neurobiol. Dis.
, vol.20
, pp. 1-11
-
-
Hickey, M.A.1
Gallant, K.2
Gross, G.G.3
Levine, M.S.4
Chesselet, M.F.5
-
19
-
-
54549087605
-
Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice
-
Hickey M.A., Kosmalska A., Enayati J., Cohen R., Zeitlin S., Levine M.S., Chesselet M.F. Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice. Neuroscience 2008, 157:280-295.
-
(2008)
Neuroscience
, vol.157
, pp. 280-295
-
-
Hickey, M.A.1
Kosmalska, A.2
Enayati, J.3
Cohen, R.4
Zeitlin, S.5
Levine, M.S.6
Chesselet, M.F.7
-
20
-
-
84856808085
-
Mouse models of mental illness and neurological disease
-
Elsevier, London, C. Watson, G. Paxinos, L. Puelles (Eds.)
-
Hickey M.A., Franich N.R., Medvedeva V., Chesselet M.F. Mouse models of mental illness and neurological disease. The Mouse Nervous System 2011, 32:752-765. Elsevier, London. C. Watson, G. Paxinos, L. Puelles (Eds.).
-
(2011)
The Mouse Nervous System
, vol.32
, pp. 752-765
-
-
Hickey, M.A.1
Franich, N.R.2
Medvedeva, V.3
Chesselet, M.F.4
-
21
-
-
0036152343
-
Environmental enrichment slows disease progression in R6/2 Huntington's disease mice
-
Hockly E., Cordery P.M., Woodman B., Mahal A., van Dellen A., Blakemore C., Lewis C.M., Hannan A.J., Bates G.P. Environmental enrichment slows disease progression in R6/2 Huntington's disease mice. Ann. Neurol. 2002, 51:235-242.
-
(2002)
Ann. Neurol.
, vol.51
, pp. 235-242
-
-
Hockly, E.1
Cordery, P.M.2
Woodman, B.3
Mahal, A.4
van Dellen, A.5
Blakemore, C.6
Lewis, C.M.7
Hannan, A.J.8
Bates, G.P.9
-
22
-
-
0037452775
-
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
-
Hockly E., Richon V.M., Woodman B., Smith D.L., Zhou X., Rosa E., Sathasivam K., Ghazi-Noori S., Mahal A., Lowden P.A., Steffan J.S., Marsh J.L., Thompson L.M., Lewis C.M., Marks P.A., Bates G.P. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:2041-2046.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 2041-2046
-
-
Hockly, E.1
Richon, V.M.2
Woodman, B.3
Smith, D.L.4
Zhou, X.5
Rosa, E.6
Sathasivam, K.7
Ghazi-Noori, S.8
Mahal, A.9
Lowden, P.A.10
Steffan, J.S.11
Marsh, J.L.12
Thompson, L.M.13
Lewis, C.M.14
Marks, P.A.15
Bates, G.P.16
-
23
-
-
29144498271
-
Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease
-
Hockly E., Tse J., Barker A.L., Moolman D.L., Beunard J.L., Revington A.P., Holt K., Sunshine S., Moffitt H., Sathasivam K., Woodman B., Wanker E.E., Lowden P.A., Bates G.P. Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease. Neurobiol. Dis. 2006, 21:228-236.
-
(2006)
Neurobiol. Dis.
, vol.21
, pp. 228-236
-
-
Hockly, E.1
Tse, J.2
Barker, A.L.3
Moolman, D.L.4
Beunard, J.L.5
Revington, A.P.6
Holt, K.7
Sunshine, S.8
Moffitt, H.9
Sathasivam, K.10
Woodman, B.11
Wanker, E.E.12
Lowden, P.A.13
Bates, G.P.14
-
24
-
-
0141639911
-
Coenzyme Q intake elevates the mitochondrial and tissue levels of Coenzyme Q and alpha-tocopherol in young mice
-
Kamzalov S., Sumien N., Forster M.J., Sohal R.S. Coenzyme Q intake elevates the mitochondrial and tissue levels of Coenzyme Q and alpha-tocopherol in young mice. J. Nutr. 2003, 133:3175-3180.
-
(2003)
J. Nutr.
, vol.133
, pp. 3175-3180
-
-
Kamzalov, S.1
Sumien, N.2
Forster, M.J.3
Sohal, R.S.4
-
25
-
-
77957742105
-
Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease
-
Kim J., Moody J.P., Edgerly C.K., Bordiuk O.L., Cormier K., Smith K., Beal M.F., Ferrante R.J. Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease. Hum. Mol. Genet. 2010, 19:3919-3935.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 3919-3935
-
-
Kim, J.1
Moody, J.P.2
Edgerly, C.K.3
Bordiuk, O.L.4
Cormier, K.5
Smith, K.6
Beal, M.F.7
Ferrante, R.J.8
-
26
-
-
0035214922
-
Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice
-
Klapstein G.J., Fisher R.S., Zanjani H., Cepeda C., Jokel E.S., Chesselet M.F., Levine M.S. Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice. J. Neurophysiol. 2001, 86:2667-2677.
-
(2001)
J. Neurophysiol.
, vol.86
, pp. 2667-2677
-
-
Klapstein, G.J.1
Fisher, R.S.2
Zanjani, H.3
Cepeda, C.4
Jokel, E.S.5
Chesselet, M.F.6
Levine, M.S.7
-
27
-
-
0031044805
-
Energy metabolism defects in Huntington's disease and effects of coenzyme Q10
-
Koroshetz W.J., Jenkins B.G., Rosen B.R., Beal M.F. Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. Ann. Neurol. 1997, 41:160-165.
-
(1997)
Ann. Neurol.
, vol.41
, pp. 160-165
-
-
Koroshetz, W.J.1
Jenkins, B.G.2
Rosen, B.R.3
Beal, M.F.4
-
28
-
-
0036710515
-
Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat
-
Kwong L.K., Kamzalov S., Rebrin I., Bayne A.C., Jana C.K., Morris P., Forster M.J., Sohal R.S. Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic. Biol. Med. 2002, 33:627-638.
-
(2002)
Free Radic. Biol. Med.
, vol.33
, pp. 627-638
-
-
Kwong, L.K.1
Kamzalov, S.2
Rebrin, I.3
Bayne, A.C.4
Jana, C.K.5
Morris, P.6
Forster, M.J.7
Sohal, R.S.8
-
29
-
-
34548399406
-
Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism
-
Lee J.M., Ivanova E.V., Seong I.S., Cashorali T., Kohane I., Gusella J.F., MacDonald M.E. Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism. PLoS Genet. 2007, 3:e135.
-
(2007)
PLoS Genet.
, vol.3
-
-
Lee, J.M.1
Ivanova, E.V.2
Seong, I.S.3
Cashorali, T.4
Kohane, I.5
Gusella, J.F.6
MacDonald, M.E.7
-
30
-
-
0032555066
-
Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
-
Matthews R.T., Yang L., Browne S., Baik M., Beal M.F. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc. Natl. Acad. Sci. 1998, 95:8892-8897.
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 8892-8897
-
-
Matthews, R.T.1
Yang, L.2
Browne, S.3
Baik, M.4
Beal, M.F.5
-
31
-
-
0034048845
-
Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease
-
Menalled L., Zanjani H., MacKenzie L., Koppel A., Carpenter E., Zeitlin S., Chesselet M.-F. Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease. Exp. Neurol. 2000, 162:328-342.
-
(2000)
Exp. Neurol.
, vol.162
, pp. 328-342
-
-
Menalled, L.1
Zanjani, H.2
MacKenzie, L.3
Koppel, A.4
Carpenter, E.5
Zeitlin, S.6
Chesselet, M.-F.7
-
32
-
-
0041691176
-
Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats
-
Menalled L.B., Sison J.D., Dragatsis I., Zeitlin S., Chesselet M.F. Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats. J. Comp. Neurol. 2003, 465:11-26.
-
(2003)
J. Comp. Neurol.
, vol.465
, pp. 11-26
-
-
Menalled, L.B.1
Sison, J.D.2
Dragatsis, I.3
Zeitlin, S.4
Chesselet, M.F.5
-
33
-
-
78149474887
-
Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline
-
Menalled L.B., Patry M., Ragland N., Lowden P.A., Goodman J., Minnich J., Zahasky B., Park L., Leeds J., Howland D., Signer E., Tobin A.J., Brunner D. Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline. PLoS One 2010, 5:e9793.
-
(2010)
PLoS One
, vol.5
-
-
Menalled, L.B.1
Patry, M.2
Ragland, N.3
Lowden, P.A.4
Goodman, J.5
Minnich, J.6
Zahasky, B.7
Park, L.8
Leeds, J.9
Howland, D.10
Signer, E.11
Tobin, A.J.12
Brunner, D.13
-
34
-
-
77955359169
-
Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into Huntington's disease molecular pathogenesis
-
Miller J., Arrasate M., Shaby B.A., Mitra S., Masliah E., Finkbeiner S. Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into Huntington's disease molecular pathogenesis. J. Neurosci. 2010, 30:10541-10550.
-
(2010)
J. Neurosci.
, vol.30
, pp. 10541-10550
-
-
Miller, J.1
Arrasate, M.2
Shaby, B.A.3
Mitra, S.4
Masliah, E.5
Finkbeiner, S.6
-
35
-
-
71549143207
-
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
-
Okamoto S., Pouladi M.A., Talantova M., Yao D., Xia P., Ehrnhoefer D.E., Zaidi R., Clemente A., Kaul M., Graham R.K., Zhang D., Vincent Chen H.S., Tong G., Hayden M.R., Lipton S.A. Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat. Med. 2009, 15:1407-1413.
-
(2009)
Nat. Med.
, vol.15
, pp. 1407-1413
-
-
Okamoto, S.1
Pouladi, M.A.2
Talantova, M.3
Yao, D.4
Xia, P.5
Ehrnhoefer, D.E.6
Zaidi, R.7
Clemente, A.8
Kaul, M.9
Graham, R.K.10
Zhang, D.11
Vincent Chen, H.S.12
Tong, G.13
Hayden, M.R.14
Lipton, S.A.15
-
37
-
-
17344392308
-
A new mathematical model for relative quantification in real-time RT-PCR
-
Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001, 29:e45.
-
(2001)
Nucleic Acids Res.
, vol.29
-
-
Pfaffl, M.W.1
-
38
-
-
61849093278
-
Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models
-
Phan J., Hickey M.A., Zhang P., Chesselet M.F., Reue K. Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models. Hum. Mol. Genet. 2009, 18:1006-1016.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 1006-1016
-
-
Phan, J.1
Hickey, M.A.2
Zhang, P.3
Chesselet, M.F.4
Reue, K.5
-
39
-
-
10844273236
-
Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation
-
Ribchester R.R., Thomson D., Wood N.I., Hinks T., Gillingwater T.H., Wishart T.M., Court F.A., Morton A.J. Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation. Eur. J. Neurosci. 2004, 20:3092-3114.
-
(2004)
Eur. J. Neurosci.
, vol.20
, pp. 3092-3114
-
-
Ribchester, R.R.1
Thomson, D.2
Wood, N.I.3
Hinks, T.4
Gillingwater, T.H.5
Wishart, T.M.6
Court, F.A.7
Morton, A.J.8
-
40
-
-
0032919205
-
Formation of polyglutamine inclusions in non-CNS tissue
-
Sathasivam K., Hobbs C., Turmaine M., Mangiarini L., Mahal A., Bertaux F., Wanker E.E., Doherty P., Davies S.W., Bates G.P. Formation of polyglutamine inclusions in non-CNS tissue. Hum. Mol. Genet. 1999, 8:813-822.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 813-822
-
-
Sathasivam, K.1
Hobbs, C.2
Turmaine, M.3
Mangiarini, L.4
Mahal, A.5
Bertaux, F.6
Wanker, E.E.7
Doherty, P.8
Davies, S.W.9
Bates, G.P.10
-
41
-
-
0032475931
-
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
-
Saudou F., Finkbeiner S., Devys D., Greenberg M.E. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 1998, 95:55-66.
-
(1998)
Cell
, vol.95
, pp. 55-66
-
-
Saudou, F.1
Finkbeiner, S.2
Devys, D.3
Greenberg, M.E.4
-
42
-
-
0035960544
-
Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model
-
Schilling G., Coonfield M.L., Ross C.A., Borchelt D.R. Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model. Neurosci. Lett. 2001, 315:149-153.
-
(2001)
Neurosci. Lett.
, vol.315
, pp. 149-153
-
-
Schilling, G.1
Coonfield, M.L.2
Ross, C.A.3
Borchelt, D.R.4
-
43
-
-
11144358364
-
Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice
-
Schilling G., Savonenko A.V., Coonfield M.L., Morton J.L., Vorovich E., Gale A., Neslon C., Chan N., Eaton M., Fromholt D., Ross C.A., Borchelt D.R. Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice. Exp. Neurol. 2004, 187:137-149.
-
(2004)
Exp. Neurol.
, vol.187
, pp. 137-149
-
-
Schilling, G.1
Savonenko, A.V.2
Coonfield, M.L.3
Morton, J.L.4
Vorovich, E.5
Gale, A.6
Neslon, C.7
Chan, N.8
Eaton, M.9
Fromholt, D.10
Ross, C.A.11
Borchelt, D.R.12
-
44
-
-
0345451597
-
Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients
-
Shults C.W., Beal M.F., Fontaine D., Nakano K., Haas R.H. Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients. Neurology 1998, 50:793-795.
-
(1998)
Neurology
, vol.50
, pp. 793-795
-
-
Shults, C.W.1
Beal, M.F.2
Fontaine, D.3
Nakano, K.4
Haas, R.H.5
-
45
-
-
3042717908
-
Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease
-
Shults C.W., Flint Beal M., Song D., Fontaine D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease. Exp. Neurol. 2004, 188:491-494.
-
(2004)
Exp. Neurol.
, vol.188
, pp. 491-494
-
-
Shults, C.W.1
Flint Beal, M.2
Song, D.3
Fontaine, D.4
-
46
-
-
63849151219
-
Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice
-
Simmons D.A., Rex C.S., Palmer L., Pandyarajan V., Fedulov V., Gall C.M., Lynch G. Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:4906-4911.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 4906-4911
-
-
Simmons, D.A.1
Rex, C.S.2
Palmer, L.3
Pandyarajan, V.4
Fedulov, V.5
Gall, C.M.6
Lynch, G.7
-
47
-
-
33745120560
-
Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice
-
Smith K.M., Matson S., Matson W.R., Cormier K., Del Signore S.J., Hagerty S.W., Stack E.C., Ryu H., Ferrante R.J. Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice. Biochim. Biophys. Acta 2006, 1762:616-626.
-
(2006)
Biochim. Biophys. Acta
, vol.1762
, pp. 616-626
-
-
Smith, K.M.1
Matson, S.2
Matson, W.R.3
Cormier, K.4
Del Signore, S.J.5
Hagerty, S.W.6
Stack, E.C.7
Ryu, H.8
Ferrante, R.J.9
-
48
-
-
31644439986
-
Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice
-
Stack E.C., Smith K.M., Ryu H., Cormier K., Chen M., Hagerty S.W., Del Signore S.J., Cudkowicz M.E., Friedlander R.M., Ferrante R.J. Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice. Biochim. Biophys. Acta 2006, 1762:373-380.
-
(2006)
Biochim. Biophys. Acta
, vol.1762
, pp. 373-380
-
-
Stack, E.C.1
Smith, K.M.2
Ryu, H.3
Cormier, K.4
Chen, M.5
Hagerty, S.W.6
Del Signore, S.J.7
Cudkowicz, M.E.8
Friedlander, R.M.9
Ferrante, R.J.10
-
49
-
-
78751614662
-
Neurocognitive signs in prodromal Huntington disease
-
Stout J.C., Paulsen J.S., Queller S., Solomon A.C., Whitlock K.B., Campbell J.C., Carlozzi N., Duff K., Beglinger L.J., Langbehn D.R., Johnson S.A., Biglan K.M., Aylward E.H. Neurocognitive signs in prodromal Huntington disease. Neuropsychology 2011, 25:1-14.
-
(2011)
Neuropsychology
, vol.25
, pp. 1-14
-
-
Stout, J.C.1
Paulsen, J.S.2
Queller, S.3
Solomon, A.C.4
Whitlock, K.B.5
Campbell, J.C.6
Carlozzi, N.7
Duff, K.8
Beglinger, L.J.9
Langbehn, D.R.10
Johnson, S.A.11
Biglan, K.M.12
Aylward, E.H.13
-
50
-
-
25844526181
-
Gene expression in Huntington's disease skeletal muscle: a potential biomarker
-
Strand A.D., Aragaki A.K., Shaw D., Bird T., Holton J., Turner C., Tapscott S.J., Tabrizi S.J., Schapira A.H., Kooperberg C., Olson J.M. Gene expression in Huntington's disease skeletal muscle: a potential biomarker. Hum. Mol. Genet. 2005, 14:1863-1876.
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 1863-1876
-
-
Strand, A.D.1
Aragaki, A.K.2
Shaw, D.3
Bird, T.4
Holton, J.5
Turner, C.6
Tapscott, S.J.7
Tabrizi, S.J.8
Schapira, A.H.9
Kooperberg, C.10
Olson, J.M.11
-
51
-
-
85009226418
-
A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease
-
The Huntington Study Group
-
The Huntington Study Group A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001, 57:397-404.
-
(2001)
Neurology
, vol.57
, pp. 397-404
-
-
-
52
-
-
77956802394
-
Safety and tolerability of high-dose coenzyme Q10 in Huntington's disease and healthy subjects
-
The Huntington Study Group Pre2CARE Investigators
-
The Huntington Study Group Pre2CARE Investigators Safety and tolerability of high-dose coenzyme Q10 in Huntington's disease and healthy subjects. Mov. Disord. 2010, 25:1924-1928.
-
(2010)
Mov. Disord.
, vol.25
, pp. 1924-1928
-
-
-
53
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
-
The Huntington's Disease Collaborative Research Group
-
The Huntington's Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72:971-983.
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
54
-
-
35348941757
-
Clinical correlates of mitochondrial function in Huntington's disease muscle
-
Turner C., Cooper J.M., Schapira A.H. Clinical correlates of mitochondrial function in Huntington's disease muscle. Mov. Disord. 2007, 22:1715-1721.
-
(2007)
Mov. Disord.
, vol.22
, pp. 1715-1721
-
-
Turner, C.1
Cooper, J.M.2
Schapira, A.H.3
-
55
-
-
77955383021
-
Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease
-
Underwood B.R., Imarisio S., Fleming A., Rose C., Krishna G., Heard P., Quick M., Korolchuk V.I., Renna M., Sarkar S., Garcia-Arencibia M., O'Kane C.J., Murphy M.P., Rubinsztein D.C. Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease. Hum. Mol. Genet. 2010, 19:3413-3429.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 3413-3429
-
-
Underwood, B.R.1
Imarisio, S.2
Fleming, A.3
Rose, C.4
Krishna, G.5
Heard, P.6
Quick, M.7
Korolchuk, V.I.8
Renna, M.9
Sarkar, S.10
Garcia-Arencibia, M.11
O'Kane, C.J.12
Murphy, M.P.13
Rubinsztein, D.C.14
-
56
-
-
36549050391
-
Increased metabolism in the R6/2 mouse model of Huntington's disease
-
van der Burg J.M., Bacos K., Wood N.I., Lindqvist A., Wierup N., Woodman B., Wamsteeker J.I., Smith R., Deierborg T., Kuhar M.J., Bates G.P., Mulder H., Erlanson-Albertsson C., Morton A.J., Brundin P., Petersen A., Bjorkqvist M. Increased metabolism in the R6/2 mouse model of Huntington's disease. Neurobiol. Dis. 2008, 29:41-51.
-
(2008)
Neurobiol. Dis.
, vol.29
, pp. 41-51
-
-
van der Burg, J.M.1
Bacos, K.2
Wood, N.I.3
Lindqvist, A.4
Wierup, N.5
Woodman, B.6
Wamsteeker, J.I.7
Smith, R.8
Deierborg, T.9
Kuhar, M.J.10
Bates, G.P.11
Mulder, H.12
Erlanson-Albertsson, C.13
Morton, A.J.14
Brundin, P.15
Petersen, A.16
Bjorkqvist, M.17
-
57
-
-
33750437278
-
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration
-
Weydt P., Pineda V.V., Torrence A.E., Libby R.T., Satterfield T.F., Lazarowski E.R., Gilbert M.L., Morton G.J., Bammler T.K., Strand A.D., Cui L., Beyer R.P., Easley C.N., Smith A.C., Krainc D., Luquet S., Sweet I.R., Schwartz M.W., La Spada A.R. Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Cell Metab. 2006, 4:349-362.
-
(2006)
Cell Metab.
, vol.4
, pp. 349-362
-
-
Weydt, P.1
Pineda, V.V.2
Torrence, A.E.3
Libby, R.T.4
Satterfield, T.F.5
Lazarowski, E.R.6
Gilbert, M.L.7
Morton, G.J.8
Bammler, T.K.9
Strand, A.D.10
Cui, L.11
Beyer, R.P.12
Easley, C.N.13
Smith, A.C.14
Krainc, D.15
Luquet, S.16
Sweet, I.R.17
Schwartz, M.W.18
La Spada, A.R.19
-
58
-
-
65549091910
-
Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases
-
Yang L., Calingasan N.Y., Wille E.J., Cormier K., Smith K., Ferrante R.J., Beal M.F. Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases. J. Neurochem. 2009, 109:1427-1439.
-
(2009)
J. Neurochem.
, vol.109
, pp. 1427-1439
-
-
Yang, L.1
Calingasan, N.Y.2
Wille, E.J.3
Cormier, K.4
Smith, K.5
Ferrante, R.J.6
Beal, M.F.7
-
59
-
-
0028847947
-
Uptake of dietary coenzyme Q supplement is limited in rats
-
Zhang Y., Aberg F., Appelkvist E.L., Dallner G., Ernster L. Uptake of dietary coenzyme Q supplement is limited in rats. J. Nutr. 1995, 125:446-453.
-
(1995)
J. Nutr.
, vol.125
, pp. 446-453
-
-
Zhang, Y.1
Aberg, F.2
Appelkvist, E.L.3
Dallner, G.4
Ernster, L.5
-
60
-
-
0029787326
-
Restricted uptake of dietary coenzyme Q is in contrast to the unrestricted uptake of alpha-tocopherol into rat organs and cells
-
Zhang Y., Turunen M., Appelkvist E.L. Restricted uptake of dietary coenzyme Q is in contrast to the unrestricted uptake of alpha-tocopherol into rat organs and cells. J. Nutr. 1996, 126:2089-2097.
-
(1996)
J. Nutr.
, vol.126
, pp. 2089-2097
-
-
Zhang, Y.1
Turunen, M.2
Appelkvist, E.L.3
|