Restricted uptake of dietary coenzyme Q is in contrast to the unrestricted uptake of α-tocopherol into rat organs and cells

Journal of Nutrition

Volumn 126, Issue 9, 1996, Pages 2089-2097

  Zhang, Yiyi ^a   Turunen, Mikael ^b   Appelkvist, Eeva Liisa ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Coenzyme Q; plasma cell organelles; rats; tocopherol

Indexed keywords

ALPHA TOCOPHEROL; UBIQUINONE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CELL ULTRASTRUCTURE; DIET SUPPLEMENTATION; GOLGI COMPLEX; INTRACELLULAR TRANSPORT; LIVER LEVEL; LYSOSOME; NONHUMAN; PROTEIN INTAKE; PROTEIN TRANSPORT; RAT; TISSUE DISTRIBUTION; TRANSPORT KINETICS; VITAMIN INTAKE;

ANIMALIA;

EID: 0029787326     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.9.2089     Document Type: Article

References (33)

1. Åberg, F., Appelkvist, E. L, Dallner, G. & Ernster, L. (1992) Distribution and redox state of ubiquinones in rat and human tissues. Arch. Biochem. Biophys. 295: 230-234.
2. Andersson, M., Elmberger, P. G., Edlund, C., Kristensson, K. & Dallner, G. (1990) Rates of cholesterol, ubiquinone, dolichol and dolichyl-P biosynthesis in the endoplasmic reticulum-Golgi system of rat liver. FEES Lett. 269: 15-18.
3. Appelkvist, E. L., Kalén, A. &. Dallner, G. (1991) Biosynthesis and regulation of coenzyme Q. In: Biomedical and Clinical Aspects of Coenzyme Q (Folkers, K., Littarru, G. P. & Yamagami, T., eds.), vol. 6, pp. 141-150. Elsevier, Amsterdam, The Netherlands.
4. Beyer, R. E. & Starnes, J. W. (1985) Coenzyme Q and myocardial function in aging and exercise. In: Pathology and Cardiovascular Injury (Stone, H. L. & Weglicki, W. B., eds.), pp. 489-511. Martinus Nijhoff, Boston, MA.
5. Bieri, J. G. (1972) Kinetics of tissue α-tocopherol depletion and repletion. Ann. N.Y. Acad. Sci. 203: 181-191.
6. Bjørneboe, A., Bjørneboe, G.-E., Aa. & Drevon, C. (1990) Absorption, transport and distribution of vitamin E. J. Nutr. 120: 233-242.
7. Chan, A. C., Tran, K., Raynor, T., Ganz, P. R. & Chow, C. K. (1991) Regeneration of vitamin E in human platelets. J. Biol. Chem. 266: 17290-17295.
8. Crane, F. L., Sun, I. L. &. Sun. E. E. (1993) The essential functions of coenzyme Q. Clin. Invest. 71: S55-S59.
9. Elmberger, P. G., Kalén, A., Appelkvist, E. L. & Dallner, G. (1987) In vitro and in vivo synthesis of dolichol and other main mevalonate products in various organs of the rat. Eur. J. Biochem. 168: 1-11.
10. Ernster, L. (1977) Facts and ideas about the functions of coenzyme Q in mitochondria. In: Biomedical and Clinical Aspects of Coenzyme Q (Folkers, K. & Yamamura, Y., eds.), pp. 15-21. Elsevier, Amsterdam, The Netherlands.
11. Ernster, L. (1993) Lipid peroxidation in biological membranes: mechanisms and implications. In: Active Oxygens, Lipid Peroxides and Antioxidants (Yagi, K., ed.), pp. 1-38. CRC Press, Boca Raton, FL.
12. Ernster, L., Forsmark, P. & Nordenbrand, K. (1992) The mode of action of lipid-soluble antioxidants in biological membranes: relationship between the effects of ubiquinol and vitamin E as inhibitors of lipid peroxidation in submitochondrial particles. BioFactors 3: 241-248.
13. 10. Clin. Invest. 71: S51-S54.
14. Forsmark, P., Åberg, F., Norling, B., Nordenbrand, K., Dallner, G. & Ernster, L. (1991) Inhibition of lipid peroxidation by ubiquinol in submitochondrial particles in the absence of vitamin E. FEBS Lett. 285: 39-43.
15. Forsmark-Andrée, P. & Ernster, L. (1994) Evidence for a protective effect of endogenous ubiquinol against oxidative damage to mitochondrial protein and DNA during lipid peroxidation. Mol. Asp. Med. 15: S73-S81.
16. Imada, I., Watanabe, M., Matsumoto, N. & Morimoto, H. (1970) Metabolism of ubiquinone-7. Biochemistry 9: 2870-2878.
17. Kagan, V., Serbinova, E. & Packer, L. (1990) Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochem. Biophys. Res. Commun. 169:851-857.
18. Kalén, A., Appelkvist, E. L., Chojnacki, T. & Dallner, G. (1990) Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver. J. Biol. Chem. 265: 1158-1164.
19. Kalén, A., Appelkvist, E. L. & Dallner, G. (1989) Age-related changes in the lipid composition of rat and human tissue. Lipids 24: 579-584.
20. Kalén, A., Norling, B., Appelkvist, E. L. & Dallner, G. (1987) Ubiquinone biosynthesis by the microsomal fraction from rat liver. Biochim. Biophys. Acta 926: 70-78.
21. 10 in health and disease. In: Highlights in Ubiquinone Research (Lenaz, G., Barbabei, O., Rabbi, A., & Battino, M., eds.), pp. 288-292. Taylor & Francis, London, UK.
22. Liebler, D. C. (1993) The role of metabolism in the antioxidant function of vitamin E. Crit. Rev. Toxicol. 23: 147-169.
23. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with the Polin phenol reagent. J. Biol. Chem. 193: 265-275.
24. 10 (ubiquinone). Clin. Invest. 71: S116-S123.
25. Nelson, J. S. (1980) Pathology of vitamin E deficiency. In: Vitamin E-A Comprehensive Treatise (Machlin, L. J., ed.), pp. 397-428. Marcel-Dekker, New York, NY.
26. Packer, J. L., Slater, T. F. & Willson, R. L (1979) Direct observation of a free radical interaction between vitamin E and vitamin C. Nature (Lond.) 278: 737-738.
27. Packer, L. (1991) The protective role of vitamin E in biological systems. Am. J. Clin. Nutr. 1050S-1055S.
28. Quinn, P. J. & Katsikas, H. (1985) Thermal characteristics of coenzyme Q and its interaction with model membrane systems. In: Coenzyme Q. Biochemistry, Bioenergetics and Clinical Applications of Ubiquinone (Lenaz, G., ed.), pp. 107-130. John Wiley, New York, NY.
29. 10 in the rat following its oral administration. Drug Metab. Disp. 20: 423-427.
30. Stocker, R., Bowry, V. W. & Frei, B. (1991) Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does α-tocopherol. Proc. Natl. Acad. Sci. U.S.A. 88: 1646-1650.
31. Takahashi, T., Okamoto, T., Mori, K., Sayo, H. & Kishi, T. (1993) Distribution of ubiquinone and ubiquinol homologues in rat tissues and subcellular fractions. Lipids 28: 803-809.
32. Tollbom, Ö., Valtersson, C., Chojnacki, T. & Dallner, G. (1988) Esterification of dolichol in rat liver. J. Biol. Chem. 263: 1347-1352.
33. Zhang, Y., Åberg, F., Appelkvist, E. L., Dallner, G. & Ernster, L. (1995) The uptake of dietary coenzyme Q supplement is limited in rats. J. Nutr. 125: 446-453.