Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism

PLoS Genetics

Volumn 3, Issue 8, 2007, Pages 1397-1406

  Lee, Jong Min ^a   Ivanova, Elena V ^a,d   Ihn, Sik Seong ^a   Cashorali, Tanya ^b   Kohane, Isaac ^b   Gusella, James F ^a,c   MacDonald, Marcy E ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c Huntington's Dis Society of America Coalition for the Cure Mitochondria and Energy Metabolism Team   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROPROPIONIC ACID; HUNTINGTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; POLYGLUTAMINE; HD PROTEIN, HUMAN; NERVE PROTEIN; NUCLEAR PROTEIN; PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; GENE EXPRESSION; GLYCOLYSIS; HUNTINGTON CHOREA; LIPID METABOLISM; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; STEROL METABOLISM; STRIATE CORTEX; ANIMAL; CELL CULTURE; CLUSTER ANALYSIS; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; CELLS, CULTURED; CLUSTER ANALYSIS; ENERGY METABOLISM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDES;

EID: 34548399406     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.0030135     Document Type: Article

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