메뉴 건너뛰기




Volumn 72, Issue 8, 2011, Pages 788-804

Inverse vaccination with islet autoantigens to halt progression of autoimmune diabetes

Author keywords

cells; LADA; negative immunization; T cells; type 1 diabetes

Indexed keywords

ALTERED PEPTIDE LIGAND INSULIN; GLUTAMATE DECARBOXYLASE 65; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 60 DERIVED PEPTIDE; INSULIN; NBI 6024; PLACEBO; PROINSULIN; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG;

EID: 83655182406     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20488     Document Type: Review
Times cited : (3)

References (113)
  • 1
    • 0033106415 scopus 로고    scopus 로고
    • T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides
    • DOI 10.1006/jaut.1998.0262
    • Abulafia-Lapid R, Elias D, Raz I, Keren-Zur Y, Atlan H, Cohen IR,. 1999. T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides. J Automimmun 12: 121-129. (Pubitemid 29130589)
    • (1999) Journal of Autoimmunity , vol.12 , Issue.2 , pp. 121-129
    • Abulafia-Lapid, R.1    Elias, D.2    Raz, I.3    Keren-Zur, Y.4    Atlan, H.5    Cohen, I.R.6
  • 3
    • 67349116493 scopus 로고    scopus 로고
    • GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes
    • Agardh CD, Lynch KF, Palmer M, Link K, Lernmark A,. 2009. GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes. Diabetologia 52: 1363-1368.
    • (2009) Diabetologia , vol.52 , pp. 1363-1368
    • Agardh, C.D.1    Lynch, K.F.2    Palmer, M.3    Link, K.4    Lernmark, A.5
  • 7
    • 0021929456 scopus 로고
    • Metabolic and immunological effects of cyclosporin in recently diagnosed type 1 diabetes mellitus
    • Assan R, Feutren G, Debray-Sachs M, Quiniou-Debrie MC, Laborie C, Thomas G, Chatenoud L, Bach JF,. 1985. Metabolic and immunological effects of cyclosporin in recently diagnosed type 1 diabetes mellitus. Lancet 1: 67-71. (Pubitemid 15189820)
    • (1985) Lancet , vol.1 , Issue.8420 , pp. 67-71
    • Assan, R.1    Feutren, G.2    Debray-Sachs, M.3
  • 8
    • 0025979363 scopus 로고
    • No evidence for serological autoimmunity to islet cell heat shock proteins in insulin dependent diabetes
    • Atkinson MA, Holmes LA, Scharp DW, Lacy PE, Maclaren NK,. 1991. No evidence for serological autoimmunity to islet cell heat shock proteins in insulin dependent diabetes. J Clin Invest 87: 721-724.
    • (1991) J Clin Invest , vol.87 , pp. 721-724
    • Atkinson, M.A.1    Holmes, L.A.2    Scharp, D.W.3    Lacy, P.E.4    MacLaren, N.K.5
  • 9
    • 0033001488 scopus 로고    scopus 로고
    • The NOD mouse model of type 1 diabetes: As good as it gets?
    • DOI 10.1038/9442
    • Atkinson MA, Leiter EH,. 1999. The NOD mouse model of type 1 diabetes: as good as it gets? Nat Med 5: 601-604. (Pubitemid 29289413)
    • (1999) Nature Medicine , vol.5 , Issue.6 , pp. 601-604
    • Atkinson, M.A.1    Leiter, E.H.2
  • 10
    • 0025472820 scopus 로고
    • Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy
    • Atkinson MA, Maclaren NK, Luchetta R,. 1990. Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes 39: 933-937.
    • (1990) Diabetes , vol.39 , pp. 933-937
    • Atkinson, M.A.1    MacLaren, N.K.2    Luchetta, R.3
  • 11
    • 77955263232 scopus 로고    scopus 로고
    • Plant-made pharmaceuticals for the prevention and treatment of autoimmune diseases: Where are we?
    • Avesani L, Bortesi L, Santi L, Falorni A, Pezzotti M,. 2010. Plant-made pharmaceuticals for the prevention and treatment of autoimmune diseases: where are we? Expert Rev Vaccines 9: 957-969.
    • (2010) Expert Rev Vaccines , vol.9 , pp. 957-969
    • Avesani, L.1    Bortesi, L.2    Santi, L.3    Falorni, A.4    Pezzotti, M.5
  • 12
    • 78651376427 scopus 로고    scopus 로고
    • Early induction of GAD(65)-reactive Th2 response in type 1 diabetic children treated with alum-formulated GAD(65)
    • Axelsson S, Hjorth M, Akerman L, Ludvigsson J, Casas R,. 2010. Early induction of GAD(65)-reactive Th2 response in type 1 diabetic children treated with alum-formulated GAD(65). Diabetes Metab Res Rev 26: 559-568.
    • (2010) Diabetes Metab Res Rev , vol.26 , pp. 559-568
    • Axelsson, S.1    Hjorth, M.2    Akerman, L.3    Ludvigsson, J.4    Casas, R.5
  • 16
    • 0016261369 scopus 로고
    • Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
    • Bottazzo GF, Florin-Christensen A, Doniach D,. 1974. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2: 1279-1283.
    • (1974) Lancet , vol.2 , pp. 1279-1283
    • Bottazzo, G.F.1    Florin-Christensen, A.2    Doniach, D.3
  • 18
    • 33947726341 scopus 로고    scopus 로고
    • Moving towards efficient therapies in type 1 diabetes: To combine or not to combine?
    • DOI 10.1016/j.autrev.2006.09.013, PII S1568997206001625
    • Bresson D, von Herrath M,. 2007. Moving towards efficient therapies in type 1 diabetes: to combine or not to combine? Autoimmunity Rev 6: 315-322. (Pubitemid 46507996)
    • (2007) Autoimmunity Reviews , vol.6 , Issue.5 , pp. 315-322
    • Bresson, D.1    Von Herrath, M.2
  • 19
    • 70349705744 scopus 로고    scopus 로고
    • Immunotherapy for the prevention and treatment of type 1 diabetes: Optimizing the path from bench to bedside
    • Bresson D, von Herrath M,. 2009. Immunotherapy for the prevention and treatment of type 1 diabetes: optimizing the path from bench to bedside. Diabetes care 32: 1753-1768.
    • (2009) Diabetes Care , vol.32 , pp. 1753-1768
    • Bresson, D.1    Von Herrath, M.2
  • 20
    • 0036190005 scopus 로고    scopus 로고
    • B receptors contribute to the modulation of glucose-stimulated insulin secretion in pancreatic beta cells
    • DOI 10.1007/s00125-001-0750-0
    • Brice NL, Varadi A, Ashcroft SJ, Molnar E,. 2002. Metabotropic glutamate and GABA(B) receptors contribute to the modulation of glucose-stimulated insulin secretion in pancreatic beta cells. Diabetologia 45: 242-252. (Pubitemid 34208387)
    • (2002) Diabetologia , vol.45 , Issue.2 , pp. 242-252
    • Brice, N.L.1    Varadi, A.2    Ashcroft, S.J.H.3    Molnar, E.4
  • 21
    • 0029619559 scopus 로고
    • A family of hsp60-related proteins in pancreatic beta cells of non-obese diabetic (NOD) mice
    • DOI 10.1016/S0896-8411(95)80022-0
    • Brudzynski K, Cunningham IA, Martinez V,. 1995. A family of hsp60-related proteins in pancreatic beta cells of non-obese diabetic (NOD) mice. J Automimmun 8: 859-874. (Pubitemid 26046549)
    • (1995) Journal of Autoimmunity , vol.8 , Issue.6 , pp. 859-874
    • Brudzynski, K.1    Cunningham, I.A.2    Martinez, V.3
  • 22
  • 24
    • 84939314060 scopus 로고
    • Inhibition of experimental drug allergy by prior feeding of the sensitizing agent
    • Chase MW,. 1946. Inhibition of experimental drug allergy by prior feeding of the sensitizing agent. Proc Soc Exp Biol Med 61: 257-259.
    • (1946) Proc Soc Exp Biol Med , vol.61 , pp. 257-259
    • Chase, M.W.1
  • 25
    • 77956614531 scopus 로고    scopus 로고
    • GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response
    • Cheramy M, Skoglund C, Johansson I, Ludvigsson J, Hampe CS, Casas R,. 2010. GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response. Clin Immunol 137: 31-40.
    • (2010) Clin Immunol , vol.137 , pp. 31-40
    • Cheramy, M.1    Skoglund, C.2    Johansson, I.3    Ludvigsson, J.4    Hampe, C.S.5    Casas, R.6
  • 26
    • 0034681356 scopus 로고    scopus 로고
    • Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues
    • DOI 10.1074/jbc.275.7.5188
    • Chessler SD, Lernmark A,. 2000. Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues. J Biol Chem 275: 5188-5192. (Pubitemid 30108922)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.7 , pp. 5188-5192
    • Chessler, S.D.1    Lernmark, A.2
  • 28
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic -cell death in type 1 and type 2 diabetes: Many differences, few similarities
    • DOI 10.2337/diabetes.54.suppl-2.S97
    • Cnop M, Welsh N, Jonas JC, Jorns A, Lenzen S, Eizirik DL,. 2005. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54: S97-107. (Pubitemid 43343337)
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Cnop, M.1    Welsh, N.2    Jonas, J.-C.3    Jorns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 29
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
    • DOI 10.1073/pnas.93.2.956
    • Daniel D, Wegmann DR,. 1996. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci USA 93: 956-960. (Pubitemid 26041202)
    • (1996) Proceedings of the National Academy of Sciences of the United States of America , vol.93 , Issue.2 , pp. 956-960
    • Daniel, D.1    Wegmann, D.R.2
  • 30
    • 0037198427 scopus 로고    scopus 로고
    • Effects of insulin in relatives of patients with type 1 diabetes mellitus
    • DPT-1
    • DPT-1. 2002. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 346: 1685-1691.
    • (2002) N Engl J Med , vol.346 , pp. 1685-1691
  • 32
    • 0024412315 scopus 로고
    • Immunological characterization of a human homolog of the 65-kilodalton mycobacterial antigen
    • Dudani AK, Gupta RS,. 1989. Immunological characterization of a human homolog of the 65-kilodalton mycobacterial antigen. Infection Immun 57: 2786-2793. (Pubitemid 19212613)
    • (1989) Infection and Immunity , vol.57 , Issue.9 , pp. 2786-2793
    • Dudani, A.K.1    Gupta, R.S.2
  • 33
    • 69249212422 scopus 로고    scopus 로고
    • Immune modulation in type 1 diabetes mellitus using DiaPep277: A short review and update of recent clinical trial results
    • Eldor R, Kassem S, Raz I,. 2009. Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial results. Diabetes Metab Res Rev 25: 316-320.
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 316-320
    • Eldor, R.1    Kassem, S.2    Raz, I.3
  • 34
    • 33845687082 scopus 로고    scopus 로고
    • DiaPep277 preserves endogenous insulin production by immunomodulation in type 1 diabetes
    • DOI 10.1196/annals.1375.052, Immunology of Diabetes IV: Progress in Our Understanding
    • Elias D, Avron A, Tamir M, Raz I,. 2006. DiaPep277 preserves endogenous insulin production by immunomodulation in type 1 diabetes. Ann NY Acad Sci 1079: 340-344. (Pubitemid 44968744)
    • (2006) Annals of the New York Academy of Sciences , vol.1079 , pp. 340-344
    • Elias, D.1    Avron, A.2    Tamir, M.3    Raz, I.4
  • 35
    • 0028215907 scopus 로고
    • Peptide therapy for diabetes in NOD mice
    • DOI 10.1016/S0140-6736(94)91582-2
    • Elias D, Cohen IR,. 1994. Peptide therapy for diabetes in NOD mice. Lancet 343: 704-706. (Pubitemid 24087851)
    • (1994) Lancet , vol.343 , Issue.8899 , pp. 704-706
    • Elias, D.1    Cohen, I.R.2
  • 36
    • 0028787305 scopus 로고
    • Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277
    • Elias D, Cohen IR,. 1995. Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277. Diabetes 44: 1132-1138.
    • (1995) Diabetes , vol.44 , pp. 1132-1138
    • Elias, D.1    Cohen, I.R.2
  • 37
    • 0025058568 scopus 로고
    • Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein
    • Elias D, Markovits D, Reshef T, van der Zee R, Cohen IR,. 1990. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci USA 87: 1576-1580.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1576-1580
    • Elias, D.1    Markovits, D.2    Reshef, T.3    Van Der Zee, R.4    Cohen, I.R.5
  • 38
    • 0030960632 scopus 로고    scopus 로고
    • Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various -cell antigens
    • Elias D, Meilin A, Ablamunits V, Birk OS, Carmi P, Konen-Waisman S, Cohen IR,. 1997. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens. Diabetes 46: 758-764. (Pubitemid 27188251)
    • (1997) Diabetes , vol.46 , Issue.5 , pp. 758-764
    • Elias, D.1    Meilin, A.2    Ablamunits, V.3    Birk, O.S.4    Carmi, P.5    Konen-Waisman, S.6    Cohen, I.R.7
  • 42
    • 0031976734 scopus 로고    scopus 로고
    • Delay of Type I diabetes in high risk, first degree relatives by parenteral antigen administration: The Schwabing insulin Prophylaxis Pilot Trial
    • DOI 10.1007/s001250050943
    • Fuchtenbusch M, Rabl W, Grassl B, Bachmann W, Standl E, Ziegler AG,. 1998. Delay of type I diabetes in high risk, first degree relatives by parenteral antigen administration: the Schwabing Insulin Prophylaxis Pilot Trial. Diabetologia 41: 536-541. (Pubitemid 28206823)
    • (1998) Diabetologia , vol.41 , Issue.5 , pp. 536-541
    • Fuchtenbusch, M.1    Rabl, W.2    Grassl, B.3    Bachmann, W.4    Standl, E.5    Ziegler, A.-G.6
  • 44
    • 33846995434 scopus 로고    scopus 로고
    • Australia set to test insulin "vaccine" for juvenile diabetes
    • Grose S,. 2007. Australia set to test insulin "vaccine" for juvenile diabetes. Nat Med 13: 111.
    • (2007) Nat Med , vol.13 , pp. 111
    • Grose, S.1
  • 45
    • 4644230843 scopus 로고    scopus 로고
    • Pancreatic -cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
    • DOI 10.2337/diacare.27.10.2348
    • Harrison LC, Honeyman MC, Steele CE, Stone NL, Sarugeri E, Bonifacio E, Couper JJ, Colman PG,. 2004. Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes. Diabetes Care 27: 2348-2355. (Pubitemid 39281384)
    • (2004) Diabetes Care , vol.27 , Issue.10 , pp. 2348-2355
    • Harrison, L.C.1    Honeyman, M.C.2    Steele, C.E.3    Stone, N.L.4    Sarugeri, E.5    Bonifacio, E.6    Couper, J.J.7    Colman, P.G.8
  • 46
    • 20044375937 scopus 로고    scopus 로고
    • A single course of anti-CD3 monoclonal antibody hOKT31(ala-ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
    • DOI 10.2337/diabetes.54.6.1763
    • Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA,. 2005. A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 54: 1763-1769. (Pubitemid 40770766)
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1763-1769
    • Herold, K.C.1    Gitelman, S.E.2    Masharani, U.3    Hagopian, W.4    Bisikirska, B.5    Donaldson, D.6    Rother, K.7    Diamond, B.8    Harlan, D.M.9    Bluestone, J.A.10
  • 47
    • 53249140520 scopus 로고    scopus 로고
    • Diamyd, an alum-formulated recombinant human GAD65 for the prevention of autoimmune diabetes
    • Hinke SA,. 2008. Diamyd, an alum-formulated recombinant human GAD65 for the prevention of autoimmune diabetes. Current opinion in molecular therapeutics 10: 516-525.
    • (2008) Current Opinion in Molecular Therapeutics , vol.10 , pp. 516-525
    • Hinke, S.A.1
  • 50
    • 0031777665 scopus 로고    scopus 로고
    • Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administration
    • DOI 10.1006/jaut.1997.0184
    • Hutchings P, Cooke A,. 1998. Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administration. J Automimmun 11: 127-130. (Pubitemid 28273008)
    • (1998) Journal of Autoimmunity , vol.11 , Issue.2 , pp. 127-130
    • Hutchings, P.1    Cooke, A.2
  • 54
    • 0024522738 scopus 로고
    • Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen
    • Jindal S, Dudani AK, Singh B, Harley CB, Gupta RS,. 1989. Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen. Mol Cell Biol 9: 2279-2283. (Pubitemid 19117837)
    • (1989) Molecular and Cellular Biology , vol.9 , Issue.5 , pp. 2279-2283
    • Jindal, S.1    Dudani, A.K.2    Singh, B.3    Harley, C.B.4    Gupta, R.S.5
  • 55
    • 79551698049 scopus 로고    scopus 로고
    • Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes
    • Johnson MC, Wang B, Tisch R,. 2011. Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes. Hum Vaccines 7: 27-36.
    • (2011) Hum Vaccines , vol.7 , pp. 27-36
    • Johnson, M.C.1    Wang, B.2    Tisch, R.3
  • 56
    • 0025168502 scopus 로고
    • Heat-shock protein 65 as a cell antigen of insulin-dependent diabetes
    • DOI 10.1016/0140-6736(90)93390-B
    • Jones DB, Hunter NR, Duff GW,. 1990. Heat-shock protein 65 as a beta cell antigen of insulin-dependent diabetes. Lancet 336: 583-585. (Pubitemid 20296916)
    • (1990) Lancet , vol.336 , Issue.8715 , pp. 583-585
    • Jones, D.B.1    Hunter, N.R.2    Duff, G.W.3
  • 59
    • 0027480065 scopus 로고
    • Insulin prophylaxis in individuals at high risk of type I diabetes
    • DOI 10.1016/0140-6736(93)91215-8
    • Keller RJ, Eisenbarth GS, Jackson RA,. 1993. Insulin prophylaxis in individuals at high risk of type I diabetes. Lancet 341: 927-928. (Pubitemid 23109113)
    • (1993) Lancet , vol.341 , Issue.8850 , pp. 927-928
    • Keller, R.J.1    Eisenbarth, G.S.2    Jackson, R.A.3
  • 60
    • 18744385526 scopus 로고    scopus 로고
    • Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
    • DOI 10.1038/nature03625
    • Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA,. 2005. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 435: 224-228. (Pubitemid 40685950)
    • (2005) Nature , vol.435 , Issue.7039 , pp. 224-228
    • Kent, S.C.1    Chen, Y.2    Bregoli, L.3    Clemmings, S.M.4    Kenyon, N.S.5    Ricordi, C.6    Hering, B.J.7    Hafler, D.A.8
  • 62
    • 77949266510 scopus 로고    scopus 로고
    • Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
    • Keymeulen B, Walter M, Mathieu C, Kaufman L, Gorus F, Hilbrands R, Vandemeulebroucke E, Van de Velde U, Crenier L, De Block C, et al. 2010. Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia 53: 614-623.
    • (2010) Diabetologia , vol.53 , pp. 614-623
    • Keymeulen, B.1    Walter, M.2    Mathieu, C.3    Kaufman, L.4    Gorus, F.5    Hilbrands, R.6    Vandemeulebroucke, E.7    Van De Velde, U.8    Crenier, L.9    De Block, C.10
  • 64
    • 34249820806 scopus 로고    scopus 로고
    • Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: A randomised, double-blind phase II study
    • DOI 10.1002/dmrr.711
    • Lazar L, Ofan R, Weintrob N, Avron A, Tamir M, Elias D, Phillip M, Josefsberg Z,. 2007. Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double-blind phase II study. Diabetes Metab Res Rev 23: 286-291. (Pubitemid 46851469)
    • (2007) Diabetes/Metabolism Research and Reviews , vol.23 , Issue.4 , pp. 286-291
    • Lazar, L.1    Ofan, R.2    Weintrob, N.3    Avron, A.4    Tamir, M.5    Elias, D.6    Phillip, M.7    Josefsberg, Z.8
  • 65
    • 0029683483 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase - Gene to antigen to disease
    • Lernmark A,. 1996. Glutamic acid decarboxylase-gene to antigen to disease. J Intern Med 240: 259-277. (Pubitemid 26388855)
    • (1996) Journal of Internal Medicine , vol.240 , Issue.5 , pp. 259-277
    • Lernmark, A.1
  • 66
    • 79960224916 scopus 로고    scopus 로고
    • Editorial Comment on type 1 diabetes and antigen-specific immunotherapy
    • Lernmark A, Larsson HE,. 2011. Editorial Comment on type 1 diabetes and antigen-specific immunotherapy. Journal of internal medicine 270: 132-135.
    • (2011) Journal of Internal Medicine , vol.270 , pp. 132-135
    • Lernmark, A.1    Larsson, H.E.2
  • 67
    • 79957602397 scopus 로고    scopus 로고
    • Immunology. Regulatory T cells get their chance to shine
    • Leslie M,. 2011. Immunology. Regulatory T cells get their chance to shine. Science 332: 1020-1021.
    • (2011) Science , vol.332 , pp. 1020-1021
    • Leslie, M.1
  • 69
    • 79953756466 scopus 로고    scopus 로고
    • Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: A randomised controlled trial
    • Ludvigsson J, Hjorth M, Cheramy M, Axelsson S, Pihl M, Forsander G, Nilsson NO, Samuelsson BO, Wood T, Aman J, et al. 2011. Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: a randomised controlled trial. Diabetologia 54: 634-640.
    • (2011) Diabetologia , vol.54 , pp. 634-640
    • Ludvigsson, J.1    Hjorth, M.2    Cheramy, M.3    Axelsson, S.4    Pihl, M.5    Forsander, G.6    Nilsson, N.O.7    Samuelsson, B.O.8    Wood, T.9    Aman, J.10
  • 71
    • 0029933512 scopus 로고    scopus 로고
    • Ontogeny and tissue distribution of human GAD expression
    • Mally MI, Cirulli V, Otonkoski T, Soto G, Hayek A,. 1996. Ontogeny and tissue distribution of human GAD expression. Diabetes 45: 496-501. (Pubitemid 26110256)
    • (1996) Diabetes , vol.45 , Issue.4 , pp. 496-501
    • Mally, M.I.1    Cirulli, V.2    Otonkoski, T.3    Soto, G.4    Hayek, A.5
  • 72
    • 79960735120 scopus 로고    scopus 로고
    • Arresting type 1 diabetes after diagnosis: GAD is not enough
    • Mathieu C, Gillard P,. 2011. Arresting type 1 diabetes after diagnosis: GAD is not enough. Lancet 378: 291-292.
    • (2011) Lancet , vol.378 , pp. 291-292
    • Mathieu, C.1    Gillard, P.2
  • 73
    • 77950649733 scopus 로고    scopus 로고
    • Developing combination immunotherapies for type 1 diabetes: Recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group
    • Matthews JB, Staeva TP, Bernstein PL, Peakman M, von Herrath M,. 2010. Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group. Clin Exp Immunol 160: 176-184.
    • (2010) Clin Exp Immunol , vol.160 , pp. 176-184
    • Matthews, J.B.1    Staeva, T.P.2    Bernstein, P.L.3    Peakman, M.4    Von Herrath, M.5
  • 74
    • 45949130640 scopus 로고
    • The regulation of immune responses to dietary protein antigens
    • Mowat AM,. 1987. The regulation of immune responses to dietary protein antigens. Immunol Today 8: 93-98.
    • (1987) Immunol Today , vol.8 , pp. 93-98
    • Mowat, A.M.1
  • 75
    • 0028861576 scopus 로고
    • Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription
    • Muir A, Peck A, Clare-Salzler M, Song YH, Cornelius J, Luchetta R, Krischer J, Maclaren N,. 1995. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription. J Clin Invest 95: 628-634.
    • (1995) J Clin Invest , vol.95 , pp. 628-634
    • Muir, A.1    Peck, A.2    Clare-Salzler, M.3    Song, Y.H.4    Cornelius, J.5    Luchetta, R.6    Krischer, J.7    MacLaren, N.8
  • 78
    • 55749104546 scopus 로고    scopus 로고
    • Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: A double-blind, randomised controlled trial
    • Nanto-Salonen K, Kupila A, Simell S, Siljander H, Salonsaari T, Hekkala A, Korhonen S, Erkkola R, Sipila JI, Haavisto L, et al. 2008. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial. Lancet 372: 1746-1755.
    • (2008) Lancet , vol.372 , pp. 1746-1755
    • Nanto-Salonen, K.1    Kupila, A.2    Simell, S.3    Siljander, H.4    Salonsaari, T.5    Hekkala, A.6    Korhonen, S.7    Erkkola, R.8    Sipila, J.I.9    Haavisto, L.10
  • 83
    • 75349111902 scopus 로고    scopus 로고
    • Association of T-cell reactivity with beta-cell function in recent onset type 1 diabetes patients
    • Pfleger C, Meierhoff G, Kolb H, Schloot NC,. 2010. Association of T-cell reactivity with beta-cell function in recent onset type 1 diabetes patients. J Automimmun 34: 127-135.
    • (2010) J Automimmun , vol.34 , pp. 127-135
    • Pfleger, C.1    Meierhoff, G.2    Kolb, H.3    Schloot, N.C.4
  • 84
    • 49449094301 scopus 로고    scopus 로고
    • Preserving beta cells in type i diabetes mellitus: The role of immunological tolerance
    • Pillemer SR,. 2008. Preserving beta cells in type I diabetes mellitus: the role of immunological tolerance. Drug Dev Res 69: 153-157.
    • (2008) Drug Dev Res , vol.69 , pp. 153-157
    • Pillemer, S.R.1
  • 87
    • 34249812097 scopus 로고    scopus 로고
    • Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: Extension of a randomized, double-blind, phase II trial
    • DOI 10.1002/dmrr.712
    • Raz I, Avron A, Tamir M, Metzger M, Symer L, Eldor R, Cohen IR, Elias D,. 2007. Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial. Diabetes Metab Res Rev 23: 292-298. (Pubitemid 46851470)
    • (2007) Diabetes/Metabolism Research and Reviews , vol.23 , Issue.4 , pp. 292-298
    • Raz, I.1    Avron, A.2    Tamir, M.3    Metzger, M.4    Symer, L.5    Eldor, R.6    Cohen, I.R.7    Elias, D.8
  • 88
    • 0035944844 scopus 로고    scopus 로고
    • -cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
    • DOI 10.1016/S0140-6736(01)06801-5
    • Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR,. 2001. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 358: 1749-1753. (Pubitemid 33152998)
    • (2001) Lancet , vol.358 , Issue.9295 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3    Tamir, M.4    Metzger, M.5    Cohen, I.R.6
  • 91
    • 0024504171 scopus 로고
    • A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus
    • Shah SC, Malone JI, Simpson NE,. 1989. A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus. N Engl J Med 320: 550-554. (Pubitemid 19070538)
    • (1989) New England Journal of Medicine , vol.320 , Issue.9 , pp. 550-554
    • Shah, S.C.1    Malone, J.I.2    Simpson, N.E.3
  • 92
    • 34247264408 scopus 로고    scopus 로고
    • Prediction and prevention of type 1 diabetes: Progress, problems, and prospects
    • DOI 10.1038/sj.clpt.6100179, PII 6100179
    • Skyler JS,. 2007. Prediction and prevention of type 1 diabetes: progress, problems, and prospects. Clin Pharmacol Ther 81: 768-771. (Pubitemid 46625122)
    • (2007) Clinical Pharmacology and Therapeutics , vol.81 , Issue.5 , pp. 768-771
    • Skyler, J.S.1
  • 93
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with type 1 diabetes: The diabetes prevention trial-type 1
    • DOI 10.2337/diacare.28.5.1068
    • Skyler JS, Krischer JP, Wolfsdorf J, Cowie C, Palmer JP, Greenbaum C, Cuthbertson D, Rafkin-Mervis LE, Chase HP, Leschek E,. 2005. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1. Diabetes Care 28: 1068-1076. (Pubitemid 40616615)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1068-1076
    • Skyler, J.S.1
  • 95
    • 0025945011 scopus 로고
    • Structural and functional considerations of GABA in islets of Langerhans
    • Sorenson RL, Garry DG, Brelje TC,. 1991. Structural and functional considerations of GABA in islets of Langerhans. Beta-cells and nerves. Diabetes 40: 1365-1374.
    • (1991) Beta-cells and Nerves. Diabetes , vol.40 , pp. 1365-1374
    • Sorenson, R.L.1    Garry, D.G.2    Brelje, T.C.3
  • 100
    • 0031831753 scopus 로고    scopus 로고
    • Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice
    • DOI 10.2337/diabetes.47.6.894
    • Tisch R, Liblau RS, Yang XD, Liblau P, McDevitt HO,. 1998. Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice. Diabetes 47: 894-899. (Pubitemid 28255662)
    • (1998) Diabetes , vol.47 , Issue.6 , pp. 894-899
    • Tisch, R.1    Liblau, R.S.2    Yang, X.-D.3    Liblau, P.4    McDevitt, H.O.5
  • 101
    • 0033178763 scopus 로고    scopus 로고
    • Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent
    • Tisch R, Wang B, Serreze DV,. 1999. Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent. J Immunol 163: 1178-1187. (Pubitemid 29352732)
    • (1999) Journal of Immunology , vol.163 , Issue.3 , pp. 1178-1187
    • Tisch, R.1    Wang, B.2    Serreze, D.V.3
  • 102
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • DOI 10.1038/366072a0
    • Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO,. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75. (Pubitemid 23345239)
    • (1993) Nature , vol.366 , Issue.6450 , pp. 72-75
    • Tisch, R.1    Yang, X.-D.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 103
    • 78751662679 scopus 로고    scopus 로고
    • Type 1 diabetes: Etiology, immunology, and therapeutic strategies
    • van Belle TL, Coppieters KT, von Herrath MG,. 2011. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 91: 79-118.
    • (2011) Physiol Rev , vol.91 , pp. 79-118
    • Van Belle, T.L.1    Coppieters, K.T.2    Von Herrath, M.G.3
  • 104
    • 70449412682 scopus 로고    scopus 로고
    • No effect of the altered peptide ligand NBI-6024 on beta-cell residual function and insulin needs in new-onset type 1 diabetes
    • Walter M, Philotheou A, Bonnici F, Ziegler AG, Jimenez R,. 2009. No effect of the altered peptide ligand NBI-6024 on beta-cell residual function and insulin needs in new-onset type 1 diabetes. Diabetes Care 32: 2036-2040.
    • (2009) Diabetes Care , vol.32 , pp. 2036-2040
    • Walter, M.1    Philotheou, A.2    Bonnici, F.3    Ziegler, A.G.4    Jimenez, R.5
  • 105
    • 84951657129 scopus 로고
    • Studies on the chemistry of anaphylaxis. III. Experiments with isolated proteins, especially those of the hen's egg
    • Wells HG,. 1911. Studies on the chemistry of anaphylaxis. III. Experiments with isolated proteins, especially those of the hen's egg. J Infect Dis 9: 147-171.
    • (1911) J Infect Dis , vol.9 , pp. 147-171
    • Wells, H.G.1
  • 108
    • 79551470267 scopus 로고    scopus 로고
    • Autoimmune markers in diabetes
    • Winter WE, Schatz DA,. 2011. Autoimmune markers in diabetes. Clin Chem 57: 168-175.
    • (2011) Clin Chem , vol.57 , pp. 168-175
    • Winter, W.E.1    Schatz, D.A.2
  • 109
    • 0028178708 scopus 로고
    • Identification of the GABAA receptor subtype mRNA in human pancreatic tissue
    • Yang W, Reyes AA, Lan NC,. 1994. Identification of the GABAA receptor subtype mRNA in human pancreatic tissue. FEBS Lett 346: 257-262.
    • (1994) FEBS Lett , vol.346 , pp. 257-262
    • Yang, W.1    Reyes, A.A.2    Lan, N.C.3
  • 111
    • 0031891701 scopus 로고    scopus 로고
    • Characterization of novel T-cell epitopes on 65 kDa and 67 kDa glutamic acid decarboxylase relevant in autoimmune responses in NOD mice
    • DOI 10.1006/jaut.1997.0178
    • Zechel MA, Elliott JF, Atkinson MA, Singh B,. 1998. Characterization of novel T-cell epitopes on 65 kDa and 67 kDa glutamic acid decarboxylase relevant in autoimmune responses in NOD mice. J Autoimmun 11: 83-95. (Pubitemid 28080731)
    • (1998) Journal of Autoimmunity , vol.11 , Issue.1 , pp. 83-95
    • Zechel, M.A.1    Elliott, J.F.2    Atkinson, M.A.3    Singh, B.4
  • 113
    • 0033016840 scopus 로고    scopus 로고
    • Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: The 2-year analysis of the German BABYDIAB Study
    • Ziegler AG, Hummel M, Schenker M, Bonifacio E,. 1999. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 48: 460-468. (Pubitemid 29106857)
    • (1999) Diabetes , vol.48 , Issue.3 , pp. 460-468
    • Ziegler, A.-G.1    Hummel, M.2    Schenker, M.3    Bonifacio, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.