Cell division and aging of the organism

Biogerontology

Volumn 12, Issue 6, 2011, Pages 503-515

  MacIeira Coelho, Alvaro ^a  

^a INSERM   (France)

Author keywords

Asymmetric cell division; DNA methylation; Fibroblasts; Immortalization; Longevity; Telomeres

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 4; ELASTIN; FIBRONECTIN; GLUCOKINASE; GLYCOSAMINOGLYCAN; NITRIC OXIDE SYNTHASE; OSTEOPROTEGERIN; PLATELET DERIVED GROWTH FACTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; TRANSFORMING GROWTH FACTOR BETA1; TYROSINE AMINOTRANSFERASE;

AGING; CELL DIVISION; CELL FUNCTION; CELL PROLIFERATION; CYTOGENETICS; EPIGENETICS; GERONTOLOGY; HUMAN; LIFE CYCLE; LONGEVITY; METAZOON; NONHUMAN; POSTNATAL DEVELOPMENT; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; REVIEW; SENESCENCE; SOMATIC CELL; TELOMERE;

AGING; ANIMALS; CELL AGING; CELL DIVISION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HUMANS; LONGEVITY; REGENERATION; SPECIES SPECIFICITY; TELOMERE;

EID: 83555165129     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-011-9346-3     Document Type: Review

References (112)

1. PM Absher RG Absher 1976 Clonal variation and aging of diploid fibroblasts. Cinematographic studies of cell pedigrees Exp Cell Res 103 247 255 1001362 1:STN:280:DyaE2s%2FmvVKluw%3D%3D 10.1016/0014-4827(76)90261-5 (Pubitemid 8011248)
2. MV Achi N Ravindranath M Dym 2000 Telomere length in male germ cells is inversely correlated with telomerase activity Biol Reprod 63 591 598 10906069 1:CAS:528:DC%2BD3cXltl2gur0%3D 10.1095/biolreprod63.2.591 (Pubitemid 30639951)
3. Adelman RC (1972) Age-dependent control of enzyme adaptation. In: Strehler B (ed) Advances in gerontological research, vol 4. Academic Press, New York, pp 1-23
4. RC Allsop H Vaziri C Patterson S Goldstein EV Younglali AB Futcher CW Greider CB Harley 1992 Telomere length predicts replicative capacity of human fibroblasts Proc Natl Acad Sci USA 89 10114 10118 10.1073/pnas.89.21.10114
5. T Ashley DC Ward 1993 A "hot spot" of recombination coincides with an interstitial telomeric sequence in the Armenian hamster Cytogenet Cell Genet 62 169 176 8428518 1:STN:280:DyaK3s7lsVWnsw%3D%3D 10.1159/000133464
6. AJ Ball F Levine 2005 Telomere-independent cellular senescence in human fetal cardiomyocytes Aging Cell 4 21 15659210 1:CAS:528:DC%2BD2MXhtlalsb4%3D 10.1111/j.1474-9728.2004.00137.x (Pubitemid 41583136)
7. P Ben 1997 Aging chromosome telomeres: parallel studies with terminal repeat and telomere associated DNA probes Mech Ageing Dev 99 153 166 10.1016/S0047-6374(97)00099-7
8. DH Betts SD Perrault WA King 2008 Low oxygen delays fibroblast senescence despite shorter telomeres Biogerontology 9 19 31 17952625 1:CAS:528: DC%2BD1cXitVWntw%3D%3D 10.1007/s10522-007-9113-7
9. EH Blackburn 2000 Telomere states and cell fates Nature 408 53 55 11081503 1:CAS:528:DC%2BD3cXotValu7Y%3D 10.1038/35040500
10. MA Blasco HW Lee MP Hande E Smaper PM Lansdorp RA De Pinho CW Greider 1997 Telomere shortening and tumor formation by mouse cells lacking telomerase Cell 91 25 34 9335332 1:CAS:528:DyaK2sXmslGgt7w%3D 10.1016/S0092-8674(01)80006-4 (Pubitemid 27431310)
11. AG Bodnar M Ouelette M Frolkis SE Holt CP Chiu GB Morin CB Harley JW Shay S Lichsteiner WE Wright 1998 Extension of life span by introduction of telomerase into normal human cells Science 279 349 352 9454332 1:CAS:528:DyaK1cXmtlOjug%3D%3D 10.1126/science.279.5349.349 (Pubitemid 28063364)
12. S Bork S Pfister H Witt P Horn B Korn AD Ho W Wagner 2010 DNA methylation pattern changes upon long-term and aging of human mesenchymal stromal cells Aging Cell 9 54 63 19895632 1:CAS:528:DC%2BC3cXhtlKntrk%3D 10.1111/j.1474-9726. 2009.00535.x
13. CA Bourgeois C Raynaud C Diatloff-Zito A Macieira-Coelho 1981 Effect of low dose rate ionizing radiation on the division potential of cells in vitro. VIII. Cytogenetic analysis of human fibroblasts Mech Ag Dev 17 225 235 1:STN:280:DyaL387gt1GisQ%3D%3D 10.1016/0047-6374(81)90060-9 (Pubitemid 12167988)
14. B Boyer P Kern A Fourtanier J Labat-Robert 1991 Age-dependent variations of the biosynthesis of fibronectin and fibrous collagens in mouse skin Exp Gerontol 26 375 383 1936196 1:CAS:528:DyaK3MXlsFGkur4%3D 10.1016/0531-5565(91) 90049-R
15. Capanna E (1973) Cytotaxonomy and vertebrate evolution. Academic Press, London
16. Capra F (1997) The web of life. Anchor Books, Doubleday, New York
17. TA Carman CA Afshari JC Barrett 1998 Cellular senescence in telomerase-expressing Syrian hamster embryo cells Exp Cell Res 244 33 42 9770346 1:CAS:528:DyaK1cXmslWmsrg%3D 10.1006/excr.1998.4207 (Pubitemid 28480851)
18. TH Chen EH Ruddle 1974 Chromosome changes revealed by the Q-band staining method during cell senescence of WI-38 Proc Soc Exp Biol Med 147 533 536 4140530 1:STN:280:DyaE2M%2FmsFygtQ%3D%3D
19. QM Chen KR Prowse V Tu S Purdom HK Linskens 2001 Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts Exp Cell Res 265 294 303 11302695 1:CAS:528:DC%2BD3MXis1ertrk%3D 10.1006/excr.2001.5182 (Pubitemid 32980218)
20. HT Cheung MJ Nadakavukaren 1983 Age-dependent changes in the cellularity and ultrastructure of the spleen of Fischer F344 rats Mech Ageing Dev 22 23 33 6621111 1:STN:280:DyaL2c%2Fht1KktA%3D%3D 10.1016/0047-6374(83)90004-0
21. + T cells throughout life, from newborns to centenarians: implications for T cell memory Mech Ageing Dev 86 173 195 8733112 1:CAS:528:DyaK28XjtV2hu7k%3D 10.1016/0047-6374(95)01691-0 (Pubitemid 26134554)
22. G Coviello-McLaughlin KR Prowse 1997 Telomere length regulation during postnatal development and ageing in Mus spretus Nucleic Acids Res 25 3051 3058 9224604 1:CAS:528:DyaK2sXltlCksrg%3D 10.1093/nar/25.15.3051 (Pubitemid 27331398)
23. VJ Cristofalo BB Sharf 1973 Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid cells Exp Cell Res 76 419 427 4568162 1:CAS:528:DyaE3sXpsFCgsg%3D%3D 10.1016/0014-4827(73)90394-7
24. VJ Cristofalo RG Allen RJ Pignolo BJ Martin JC Beck 1998 Relationship between donor age and the replicative lifespan oh human cells in culture. A reevaluation Proc Natl Acad Sci USA 95 10614 10619 9724752 1:CAS:528: DyaK1cXlvFWgtro%3D 10.1073/pnas.95.18.10614 (Pubitemid 28413116)
25. LM Decker E Chavez I Vulto PM Lansdorp 2009 Telomere length in Hutchinson-Gilford Progeria syndrome Mech Ag Dev 130 377 383 1:CAS:528:DC%2BD1MXls1ynsbg%3D 10.1016/j.mad.2009.03.001
26. G Dimri G Lee M Basile M Acosta G Scott C Roskelly E Medranos M Linskens I Rubellj OM Pereira-Smith M Peacocke J Campisi 1995 A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proc Natl Acad Sci USA 92 9363 9367 7568133 1:CAS:528:DyaK2MXosVWlur0%3D 10.1073/pnas.92.20.9363
27. H Duan F Gao S Li T Nagata 1993 Postnatal development and aging of esophageal epithelium in mouse: a light and electron microscopic radioautographyh study Cell Mol Biol 39 309 316 8334384 1:CAS:528: DyaK3sXltlKhsbs%3D
28. CH Evans HJ Georgescu 1983 Observations on the senescence of cells derived from articular cartilage Mech Ageing Dev 22 179 191 6632992 1:STN:280:DyaL2c%2FjvVahsQ%3D%3D 10.1016/0047-6374(83)90111-2 (Pubitemid 13020111)
29. RJ Evans FS Wyllie D Wynford-Thomas D Kipling CJ Jones 2003 A p-53-dependent, telomere-independent proliferative life span barrier in human astrocytes consistent with the molecular genetics of glioma development Cancer Res 63 4854 4861 12941806 1:CAS:528:DC%2BD3sXms12nsrg%3D (Pubitemid 37022617)
30. F Farinati S Formentini G Della Libera F Valiante MC Fanton F Di Mario F Vianello A Pilotto R Naccarato 1993 Changes in parietal and mucous cell mass in the gastric mucosa of normal subjects with age Gerontology 39 146 151 8406057 1:STN:280:DyaK2c%2FhtVelsA%3D%3D 10.1159/000213526 (Pubitemid 23240976)
31. S Fedoroff I Ahmed E Wang 1990 The relationship of expression of statin, the nuclear protein of non-proliferating cells, to the differentiation and cell cycle of astroglia in cultures and in situ J Neurosci Res 26 1 15 2359142 1:CAS:528:DyaK3cXkt1Whtrg%3D 10.1002/jnr.490260102 (Pubitemid 20175048)
32. R Fleischmajer JS Perlish RI Bashey 1972 Human dermal glycosaminoglycans and aging Biochem Biophys Acta 279 265 275 4263641 1:CAS:528:DyaE38XlsFSju7Y%3D 10.1016/0304-4165(72)90142-0
33. NR Forsyth FFB Elder JW Shay WE Wright 2005 Lagomorphs (rabbits, pikas and hares) do not use telomere-directed replicative aging in vitro Mech Ag Dev 126 685 691 1:CAS:528:DC%2BD2MXktVKqsLc%3D 10.1016/j.mad.2005.01.003 (Pubitemid 40693292)
34. RW Frenck Jr EH Blackburn KM Shannon 1998 The rate of telomere sequence loss in human leukocytes varies with age Proc Natl Acad Sci USA 95 5607 5610 9576930 1:CAS:528:DyaK1cXjtFWktbg%3D 10.1073/pnas.95.10.5607 (Pubitemid 28224142)
35. GH Gibbons VJ Dzau 1994 The emerging concept of vascular remodeling New Engl J Med 330 1431 1438 8159199 1:STN:280:DyaK2c3htFantA%3D%3D 10.1056/NEJM199405193302008 (Pubitemid 24139238)
36. A Globerson RB Effros 2000 Ageing of lymphocytes in the aged Immunol Today 21 515 521 11071531 1:CAS:528:DC%2BD3cXmvFylt78%3D 10.1016/S0167-5699(00) 01714-X
37. S Goldstein EJ Moerman JS Soeldner RE Gleason DM Barnett 1978 Chronologic and physiologic age affect replicative lifespan of fibroblasts from diabetic, prediabetic and normal donors Science 199 781 783 622567 1:STN:280: DyaE1c%2Fps1Gjtw%3D%3D 10.1126/science.622567
38. H Green 1977 Terminal differentiation of cultured human epidermal cells Cell 11 405 416 302145 1:CAS:528:DyaE2sXkvVaisro%3D 10.1016/0092-8674(77)90058-7 (Pubitemid 8139151)
39. CB Harley 1991 Telomere loss: mitotic clock or genetic time bomb Mutat Res 256 271 283 1722017 1:CAS:528:DyaK38Xls1SisQ%3D%3D
40. DG Harnden PA Benn JM Oxford AMR Taylor TP Webb 1976 Cytogenetically marked clones in human fibroblasts cultured from normal subjects Somatic Cell Genet 2 55 60 1028160 1:STN:280:DyaE2s3hs1eksw%3D%3D 10.1007/BF01539242
41. L Hayflick 1965 The limited in vitro lifetime of human diploid cell strains Exp Cell Res 37 614 636 14315085 1:STN:280:DyaF2M7hvFOntw%3D%3D 10.1016/0014-4827(65)90211-9
42. Hayflick L (1977) The cellular basis for biological aging. In: Finch CE, Hayflick L (eds) Handbook of the biology of aging. Van Nostrand Reinhold Company, New York, pp 159-186
43. L Hayflick PS Moorhead 1961 The serial subcultivation of human diploid cell strains Exp Cell Res 25 585 621 10.1016/0014-4827(61)90192-6
44. U Herbig WA Jobling BP Chen DJ Chen JM Sedivy 2004 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIPI), but not p16(INK4a) Mol Cell 14 420 430 10.1016/S1097-2765(04)00256-4 (Pubitemid 38648803)
45. U Herbig M Ferreira D Condel D Carey M Sedivy 2006 Cellular senescence in aging primates Science 311 1257 16456035 1:CAS:528:DC%2BD28XitV2hsbk%3D 10.1126/science.1122446 (Pubitemid 43334708)
46. PJ Hornsby LQ Yang SG Raju CY Cheng 1991 Changes in gene expression and DNA methylation in adrenocortical cells senescing in culture Mutat Res 256 103 113
47. JC Houck VK Sharma L Hayflick 1971 Functional failures of cultured human diploid fibroblasts after continued population doublings Proc Soc Exp Biol Med 137 331 333 5581670 1:STN:280:DyaE3M3ht1Oksw%3D%3D
48. S Kakuo K Asaoka T Ide 1999 Human is a unique species among primates in terms of telomere length Biochem Biophys Res Commun 263 308 314 10491289 1:CAS:528:DyaK1MXlvFanur4%3D 10.1006/bbrc.1999.1385 (Pubitemid 29467192)
49. MK Kang W Guo NH Park 1998 Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres Cell Growth Differ 9 85 95 9438392 1:CAS:528: DyaK1cXks1ejsg%3D%3D (Pubitemid 28049531)
50. D Kipling HJ Cook 1990 Hypervariable ultra-long telomeres in mice Nature 347 400 402 2170845 1:CAS:528:DyaK3cXmt1Gmt7Y%3D 10.1038/347400a0 (Pubitemid 20332312)
51. CM Koch CV Suchek Q Lin S Bork M Georgens S Joussen N Pallua AD Ho M Zenke W Wagner 2011 Specific age-associated DNA methylation changes in human dermal fibroblasts PLoS 6 e16679 1:CAS:528:DC%2BC3MXitlOqsL4%3D
52. MH Kormann-Bortolotto B Borsatto MAC Smith 1996 Telomere shortening, ageing, and chromosome damage Mech Ageing Dev 89 45 49 8819105 1:STN:280:DyaK28vhs1Wquw%3D%3D 10.1016/0047-6374(96)01742-3 (Pubitemid 26234076)
53. R Krishnaj G Blandford 1987 Age-associated alterations in human natural killer cells. I. Increased activity as per conventional and kinetic analysis Clin Immunol Immunopathol 45 268 285 10.1016/0090-1229(87)90042-0 (Pubitemid 17148620)
54. EV Linardopoulou EM Williams Y Fan C Friedman JM Young BJ Trask 2005 Human subtelomeres are hotspots of interchromosomal recombination and segmental duplication Nature 437 94 100 16136133 1:CAS:528:DC%2BD2MXpslalsbg%3D 10.1038/nature04029 (Pubitemid 41613430)
55. JA Londono-Vallejo H Der-Sarkissian L Cazes S Bacchetti RR Reddel 2004 Alternative lengthening of telomeres is characterized by high rates of telomeric exchange Cancer Res 64 2324 2327 15059879 1:CAS:528:DC%2BD2cXis1yjt70%3D 10.1158/0008-5472.CAN-03-4035 (Pubitemid 38523881)
56. S Luke R Birnbaum RS Verma 1994 Centromeric and telomeric repeats are stable in nonagenarians as revealed by the double hybridization fluorescent in situ technique Genet Anal Tech Appl 11 77 80 7803133 1:CAS:528: DyaK2MXhtFWltLY%3D
57. A Macieira-Coelho 1967 Influence of cell density on growth inhibition of human fibroblasts in vitro Proc Soc Exp Biol Med 125 548 552 6028580 1:STN:280:DyaF2s7nslGntg%3D%3D
58. A Macieira-Coelho 1974 Are non-dividing cells present in ageing cell cultures? Nature 248 421 422 4856761 1:CAS:528:DyaE2cXksVOqtrg%3D 10.1038/248421a0
59. Macieira-Coelho A (1988) Biology of normal proliferating cells in vitro. Relevance for in vivo aging. Karger SA, Basel
60. A Macieira-Coelho 1991 Chromatin reorganization during senescence of proliferating cells Mutat Res 256 81 104 1722025 1:CAS:528:DyaK38Xls1SjtQ%3D%3D
61. A Macieira-Coelho 1995 Chaos in DNA partition during the last mitoses of the proliferative life-span of human fibroblasts FEBS Lett 358 126 128 7828720 1:CAS:528:DyaK2MXjtlOmtbs%3D 10.1016/0014-5793(94)01407-R
62. Macieira-Coelho A (2000) Cell Immortalization. Progr Mol Subcell Biol, vol 24. Springer, Heidelberg
63. Macieira-Coelho A (2003) Biology of Aging Progr Mol Subcell Biol, vol 30. Springer, Heidelberg
64. A Macieira-Coelho 2010 Cancers and the concept of cell senescence Biogerontology 11 211 227 19609709 10.1007/s10522-009-9241-3
65. A Macieira-Coelho B Azzarone 1982 Aging of human fibroblasts is a succession of subtle changes in the cell cycle and has a final short stage with abrupt events Exp Cell Res 141 325 332 7140842 1:STN:280:DyaL3s%2FltlGrsg%3D%3D 10.1016/0014-4827(82)90220-8 (Pubitemid 13170937)
66. A Macieira-Coelho B Azzarone 1988 The transition from primary culture to spontaneous immortalization in mouse fibroblast populations Anticancer Res 8 669 676 3178157 1:STN:280:DyaL1M%2FisVCksA%3D%3D
67. A Macieira-Coelho F Taboury 1982 A re-evaluation of the changes in proliferation in human fibroblasts during aging in vitro Cell Tissue Kinetics 15 213 224 1:STN:280:DyaL387mt1Kltg%3D%3D (Pubitemid 12192493)
68. A Macieira-Coelho J Pontén L Philipson 1966 The division cycle and RNA synthesis in diploid human cells at different passage levels in vitro Exp Cell Res 42 673 684 5922078 1:STN:280:DyaF2s%2FktVWltg%3D%3D 10.1016/0014-4827(66)90280-1
69. A Macieira-Coelho A Bengtsson M Van der Ploeg 1982 Distribution of DNA between sister cells during serial subcultivaton of human fibroblasts Histochemistry 75 11 21 7118581 1:CAS:528:DyaL38XltVOrsbY%3D 10.1007/BF00492529
70. 2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase Exp Geront 39 1379 1389 10.1016/j.exger.2004.06.004 1:CAS:528:DC%2BD2cXos1eqtLY%3D (Pubitemid 39360379)
71. HA Makhluf SM Mueller S Mizuno J Glowacki 2000 Age-related decline in osteoprotegerin expression by human bone marrow cells cultured in three-dimensional collagen sponges Biochem Biophys Res Commun 268 669 672 10679262 1:CAS:528:DC%2BD3cXhtFGju7c%3D 10.1006/bbrc.2000.2182 (Pubitemid 30150848)
72. UM Martens EA Chavez SSS Poon C Schmoor PM Landsorp 2000 Accumulation of short telomeres in human fibroblasts prior to replicative senescence Exp Cell Res 256 291 299 10739676 1:CAS:528:DC%2BD3cXitVajsr0%3D 10.1006/excr.2000.4823 (Pubitemid 30211191)
73. GM Martin CA Sprague TH Norwood WR Pendergrass 1974 Clonal selection, attenuation, and differentiation in an in vitro model of hyperplasia Am J Path 74 137 154 4809311 1:STN:280:DyaE2c%2FmvVahtg%3D%3D
74. B McClintock 1943 Maize genetics Yearbook Carnegie Inst 42 148 152
75. PS Meltzer XY Guan JM Trent 1993 Telomere capture stabilizes chromosome breakage Nat Genet 4 252 255 8358433 1:CAS:528:DyaK3sXlslGhsbc%3D 10.1038/ng0793-252 (Pubitemid 23205173)
76. GS Merz JD Ross 1969 Viability of human diploid cells as a function of in vitro age J Cell Physiol 74 219 223 5358258 10.1002/jcp.1040740302
77. AL Muggleton-Harris K Hardy N Higbee 1987 Rescue of developmental lens abnormalities in chimaeras of noncataractous and congenital cataractous mice Development 99 473 480 3665766 1:STN:280:DyaL1c%2FivFSrug%3D%3D (Pubitemid 17057491)
78. MT Pieraggi M Julian H Bouissou 1984 Fibroblast changes in cutaneous ageing Virchows Arch [Pathol Anat] 402 275 287 1:STN:280:DyaL2c7kvVersg%3D%3D 10.1007/BF00695081 (Pubitemid 14181489)
79. CS Potten JH Hendry JV Moore 1987 Estimates of the number of clonogenic cells in crypts of murine small intestine Virchows Arch B Cell Pathol 66 227 234 (Pubitemid 17129430)
80. KR Prowse CW Greider 1995 Developmental and tissue-specific regulation of mouse telomerase and telomere length Proc Natl Acad Sci USA 92 4818 4820 7761406 1:CAS:528:DyaK2MXlvFyis7o%3D 10.1073/pnas.92.11.4818
81. RJS Reis S Goldstein 1982 Variability of DNA methylation patterns during serial passage of human diploid fibroblasts Proc Natl Acad Sc USA 79 3949 3953 1:CAS:528:DyaL38XkvVKht78%3D 10.1073/pnas.79.13.3949 (Pubitemid 12035069)
82. JG Rheinwald JH Green 1977 Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes Nature 265 421 424 299924 1:STN:280:DyaE2s7gtVequg%3D%3D 10.1038/265421a0 (Pubitemid 8023596)
83. JG Rheinwald WC Hahn MR Ramsey JY Wu Z Guo H Tsao M de Luca C Catricalà M O'Toole 2002 A two-stage, p16INK4A and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status Mol Cell Biol 22 5157 5172 12077343 1:CAS:528: DC%2BD38XltVOqtrc%3D 10.1128/MCB.22.14.5157-5172.2002 (Pubitemid 34700705)
84. L Robert MP Jacob C Frances G Godeau W Hornebeck 1984 Interaction between elastin and elastases and its role in the aging of the arterial wall, skin and other connective tissues. A review Mech Ageing Dev 28 155 166 6394911 1:CAS:528:DyaL2MXns1ajug%3D%3D 10.1016/0047-6374(84)90015-0 (Pubitemid 15175749)
85. P Rogalla C Rohen Y Henning U Deichert U Bonk J Bullerdiek 1995 Telomere repeat fragment sizes do not limit the growth potential of uterine leiomyomas Biochem Biophys Res Commun 211 175 182 7779084 1:CAS:528:DyaK2MXmtFOjsL4%3D 10.1006/bbrc.1995.1793
86. D Röhme 1981 Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo Proc Natl Acad Sci USA 78 5009 5013 6946449 10.1073/pnas.78.8.5009 (Pubitemid 12225611)
87. PJM Roholl E Blauw C Zurcher JAMA Dormans HM Theuns 1994 Evidence for a diminished maturation of preosteoblasts into osteoblasts during aging in rats: an ultrastructural analysis J Bone Mineral Res 9 355 366 1:STN:280: DyaK2c3kvFCntA%3D%3D 10.1002/jbmr.5650090310 (Pubitemid 24080573)
88. KL Rudolph S Chang H-W Lee M Blasco GJ Gottleib C Greider RA DePinho 1999 Longevity, stress response, and cancer in aging telomerase-deficient mice Cell 96 701 712 10089885 1:CAS:528:DyaK1MXitVChs7w%3D 10.1016/S0092-8674(00)80580-2 (Pubitemid 29122812)
89. E Saksela PS Moorhead 1963 Aneuploidy in the degenerative phase of serial cultivation of human cell studies Proc Natl Acad Sci USA 50 390 395 14060661 1:STN:280:DyaF2c%2FhvVarug%3D%3D 10.1073/pnas.50.2.390
90. D Salk 1982 Werner syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells and chromosome aberrations Hum Genet 62 1 25 6759366 1:STN:280:DyaL3s7gslWlug%3D%3D 10.1007/BF00295598 (Pubitemid 13201988)
91. S Schaetzlein A Lucas-Hahn E Lemme WA Kues M Dorsch MP Manns H Niemann K Lenhard-Rudolph 2004 Telomere length is reset during early mammalian embryogenesis Proc Natl Acad Sci USA 101 8034 8038 15148368 1:CAS:528: DC%2BD2cXkslCisbs%3D 10.1073/pnas.0402400101 (Pubitemid 38698049)
92. H Schmitt N Blin H Zankl H Scherthan 1994 Telomere length variation in normal and malignant human tissues Genes Chromos Cancer 11 171 177 7530486 1:STN:280:DyaK2M7jsVOjuw%3D%3D 10.1002/gcc.2870110306 (Pubitemid 24333392)
93. EL Schneider B Gilman 1979 Sister chromatid exchanges in human diploid fibroblasts Hum Genet 46 57 62 429008 1:CAS:528:DyaE1MXhs1ejsLo%3D 10.1007/BF00278902 (Pubitemid 9244843)
94. VP Schultz VA Zakian CE Ogburn J McKay AA Jarzebowicz SD Edland GM Martin 1996 Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells Hum Genet 97 750 754 10.1007/BF02346184 (Pubitemid 26150843)
95. PG Shiels AJ Kind KHS Campbell D Waddington I Wilmut A Colman AE Schnieke 1999 Analysis of telomere length in cloned sheep Nature 399 316 317 10360570 1:CAS:528:DyaK1MXjs1Wgt7c%3D 10.1038/20580 (Pubitemid 29318121)
96. M Simon H Green 1984 Participation of membrane-associated proteins in the formation of the cross-linked envelope of the keratinocyte Cell 36 827 834 6200236 1:CAS:528:DyaL2cXitVKqu70%3D 10.1016/0092-8674(84)90032-1 (Pubitemid 14077947)
97. L Simonneau B Hervé E Jacquemin Y Courtois 1983 State of differentiation of bovine epithelial lens cells in vitro Exp Cell Res 145 433 446 6407854 1:CAS:528:DyaL3sXks1yjs7w%3D 10.1016/0014-4827(83)90022-8
98. Smith SS (1994) Species-specific differences in tumorigenesis and senescence. Trends Genet 10:305-306
99. JF Stanley D Pye A MacGregor 1975 Comparison of doubling numbers attained by cultured animal cells with life span of species Nature 255 158 159 805376 1:STN:280:DyaE2M7ls1GjsA%3D%3D 10.1038/255158a0
100. S Steinert DM White Y Zou JW Shay WE Wright 2002 Telomere biology and cellular aging in nonhuman primate cells Exp Cell Res 272 146 152 11777339 1:CAS:528:DC%2BD38XotVSm 10.1006/excr.2001.5409 (Pubitemid 34920682)
101. H Strasser M Tiefenthaler M Steinlechner G Bartsch G Konwalinka 1999 Urinary incontinence in the elderly and age-dependent apoptosis of rhabdosphincter cells Lancet 354 918 919 10489956 1:STN:280:DyaK1MvhvVCrug%3D%3D 10.1016/S0140-6736(99)02588-X (Pubitemid 29424027)
102. K Suzuki I Mori Y Nakayama M Miyakoda S Kodama M Watanabe 2001 Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening Radiat Res 155 248 253 11121242 1:CAS:528: DC%2BD3MXmtFCisw%3D%3D 10.1667/0033-7587(2001)155[0248:RISLGA]2.0.CO;2 (Pubitemid 33723546)
103. Y Takenaka T Matsuura N Haga Y Mitsui 2001 Expression of telomerase reverse trranscriptase and telomere elongation during sexual maturation in Paramecium caudatum Gene 264 153 161 11250070 1:CAS:528:DC%2BD3MXhsleksro%3D 10.1016/S0378-1119(01)00337-7 (Pubitemid 32206636)
104. K Takubo M Izumiyama-Shimomura N Homa M Sawabe T Arai M Kato M Oshimura K-I Nakamura 2002 Telomere lengths are characteristic in each human individual Exp Geront 37 523 531 1:CAS:528:DC%2BD38XhtVKktLo%3D 10.1016/S0531-5565(01) 00218-2 (Pubitemid 34119157)
105. GA Ulaner JF Hu TH Vu LC Giudice AR Hoffman 2001 Tissue-specific alternate splicing of human telomerase reverse transcriptase (HTERT) influences telomere lengths during human development Int J Cancer 91 644 649 11267974 1:CAS:528:DC%2BD3MXht1ygsLk%3D 10.1002/1097-0215(200002)9999:9999<::AID- IJC1103>3.0.CO;2-V (Pubitemid 32115258)
106. EM Ullian SK Sapperstein KS Christopherson BA Barres 2001 Control of synapse number by glia Science 291 657 660 11158678 1:CAS:528: DC%2BD3MXntlWktQ%3D%3D 10.1126/science.291.5504.657 (Pubitemid 32150425)
107. BM Unryn LS Cook KT Riabowoll 2005 Paternal age is positively linked to telomere length of children Aging Cell 97 97 10.1111/j.1474-9728.2005.00144.x 1:CAS:528:DC%2BD2MXjtFCgtb0%3D (Pubitemid 41632908)
108. H Vaziri F Schächter I Uchida L Wei X Zhu R Effros D Cohen CB Harley 1993 Loss of telomeric DNA during aging of normal and trisomic 21 human lymphocytes Am J Hum Genet 52 661 667 8460632 1:CAS:528:DyaK2cXhs1Sks7c%3D (Pubitemid 23310132)
109. RN Venkatesan C Price 1998 Telomerase expression in chickens: Constitutive activity in somatic tissues and down-regulation in culture Proc Natl Acad Sci USA 95 14763 14768 9843963 1:STN:280:DyaK1M%2FmtF2nsw%3D%3D 10.1073/pnas.95.25.14763 (Pubitemid 29003704)
110. T Wakayama Y Shinkai KLK Tamashiro H Niida DC Blanchard A Ogura A Tanemura M Tachibana ACF Perry DF Colgan P Mombaerts R Yanagimashi 2000 Cloning of mice to six generations Nature 407 318 319 11014179 1:CAS:528: DC%2BD3cXntFykt7c%3D 10.1038/35030301
111. VL Wilson PA Jones 1983 DNA methylation decreases in aging but not in immortal cells Science 220 1055 1056 6844925 1:CAS:528:DyaL3sXktVenurk%3D 10.1126/science.6844925
112. J Zhu H Wang JM Bishop EH Blackburn 1999 Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening Proc Natl Acad Sci USA 96 3723 3728 10097104 1:CAS:528:DyaK1MXjslCiu70%3D 10.1073/pnas.96.7. 3723 (Pubitemid 29168977)