Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres

Cell Growth and Differentiation

Volumn 9, Issue 1, 1998, Pages 85-95

  Kang, Mo K ^a   Guo, Wentong ^a   Park, No Hee ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UCLA SCHOOL OF DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

ARTICLE; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KERATINOCYTE; MOUTH CARCINOMA; MOUTH MUCOSA; PRIORITY JOURNAL; SENESCENCE; TELOMERE;

ADULT; CELL AGING; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL LINE, TRANSFORMED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; HUMANS; KERATINOCYTES; MIDDLE AGED; MOUTH MUCOSA; TELOMERASE; TELOMERE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031964914     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Allshire, R. C., Dempster, M., and Hastie, N. D. Human telomeres contain at least three types of G-rich repeat distributed non-randomly. Nucleic Acids Res., 17: 4611-4627, 1989.
2. Chang, J. F., Smith, C. L., and Cantor, C. R. Isolation and characterization of a human telGiorgioomere. Nucleic Acids Res., 17: 6109-6127, 1989.
3. Blackburn, E. H. Structure and function of telomeres. Nature (Lond.), 350: 569-573, 1991.
4. Blackburn, E. H. Telomeres. No end in sight. Cell, 77: 621-623, 1994.
5. Greider, C. W. Mammalian telomere dynamics: healing fragmentation shortening and stabilization. Curr. Opin. Genet. Dev., 4: 203-211, 1995.
6. Zakian, V. A. Structure and function of telomeres. Anna Rev. Genet., 23: 579-604, 1989.
7. Allsopp, R. C., and Harley, C. B. Evidence for a critical telomere length in senescent human fibroblasts. Exp. Cell Res., 219: 130-136, 1995.
8. Cheng, E., and Harley, C. B. Telomere length and replicative aging in human vascular tissues. Proc. Natl. Acad. Sci. USA, 92: 11190-11194, 1995.
9. Effros, R. B., Allsopp, R., Chiu, C. P., Hausner, M. A., Hirji, K., Wang, L., Harley, C. B., Villeponteau, B., West, M. D., and Giorgi, J. V. Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. Aids, 10: F17-F22, 1996.
10. Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., and Bacchetti, S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J., 11: 1921-1929, 1992.
11. Allsopp, R. C., Chang, E., Kashefi-Aazam, M., Rogaev, E. I., Piatyszek, M. A., Shay, J. W., and Harley, C. B. Telomere shortening is associated with cell division in vitro and in vivo. Exp. Cell Res., 220: 194-200, 1995.
12. Broccoli, D., Godley, L. A., Donehower, L. A., Varmus, H. E., and deLange, T. Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol. Cell. Biol., 16: 3765-3772, 1996.
13. Harley, C. B., Futcher, B., and Greider, C. W. Telomeres shorten during ageing of human fibroblasts. Nature (Lond.), 345: 458-460, 1990.
14. Kruk, P. A., Balajee, A. S., Rao, K. S., and Bohr, V. A. Telomere reduction and telomerase inactivation during neuronal cell differentiation. Biochem. Biophys. Res. Commun., 224: 487-492, 1996.
15. Shay, J. W., Werbin, H., and Wright, W. E. You haven't heard the end of it: telomere loss may link human aging with cancer. Can. J. Aging, 14: 511-524, 1995.
16. Yegorov, Y. E., Chemov, D. N., Akimov, S. S., Bolsheva, N. L., Krayevsky, A. A., and Zelenin, A. V. Reverse transcriptase inhibitors suppress telomerase function and induce senescence-like processes in cultured mouse fibroblasts. FEBS Lett., 389: 115-118, 1996.
17. Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., and Cech, T. R. Telomerase catalytic subunit homologs from fission yeast and human. Science (Washington DC), 277: 955-959, 1997.
18. Counter, C. M., Hirte, H. W., Bacchetti, S., and Hartey, C. B. Telomerase activity in human ovarian carcinoma. Proc. Natl. Acad. Sci. USA, 91: 2900-2904, 1994.
19. Harie-Bachor, C., and Boukamp, P. Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes. Proc. Natl. Acad. Sci. USA, 93: 6476-6481, 1996.
20. de Lange, T. Activation of telomerase in a human tumor. Proc. Natl. Acad. Sci. USA. 91: 2882-2885, 1994.
21. Gollahon, L S., and Shay, J. W. Immortalization of human mammary epithelial cells transfected with mutant p53 (273his). Onoogene, 12: 715-725, 1996.
22. Mutirangura, A., Supiyaphun, P., Trirekapan, S., Sriuranpong, V., Sakuntabhai, A., Yenrudi, S., and Voravud, N. Telomerase activity in oral leukoplakia and head and neck squamous cell carcinoma. Cancer Res., 56: 3530-3533, 1996.
23. Yasumoto, S., Kunimura, C., Kikuchi, K., Tahara, H., Ohji, H., Yamamoto, H., Ide, T., and Utakoji, T. Telomerase activity in normal human epithelial cells. Oncogene. 13: 433-439, 1996.
24. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L C., Coviello, G. M., Wright, W. E., Weinrich, S. L. and Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science (Washington DC), 266: 2011-2015, 1994.
25. Vaziri, H., and Benchimol, S. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of aging. Exp. Gerontol., 31: 295-301, 1996.
26. El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, E., Kinzler, K. W., and Vogelstein, B. WAF1, a potent mediator of p53 tumor suppression. Cell, 75: 817-825, 1993.
27. Kulju, K. S., and Lehman, J. M. Increased p53 protein associated with aging in human diploid fibroblasts. Exp. Cell Res., 217: 336-345, 1995.
28. Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M., and Smith, J. R. Clonging of senescent-cell derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res., 211: 90-98, 1994.
29. WAF1/CIP1 gene in normal diploid human fibroblasts. Science (Washington DC), 277: 831-834, 1997.
30. Wynford-Thomas, D. Telomeres, p53 and cellular senescence. Oncol. Res., 8: 387-398, 1997.
31. Sugrue, M. M., Shin, D. Y., Lee, S. W., and Aaronson, S. A. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc. Natl. Acad. Sci. USA, 94: 9648-9653, 1997.
32. Gallimore, P. H., Lecane, P. S., Hann, B., and Grand, R. J. Differentiation is inhibited and a senescence pathway is activated when simian virus 40 tsA 58-transformed human retinoblasts are grown at the restrictive temperature. Cell Growth Differ., 8: 763-771, 1997.
33. Klingelhutz, A. J., Foster, S. A., and McDougall, J. K. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature (Lond.). 380: 79-82, 1996.
34. 1-S cell cycle mediators in cellular senescence. Exp. Cell Res., 209: 231-237, 1993.
35. Oshima, J., Campisi, J., Tannock, C. A., and Martin, G. M. Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J. Cell Physiol., 162: 277-283, 1995.
36. Park, N. H., Min, B. M., Li, S. L., Huang, M. Z., Cherrick, H. M., and Doniger, J. Immortalization of normal human oral keratinocytes with type 16 human papillomavirus. Carcinogenesis (Lond.), 12: 1627-1631, 1991.
37. Klingelhutz, A. J., Barber, S. A., Smith, P. P., Dyer, K., and McDougall, J. K. Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells. Mol. Cell. Biol., 14: 961-969, 1994.
38. Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Futcher, A. B., Greider, C. W., and Harley, C. B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA, 89: 10114-10118, 1992.
39. Robinson, N. A., Lapic, S., Welter, J. F., and Eckert, R. L. S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich protein, plasminogen activator inhibitor-2, and involucrin are components of the comified envelope of cultured human epiderman keratinocytes. J. Biol. Chem., 272: 12035-12046, 1997.
40. Krishna, T. S., Kong, X. P., Gary, S., Burgers, P. M., and Kuriyan, J. Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell, 79: 1233-1243, 1994.
41. Mathews, M. B., Bernstein, R. M., Franza, B. R., Jr., and Garrels, J. I. Identity of the proliferating cell nuclear antigen and cyclin. Nature (Lond.), 309: 374-376, 1984.
42. Hu, B. T., Lee, S. C., Mann, E., Ryan, D. H., and Insel, R. A. Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro. J. Immunol., 159: 1068-1071, 1997.
43. Pan, C., Xue, B. H., Ellis, T. M., Peace, D. J., and Diaz, M. O. Changes in telomerase activity and telomere length during human T lymphocyte senescence. Exp. Cell Res., 231: 346-353, 1997.
44. Salto, T., Schneider, A., Martel, N , Mizumoto, H., Bulgay-Moerschel, M., Kudo, R., and Nakazawa, H. Proliferation-associated regulation of telomerase activity in human endometrium and its potential implication in early cancer diagnosis. Biochem. Biophys. Res. Commun., 231: 610-614, 1997.
45. Ramirez, R. D., Wright, W. E., Shay, J. W., and Taylor, R. S. Telomerase activity concentrates in the mitotically active segments of human hair follicles. J. Invest. Dermatol., 108: 113-117, 1997.
46. Harley, C. B. Telomere loss: mitotic clock or genetic time bomb? Mutat. Res., 256: 271-282, 1991.
47. Olovnikov, A. M. A theory of marginotomy: the incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol., 41: 181-190, 1973.
48. Hayflick, L., and Moorhead, P. The serial cultivation of human diploid cell strains. Exp. Cell Res., 25: 585-621, 1961.
49. Lindsey, J., McGill, N. I., Lindsey, L. A., Green, D. K., and Cooke, H. J. In vivo loss of telomeric repeats with age in human. Mutat. Res., 256: 45-48, 1991.
50. Park, N. H., Gujuluva, C. N., Baek, J. H., Cherrick, H. M., Shin, K. H., and Min, B. M. Combined oral carcinogenicity of HPV-16 and benzo(a)pyrene: an in vitro multistep carcinogenesis model. Oncogene, 10: 2145-2153, 1995.