메뉴 건너뛰기




Volumn 11, Issue 2, 2010, Pages 211-227

Cancers and the concept of cell senescence

Author keywords

Aging; Cancers; Cell differentiation; Cell division cycle; Cell proliferation; Cell senescence; Telomeres

Indexed keywords

AZACITIDINE; BETA GALACTOSIDASE; CELL MARKER; METHOXSALEN; PROTEIN P53; TELOMERASE;

EID: 77950858527     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-009-9241-3     Document Type: Review
Times cited : (9)

References (172)
  • 1
    • 0017029812 scopus 로고
    • Clonal variation and aging of diploid fibroblasts. Cinematographic studies of cell pedigrees
    • Absher PM, Absher RG (1976) Clonal variation and aging of diploid fibroblasts. Cinematographic studies of cell pedigrees. Exp Cell Res 103:247-255
    • (1976) Exp Cell Res , vol.103 , pp. 247-255
    • Absher, P.M.1    Absher, R.G.2
  • 3
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    • Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D, Barrett JC (1996) Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci USA 93:13742-13747
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Phelps, D.3    Hannon, G.4    Beach, D.5    Barrett, J.C.6
  • 7
  • 8
    • 0027407146 scopus 로고
    • A "hot spot" of recombination coincides with an interstitial telomeric sequence in the Armenian hamster
    • Ashley T, Ward DC (1993) A "hot spot" of recombination coincides with an interstitial telomeric sequence in the Armenian hamster. Cytogenet Cell Genet 62:169-176
    • (1993) Cytogenet Cell Genet , vol.62 , pp. 169-176
    • Ashley, T.1    Ward, D.C.2
  • 10
    • 0021264847 scopus 로고
    • Abnormal properties of skin fibroblasts from cancer patients with breast cancer
    • Azzarone B, Scemama P, Macieira-Coelho A (1984) Abnormal properties of skin fibroblasts from cancer patients with breast cancer. Intern J Cancer 33:759-764
    • (1984) Intern J Cancer , vol.33 , pp. 759-764
    • Azzarone, B.1    Scemama, P.2    MacIeira-Coelho, A.3
  • 12
  • 13
    • 0008537021 scopus 로고    scopus 로고
    • Aging chromosome telomeres: Parallel studies with terminal repeat and telomere associated DNA probes
    • Ben P (1997) Aging chromosome telomeres: parallel studies with terminal repeat and telomere associated DNA probes. Mech Ageing Dev 99:153-166
    • (1997) Mech Ageing Dev. , vol.99 , pp. 153-166
    • Ben, P.1
  • 15
  • 16
    • 38049001556 scopus 로고    scopus 로고
    • Low oxygen delays fibroblast senescence despite shorter telomeres
    • Betts DH, Perrault SD, King WA (2008) Low oxygen delays fibroblast senescence despite shorter telomeres. Biogerontology 9:19-31
    • (2008) Biogerontology , vol.9 , pp. 19-31
    • Betts, D.H.1    Perrault, S.D.2    King, W.A.3
  • 17
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn EH (2001) Switching and signaling at the telomere. Cell 106:661-673
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 18
    • 0030911124 scopus 로고    scopus 로고
    • Response of a primary human fibroblast cell line toH2O2: Senescence-like growth arrest or apoptosis?
    • Bladier C, Wolvetang EJ, Hutchinson P, de Haan JB, Kola I (1997) Response of a primary human fibroblast cell line toH2O2: senescence-like growth arrest or apoptosis? Cell Growth Differ 8:589-598
    • (1997) Cell Growth Differ , vol.8 , pp. 589-598
    • Bladier, C.1    Wolvetang, E.J.2    Hutchinson, P.3    De Haan, J.B.4    Kola, I.5
  • 20
    • 0029841549 scopus 로고    scopus 로고
    • Evidence that transcriptional activation by p53 plays a direct role in the induction of cell senescence
    • Bond JA, Haughton M, Blaydes J, Gire V, Wynford-Thomas D, Wyllie F (1996) Evidence that transcriptional activation by p53 plays a direct role in the induction of cell senescence. Oncogene 13:2097-2104
    • (1996) Oncogene , vol.13 , pp. 2097-2104
    • Bond, J.A.1    Haughton, M.2    Blaydes, J.3    Gire, V.4    Wynford-Thomas, D.5    Wyllie, F.6
  • 22
    • 0019949827 scopus 로고
    • Alpha-2-macroglobulin production by cultured human fibroblasts
    • Brissenden JE, Cox DW (1982) Alpha-2-macroglobulin production by cultured human fibroblasts. Som Cell Genet 8:289-305
    • (1982) Som Cell Genet. , vol.8 , pp. 289-305
    • Brissenden, J.E.1    Cox, D.W.2
  • 23
    • 0020512437 scopus 로고
    • Limited importance of cancer and competing risk theories in aging
    • Brody S (1983) Limited importance of cancer and competing risk theories in aging. J Clin Exp Geront 5:141-154
    • (1983) J Clin Exp Geront. , vol.5 , pp. 141-154
    • Brody, S.1
  • 24
    • 39049185160 scopus 로고    scopus 로고
    • Developmental biology of fibroblasts and neoplastic disease
    • Macieira-Coelho A (ed) Developmental biology of neoplastic growth. Springer, Heidelberg
    • Brouty-Boyé D (2005) Developmental biology of fibroblasts and neoplastic disease. In: Macieira-Coelho A (ed) Developmental biology of neoplastic growth. Progress in molecular and subcellular biology, vol 40. Springer, Heidelberg, pp 55-74
    • (2005) Progress in Molecular and Subcellular Biology , vol.40 , pp. 55-74
    • Brouty-Boyé, D.1
  • 25
    • 0018886535 scopus 로고
    • Selective elimination of proliferating cells in human diploid cell cultures by treatment with BrdU, 33258 Hoechst and visible light
    • Burmer GC, Norwood TH (1980) Selective elimination of proliferating cells in human diploid cell cultures by treatment with BrdU, 33258 Hoechst and visible light. Mech Age Dev 12:151-159
    • (1980) Mech Age Dev , vol.12 , pp. 151-159
    • Burmer, G.C.1    Norwood, T.H.2
  • 26
    • 0035500487 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-suppressor mechanism
    • Campisi J (2001) Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 11:27-31
    • (2001) Trends Cell Biol. , vol.11 , pp. 27-31
    • Campisi, J.1
  • 27
    • 0028856794 scopus 로고
    • Telomere length and replicative aging in human vascular tissues
    • Chang E, Harley CB (1995) Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci USA 92:11190-11194
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11190-11194
    • Chang, E.1    Harley, C.B.2
  • 28
    • 0028345161 scopus 로고
    • Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
    • Chen Q, Ames BN (1994) Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci USA 91:4130-4134
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4130-4134
    • Chen, Q.1    Ames, B.N.2
  • 29
    • 0035325264 scopus 로고    scopus 로고
    • Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts
    • Chen QM, Prowse KR, Vc Tu, Purdom S, Linskens HK (2001) Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts. Exp Cell Res 265:294-303
    • (2001) Exp Cell Res. , vol.265 , pp. 294-303
    • Chen, Q.M.1    Prowse, K.R.2    Vc, Tu.3    Purdom, S.4    Linskens, H.K.5
  • 30
    • 0027746111 scopus 로고
    • Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stem-like) cells by the hepatic environment
    • Coleman WB, Wennerberg AE, Smith GJ, Grisham JW (1993) Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stem-like) cells by the hepatic environment. Am J Pathol 142:1372-1382
    • (1993) Am J Pathol. , vol.142 , pp. 1372-1382
    • Coleman, W.B.1    Wennerberg, A.E.2    Smith, G.J.3    Grisham, J.W.4
  • 31
    • 42949129074 scopus 로고    scopus 로고
    • Many roads lead to oncogene-induced senescence
    • Courtois-Cox S, Jones SL, Cichowski K (2008) Many roads lead to oncogene-induced senescence. Oncogene 27:2801-2809
    • (2008) Oncogene , vol.27 , pp. 2801-2809
    • Courtois-Cox, S.1    Jones, S.L.2    Cichowski, K.3
  • 32
    • 0015580671 scopus 로고
    • Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid cells
    • Cristofalo VJ, Sharf BB (1973) Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid cells. Exp Cell Res 76:419-427
    • (1973) Exp Cell Res , vol.76 , pp. 419-427
    • Cristofalo, V.J.1    Sharf, B.B.2
  • 33
    • 77950860754 scopus 로고
    • Effects of sex hormones on epithelial cells are mediated via trophin influences from stroma
    • Cunha GR (1986) Effects of sex hormones on epithelial cells are mediated via trophin influences from stroma. In Vitro Cell Dev Biol 22:49
    • (1986) In Vitro Cell Dev Biol. , vol.22 , pp. 49
    • Cunha, G.R.1
  • 34
    • 0032536049 scopus 로고    scopus 로고
    • Telomeres and senescence: Ending the debate
    • de Lange T (1998) Telomeres and senescence: ending the debate. Science 279:334-335
    • (1998) Science , vol.279 , pp. 334-335
    • De Lange, T.1
  • 35
    • 0016573396 scopus 로고
    • Breast cancer incidence and nutritional status with particular reference to body weight and height
    • de Waard F (1975) Breast cancer incidence and nutritional status with particular reference to body weight and height. Cancer Res 35:3351-3356
    • (1975) Cancer Res. , vol.35 , pp. 3351-3356
    • De Waard, F.1
  • 36
    • 0018353595 scopus 로고
    • Effect of low dose rate irradiation on the division potential of cells in vitro. V. Human skin fibroblasts from donors with a high risk of cancer
    • Diatloff C, Macieira-Coelho A (1979) Effect of low dose rate irradiation on the division potential of cells in vitro. V. Human skin fibroblasts from donors with a high risk of cancer. J Natl Canc Inst 63:55-61
    • (1979) J Natl Canc Inst. , vol.63 , pp. 55-61
    • Diatloff, C.1    MacIeira-Coelho, A.2
  • 38
    • 0018160921 scopus 로고
    • An epidemiological perspective of the biology of cancer
    • Doll R (1978) An epidemiological perspective of the biology of cancer. Cancer Res 38:3573-3580
    • (1978) Cancer Res. , vol.38 , pp. 3573-3580
    • Doll, R.1
  • 39
    • 0014903874 scopus 로고
    • Cancers of the lung and nasal sinuses in nickel workers
    • Doll R, Morgan LG, Speizer FE (1970) Cancers of the lung and nasal sinuses in nickel workers. Br J Cancer 24:624-632
    • (1970) Br J Cancer , vol.24 , pp. 624-632
    • Doll, R.1    Morgan, L.G.2    Speizer, F.E.3
  • 42
    • 0022911360 scopus 로고
    • Inhibition of queuine uptake in diploid human fibroblasts by phorbol-12, 13-didecanoate
    • Elliot GC, Katze JR (1986) Inhibition of queuine uptake in diploid human fibroblasts by phorbol-12, 13-didecanoate. J Biol Chem 261:13019-13025
    • (1986) J Biol Chem. , vol.261 , pp. 13019-13025
    • Elliot, G.C.1    Katze, J.R.2
  • 43
    • 0023249611 scopus 로고
    • The change in aggressiveness of neoplasms with age
    • Ershler WB (1987) The change in aggressiveness of neoplasms with age. Geriatrics 42:99-103
    • (1987) Geriatrics , vol.42 , pp. 99-103
    • Ershler, W.B.1
  • 44
    • 0025306741 scopus 로고
    • The relationship of expression of statin, the nuclear protein of non-proliferating cells, to the differentiation and cell cycle of astroglia in cultures and in situ
    • Fedoroff S, Ahmed I, Wang E (1990) The relationship of expression of statin, the nuclear protein of non-proliferating cells, to the differentiation and cell cycle of astroglia in cultures and in situ. J Neurosci Res 26:1-15
    • (1990) J Neurosci Res. , vol.26 , pp. 1-15
    • Fedoroff, S.1    Ahmed, I.2    Wang, E.3
  • 45
    • 0014321641 scopus 로고
    • Breast cancer and artificial menopause: A cohort study
    • Feinlieb M (1968) Breast cancer and artificial menopause: a cohort study. J Natl Cancer Inst 41:315-329
    • (1968) J Natl Cancer Inst. , vol.41 , pp. 315-329
    • Feinlieb, M.1
  • 46
    • 0002781901 scopus 로고
    • The natural history of cancer
    • Foulds L (1958) The natural history of cancer. J Chron Dis 8:2-37
    • (1958) J Chron Dis. , vol.8 , pp. 2-37
    • Foulds, L.1
  • 47
    • 0345475654 scopus 로고
    • Frog embryos (haploid lines)
    • Kruse PF Jr, Patterson MK (eds) . Academic Press, New York
    • Freed JJ, Metzger-Freed J (1973) Frog embryos (haploid lines). In: Kruse PF Jr, Patterson MK (eds) Tissue culture, methods and applications. Academic Press, New York, pp 123-128
    • (1973) Tissue Culture, Methods and Applications , pp. 123-128
    • Freed, J.J.1    Metzger-Freed, J.2
  • 48
    • 13144305133 scopus 로고    scopus 로고
    • The rate of telomere sequence loss in human leukocytes varies with age
    • Frenck RW, Blackburn EH, Shannon KM (1998) The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci USA 95:5607-5610
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5607-5610
    • Frenck, R.W.1    Blackburn, E.H.2    Shannon, K.M.3
  • 49
    • 84990622726 scopus 로고
    • Bone marrow osteogenic stem cells: In vitro cultivation and transplantation in diffusion chambers
    • Friedenstein AJ, Chailakhyan RK, Gerasimov UV (1987) Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet 20:263-267
    • (1987) Cell Tissue Kinet , vol.20 , pp. 263-267
    • Friedenstein, A.J.1    Chailakhyan, R.K.2    Gerasimov, U.V.3
  • 50
    • 0025974356 scopus 로고
    • Carcinoma of the prostate
    • Gittes RF (1991) Carcinoma of the prostate. New Engl J Med 324:2d36-2d235
    • (1991) New Engl J Med , vol.324
    • Gittes, R.F.1
  • 51
    • 0035178727 scopus 로고    scopus 로고
    • Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres
    • Goodwin EC, DiMaio D (2001) Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres. Cell Growth Differ12:525-534
    • (2001) Cell Growth Differ , vol.12 , pp. 525-534
    • Goodwin, E.C.1    Dimaio, D.2
  • 53
    • 0019444916 scopus 로고
    • Variations in steroid 5 alpha-reductase activity in cloned human skin fibroblasts. Shift in phenotype expression from high to low activity upon subcloning
    • Griffin JE, Allman DR, Durrant JL, Wilson JD (1981) Variations in steroid 5 alpha-reductase activity in cloned human skin fibroblasts. Shift in phenotype expression from high to low activity upon subcloning. J Biol Chem 256:3662-3666
    • (1981) J Biol Chem , vol.256 , pp. 3662-3666
    • Griffin, J.E.1    Allman, D.R.2    Durrant, J.L.3    Wilson, J.D.4
  • 54
    • 0004320666 scopus 로고    scopus 로고
    • Scaling up of animal cell cultures
    • Masters JR (ed) . Oxford University Press, Oxford New York
    • Griffiths B (2000) Scaling up of animal cell cultures. In: Masters JR (ed) Animal cell cultures, a practical approach. Oxford University Press, Oxford New York, pp 19-30
    • (2000) Animal Cell Cultures, A Practical Approach , pp. 19-30
    • Griffiths, B.1
  • 55
    • 0001815423 scopus 로고
    • Spontaneous leukemia developing in C3H mice following inoculation in infancy with AK-leukemic extracts of AK embryos
    • Gross L (1951) Spontaneous leukemia developing in C3H mice following inoculation in infancy with AK-leukemic extracts of AK embryos. Proc Soc Exp Biol Med 76:27-33
    • (1951) Proc Soc Exp Biol Med. , vol.76 , pp. 27-33
    • Gross, L.1
  • 57
    • 0003784240 scopus 로고
    • Age distribution of breast cancer cases
    • Hankey BF (1994) Age distribution of breast cancer cases. J Natl Cancer Inst 86:1441
    • (1994) J Natl Cancer Inst. , vol.86 , pp. 1441
    • Hankey, B.F.1
  • 60
    • 0025787643 scopus 로고
    • Telomere loss: Mitotic clock or genetic time bomb
    • Harley CB (1991) Telomere loss: mitotic clock or genetic time bomb. Mutat Res 256:271-283
    • (1991) Mutat Res. , vol.256 , pp. 271-283
    • Harley, C.B.1
  • 61
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L, Moorhead PS (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25:585-621
    • (1961) Exp Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 62
    • 0035489712 scopus 로고    scopus 로고
    • Signalling pathways in mammary gland development
    • Henninghausen L, Robinson GW (2001) Signalling pathways in mammary gland development. Dev Cell 1:467-475
    • (2001) Dev Cell. , vol.1 , pp. 467-475
    • Henninghausen, L.1    Robinson, G.W.2
  • 63
    • 28244469090 scopus 로고    scopus 로고
    • Regulation of growth arrest in senescence: Telomere damage is not the end of the story
    • Herbig U, Sedivy JM (2006) Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mech Ageing Dev 127:16-24
    • (2006) Mech Ageing Dev. , vol.127 , pp. 16-24
    • Herbig, U.1    Sedivy, J.M.2
  • 64
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1) but not p16(INK4a)
    • Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14:420-430
    • (2004) Mol Cell , vol.14 , pp. 420-430
    • Herbig, U.1    Jobling, W.A.2    Chen, B.P.3    Chen, D.J.4    Sedivy, J.M.5
  • 67
    • 0033789360 scopus 로고    scopus 로고
    • Spontaneous and radiationinduced differentiation of fibroblasts
    • Herskind C, Rodemann HP (2000) Spontaneous and radiationinduced differentiation of fibroblasts. Exp Geront 35:747-755
    • (2000) Exp Geront , vol.35 , pp. 747-755
    • Herskind, C.1    Rodemann, H.P.2
  • 68
    • 0345238696 scopus 로고
    • Rapid transformation of human fibroblast cultures by simian virus 40
    • Jensen F, Koprowski H (1963) Rapid transformation of human fibroblast cultures by simian virus 40. Proc Natl Acad Sci USA 50:343-348
    • (1963) Proc Natl Acad Sci USA , vol.50 , pp. 343-348
    • Jensen, F.1    Koprowski, H.2
  • 69
    • 0031964914 scopus 로고    scopus 로고
    • Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres
    • Kang MK, Guo W, Park NH (1998) Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres. Cell Growth Differ 9:85-95 (Pubitemid 28049531)
    • (1998) Cell Growth and Differentiation , vol.9 , Issue.1 , pp. 85-95
    • Kang, M.K.1    Guo, W.2    Park, N.-H.3
  • 70
    • 0033525019 scopus 로고    scopus 로고
    • Transforming growth factor β triggers two independent-senescent programs in cancer cells
    • Katakura Y, Nakata E, Miura T, Shirahata S (1999) Transforming growth factor β triggers two independent-senescent programs in cancer cells. Biochem Biophys Res Commun 255:110-115
    • (1999) Biochem Biophys Res Commun. , vol.255 , pp. 110-115
    • Katakura, Y.1    Nakata, E.2    Miura, T.3    Shirahata, S.4
  • 71
    • 0016598165 scopus 로고
    • Qualitative differences as an indication of cellular heterogeneity in fibroblast monolayers derived from human prepucial skin
    • Kaufman M, Pinsky L, Straisfeld X, Shanfield B, Zilahi B(1975) Qualitative differences as an indication of cellular heterogeneity in fibroblast monolayers derived from human prepucial skin. Exp Cell Res 96:31-36
    • (1975) Exp Cell Res , vol.96 , pp. 31-36
    • Kaufman, M.1    Pinsky, L.2    Straisfeld, X.3    Shanfield, B.4    Zilahi, B.5
  • 72
    • 0028946688 scopus 로고
    • Influence of age on colorectal cancer's 5-year survey
    • Kemppainen M, Raiha I, Sourander L (1995) Influence of age on colorectal cancer's 5-year survey. Gerontology 41:145-151
    • (1995) Gerontology , vol.41 , pp. 145-151
    • Kemppainen, M.1    Raiha, I.2    Sourander, L.3
  • 73
    • 40649090823 scopus 로고    scopus 로고
    • Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system
    • Kim TW, Kim HJ, Lee CH, Kim HY, Baek SH, Kim JH, Kwon KS, Kim JR (2008) Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system. Exp Geront 43:286-295
    • (2008) Exp Geront , vol.43 , pp. 286-295
    • Kim, T.W.1    Kim, H.J.2    Lee, C.H.3    Kim, H.Y.4    Baek, S.H.5    Kim, J.H.6    Kwon, K.S.7    Kim, J.R.8
  • 74
    • 59049088856 scopus 로고    scopus 로고
    • Interferon-a induces cellular senescence through p53- dependent DNA damage signaling in human endothelial cells
    • Kim KS, Kang KW, Seu YB, Baek SH, Kim JR (2009) Interferon-a induces cellular senescence through p53- dependent DNA damage signaling in human endothelial cells. Mech Ageing Dev 130:179-218
    • (2009) Mech Ageing Dev. , vol.130 , pp. 179-218
    • Kim, K.S.1    Kang, K.W.2    Seu, Y.B.3    Baek, S.H.4    Kim, J.R.5
  • 78
    • 0014548693 scopus 로고
    • Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse
    • Kratochwill K (1969) Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse. Devol Biol 20:46-71
    • (1969) Devol Biol. , vol.20 , pp. 46-71
    • Kratochwill, K.1
  • 79
    • 0024275861 scopus 로고
    • Rising incidence of breast cancer
    • Krieger N (1988) Rising incidence of breast cancer. J Natl Cancer Inst 80:2
    • (1988) J Natl Cancer Inst. , vol.80 , pp. 2
    • Krieger, N.1
  • 80
    • 0032764992 scopus 로고    scopus 로고
    • Does Ph 6 bgalactosidase activity indicate cell senescence?
    • Krishna DR, Sperker B, Fritz P, Klotz U (1999) Does Ph 6 bgalactosidase activity indicate cell senescence? Mech Ageing Dev 109:113-123
    • (1999) Mech Ageing Dev , vol.109 , pp. 113-123
    • Krishna, D.R.1    Sperker, B.2    Fritz, P.3    Klotz, U.4
  • 81
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between epithelial cell growth and aging
    • Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J (2001) Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between epithelial cell growth and aging. Proc Natl Acad Sci USA 98:12072-12077
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12072-12077
    • Krtolica, A.1    Parrinello, S.2    Lockett, S.3    Desprez, P.Y.4    Campisi, J.5
  • 82
    • 0018742013 scopus 로고
    • Comparison of the metabolism and receptor binding of testosterone in normal skin fibroblast cultures. Influence of origin and passage number
    • Lamberigts G, Diericks P, de Moor P, Verhoeven G (1979) Comparison of the metabolism and receptor binding of testosterone in normal skin fibroblast cultures. Influence of origin and passage number. J Clin Endocr Metab 48:924-930
    • (1979) J Clin Endocr Metab. , vol.48 , pp. 924-930
    • Lamberigts, G.1    Diericks, P.2    De Moor, P.3    Verhoeven, G.4
  • 83
    • 0034696336 scopus 로고    scopus 로고
    • Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer
    • Li Y, Hively WP, Varmus HE (2000) Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene 19:1002-1006
    • (2000) Oncogene , vol.19 , pp. 1002-1006
    • Li, Y.1    Hively, W.P.2    Varmus, H.E.3
  • 84
    • 0022551801 scopus 로고
    • Increased level of cAMP-dependent protein kinase in aging human fibroblasts
    • Liu AYC, Chang ZF, Chen KY (1986) Increased level of cAMP-dependent protein kinase in aging human fibroblasts. J Cell Phys 128:149-154
    • (1986) J Cell Phys. , vol.128 , pp. 149-154
    • Liu, A.Y.C.1    Chang, Z.F.2    Chen, K.Y.3
  • 85
    • 0027269711 scopus 로고
    • Deregulation of cyclins D1 and e and suppression of cdk2 and cdk4 in senescent human fibroblasts
    • Lucibello FC, Sewing A, Brüsselbach S, Bürger C, Müller R (1993) Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts. J Cell Sci 105:123-133
    • (1993) J Cell Sci. , vol.105 , pp. 123-133
    • Lucibello, F.C.1    Sewing, A.2    Brüsselbach, S.3    Bürger, C.4    Müller, R.5
  • 86
    • 0027975012 scopus 로고
    • Centromeric and telomeric repeats are stable in nonagenarians as revealed by the double hybridization fluorescent in situ technique
    • Luke S, Birnbaum R, Verma RS (1994) Centromeric and telomeric repeats are stable in nonagenarians as revealed by the double hybridization fluorescent in situ technique. Genet Anal Tech Appl 11:77-80
    • (1994) Genet Anal Tech Appl. , vol.11 , pp. 77-80
    • Luke, S.1    Birnbaum, R.2    Verma, R.S.3
  • 87
    • 0014096001 scopus 로고
    • Influence of cell density on growth inhibition of human fibroblasts in vitro
    • Macieira-Coelho A (1967) Influence of cell density on growth inhibition of human fibroblasts in vitro. Proc Soc Exp Biol Med 125:548-552
    • (1967) Proc Soc Exp Biol Med , vol.125 , pp. 548-552
    • MacIeira-Coelho, A.1
  • 88
    • 0016318592 scopus 로고
    • Are non-dividing cells present in ageing cell cultures?
    • Macieira-Coelho A (1974) Are non-dividing cells present in ageing cell cultures? Nature 248:421-422
    • (1974) Nature , vol.248 , pp. 421-422
    • MacIeira-Coelho, A.1
  • 89
    • 0002098658 scopus 로고
    • Biology of normal proliferating cells in vitro. Relevance for in vivo aging
    • von Hahn HP (ed) . Karger SA,Basel
    • Macieira-Coelho A (1988) Biology of normal proliferating cells in vitro. Relevance for in vivo aging. In: von Hahn HP (ed) Interdisciplinary topics in gerontology. Karger SA, Basel
    • (1988) Interdisciplinary Topics in Gerontology
    • MacIeira-Coelho, A.1
  • 90
    • 0343063860 scopus 로고
    • Reorganization in the different hierarchical structures of DNA during cell senescence
    • In: Finch CE, Johnson TE (eds) . Wiley-Liss, New York
    • Macieira-Coelho A (1990) Reorganization in the different hierarchical structures of DNA during cell senescence. In: Finch CE, Johnson TE (eds) Molecular biology of aging, UCLA symposia on molecular and cellular biology, vol 123. Wiley-Liss, New York, pp 351-364
    • (1990) Molecular Biology of Aging, UCLA Symposia on Molecular and Cellular Biology , vol.123 , pp. 351-364
    • MacIeira-Coelho, A.1
  • 91
    • 0029086288 scopus 로고
    • The last mitoses of the human fibroblast proliferative life span, physiopathologic implications
    • Macieira-Coelho A (1995) The last mitoses of the human fibroblast proliferative life span, physiopathologic implications. Mech Ageing Dev 82:91-104
    • (1995) Mech Ageing Dev. , vol.82 , pp. 91-104
    • MacIeira-Coelho, A.1
  • 92
    • 0033990110 scopus 로고    scopus 로고
    • Comparative biology of cell immortalization
    • Macieira-Coelho A (ed) . Springer, Berlin, Heidelberg
    • Macieira-Coelho A (2000) Comparative biology of cell immortalization. In: Macieira-Coelho A (ed) Cell immortalization, progress in molecular and subcellular biology, vol 24. Springer, Berlin, Heidelberg, pp 51-80
    • (2000) Cell Immortalization, Progress in Molecular and Subcellular Biology , vol.24 , pp. 51-80
    • MacIeira-Coelho, A.1
  • 94
    • 0020352012 scopus 로고
    • Aging of human fibroblasts is a succession of subtle changes in the cell cycle and has a final short stage with abrupt events
    • Macieira-Coelho A, Azzarone B (1982) Aging of human fibroblasts is a succession of subtle changes in the cell cycle and has a final short stage with abrupt events. Exp Cell Res 141:325-332
    • (1982) Exp Cell Res. , vol.141 , pp. 325-332
    • MacIeira-Coelho, A.1    Azzarone, B.2
  • 95
    • 84982617553 scopus 로고
    • A reevaluation of the changes in proliferation in human fibroblasts during ageing in vitro
    • Macieira-Coelho A, Taboury F (1982) A reevaluation of the changes in proliferation in human fibroblasts during ageing in vitro. Cell Tiss Kinet 15:213-224
    • (1982) Cell Tiss Kinet , vol.15 , pp. 213-224
    • MacIeira-Coelho, A.1    Taboury, F.2
  • 96
    • 0013918813 scopus 로고
    • The division cycle and RNA synthesis in diploid human cells at different passage levels in vitro
    • Macieira-Coelho A, Pontén J, Philipson L (1966) The division cycle and RNA synthesis in diploid human cells at different passage levels in vitro. Exp Cell Res 42:673-684
    • (1966) Exp Cell Res. , vol.42 , pp. 673-684
    • MacIeira-Coelho, A.1    Pontén, J.2    Philipson, L.3
  • 97
    • 0015156520 scopus 로고
    • Changes in lysosomal enzymes associated structures in human fibroblasts kept in resting stage
    • Macieira-Coelho A, Garcia-Giralt E, Adrian M (1971) Changes in lysosomal enzymes associated structures in human fibroblasts kept in resting stage. Proc Soc Exp Biol Med 138:712-718
    • (1971) Proc Soc Exp Biol Med. , vol.138 , pp. 712-718
    • MacIeira-Coelho, A.1    Garcia-Giralt, E.2    Adrian, M.3
  • 100
    • 8344230643 scopus 로고    scopus 로고
    • Senescent fibroblast resist apoptosis by downregulating caspase-3
    • Marcotte R, Lacell C, Wang E (2004) Senescent fibroblast resist apoptosis by downregulating caspase-3. Mech Ageing Dev 125:777-783
    • (2004) Mech Ageing Dev. , vol.125 , pp. 777-783
    • Marcotte, R.1    Lacell, C.2    Wang, E.3
  • 101
    • 0015966119 scopus 로고
    • Clonal selection, attenuation, and differentiation in an in vitro model of hyperplasia
    • Martin GM, Sprague CA, Norwood TH, Pendergrass WR (1974) Clonal selection, attenuation, and differentiation in an in vitro model of hyperplasia. Am J Path 74:137-154
    • (1974) Am J Path. , vol.74 , pp. 137-154
    • Martin, G.M.1    Sprague, C.A.2    Norwood, T.H.3    Pendergrass, W.R.4
  • 102
    • 0018220053 scopus 로고
    • Evidence for clonal attenuation of growth potential inHeLa cells
    • Martinez AO, Norwood TH, Prothero JW, Martin GM (1978) Evidence for clonal attenuation of growth potential inHeLa cells. In Vitro 14:996-1002
    • (1978) In Vitro , vol.14 , pp. 996-1002
    • Martinez, A.O.1    Norwood, T.H.2    Prothero, J.W.3    Martin, G.M.4
  • 105
    • 0022638060 scopus 로고
    • Abnormal sensitivity of human fibroblasts from Xeroderma pigmentosum variants to transformation to anchorage independence by ultraviolet radiation
    • McCormick JJ, Kately-Kohler S, Watanabe M, Mahler VM (1986) Abnormal sensitivity of human fibroblasts from Xeroderma pigmentosum variants to transformation to anchorage independence by ultraviolet radiation. Cancer Res 46:489-493
    • (1986) Cancer Res. , vol.46 , pp. 489-493
    • McCormick, J.J.1    Kately-Kohler, S.2    Watanabe, M.3    Mahler, V.M.4
  • 106
    • 0029818858 scopus 로고    scopus 로고
    • Expression of p21 is not required for senescence of human fibroblasts
    • Medcalf ASC, Lein-Szanto JP, Cristofalo VJ (1996) Expression of p21 is not required for senescence of human fibroblasts. Cancer Res 56:4582-4585
    • (1996) Cancer Res. , vol.56 , pp. 4582-4585
    • Medcalf, A.S.C.1    Lein-Szanto, J.P.2    Cristofalo, V.J.3
  • 107
    • 0027325817 scopus 로고
    • Telomere capture stabilizes chromosome breakage
    • Meltzer PS, Guan XY, Trent JM (1993) Telomere capture stabilizes chromosome breakage. Nature Genet 4:252-255
    • (1993) Nature Genet. , vol.4 , pp. 252-255
    • Meltzer, P.S.1    Guan, X.Y.2    Trent, J.M.3
  • 108
  • 109
    • 0014638628 scopus 로고
    • Viability of human diploid cells as a function of in vitro age
    • Merz GS, Ross J (1969) Viability of human diploid cells as a function of in vitro age. J Cell Physiol 74:219-223
    • (1969) J Cell Physiol , vol.74 , pp. 219-223
    • Merz, G.S.1    Ross, J.2
  • 110
    • 0022451082 scopus 로고
    • Conditions for transformation of human fibroblasts cells: An overview
    • Milo GE, Casto BC (1986) Conditions for transformation of human fibroblasts cells: an overview. Cancer Lett 31:1-15
    • (1986) Cancer Lett , vol.31 , pp. 1-15
    • Milo, G.E.1    Casto, B.C.2
  • 111
    • 0003785077 scopus 로고
    • Age at breast cancer diagnosis as a predictor of subsequent survival
    • Macieira-Coelho A, Nordenskjöld B (eds) . CRC Press, Boca Raton, FL
    • Mohle-Betani J (1990) Age at breast cancer diagnosis as a predictor of subsequent survival. In: Macieira-Coelho A, Nordenskjöld B (eds) Cancer and aging. CRC Press, Boca Raton, FL, pp 245-254
    • (1990) Cancer and Aging , pp. 245-254
    • Mohle-Betani, J.1
  • 112
    • 33745363911 scopus 로고    scopus 로고
    • DNA damage signaling and p53- dependent senescence after prolonged b-interferon stimulation
    • Moiseeva O, Mallette FA, Mukhopadhyay UK, Moores A, Ferbeyre G (2006) DNA damage signaling and p53- dependent senescence after prolonged b-interferon stimulation. Mol Biol Cell 1:1583-1592
    • (2006) Mol Biol Cell. , vol.1 , pp. 1583-1592
    • Moiseeva, O.1    Mallette, F.A.2    Mukhopadhyay, U.K.3    Moores, A.4    Ferbeyre, G.5
  • 113
    • 0029835531 scopus 로고    scopus 로고
    • Premature senescence of skin fibroblasts from insulin-dependent diabetic patients with kidney disease
    • Morocutti A, Earle KA, Sethi M, Piras G, Richards D, Rodemann P, Viberti G (1996) Premature senescence of skin fibroblasts from insulin-dependent diabetic patients with kidney disease. Kidney Intern 50:250-256
    • (1996) Kidney Intern , vol.50 , pp. 250-256
    • Morocutti, A.1    Earle, K.A.2    Sethi, M.3    Piras, G.4    Richards, D.5    Rodemann, P.6    Viberti, G.7
  • 114
    • 0003848099 scopus 로고
    • Geographical pattern of cancer: Role of environment
    • Macieira-Coelho A, Nordenskjöld B (eds) . CRC Press, Boca Raton, FL
    • Muir CS (1990) Geographical pattern of cancer: role of environment. In: Macieira-Coelho A, Nordenskjöld B (eds) Cancer and aging. CRC Press, Boca Raton, FL, pp 187-206
    • (1990) Cancer and Aging , pp. 187-206
    • Muir, C.S.1
  • 115
    • 0003131646 scopus 로고
    • Reproductive and hormonal factors in relation to cancer occurrence in the breast, prostate, testis, uterine corpus, ovary, uterine cervix, and thyroid gland
    • Macieira-Coelho A, Nordenskjöld B (eds) . CRC Press, Boca Raton, FL
    • Olsson H (1990) Reproductive and hormonal factors in relation to cancer occurrence in the breast, prostate, testis, uterine corpus, ovary, uterine cervix, and thyroid gland. In: Macieira-Coelho A, Nordenskjöld B (eds) Cancer and aging. CRC Press, Boca Raton, FL, pp 109-126
    • (1990) Cancer and Aging , pp. 109-126
    • Olsson, H.1
  • 118
    • 77950857918 scopus 로고
    • Relationship between age and the incidence of liver metastases
    • Macieira-Coelho A, Nordenskjöld B (eds) . CRC Press, Boca Raton, FL
    • Pejchl S (1990) Relationship between age and the incidence of liver metastases. In: Macieira-Coelho A, Nordenskjöld B (eds) Cancer and aging. CRC Press, Boca Raton, FL, pp 255-262
    • (1990) Cancer and Aging , pp. 255-262
    • Pejchl, S.1
  • 119
    • 0019494232 scopus 로고
    • Expression of SV40 antigen in finite life-span hybrids of normal and SV40-transformed fibroblasts
    • Pereira-Smith OM, Smith JR (1981) Expression of SV40 antigen in finite life-span hybrids of normal and SV40-transformed fibroblasts. Som Cell Genet 7:411-421
    • (1981) Som Cell Genet , vol.7 , pp. 411-421
    • Pereira-Smith, O.M.1    Smith, J.R.2
  • 120
    • 0023682723 scopus 로고
    • Cancer and aging: From the kinetics of biological parameters to the kinetics of cancer incidence and mortality
    • Piantanelli L (1988) Cancer and aging: from the kinetics of biological parameters to the kinetics of cancer incidence and mortality. Ann N Y Acad Sci 521:99-109
    • (1988) Ann N y Acad Sci. , vol.521 , pp. 99-109
    • Piantanelli, L.1
  • 121
    • 0027502881 scopus 로고
    • Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the Go state
    • Pignolo RJ, Cristofalo VJ, Rotenberg MO (1993) Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the Go state. J Biol Chem 268:8949-8957
    • (1993) J Biol Chem. , vol.268 , pp. 8949-8957
    • Pignolo, R.J.1    Cristofalo, V.J.2    Rotenberg, M.O.3
  • 122
    • 36549028795 scopus 로고    scopus 로고
    • Exposure of human diploid fibroblasts to hypoxia extends proliferative life span
    • Poulios E, Trougakos IP, Chondrogianni N, Gonos ES (2007) Exposure of human diploid fibroblasts to hypoxia extends proliferative life span. Ann N Y Acad Sci 1119:9-19
    • (2007) Ann N y Acad Sci. , vol.1119 , pp. 9-19
    • Poulios, E.1    Trougakos, I.P.2    Chondrogianni, N.3    Gonos, E.S.4
  • 123
    • 0030889354 scopus 로고    scopus 로고
    • Marrow stromal cells as stem cells for nonhematopoietic tissues
    • Prockop DJ (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71-74
    • (1997) Science , vol.276 , pp. 71-74
    • Prockop, D.J.1
  • 124
    • 0029040101 scopus 로고
    • Developmental and tissuespecific regulation of mouse telomerase and telomere length
    • Prowse KR, Greider CW (1995) Developmental and tissuespecific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci USA 92:4818-4820
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4818-4820
    • Prowse, K.R.1    Greider, C.W.2
  • 125
    • 0024587440 scopus 로고
    • Chromatin and nucleolar changes in xeroderma Pigmentosum cells resemble agingrelatedevents
    • Puvion-Dutilleul F, Sarrasin A (1989) Chromatin and nucleolar changes in xeroderma Pigmentosum cells resemble agingrelatedevents. Mutat Res 219:57-70
    • (1989) Mutat Res. , vol.219 , pp. 57-70
    • Puvion-Dutilleul, F.1    Sarrasin, A.2
  • 126
    • 58349119028 scopus 로고    scopus 로고
    • Expression of senescence-associated b-galactosidase (SA-b-Gal) by human skin fibroblasts, effect of advanced glycation end products and fucose or rhamnose-rich polysaccharides
    • Ravelojaona V, Robert AM, Robert L (2009) Expression of senescence-associated b-galactosidase (SA-b-Gal) by human skin fibroblasts, effect of advanced glycation end products and fucose or rhamnose-rich polysaccharides. Arch Geront Geriatr 48:151-154
    • (2009) Arch Geront Geriatr. , vol.48 , pp. 151-154
    • Ravelojaona, V.1    Robert, A.M.2    Robert, L.3
  • 127
    • 0026599596 scopus 로고
    • Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging
    • Riabowol K, Schiff J, Gilman MZ (1992) Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging. Proc Natl Acad Sci USA 89:157-161
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 157-161
    • Riabowol, K.1    Schiff, J.2    Gilman, M.Z.3
  • 128
    • 0034986682 scopus 로고    scopus 로고
    • Energetic stress induces premature aging of diploid human fibroblasts (WI-38) in vitro
    • Richelt J, Dietrich J, Schachtschabel D (2001) Energetic stress induces premature aging of diploid human fibroblasts (WI-38) in vitro. Arch Geront Geriatr 32:219-231
    • (2001) Arch Geront Geriatr , vol.32 , pp. 219-231
    • Richelt, J.1    Dietrich, J.2    Schachtschabel, D.3
  • 129
    • 0024791241 scopus 로고
    • Differential degradation of intracellular proteins in human skin fibroblasts of mitotic and mitomycin-C(MMC)-induced postmitotic differentiation states
    • Rodemann HP (1989) Differential degradation of intracellular proteins in human skin fibroblasts of mitotic and mitomycin-C(MMC)-induced postmitotic differentiation states. Differentiation 42:37-43
    • (1989) Differentiation , vol.42 , pp. 37-43
    • Rodemann, H.P.1
  • 130
    • 0024342761 scopus 로고
    • The differentiation of normal and transformed human fibroblasts in vitro is influenced by electromagnetic fields
    • Rodemann HP, Bayreuther K, Pfleiderer G (1989) The differentiation of normal and transformed human fibroblasts in vitro is influenced by electromagnetic fields. Exp Cell Res 182:610-621
    • (1989) Exp Cell Res. , vol.182 , pp. 610-621
    • Rodemann, H.P.1    Bayreuther, K.2    Pfleiderer, G.3
  • 132
    • 0022591979 scopus 로고
    • The pathogenesis of atherosclerosis. Impairment of cellular interactions in the arterial wall. An update
    • Ross R (1986) The pathogenesis of atherosclerosis. Impairment of cellular interactions in the arterial wall. An update. New Engl J Med 314:488-500
    • (1986) New Engl J Med. , vol.314 , pp. 488-500
    • Ross, R.1
  • 133
    • 0016365405 scopus 로고
    • Age-dependent regulation of mammalian DNA synthesis and cell division by glucocorticoids
    • Roth GS, Adelman RC (1974) Age-dependent regulation of mammalian DNA synthesis and cell division by glucocorticoids. Exp Geront 9:27-31
    • (1974) Exp Geront. , vol.9 , pp. 27-31
    • Roth, G.S.1    Adelman, R.C.2
  • 134
    • 0030743137 scopus 로고    scopus 로고
    • Cell aging in vivo and in vitro
    • Rubin H (1997) Cell aging in vivo and in vitro. Mech Ageing Dev 98:1-35
    • (1997) Mech Ageing Dev. , vol.98 , pp. 1-35
    • Rubin, H.1
  • 135
    • 0018875094 scopus 로고
    • Influence of differentiation and cell kinetics on the susceptibility of the rat mammary gland to carcinogenesis
    • Russo J, Russo IH (1980) Influence of differentiation and cell kinetics on the susceptibility of the rat mammary gland to carcinogenesis. Cancer Res 40:2677-2687
    • (1980) Cancer Res. , vol.40 , pp. 2677-2687
    • Russo, J.1    Russo, I.H.2
  • 136
    • 0018379524 scopus 로고
    • The kinetics of chick cell populations aging in vitro
    • Ryan JM (1979) The kinetics of chick cell populations aging in vitro. J Cell Phys 99:67-78
    • (1979) J Cell Phys. , vol.99 , pp. 67-78
    • Ryan, J.M.1
  • 137
    • 0023321971 scopus 로고
    • Differential metastatic mode of gastric cancer by age and histologic type
    • Sakamoto M (1988) Differential metastatic mode of gastric cancer by age and histologic type. Nippon Gageeka Gakkai Zasshi 4:440-446
    • (1988) Nippon Gageeka Gakkai Zasshi. , vol.4 , pp. 440-446
    • Sakamoto, M.1
  • 138
    • 0017257768 scopus 로고
    • Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis
    • Schneider EL, Fowlkes BJ (1976) Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis. Exp Cell Res 98:298-302
    • (1976) Exp Cell Res. , vol.98 , pp. 298-302
    • Schneider, E.L.1    Fowlkes, B.J.2
  • 139
    • 0018319205 scopus 로고
    • Sister chromatid exchanges in human diploid fibroblasts
    • Schneider EL, Gilman B (1979) Sister chromatid exchanges in human diploid fibroblasts. Hum Genet 46:57-62
    • (1979) Hum Genet. , vol.46 , pp. 57-62
    • Schneider, E.L.1    Gilman, B.2
  • 140
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593-602
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 141
    • 0025052004 scopus 로고
    • Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
    • Seshadri T, Campisi J (1989) Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts. Science 247:205-209
    • (1989) Science , vol.247 , pp. 205-209
    • Seshadri, T.1    Campisi, J.2
  • 142
  • 143
    • 33747819484 scopus 로고    scopus 로고
    • Divorcing ARF and P53: An unsettled case
    • Sherr CJ (2006) Divorcing ARF and P53: an unsettled case. Nature Rev Cancer 6:663-673
    • (2006) Nature Rev Cancer , vol.6 , pp. 663-673
    • Sherr, C.J.1
  • 144
    • 0018935363 scopus 로고
    • Continued in vitro growth of fibroblast-like cells (RBCF-1) derived from the caudal fin of the fish Carassius auratus
    • Shima A, Nikaido O, Shinohara S, Egami N (1980) Continued in vitro growth of fibroblast-like cells (RBCF-1) derived from the caudal fin of the fish Carassius auratus. Exp Geront 15:305-314
    • (1980) Exp Geront. , vol.15 , pp. 305-314
    • Shima, A.1    Nikaido, O.2    Shinohara, S.3    Egami, N.4
  • 145
    • 0344613303 scopus 로고
    • Marine teleost fish tissues
    • Kruse PF Jr, Patterson MK (eds) . Academic Press, New York
    • Sigel MM, Beasley AR (1973) Marine teleost fish tissues. In: Kruse PF Jr, Patterson MK (eds) Tissue culture, methods and applications. Academic Press, New York, pp 123-128
    • (1973) Tissue Culture, Methods and Applications , pp. 123-128
    • Sigel, M.M.1    Beasley, A.R.2
  • 146
    • 0023277383 scopus 로고
    • Immortalization in culture: Occurrence at a late stage in the progression of breast cancer
    • Smith HS, Wolman SR, Dairkee SH, Hancock MC (1987) Immortalization in culture: occurrence at a late stage in the progression of breast cancer. J Natl Cancer Inst 78:611-615
    • (1987) J Natl Cancer Inst , vol.78 , pp. 611-615
    • Smith, H.S.1    Wolman, S.R.2    Dairkee, S.H.3    Hancock, M.C.4
  • 147
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L (2009) Gene-expression signatures in breast cancer. New Engl J Med 360:790-800
    • (2009) New Engl J Med. , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 148
    • 0021795268 scopus 로고
    • C-Ha-ras-1 protooncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts
    • Srivastava A, Norris JS, Shmookler-Reis RJ, Goldstein S (1985) C-Ha-ras-1 protooncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts. J Biol Chem 260:6404-6409
    • (1985) J Biol Chem. , vol.260 , pp. 6404-6409
    • Srivastava, A.1    Norris, J.S.2    Shmookler-Reis, R.J.3    Goldstein, S.4
  • 149
    • 0027190635 scopus 로고
    • Age distribution of histologic types of breast carcinoma
    • Stalsberg H, Thomas DB (1993) Age distribution of histologic types of breast carcinoma. Int J Cancer 54:1-7
    • (1993) Int J Cancer , vol.54 , pp. 1-7
    • Stalsberg, H.1    Thomas, D.B.2
  • 150
    • 0345475655 scopus 로고
    • The control of growth in plant cells
    • Steward FC (1963) The control of growth in plant cells. Sci Am 209:104-112
    • (1963) Sci Am , vol.209 , pp. 104-112
    • Steward, F.C.1
  • 151
    • 0020065765 scopus 로고
    • Alpha-glutamyl transpeptidase and glutathione in aging IMR-90 fibroblasts and in differentiating 3T3 LI preadipocytes
    • Takahashi S, Zeydel M (1982) Alpha-glutamyl transpeptidase and glutathione in aging IMR-90 fibroblasts and in differentiating 3T3 LI preadipocytes. Arch Biochem Biophys 214:260-268
    • (1982) Arch Biochem Biophys. , vol.214 , pp. 260-268
    • Takahashi, S.1    Zeydel, M.2
  • 152
    • 0343845068 scopus 로고
    • Rapid transformation of human fibroblasts with low growth potential into established cell lines by SV40
    • Todaro GJ, Wolman SR, Green H (1963) Rapid transformation of human fibroblasts with low growth potential into established cell lines by SV40. J Cell Comp Physiol 62:257-265
    • (1963) J Cell Comp Physiol , vol.62 , pp. 257-265
    • Todaro, G.J.1    Wolman, S.R.2    Green, H.3
  • 153
    • 0003850408 scopus 로고
    • Late radiation effects in atomicbomb survivors: A review
    • Macieira-Coelho A, Nordenskjöld B (eds) . CRC Press, Boca Raton, FL
    • Tokuoka S, Inai K (1990) Late radiation effects in atomicbomb survivors: a review. In: Macieira-Coelho A, Nordenskjöld B (eds) Cancer and aging. CRC Press, Boca Raton, FL, pp 163-186
    • (1990) Cancer and Aging , pp. 163-186
    • Tokuoka, S.1    Inai, K.2
  • 154
    • 84980144367 scopus 로고
    • Morphogenesis in relation to chromosomal constitution in long-term plant tissue cultures
    • Torrey JG (1967) Morphogenesis in relation to chromosomal constitution in long-term plant tissue cultures. Physiol Plant 20:265-275
    • (1967) Physiol Plant , vol.20 , pp. 265-275
    • Torrey, J.G.1
  • 155
    • 0033016225 scopus 로고    scopus 로고
    • Effects of donor age on the expression of a marker of replicative senescence (EPC-1) in human dermal fibroblasts
    • Tresini M, Pignolo RJ, Allen RG, Cristofalo VJ (1999) Effects of donor age on the expression of a marker of replicative senescence (EPC-1) in human dermal fibroblasts. J Cell Phys 179:11-17
    • (1999) J Cell Phys. , vol.179 , pp. 11-17
    • Tresini, M.1    Pignolo, R.J.2    Allen, R.G.3    Cristofalo, V.J.4
  • 156
    • 0035283896 scopus 로고    scopus 로고
    • Tissue-specific alternate splicing of human telomerase reverse transcriptase (HTERT) influences telomerelengths during human development
    • Ulaner GA, Hu JF, Vu TH, Giudice LC, Hoffman AR (2001)Tissue-specific alternate splicing of human telomerase reverse transcriptase (HTERT) influences telomerelengths during human development. Int J Cancer 91:644-649
    • (2001) Int J Cancer , vol.91 , pp. 644-649
    • Ulaner, G.A.1    Hu, J.F.2    Vu, T.H.3    Giudice, L.C.4    Hoffman, A.R.5
  • 157
    • 34548710739 scopus 로고    scopus 로고
    • Telomere dynamics in arteries and mononuclear cells of diabetic patients: Effect of diabetes and of glycemic control
    • Uziel O, Singer JA, Danicek V, Sahar G, Berkov E, Luchansky M, Fraser A, Ram R, Lahav M (2007) Telomere dynamics in arteries and mononuclear cells of diabetic patients: effect of diabetes and of glycemic control. Exp Geront 42:971-978
    • (2007) Exp Geront. , vol.42 , pp. 971-978
    • Uziel, O.1    Singer, J.A.2    Danicek, V.3    Sahar, G.4    Berkov, E.5    Luchansky, M.6    Fraser, A.7    Ram, R.8    Lahav, M.9
  • 158
    • 0027057374 scopus 로고
    • Arteriosclerosis. Impairment of cellular interactions in the arterial wall
    • Van Hinsberg VWM (1992) Arteriosclerosis. Impairment of cellular interactions in the arterial wall. Ann N Y Acad Sci 673:321-330
    • (1992) Ann N y Acad Sci. , vol.673 , pp. 321-330
    • Van Hinsberg, V.W.M.1
  • 160
    • 0023946326 scopus 로고
    • A unifying concept of the etiology of breast cancer
    • Waard de F, Trichopoulos D (1988) A unifying concept of the etiology of breast cancer. Int J Cancer 41:666-669
    • (1988) Int J Cancer , vol.41 , pp. 666-669
    • De, W.F.1    Trichopoulos, D.2
  • 161
    • 0028788268 scopus 로고
    • Myogenic cells derived from rat bone marrow mesenchymal stem cell exposed to 5-azacytidine
    • Wakitani S, Saito T, Caplan AI (1995) Myogenic cells derived from rat bone marrow mesenchymal stem cell exposed to 5-azacytidine. Muscle Nerve 12:1417-1426
    • (1995) Muscle Nerve , vol.12 , pp. 1417-1426
    • Wakitani, S.1    Saito, T.2    Caplan, A.I.3
  • 162
    • 0029023626 scopus 로고
    • Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved
    • Wang E (1995) Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res 55:2284-2292
    • (1995) Cancer Res. , vol.55 , pp. 2284-2292
    • Wang, E.1
  • 163
    • 0015798003 scopus 로고
    • Ultrastructure characteristics of osteoarthritis
    • Weiss C (1973) Ultrastructure characteristics of osteoarthritis. Federation Proc 32:1459-1466
    • (1973) Federation Proc. , vol.32 , pp. 1459-1466
    • Weiss, C.1
  • 164
    • 0027478676 scopus 로고
    • Induction of replicative senescence by 5-azacytidine: Fundamental cell kinetic differences between human diploid fibroblasts and NIH-3T3 cells
    • Weller EM, Poot M, Hoehn H (1993) Induction of replicative senescence by 5-azacytidine: fundamental cell kinetic differences between human diploid fibroblasts and NIH-3T3 cells. Cell Prolif 26:45-54
    • (1993) Cell Prolif. , vol.26 , pp. 45-54
    • Weller, E.M.1    Poot, M.2    Hoehn, H.3
  • 167
    • 84965825755 scopus 로고
    • Further studies on the mode of origin of carcinomas of the skin
    • Willis RA (1945) Further studies on the mode of origin of carcinomas of the skin. Cancer Res 5:469-479
    • (1945) Cancer Res. , vol.5 , pp. 469-479
    • Willis, R.A.1
  • 168
    • 0037052448 scopus 로고    scopus 로고
    • Stromal effects on mammary gland development and breast cancer
    • Wiseman BS, Werb Z (2002) Stromal effects on mammary gland development and breast cancer. Science 296:1046-1049
    • (2002) Science , vol.296 , pp. 1046-1049
    • Wiseman, B.S.1    Werb, Z.2
  • 170
    • 26244445013 scopus 로고    scopus 로고
    • The limitations and validities of senescence associated beta-galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells
    • Yang N-C, Hu M-L (2005) The limitations and validities of senescence associated beta-galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells. Exp Geront 40:813-819
    • (2005) Exp Geront. , vol.40 , pp. 813-819
    • Yang, N.-C.1    Hu, M.-L.2
  • 171
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic Raf
    • Zhu J, Woods D, McMahon M, Bishop JM (1998) Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 12:2997-3007
    • (1998) Genes Dev. , vol.12 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 172
    • 0032481191 scopus 로고    scopus 로고
    • Exposure and habits early in life may influence breast cancer risk
    • Ziegler J (1998) Exposure and habits early in life may influence breast cancer risk. J Natl Cancer Inst 90:187-188
    • (1998) J Natl Cancer Inst. , vol.90 , pp. 187-188
    • Ziegler, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.