-
1
-
-
0001565934
-
Necessity of certain lipins in the diet during growth
-
E.V. McCollum, and M. Davis Necessity of certain lipins in the diet during growth J. Biol. Chem. 15 1913 167 175
-
(1913)
J. Biol. Chem.
, vol.15
, pp. 167-175
-
-
McCollum, E.V.1
Davis, M.2
-
2
-
-
0002386911
-
Carotenoids and the vitamin A cycle in vision
-
E. Wald Carotenoids and the vitamin A cycle in vision Nature 143 1934 65
-
(1934)
Nature
, vol.143
, pp. 65
-
-
Wald, E.1
-
3
-
-
84989611379
-
Tissue changes following deprivation of fat-soluble A vitamin
-
S.B. Wolbach, and P.R. Howe Tissue changes following deprivation of fat-soluble A vitamin J. Exp. Med. 42 1925 753 777
-
(1925)
J. Exp. Med.
, vol.42
, pp. 753-777
-
-
Wolbach, S.B.1
Howe, P.R.2
-
4
-
-
0002719340
-
Synthetic retinoids in dermatology
-
M.B. Sporn, A.B. Roberts, D.S. Goodman, 2nd ed. Raven Press New York
-
G.L. Peck, and J.J. DiGiovanna Synthetic retinoids in dermatology M.B. Sporn, A.B. Roberts, D.S. Goodman, The Retinoids: Biology, Chemistry, and Medicine 2nd ed. 1994 Raven Press New York 630 658
-
(1994)
The Retinoids: Biology, Chemistry, and Medicine
, pp. 630-658
-
-
Peck, G.L.1
Digiovanna, J.J.2
-
5
-
-
0003060912
-
Retinoids and cancer in experimental animals
-
M.B. Sporn, A.B. Roberts, D.S. Goodman, 2nd ed. Raven Press New York
-
R.C. Moon, R.G. Mehta, and K.V.N. Rao Retinoids and cancer in experimental animals M.B. Sporn, A.B. Roberts, D.S. Goodman, The Retinoids: Biology, Chemistry, and Medicine 2nd ed. 1994 Raven Press New York 573 595
-
(1994)
The Retinoids: Biology, Chemistry, and Medicine
, pp. 573-595
-
-
Moon, R.C.1
Mehta, R.G.2
Rao, K.V.N.3
-
6
-
-
0001319804
-
Retinoids and human cancer
-
M.B. Sporn, A.B. Roberts, D.S. Goodman, 2nd ed. Raven Press New York
-
W.K. Hong, and L.M. Itri Retinoids and human cancer M.B. Sporn, A.B. Roberts, D.S. Goodman, The Retinoids: Biology, Chemistry, and Medicine 2nd ed. 1994 Raven Press New York 597 630
-
(1994)
The Retinoids: Biology, Chemistry, and Medicine
, pp. 597-630
-
-
Hong, W.K.1
Itri, L.M.2
-
7
-
-
0000531829
-
The Wittig reaction
-
A. Maercker The Wittig reaction Org. React. 14 1965 270 490
-
(1965)
Org. React.
, vol.14
, pp. 270-490
-
-
Maercker, A.1
-
8
-
-
0021234834
-
Ethyl 13,14-dihydro-13,14-methyleneretinoates: Analogues of all-trans and 13-cis-retinoic acid
-
R.W. Curley Jr., and H.F. DeLuca Ethyl 13,14-dihydro-13,14- methyleneretinoates: analogues of all-trans and 13-cis-retinoic acid J. Org. Chem. 49 1984 1944 1946
-
(1984)
J. Org. Chem.
, vol.49
, pp. 1944-1946
-
-
Curley, Jr.R.W.1
Deluca, H.F.2
-
9
-
-
37049120494
-
Carotenoids and related compounds. Part XXVI. Synthesis of methyl natural bixin
-
G. Pattenden, J.E. Way, and B.C.L. Weedon Carotenoids and related compounds. Part XXVI. Synthesis of methyl natural bixin J. Chem. Soc. C: Org. 1970 235 241
-
(1970)
J. Chem. Soc. C: Org.
, pp. 235-241
-
-
Pattenden, G.1
Way, J.E.2
Weedon, B.C.L.3
-
10
-
-
0005704678
-
A convenient synthesis of important retinoid synthon ethyl 3-formyl-2-butenoate
-
R.W. Curley Jr., and C.J. Ticoras A convenient synthesis of important retinoid synthon ethyl 3-formyl-2-butenoate Synth. Commun. 16 1986 627 631
-
(1986)
Synth. Commun.
, vol.16
, pp. 627-631
-
-
Curley, Jr.R.W.1
Ticoras, C.J.2
-
11
-
-
0000929942
-
An efficient preparation of trans, trans-β-ionylideneacetaldehyde
-
R.W. Dugger, and C.H. Heathcock An efficient preparation of trans, trans-β-ionylideneacetaldehyde Synth. Commun. 10 1980 509 515
-
(1980)
Synth. Commun.
, vol.10
, pp. 509-515
-
-
Dugger, R.W.1
Heathcock, C.H.2
-
13
-
-
0001739898
-
Use of sulfones in synthesis. III. Synthesis of vitamin A
-
M. Julia, and D. Arnould Use of sulfones in synthesis. III. Synthesis of vitamin A Bull. Soc. Chim. Fr. 1973 746 750
-
(1973)
Bull. Soc. Chim. Fr.
, pp. 746-750
-
-
Julia, M.1
Arnould, D.2
-
14
-
-
0031051438
-
Steric hindrance between chromophore substituents as the driving force of rhodopsin isomerization: 10-methyl-13-demethyl retinal containing rhodopsin
-
D. Koch, and W. Gartner Steric hindrance between chromophore substituents as the driving force of rhodopsin isomerization: 10-methyl-13-demethyl retinal containing rhodopsin Photochem. Photobiol. 65 1997 181 186
-
(1997)
Photochem. Photobiol.
, vol.65
, pp. 181-186
-
-
Koch, D.1
Gartner, W.2
-
15
-
-
0021984235
-
The growth supporting activity of a retinoidal benzoic acid derivative and 4,4-difluororetinoic acid
-
A. Stephens-Jarnagin, D.A. Miller, and H.F. DeLuca The growth supporting activity of a retinoidal benzoic acid derivative and 4,4-difluororetinoic acid Arch. Biochem. Biophys. 237 1985 11 16
-
(1985)
Arch. Biochem. Biophys.
, vol.237
, pp. 11-16
-
-
Stephens-Jarnagin, A.1
Miller, D.A.2
Deluca, H.F.3
-
16
-
-
0001980367
-
The synthetic chemistry of retinoids
-
M.B. Sporn, A.B. Roberts, D.S. Goodman, 2nd ed. Raven Press New York
-
M.I. Dawson, and P.D. Hobbs The synthetic chemistry of retinoids M.B. Sporn, A.B. Roberts, D.S. Goodman, The Retinoids: Biology, Chemistry, and Medicine 2nd ed. 1994 Raven Press New York 5 178
-
(1994)
The Retinoids: Biology, Chemistry, and Medicine
, pp. 5-178
-
-
Dawson, M.I.1
Hobbs, P.D.2
-
18
-
-
33746373200
-
Chemistry of natural retinoids and carotenoids: Challenges for the future
-
A.R. Valla, D.L. Cartier, and R. Labia Chemistry of natural retinoids and carotenoids: challenges for the future Curr. Org. Synth. 1 2004 167 209
-
(2004)
Curr. Org. Synth.
, vol.1
, pp. 167-209
-
-
Valla, A.R.1
Cartier, D.L.2
Labia, R.3
-
19
-
-
0028087742
-
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids
-
M.F. Boehm, L. Zhang, B.A. Badea, S.K. White, D.E. Mais, E. Berger, C.M. Suto, M.E. Goldman, and R.A. Heyman Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids J. Med. Chem. 37 1994 2930 2941
-
(1994)
J. Med. Chem.
, vol.37
, pp. 2930-2941
-
-
Boehm, M.F.1
Zhang, L.2
Badea, B.A.3
White, S.K.4
Mais, D.E.5
Berger, E.6
Suto, C.M.7
Goldman, M.E.8
Heyman, R.A.9
-
20
-
-
0000530241
-
The retinoid receptors
-
M.B. Sporn, A.B. Roberts, D.S. Goodman, 2nd ed. Raven Press New York
-
D.J. Mangelsdorf, K. Umesono, and R.M. Evans The retinoid receptors M.B. Sporn, A.B. Roberts, D.S. Goodman, The Retinoids: Biology, Chemistry, and Medicine 2nd ed. 1994 Raven Press New York 319 349
-
(1994)
The Retinoids: Biology, Chemistry, and Medicine
, pp. 319-349
-
-
Mangelsdorf, D.J.1
Umesono, K.2
Evans, R.M.3
-
21
-
-
0034095669
-
Recent developments in receptor-selective retinoids
-
S. Nagpal, and R.A.S. Chandraratna Recent developments in receptor-selective retinoids Curr. Pharm. Des. 6 2000 919 931
-
(2000)
Curr. Pharm. Des.
, vol.6
, pp. 919-931
-
-
Nagpal, S.1
Chandraratna, R.A.S.2
-
22
-
-
0035427940
-
Molecular basis for designing selective modulators of retinoic acid receptor transcriptional activities
-
P. Lefebvre Molecular basis for designing selective modulators of retinoic acid receptor transcriptional activities Curr. Drug Targets 1 2001 153 164
-
(2001)
Curr. Drug Targets
, vol.1
, pp. 153-164
-
-
Lefebvre, P.1
-
23
-
-
0036897019
-
Selective retinoids and rexinoids in cancer therapy and chemoprevention
-
F.C. Zusi, M.V. Lorenzi, and V. Vivat-Hannah Selective retinoids and rexinoids in cancer therapy and chemoprevention Drug Discov. Today 7 2002 1165 1174
-
(2002)
Drug Discov. Today
, vol.7
, pp. 1165-1174
-
-
Zusi, F.C.1
Lorenzi, M.V.2
Vivat-Hannah, V.3
-
24
-
-
22944486325
-
Retinoids as therapeutic agents: Today and tomorrow
-
V. Vivat-Hannah, and F.C. Zusi Retinoids as therapeutic agents: today and tomorrow Mini-Rev. Med. Chem. 5 2005 755 760
-
(2005)
Mini-Rev. Med. Chem.
, vol.5
, pp. 755-760
-
-
Vivat-Hannah, V.1
Zusi, F.C.2
-
25
-
-
34848862778
-
Design of selective nuclear receptor modulators, RAR and RXR as a case study
-
A.R. de Lera, W. Bourguet, L. Altucci, and H. Gronemeyer Design of selective nuclear receptor modulators, RAR and RXR as a case study Nat. Rev. Drug Discovery 6 2007 811 820
-
(2007)
Nat. Rev. Drug Discovery
, vol.6
, pp. 811-820
-
-
De Lera, A.R.1
Bourguet, W.2
Altucci, L.3
Gronemeyer, H.4
-
26
-
-
77953717132
-
The peptidomimetic, 1-adamantyl-substituted, and flex-het classes of retinoid-derived molecules: Their structure-activity relationships and retinoid receptor-independent activities
-
M.I. Dawson, and J.A. Fontana The peptidomimetic, 1-adamantyl- substituted, and flex-het classes of retinoid-derived molecules: their structure-activity relationships and retinoid receptor-independent activities Mini-Rev. Med. Chem. 10 2010 455 491
-
(2010)
Mini-Rev. Med. Chem.
, vol.10
, pp. 455-491
-
-
Dawson, M.I.1
Fontana, J.A.2
-
27
-
-
0018778594
-
N-(4-Hydroxyphenyl) retinamide, a new retinoid for prevention of breast cancer in the rat
-
R.C. Moon, H.J. Thompson, P.J. Becci, C.J. Grubb, R.J. Gander, D.L. Newton, J.M. Smith, S.L. Phillips, W.R. Henderson, L.T. Mullen, C.C. Brown, and M.B. Sporn N-(4-Hydroxyphenyl) retinamide, a new retinoid for prevention of breast cancer in the rat Cancer Res. 39 1979 1339 1346
-
(1979)
Cancer Res.
, vol.39
, pp. 1339-1346
-
-
Moon, R.C.1
Thompson, H.J.2
Becci, P.J.3
Grubb, C.J.4
Gander, R.J.5
Newton, D.L.6
Smith, J.M.7
Phillips, S.L.8
Henderson, W.R.9
Mullen, L.T.10
Brown, C.C.11
Sporn, M.B.12
-
28
-
-
1642378141
-
Retinoids and retinoid receptors in the control of energy balance: Novel pharmacological strategies in obesity and diabetes
-
F. Villaroya, R. Iglesias, and M. Giralt Retinoids and retinoid receptors in the control of energy balance: novel pharmacological strategies in obesity and diabetes Curr. Med. Chem. 11 2004 795 805
-
(2004)
Curr. Med. Chem.
, vol.11
, pp. 795-805
-
-
Villaroya, F.1
Iglesias, R.2
Giralt, M.3
-
29
-
-
0027980262
-
Retinoids are positive effectors of adipose cell differentiation
-
I. Safranova, C. Darimont, E.Z. Amri, P. Grimaldi, G. Ailhaud, U. Reichert, and B. Shroot Retinoids are positive effectors of adipose cell differentiation Mol. Cell. Endocrinol. 104 1994 201 211
-
(1994)
Mol. Cell. Endocrinol.
, vol.104
, pp. 201-211
-
-
Safranova, I.1
Darimont, C.2
Amri, E.Z.3
Grimaldi, P.4
Ailhaud, G.5
Reichert, U.6
Shroot, B.7
-
30
-
-
0029919647
-
Distinct stages of adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARγ
-
J.-C. Xue, E.J. Schwarz, A. Chawla, and M.A. Lazar Distinct stages of adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARγ Mol. Cell. Biol. 16 1996 1567 1575
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1567-1575
-
-
Xue, J.-C.1
Schwarz, E.J.2
Chawla, A.3
Lazar, M.A.4
-
31
-
-
51749104448
-
Synergic effect of vitamin A and high fat diet in adipose tissue development and nuclear receptor expression in young rats
-
A. Redonnet, C. Ferrand, C. Bairras, P. Higueret, C. Noel-Suberville, P. Cassand, and C. Atgie Synergic effect of vitamin A and high fat diet in adipose tissue development and nuclear receptor expression in young rats Br. J. Nutr. 100 2008 722 730
-
(2008)
Br. J. Nutr.
, vol.100
, pp. 722-730
-
-
Redonnet, A.1
Ferrand, C.2
Bairras, C.3
Higueret, P.4
Noel-Suberville, C.5
Cassand, P.6
Atgie, C.7
-
32
-
-
0142149220
-
Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor β/δ
-
N. Shaw, M. Elholm, and N. Noy Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor β/δ J. Biol. Chem. 278 2003 41589 41592
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 41589-41592
-
-
Shaw, N.1
Elholm, M.2
Noy, N.3
-
33
-
-
67649211584
-
Acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor β/δ and retinoic acid receptor
-
D.C. Berry, and N. Noy All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor β/δ and retinoic acid receptor Mol. Cell. Biol. 29 2009 3286 3296
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 3286-3296
-
-
Berry, D.C.1
Noy All-Trans-Retinoic, N.2
-
34
-
-
0034493616
-
Carotenoids and retinoids as suppressors on adipocyte differentiation via nuclear receptors
-
T. Kawada, Y. Kamei, A. Fujita, Y. Hida, E. Sugimoto, and T. Fushiki Carotenoids and retinoids as suppressors on adipocyte differentiation via nuclear receptors BioFactors 13 2000 103 109
-
(2000)
BioFactors
, vol.13
, pp. 103-109
-
-
Kawada, T.1
Kamei, Y.2
Fujita, A.3
Hida, Y.4
Sugimoto, E.5
Fushiki, T.6
-
35
-
-
34249977327
-
Retinaldehyde represses adipogenesis and diet-induced obesity
-
O. Ziouzenkova, G. Orasanu, M. Sharlach, T.E. Akiyama, J.B. Berger, J. Viereck, J.A. Hamilton, G. Tang, G.G. Dolnikowski, S. Vogel, G. Duester, and J. Plutzky Retinaldehyde represses adipogenesis and diet-induced obesity Nat. Med. 13 2007 695 702
-
(2007)
Nat. Med.
, vol.13
, pp. 695-702
-
-
Ziouzenkova, O.1
Orasanu, G.2
Sharlach, M.3
Akiyama, T.E.4
Berger, J.B.5
Viereck, J.6
Hamilton, J.A.7
Tang, G.8
Dolnikowski, G.G.9
Vogel, S.10
Duester, G.11
Plutzky, J.12
-
36
-
-
0141704319
-
Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid
-
A. Molotkov, and G. Duester Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid J. Biol. Chem. 278 2003 36085 36090
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 36085-36090
-
-
Molotkov, A.1
Duester, G.2
-
38
-
-
37549038650
-
Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex
-
O. Ziouzenkova, and J. Plutzky Retinoid metabolism and nuclear receptor responses: new insights into coordinated regulation of the PPAR-RXR complex FEBS Lett. 582 2008 32 38
-
(2008)
FEBS Lett.
, vol.582
, pp. 32-38
-
-
Ziouzenkova, O.1
Plutzky, J.2
-
39
-
-
0025963887
-
Enzymatic conversion of β-carotene into β-apo-carotenals and retinoids by human, monkey, ferret, and rat tissues
-
X.D. Wang, G.W. Tang, J.G. Fox, N.I. Krinsky, and R.M. Russell Enzymatic conversion of β-carotene into β-apo-carotenals and retinoids by human, monkey, ferret, and rat tissues Arch. Biochem. Biophys. 285 1991 8 16
-
(1991)
Arch. Biochem. Biophys.
, vol.285
, pp. 8-16
-
-
Wang, X.D.1
Tang, G.W.2
Fox, J.G.3
Krinsky, N.I.4
Russell, R.M.5
-
40
-
-
77957899316
-
The eccentric cleavage product of β-carotene, β-apo-13- carotenone, functions as an antagonist of RXRα
-
A. Eroglu, D.P. Hruszkewycz, R.W. Curley Jr., and E.H. Harrison The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα Arch. Biochem. Biophys. 504 2010 11 16
-
(2010)
Arch. Biochem. Biophys.
, vol.504
, pp. 11-16
-
-
Eroglu, A.1
Hruszkewycz, D.P.2
Curley, Jr.R.W.3
Harrison, E.H.4
-
41
-
-
39749173811
-
Bioactive lipids in metabolic syndrome
-
K. Nagao, and T. Yanagita Bioactive lipids in metabolic syndrome Prog. Lipid Res. 47 2008 127 146
-
(2008)
Prog. Lipid Res.
, vol.47
, pp. 127-146
-
-
Nagao, K.1
Yanagita, T.2
-
42
-
-
33845865254
-
Topical ER36009, a RARγ selective retinoid, decreases abdominal white adipose tissue and elicits changes in expression of genes related to adiposity and thermogenesis
-
T. Sakuta, T. Uchiyama, and T. Kanayama Topical ER36009, a RARγ selective retinoid, decreases abdominal white adipose tissue and elicits changes in expression of genes related to adiposity and thermogenesis Endocrine 30 2006 113 119
-
(2006)
Endocrine
, vol.30
, pp. 113-119
-
-
Sakuta, T.1
Uchiyama, T.2
Kanayama, T.3
-
43
-
-
0031813879
-
Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor γ (PPARγ) heterodimers: Intermolecular synergy requires only the PPARγ hormone-dependent activation function
-
I.G. Schulman, G. Shao, and R.A. Heyman Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor γ (PPARγ) heterodimers: intermolecular synergy requires only the PPARγ hormone-dependent activation function Mol. Cell. Biol. 18 1998 3483 3494
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 3483-3494
-
-
Schulman, I.G.1
Shao, G.2
Heyman, R.A.3
-
44
-
-
0034326254
-
Induction of adipocyte-specific gene expression as correlated with mammary tumor regression by the retinoid X receptor-ligand LGD1069 (Targretin)
-
V.R. Agarwal, E.D. Bischoff, T. Hermann, and W.W. Lamph Induction of adipocyte-specific gene expression as correlated with mammary tumor regression by the retinoid X receptor-ligand LGD1069 (Targretin) Cancer Res. 60 2000 6033 6038
-
(2000)
Cancer Res.
, vol.60
, pp. 6033-6038
-
-
Agarwal, V.R.1
Bischoff, E.D.2
Hermann, T.3
Lamph, W.W.4
-
45
-
-
12644265334
-
Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor
-
P. Tontonoz, S. Singer, B.M. Forman, P. Sarraf, J.A. Fletcher, C.D.M. Fletcher, R.P. Brun, E. Mueller, S. Altiok, H. Oppenheim, R.M. Evans, and B.M. Spiegelman Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor Proc. Natl. Acad. Sci. U. S. A. 94 1997 237 241
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 237-241
-
-
Tontonoz, P.1
Singer, S.2
Forman, B.M.3
Sarraf, P.4
Fletcher, J.A.5
Fletcher, C.D.M.6
Brun, R.P.7
Mueller, E.8
Altiok, S.9
Oppenheim, H.10
Evans, R.M.11
Spiegelman, B.M.12
-
46
-
-
37649030471
-
Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome
-
10.1155/2007/94156
-
J.A. Pinaire, and A. Reifel-Miller Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome PPAR Res. 2007 2007 94156 10.1155/2007/94156
-
(2007)
PPAR Res.
, vol.2007
, pp. 94156
-
-
Pinaire, J.A.1
Reifel-Miller, A.2
-
47
-
-
23444431623
-
Retinoid X receptor heterodimers in the metabolic syndrome
-
A.I. Shulman, and D.J. Mangelsdorf Retinoid X receptor heterodimers in the metabolic syndrome N. Engl. J. Med. 353 2005 604 615
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 604-615
-
-
Shulman, A.I.1
Mangelsdorf, D.J.2
-
48
-
-
34848834842
-
RAR and RXR modulation in cancer and metabolic disease
-
L. Altucci, M.D. Leibowitz, K.M. Ogilvie, A.R. de Lera, and H. Gronemeyer RAR and RXR modulation in cancer and metabolic disease Nat. Rev. Drug Discovery 6 2007 793 810
-
(2007)
Nat. Rev. Drug Discovery
, vol.6
, pp. 793-810
-
-
Altucci, L.1
Leibowitz, M.D.2
Ogilvie, K.M.3
De Lera, A.R.4
Gronemeyer, H.5
-
49
-
-
0034686061
-
An efficient, stereospecific synthesis of the dimmer-selective retinoid X receptor modulator (2E, 4E, 6Z)-7-[5, 6, 7, 8]-tetrahydro-5, 5, 8, 8-tetramethyl-2-(n-propyloxy)naphthalen-3-yl]-3-methylocta-2, 4, 6-trienoic acid
-
L.G. Hamann An efficient, stereospecific synthesis of the dimmer-selective retinoid X receptor modulator (2E, 4E, 6Z)-7-[5, 6, 7, 8]-tetrahydro-5, 5, 8, 8-tetramethyl-2-(n-propyloxy)naphthalen-3-yl]-3- methylocta-2, 4, 6-trienoic acid J. Org. Chem. 65 2000 3233 3235
-
(2000)
J. Org. Chem.
, vol.65
, pp. 3233-3235
-
-
Hamann, L.G.1
-
50
-
-
0034895388
-
The rexinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo
-
R.M. Cesario, K. Klausing, H. Razzaghi, D. Crombie, D. Rungta, R.A. Heyman, and D.S. Lala The rexinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo Mol. Endocrinol. 15 2001 1360 1369
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 1360-1369
-
-
Cesario, R.M.1
Klausing, K.2
Razzaghi, H.3
Crombie, D.4
Rungta, D.5
Heyman, R.A.6
Lala, D.S.7
-
51
-
-
0038454672
-
Novel (2E, 4E, 6Z)-7-(2-alkoxy-3, 5-dialkylbenzene)-3-methylocta-2, 4, 6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes
-
P.Y. Michellys, R.J. Ardecky, J.H. Chen, D.L. Crombie, G.J. Etgen, M.M. Faul, A.L. Faulkner, T.S. Grese, R.A. Heyman, D.S. Karanewsky, K. Klausing, M.D. Leibowitz, S. Liu, D.A. Mais, C.M. Mapes, K.B. Marschke, A. Reifel-Miller, K.M. Ogilvie, D. Rungta, A.W. Thompson, J.S. Tyhonas, and M.F. Boehm Novel (2E, 4E, 6Z)-7-(2-alkoxy-3, 5-dialkylbenzene)-3-methylocta-2, 4, 6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes J. Med. Chem. 46 2003 2683 2696
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2683-2696
-
-
Michellys, P.Y.1
Ardecky, R.J.2
Chen, J.H.3
Crombie, D.L.4
Etgen, G.J.5
Faul, M.M.6
Faulkner, A.L.7
Grese, T.S.8
Heyman, R.A.9
Karanewsky, D.S.10
Klausing, K.11
Leibowitz, M.D.12
Liu, S.13
Mais, D.A.14
Mapes, C.M.15
Marschke, K.B.16
Reifel-Miller, A.17
Ogilvie, K.M.18
Rungta, D.19
Thompson, A.W.20
Tyhonas, J.S.21
Boehm, M.F.22
more..
-
52
-
-
30944433200
-
Biological characterization of a heterodimer-selective retinoid X receptor modulator: Potential benefits for the treatment of type 2 diabetes
-
M.D. Leibowitz, R.J. Ardecky, M.F. Boehm, C.L. Broderick, M.A. Carfagna, D.L. Crombie, J. D'Arrigo, G.T. Etgen, M.M. Faul, T.A. Grese, H. Havel, N.I. Hein, R.A. Heyman, D. Jolley, K. Klausing, S. Liu, D.E. Mais, C.M. Mapes, K.B. Marschke, P.-Y. Michellys, C. Montrose-Rafizadeh, K.M. Olgivie, B. Pascual, D. Rungta, J.S. Tyhonas, M.S. Urcan, M. Wardlow, N. Yumibe, and A. Reifel-Miller Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes Endocrinology 147 2006 1044 1053
-
(2006)
Endocrinology
, vol.147
, pp. 1044-1053
-
-
Leibowitz, M.D.1
Ardecky, R.J.2
Boehm, M.F.3
Broderick, C.L.4
Carfagna, M.A.5
Crombie, D.L.6
D'Arrigo, J.7
Etgen, G.T.8
Faul, M.M.9
Grese, T.A.10
Havel, H.11
Hein, N.I.12
Heyman, R.A.13
Jolley, D.14
Klausing, K.15
Liu, S.16
Mais, D.E.17
Mapes, C.M.18
Marschke, K.B.19
Michellys, P.-Y.20
Montrose-Rafizadeh, C.21
Olgivie, K.M.22
Pascual, B.23
Rungta, D.24
Tyhonas, J.S.25
Urcan, M.S.26
Wardlow, M.27
Yumibe, N.28
Reifel-Miller, A.29
more..
-
53
-
-
3843117675
-
Retinoid X receptor γ-deficient mice have increased skeletal muscle lipoprotein lipase activity and less weight gain when fed a high-fat diet
-
B.R. Haugen, D.R. Jensen, V. Sharma, L.K. Pulawa, W.R. Hays, W. Krezel, P. Chambon, and R.H. Eckel Retinoid X receptor γ-deficient mice have increased skeletal muscle lipoprotein lipase activity and less weight gain when fed a high-fat diet Endocrinology 145 2004 3679 3685
-
(2004)
Endocrinology
, vol.145
, pp. 3679-3685
-
-
Haugen, B.R.1
Jensen, D.R.2
Sharma, V.3
Pulawa, L.K.4
Hays, W.R.5
Krezel, W.6
Chambon, P.7
Eckel, R.H.8
-
54
-
-
17844394150
-
A retinoid X receptor antagonist, HX531, improves leptin resistance without increasing plasma leptin levels in KK-Ay mice under normal dietary conditions
-
T. Yotsumoto, T. Naitoh, T. Kanaki, and N. Tsuruzoe A retinoid X receptor antagonist, HX531, improves leptin resistance without increasing plasma leptin levels in KK-Ay mice under normal dietary conditions Metab Clin. Exp. 54 2005 573 578
-
(2005)
Metab Clin. Exp.
, vol.54
, pp. 573-578
-
-
Yotsumoto, T.1
Naitoh, T.2
Kanaki, T.3
Tsuruzoe, N.4
-
55
-
-
66249139527
-
Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3- alkoxy-5, 5, 8, 8-tetramethyl-5, 6, 7, 8-tetrahydronaphthalen-2-yl)phenyl] acrylic acids and their 4-alkoxy isomers
-
E.P. Santin, P. Germain, F. Quillard, H. Khanwalkar, F. Rodriguez-Barrios, H. Gronemeyer, A.R. de Lera, and W. Bourguet Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5, 5, 8, 8-tetramethyl-5, 6, 7, 8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers J. Med. Chem. 52 2009 3150 3158
-
(2009)
J. Med. Chem.
, vol.52
, pp. 3150-3158
-
-
Santin, E.P.1
Germain, P.2
Quillard, F.3
Khanwalkar, H.4
Rodriguez-Barrios, F.5
Gronemeyer, H.6
De Lera, A.R.7
Bourguet, W.8
-
56
-
-
34249304805
-
Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia
-
B. Lagu, R. Lebedev, B. Pio, M. Yang, and P.D. Pelton Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia Bioorg. Med. Chem. Lett. 17 2007 3491 3496
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 3491-3496
-
-
Lagu, B.1
Lebedev, R.2
Pio, B.3
Yang, M.4
Pelton, P.D.5
-
57
-
-
34547531502
-
Synthesis and structure-activity relationship of novel RXR antagonists: Orally active anti-diabetic and anti-obesity agents
-
J. Sakaki, M. Kishida, K. Konishi, H. Gunji, A. Toyao, Y. Matsumoto, T. Kanazawa, H. Uchiyama, H. Fukaya, H. Mitani, Y. Arai, and M. Kimura Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents Bioorg. Med. Chem. Lett. 17 2007 4804 4807
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 4804-4807
-
-
Sakaki, J.1
Kishida, M.2
Konishi, K.3
Gunji, H.4
Toyao, A.5
Matsumoto, Y.6
Kanazawa, T.7
Uchiyama, H.8
Fukaya, H.9
Mitani, H.10
Arai, Y.11
Kimura, M.12
-
58
-
-
58849150709
-
Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity
-
K. Morishita, N. Yakushiji, F. Ohsawa, K. Takamatsu, N. Matsuura, M. Makishima, M. Kawahata, K. Yamaguchi, A. Tai, K. Sasaki, and H. Kakuta Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity Bioorg. Med. Chem. Lett. 19 2009 1001 1003
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 1001-1003
-
-
Morishita, K.1
Yakushiji, N.2
Ohsawa, F.3
Takamatsu, K.4
Matsuura, N.5
Makishima, M.6
Kawahata, M.7
Yamaguchi, K.8
Tai, A.9
Sasaki, K.10
Kakuta, H.11
-
59
-
-
77955654529
-
Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation
-
S. Fujii, F. Ohsawa, S. Yamada, R. Shinozaki, R. Fukai, M. Makishima, S. Enomoto, A. Tai, and H. Kakuta Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation Bioorg. Med. Chem. Lett. 20 2010 5139 5142
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 5139-5142
-
-
Fujii, S.1
Ohsawa, F.2
Yamada, S.3
Shinozaki, R.4
Fukai, R.5
Makishima, M.6
Enomoto, S.7
Tai, A.8
Kakuta, H.9
-
60
-
-
78650207455
-
Modification at the lipophilic domain of RXR agonists differentially influences activation of RXR heterodimers
-
F. Ohsawa, K. Morishita, S. Yamada, M. Makishima, and H. Kakuta Modification at the lipophilic domain of RXR agonists differentially influences activation of RXR heterodimers ACS Med. Chem. Lett. 1 2010 521 525
-
(2010)
ACS Med. Chem. Lett.
, vol.1
, pp. 521-525
-
-
Ohsawa, F.1
Morishita, K.2
Yamada, S.3
Makishima, M.4
Kakuta, H.5
-
61
-
-
77955661848
-
Fluorescent retinoid X receptor ligands for fluorescence polarization assay
-
S. Yamada, F. Ohsawa, S. Fujii, R. Shinozaki, M. Makashima, H. Naitou, S. Enomoto, A. Tai, and H. Kakuta Fluorescent retinoid X receptor ligands for fluorescence polarization assay Bioorg. Med. Chem. Lett. 20 2010 5143 5146
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 5143-5146
-
-
Yamada, S.1
Ohsawa, F.2
Fujii, S.3
Shinozaki, R.4
Makashima, M.5
Naitou, H.6
Enomoto, S.7
Tai, A.8
Kakuta, H.9
-
62
-
-
0023709173
-
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity
-
H. Kagechika, E. Kawachi, Y. Hashimoto, T. Himi, and K. Shudo Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity J. Med. Chem. 31 1988 2182 2192
-
(1988)
J. Med. Chem.
, vol.31
, pp. 2182-2192
-
-
Kagechika, H.1
Kawachi, E.2
Hashimoto, Y.3
Himi, T.4
Shudo, K.5
-
63
-
-
59949095296
-
Oral administration of synthetic retinoid Am80 inhibits the development of type 1 diabetes in non-obese diabetic (NOD) mice
-
I. Miwako, and K. Shudo Oral administration of synthetic retinoid Am80 inhibits the development of type 1 diabetes in non-obese diabetic (NOD) mice Biol. Pharm. Bull. 32 2009 157 159
-
(2009)
Biol. Pharm. Bull.
, vol.32
, pp. 157-159
-
-
Miwako, I.1
Shudo, K.2
-
64
-
-
0142257901
-
Hydrolysis of 4-HPR to atRA occurs in vivo but is not required for retinamide-induced apoptosis
-
J.S. Chapman, K.L. Weiss, R.W. Curley Jr., M.A. Highland, and M. Clagett-Dame Hydrolysis of 4-HPR to atRA occurs in vivo but is not required for retinamide-induced apoptosis Arch. Biochem. Biophys. 419 2003 234 243
-
(2003)
Arch. Biochem. Biophys.
, vol.419
, pp. 234-243
-
-
Chapman, J.S.1
Weiss, K.L.2
Curley, Jr.R.W.3
Highland, M.A.4
Clagett-Dame, M.5
-
65
-
-
34447118872
-
The unhydrolyzable fenretinide analogue 4-hydroxybenzylretinone induces the proapoptotic genes GADD153 (CHOP) and Bcl-2-binding component 3 (PUMA) and apoptosis that is caspase-dependent and independent of the retinoic acid receptor
-
A.L. Anding, J.S. Chapman, D.W. Barnett, R.W. Curley Jr., and M. Clagett-Dame The unhydrolyzable fenretinide analogue 4-hydroxybenzylretinone induces the proapoptotic genes GADD153 (CHOP) and Bcl-2-binding component 3 (PUMA) and apoptosis that is caspase-dependent and independent of the retinoic acid receptor Cancer Res. 67 2007 6270 6277
-
(2007)
Cancer Res.
, vol.67
, pp. 6270-6277
-
-
Anding, A.L.1
Chapman, J.S.2
Barnett, D.W.3
Curley, Jr.R.W.4
Clagett-Dame, M.5
-
67
-
-
0026667156
-
In vitro interaction of fenretinide with plasma retinol-binding protein and its functional consequences
-
R. Berni, and F. Formelli In vitro interaction of fenretinide with plasma retinol-binding protein and its functional consequences FEBS Lett. 308 1992 43 45
-
(1992)
FEBS Lett.
, vol.308
, pp. 43-45
-
-
Berni, R.1
Formelli, F.2
-
68
-
-
22944434929
-
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
-
Q. Yang, T.E. Graham, N. Mody, F. Preitner, O.D. Peroni, J.M. Zabolotny, K. Kotani, L. Quadro, and B.B. Kahn Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes Nature 436 2005 356 362
-
(2005)
Nature
, vol.436
, pp. 356-362
-
-
Yang, Q.1
Graham, T.E.2
Mody, N.3
Preitner, F.4
Peroni, O.D.5
Zabolotny, J.M.6
Kotani, K.7
Quadro, L.8
Kahn, B.B.9
-
69
-
-
72249122097
-
Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis
-
F. Preitner, N. Mody, T.E. Graham, O.D. Peroni, and B.B. Kahn Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis Am. J. Physiol. Endocrinol. Metab. 297 2009 E1420 E1429
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.297
-
-
Preitner, F.1
Mody, N.2
Graham, T.E.3
Peroni, O.D.4
Kahn, B.B.5
-
70
-
-
0018976176
-
Structure-activity relationships of retinoids in hamster tracheal organ culture
-
D.L. Newton, W.R. Henderson, and M.B. Sporn Structure-activity relationships of retinoids in hamster tracheal organ culture Cancer Res. 40 1980 3413 3425
-
(1980)
Cancer Res.
, vol.40
, pp. 3413-3425
-
-
Newton, D.L.1
Henderson, W.R.2
Sporn, M.B.3
-
71
-
-
0021256309
-
Synthesis and properties of some 13-cis- and all-trans-retinamides
-
Y.F. Shealy, J.L. Frye, C.A. O'Dell, M.C. Thorpe, M.C. Kirk, W.C. Coburn Jr., and M.B. Sporn Synthesis and properties of some 13-cis- and all-trans-retinamides J. Pharm. Sci. 73 1984 745 751
-
(1984)
J. Pharm. Sci.
, vol.73
, pp. 745-751
-
-
Shealy, Y.F.1
Frye, J.L.2
O'Dell, C.A.3
Thorpe, M.C.4
Kirk, M.C.5
Coburn, Jr.W.C.6
Sporn, M.B.7
-
72
-
-
0030848431
-
A rapid, mild and acid-free procedure for the preparation of acyl chlorides including formyl chloride
-
G.B. Villeneuve, and T.H. Chan A rapid, mild and acid-free procedure for the preparation of acyl chlorides including formyl chloride Tetrahedron Lett. 38 1997 6489 6492
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 6489-6492
-
-
Villeneuve, G.B.1
Chan, T.H.2
-
73
-
-
33846255890
-
Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogs
-
S.M. Mershon, A.L. Anding, J.S. Chapman, M. Clagett-Dame, L.A. Stonerock, and R.W. Curley Jr. Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogs Bioorg. Med. Chem. Lett. 17 2007 836 840
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 836-840
-
-
Mershon, S.M.1
Anding, A.L.2
Chapman, J.S.3
Clagett-Dame, M.4
Stonerock, L.A.5
Curley, Jr.R.W.6
-
74
-
-
66849099394
-
Retinoid-related orphan receptors (RORs): Critical roles in development, immunity, circadian rhythm, and cellular metabolism
-
10.1621/nrs.07003
-
A. Jetten Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism Nucl. Recept. Signal. 7 2009 e003 10.1621/nrs.07003
-
(2009)
Nucl. Recept. Signal.
, vol.7
, pp. 003
-
-
Jetten, A.1
-
75
-
-
77952358850
-
Ligand regulation of retinoic acid receptor-related orphan receptors: Implications for development of novel therapeutics
-
L.A. Solt, P.R. Griffin, and T.P. Burris Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics Curr. Opin. Lipidol. 21 2010 204 211
-
(2010)
Curr. Opin. Lipidol.
, vol.21
, pp. 204-211
-
-
Solt, L.A.1
Griffin, P.R.2
Burris, T.P.3
-
76
-
-
27644466788
-
Retinoid metabolism during development of liver cirrhosis
-
S.K. Natarajan, S. Thomas, A. Ramachandran, A.B. Pulimood, and K.A. Balsubramanian Retinoid metabolism during development of liver cirrhosis Arch. Biochem. Biophys. 443 2005 93 100
-
(2005)
Arch. Biochem. Biophys.
, vol.443
, pp. 93-100
-
-
Natarajan, S.K.1
Thomas, S.2
Ramachandran, A.3
Pulimood, A.B.4
Balsubramanian, K.A.5
-
77
-
-
77954358490
-
Genetic analysis of expression profile involved in retinoid metabolism in non-alcoholic fatty liver disease
-
A.A. Ashia, Y. Hoshikawa, H. Tsuchiya, K. Hashiguchi, M. Enjoji, M. Nakamuta, A. Taketomi, Y. Maehara, K. Shomori, A. Kurimasa, I. Hisatome, H. Ito, and G. Shiota Genetic analysis of expression profile involved in retinoid metabolism in non-alcoholic fatty liver disease Hepatol. Res. 40 2010 594 604
-
(2010)
Hepatol. Res.
, vol.40
, pp. 594-604
-
-
Ashia, A.A.1
Hoshikawa, Y.2
Tsuchiya, H.3
Hashiguchi, K.4
Enjoji, M.5
Nakamuta, M.6
Taketomi, A.7
Maehara, Y.8
Shomori, K.9
Kurimasa, A.10
Hisatome, I.11
Ito, H.12
Shiota, G.13
-
78
-
-
33749014695
-
The role of retinoid X receptor α in regulating alcohol metabolism
-
M.A. Gyamfi, M.G. Kocsis, L. He, G. Dai, A.J. Mendy, and Y.-J.Y. Wan The role of retinoid X receptor α in regulating alcohol metabolism J. Pharmacol. Exp. Ther. 319 2006 360 368
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.319
, pp. 360-368
-
-
Gyamfi, M.A.1
Kocsis, M.G.2
He, L.3
Dai, G.4
Mendy, A.J.5
Wan, Y.-J.Y.6
-
79
-
-
72349100164
-
Peroxisome proliferator-activated receptor and retinoic X receptor in alcoholic liver disease
-
10.1155/2009/748174
-
T. Mello, S. Polvani, and A. Galli Peroxisome proliferator-activated receptor and retinoic X receptor in alcoholic liver disease PPAR Res. 2009 2009 748174 10.1155/2009/748174
-
(2009)
PPAR Res.
, vol.2009
, pp. 748174
-
-
Mello, T.1
Polvani, S.2
Galli, A.3
-
80
-
-
21644480926
-
Retinoids in nephrology: Promises and pitfalls
-
Q. Xu, J. Lucio-Cazana, M. Kitamura, X. Ruan, L.G. Fine, and J.T. Norman Retinoids in nephrology: promises and pitfalls Kidney Int. 66 2004 2119 2131
-
(2004)
Kidney Int.
, vol.66
, pp. 2119-2131
-
-
Xu, Q.1
Lucio-Cazana, J.2
Kitamura, M.3
Ruan, X.4
Fine, L.G.5
Norman, J.T.6
-
81
-
-
9444258635
-
Effect of retinoic acid in experimental diabetic nephropathy
-
S.-Y. Han, G. So, Y.-H. Jee, K.-H. Han, Y.-S. Kang, H.-K. Kim, S.-W. Kang, D.-S. Han, J.-Y. Han, and D.-R. Cha Effect of retinoic acid in experimental diabetic nephropathy Immunol. Cell Biol. 82 2004 568 576
-
(2004)
Immunol. Cell Biol.
, vol.82
, pp. 568-576
-
-
Han, S.-Y.1
So, G.2
Jee, Y.-H.3
Han, K.-H.4
Kang, Y.-S.5
Kim, H.-K.6
Kang, S.-W.7
Han, D.-S.8
Han, J.-Y.9
Cha, D.-R.10
-
82
-
-
66449107984
-
Ligands for retinoid acid receptors are elevated in osteoarthritis and may contribute to pathologic processes in the osteoarthritic joint
-
M.R. Davies, L.R. Ribeiro, M. Downey-Jones, M.R.C. Needham, C. Oakley, and J. Wardale Ligands for retinoid acid receptors are elevated in osteoarthritis and may contribute to pathologic processes in the osteoarthritic joint Arthritis Rheum. 60 2009 1722 1732
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 1722-1732
-
-
Davies, M.R.1
Ribeiro, L.R.2
Downey-Jones, M.3
Needham, M.R.C.4
Oakley, C.5
Wardale, J.6
|