Topical ER36009, a RARγ-selective retinoid, decreases abdominal white adipose tissue and elicits changes in expression of genes related to adiposity and thermogenesis

Endocrine

Volumn 30, Issue 1, 2006, Pages 113-119

  Sakuta, Tomohiro ^a   Uchiyama, Taro ^a   Kanayama, Toshiji ^a  

^a SHISEIDO RESEARCH CENTER   (Japan)

Author keywords

Abdominal white adipose tissue; ER36009; Obesity; RAR ; Retinoid

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ER 36009; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BAX; PROTEIN BCL 2; RETINOIC ACID RECEPTOR GAMMA; RETINOID; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 3; 4 (4 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 QUINOXALINYL) 1,3 THIAZOL 2 YL)BENZOIC ACID; 4-(4-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-QUINOXALINYL)-1,3-THIAZOL-2-YL)BENZOIC ACID; BAX PROTEIN, RAT; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 3; QUINOXALINE DERIVATIVE; THIAZOLE DERIVATIVE;

ABDOMINAL FAT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DRUG EFFECT; ENERGY BALANCE; ENZYME BLOOD LEVEL; EPIDIDYMIS FAT; FOOD INTAKE; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; HORMONE BLOOD LEVEL; LONG TERM CARE; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; RECEPTOR UPREGULATION; STATISTICAL SIGNIFICANCE; THERMOGENESIS; WHITE ADIPOSE TISSUE; ANIMAL; BIOSYNTHESIS; BODY WEIGHT; DRUG ANTAGONISM; EATING; GENETICS; METABOLISM; NORTHERN BLOTTING; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; UPREGULATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ADIPOSITY; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, NORTHERN; BODY WEIGHT; EATING; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; PPAR GAMMA; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THERMOGENESIS; THIAZOLES; UP-REGULATION;

EID: 33845865254     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1385/ENDO:30:1:113     Document Type: Article

References (63)

1. Grundy, S. M. (1999). Am. J. Cardiol. 83, 25F-29F.
2. Kahn, B. B. and Flier, J. S. (2000). J. Clin. Invest. 106, 473-481.
3. Kissebah, A. H., Vydelingum, N., Murray, R., et al. (1982). J. Clin. Endocrinol. Metab. 54, 254-260.
4. Fujioka, S., Matsuzawa, Y., Tokunaga, K., and Tarui, S. (1987). Metabolism 36, 54-59.
5. Nielsen, S. and Jensen, M. D. (1997). Curr. Opin. Lipidol. 8, 200-204.
6. Nakamura, T., Tokunaga, K., Shimomura, I., et al. (1994). Atherosclerosis 107, 239-246.
7. Matsuzawa, Y., Nakamura, T., Shimomura, I., and Kotani, K. (1995). Obes. Res. 3(Suppl 5), 645S-647S.
8. Leid, M., Kastner, P., and Chambon, P. (1992). Trends Biochem. Sci. 17, 427-433.
9. Kamei, Y., Kawada, T., and Kazuki, R. E. S. (1993). Biochem. J. 293, 807-812.
10. Villarroya, F., Giralt, M., and Iglesias, R. (1999). Int. J. Obes. Relat. Metab. Disord. 23, 1-6.
11. Alvarez, R., de Andres, J., Yubero, P., et al. (1995). J. Biol. Chem. 270, 5666-5673.
12. Ribot, J., Bonet, M. L., Felipe, F., and Palou, A. (2002). In: Obesity and functional foods in Europe. Palou, A., Bonet, M. L., and Serra, F., (eds.). European Commission, Belgium, pp. 128-142.
13. Bonet, M. L., Ribot, J., and Felipe, F. (1995). Cell. Mol. Life Sci. 60, 1311-1321.
14. Villarroya, F., Iglesias, R., and Giralt, M. (2004). Curr. Med. Chem. 11, 795-805.
15. Kumar, M. V., Sunvold. G. D., and Scarpace, P. J. (1999). J. Lipid Res. 40, 824-829.
16. Bonet, M. L., Oliver, J., Pico, C., et al. (2000). J. Endocrinol. 166, 511-517.
17. Puigserver, P., Vazquez, F., Bonet, M. L., Pico. C., and Palou, A. (1996). Biochem. J. 317, 827-833.
18. Schwarz, E. J., Reginato, M. J., Shao, D., Krakow, S. L., and Lazar, M. A. (1997). Mol. Cell. Biol. 17, 1552-1561.
19. Xue, J. C., Schwarz, E. J., Chawla, A., and Lazar, M. A. (1996). Mol. Cell. Biol. 16, 1567-1575.
20. Stone, R. L. and Bernlohr, D. A. (1990). Differentiation 45, 119-127.
21. Chawla, A. and Lazar, M. A. (1994). Proc. Natl. Acad. Sci. USA 91, 1786-1790.
22. Kim, H. S., Hausman, D. B., Compton, M. M., et al. (2000). Biochem. Biophys. Res. Commun. 270, 76-80.
23. Kumar, M. V. and Scarpace, P. J. (1998). J. Endocrinol. 157, 237-243.
24. Felipe, F., Bonet, M. L., Ribot, J., and Palou, A. (2003). Int. J. Obes. Relat. Metab. Disord. 27, 60-69
25. Orfanos, C. E., Ehlert, R., and Gollnick, H. (1987). Drugs 34, 459-503.
26. Gollnick, H., Ehlert, R., Rinck, G., et al. (1990). Meth. Enzymol. 190, 291-304.
27. Sober, A. J. and Fitzpatrick, T. B. (1995). In: The yearbook of dermatology. Peck, G. L. and Walton, D. A. (eds.). Mosby: St. Louis, MO, pp. 1-32.
28. Boehm, M. F., Heyman, R. A., Patel, S., et al. (1995). Exp. Opin. Invest. Drugs 4, 593-612.
29. Thacher, S. M., Vasudevan, J., and Chandraratna, R. A. (2000). Curr. Pharm. Des. 6, 25-58.
30. Stratigos, A. J. and Katsambas, A. D. (2005). Drugs 65, 1061-1072.
31. Kikuchi, K., Hibi, S., Yoshimura, H., et al. (2000). J. Med. Chem. 43, 409-419.
32. Sakuta, T. and Kanayama, T. (2005). Eur. J. Dermatol. 15, 459-464.
33. Sakuta, T. and Kanayama, T. (2006). Int. J. Dermatol., in press.
34. Cannon, B., Hedin, A., and Nedergaard, J. (1982). FEBS Lett. 150, 129-132.
35. Lowell, B. B., S-Susulic, V., Hamann, A., et al. (1993). Nature 366, 740-742.
36. Rothwell, N. J. and Stock, M. J. (1979). Nature 281, 31-35.
37. Clapham, J. C., Arch, J. R. S., Chapman, H., et al. (2000). Nature 406, 415-418.
38. Li, B., Nolte, L. A., Ju, J.-S., et al. (2000). Nat. Med. 6, 1115-1120.
39. Son, C., Hosoda, K., Ishihara, K., et al. (2004). Diabetologia 47, 47-54.
40. Echtay, K. S., Roussel, D., St-Pierre, J., et al. (2002). Nature 415, 96-99.
41. Chung, W. K., Luke, A., Cooper, R. S., et al. (1999). Diabetes 48, 1890-1895.
42. Rosen, E. D., Walkey, C. J., Puigserver, P., and Spiegelman, B. M. (2000). Genes Dev. 14, 1293-1307.
43. Wu, Z., Puigserver, P., and Spiegelman, B. M. (1999). Curr. Opin. Cell. Biol. 11, 689-694.
44. Spiegelman, B. M. and Flier, J. S. (1996). Cell 87, 377-389.
45. Brun, R. P., Kim, J. B., Hu, E., and Spiegelman, B. M. (1997). Curr. Opin. Lipidol. 8, 212-218.
46. Ribot, J., Rantala, M., Kesaniemi, Y. A., Palou, A., and Savolainen, M, J. (2001). Pflugers Arch. 441, 498-505.
47. Gullicksen, P. S., Hausman, D. B., Dean, R. G., Hartzell, D. L., and Baile, C. A. (2003). Int. J. Obes. Relat. Metab. Disord. 27, 302-312.
48. Gong, H. X., Guo, X. R., Fei, L., Guo, M., Liu, Q. Q., and Chen, R. H. (2003). Acta Pharmacol. Sin. 24, 569-575.
49. Masuzaki, H., Paterson, J., Shinyama, H., et al. (2001). Science 294, 2166-2170.
50. Kotelevtsev, Y., Holmes, M. C., Burchell, A., et al. (1997). Proc. Natl. Acad. Sci. USA 94, 14924-14929.
51. Morton, N. M., Paterson, J. M., Masuzaki, H., et al. (2004). Diabetes 53, 931-938.
52. Hermanowski-Vosatka, A., Balkovec, J. M., Cheng, K., et al. (2005). J. Exp. Med. 202, 517-527.
53. Berger, J., Tanen, M., Elbrecht, A., et al. (2001). J. Biol. Chem. 276, 12629-12635.
54. Haq, R. and Chytil, F. (1991). Biochem. Biophys. Res. Commun. 176, 1539-1544.
55. Zelent, A., Krust, A., Petkovich, M., Kastner, P., and Chambon, P. (1989). Nature 339, 714-717.
56. Hibi, S., Kikuchi, K., Yoshimura, H., Nagai, M., Tai, K., and Hida, T. (1998). J. Med. Chem. 41, 3245-3252.
57. Escher, P., Braissant, O., Basu-Modak, S., Michalik, L., Wahli, W., and Desvergne, B. (2001). Endocrinology 142, 4195-4202
58. Sato, T., Irie, S., Krajewski, S., and Reed, J. C. (1994). Gene 140, 291-292.
59. Tilly, J. L., Tilly, K. I., Kenton, M. L., and Johnson, A. L. (1995). Endocrinology 136, 232-241.
60. Agarwal, A. K., Monder, C., Eckstein, B., and White, P. C. (1989). J. Biol. Chem. 264, 18939-18943.
61. Tso, J. Y., Sun, X. H., Kao, T. H., Reece, K. S., and Wu, R. (1985). Nucleic Acids Res. 13, 2485-2502.
62. Bouillaud, F., Weissenbach, J., and Ricquier, D. (1986). J. Biol. Chem. 261, 1487-1490.
63. Matsuda, J., Hosoda, K., Itoh, H., et al. (1997). FEBS Lett. 418, 200-204.