Link between allosteric signal transduction and functional dynamics in a multisubunit enzyme: S-adenosylhomocysteine hydrolase

Journal of the American Chemical Society

Volumn 133, Issue 49, 2011, Pages 19807-19815

  Lee, Yoonji ^a   Jeong, Lak Shin ^a,b   Choi, Sun ^a   Hyeon, Changbong ^c  

^a National Core Research Center for Cell Signaling and Drug Discovery Research   (South Korea)

^b Ewha Womans University   (South Korea)

^c Korea Institute for Advanced Study   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALLOSTERIC COMMUNICATION; ALLOSTERIC COUPLING; ALLOSTERIC MODULATION; ANTIVIRAL AGENTS; BROWNIAN DYNAMICS SIMULATIONS; CELLULAR ENZYMES; CLOSURE DYNAMICS; COARSE GRAINED MODELS; CONFORMATIONAL DYNAMICS; DRUG TARGETS; ENZYMATIC FUNCTIONS; INDUCED FIT; LIGAND BINDING; METHYLATION REACTION; MOLECULAR ORIGINS; MULTI-SUBUNIT ENZYMES; NATIVE TOPOLOGY; S-ADENOSYLHOMOCYSTEINE HYDROLASE; SHIFT MECHANISM; SIGNALING NETWORKS; STRAIGHTFORWARD STRATEGY; TETRAMERIC STRUCTURES; TRANSITION-STATE;

ALKYLATION; BACTERIOPHAGES; BROWNIAN MOVEMENT; COMPUTER SIMULATION; DIMERS; DYNAMICS; HYDROLASES; LIGANDS; SIGNAL TRANSDUCTION; SIGNALING;

ENZYME INHIBITION;

ADENOSYLHOMOCYSTEINASE;

ARTICLE; CHEMICAL STRUCTURE; ENZYME LOCALIZATION; LIGAND BINDING; MOLECULAR DYNAMICS; SIGNAL TRANSDUCTION; SIMULATION;

ADENOSYLHOMOCYSTEINASE; ALLOSTERIC REGULATION; BINDING SITES; HUMANS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; PROTEIN SUBUNITS; SIGNAL TRANSDUCTION;

EID: 83055197093     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2066175     Document Type: Article

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