Catalytic strategy of S-Adenosyl-L-homocysteine hydrolase: Transition-state stabilization and the avoidance of abortive reactions

Biochemistry

Volumn 42, Issue 7, 2003, Pages 1900-1909

  Yang, Xiaoda ^a,b   Hu, Yongbo ^a,c   Yin, Daniel H ^a,d   Turner, Mary A ^e   Wang, Mengmeng ^a   Borchardt, Ronald T ^a   Howell, P Lynne ^e,f   Kuczera, Krzysztof ^a   Schowen, Richard L ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c WYETH RESEARCH   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

^e HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONFORMATIONS; CRYSTAL STRUCTURE; CRYSTALLIZATION; OXIDATION; REACTION KINETICS; REDOX REACTIONS;

PROTONATION;

ENZYMES;

ADENOSINE; ADENOSYLHOMOCYSTEINASE; HOMOCYSTEINE; NEPLANOCIN A; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; MOLECULAR INTERACTION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTON TRANSPORT;

ADENOSINE; ADENOSYLHOMOCYSTEINASE; BINDING SITES; BUFFERS; CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ENZYME STABILITY; HUMANS; HYDROLASES; HYDROLYSIS; NAD; OXIDATION-REDUCTION; PREGNANCY PROTEINS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; WATER;

PHOCIDAE;

EID: 0037465432     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0262350     Document Type: Article

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