Death and dessert: Nutrient signalling pathways and ageing

Current Opinion in Cell Biology

Volumn 23, Issue 6, 2011, Pages 738-743

  Alic, Nazif ^a   Partridge, Linda ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; SOMATOMEDIN;

AGING; CANCER INHIBITION; DIET RESTRICTION; DOWN REGULATION; DROSOPHILA; ESCHERICHIA COLI; FOOD INTAKE; GENETIC CONSERVATION; HUMAN; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

AGING; ANIMALS; CALORIC RESTRICTION; DIET; HUMANS; LONGEVITY; SIGNAL TRANSDUCTION;

PRIMATES;

EID: 82555167091     PISSN: 09550674     EISSN: 18790410     Source Type: Journal    
DOI: 10.1016/j.ceb.2011.07.006     Document Type: Review

References (62)

1. McCay C.M., Crowell M.F., Maynard L.A. The effect of retarderd growth upon the lenght of lifespan and upon the ultimate body size. J Nutr 1935, 10:63-79.
2. Fontana L., Partridge L., Longo V.D. Extending healthy life span - from yeast to humans. Science 2010, 328:321-326.
3. Colman R.J., Anderson R.M., Johnson S.C., Kastman E.K., Kosmatka K.J., Beasley T.M., Allison D.B., Cruzen C., Simmons H.A., Kemnitz J.W., et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009, 325:201-204.
4. Anderson R.M., Shanmuganayagam D., Weindruch R. Caloric restriction and aging: studies in mice and monkeys. Toxicol Pathol 2009, 37:47-51.
5. Fontana L., Klein S. Aging, adiposity, and calorie restriction. JAMA 2007, 297:986-994.
6. Greer E.L., Brunet A. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 2009, 8:113-127.
7. Grandison R.C., Piper M.D., Partridge L. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 2009, 462:1061-1064.
8. Holliday R. Food, reproduction and longevity: is the extended lifespan of calorie-restricted animals an evolutionary adaptation?. Bioessays 1989, 10:125-127.
9. Libert S., Zwiener J., Chu X., Vanvoorhies W., Roman G., Pletcher S.D. Regulation of Drosophila life span by olfaction and food-derived odors. Science 2007, 315:1133-1137.
10. Poon P.C., Kuo T.H., Linford N.J., Roman G., Pletcher S.D. Carbon dioxide sensing modulates lifespan and physiology in Drosophila. PLoS Biol 2010, 8:e1000356.
11. Apfeld J., Kenyon C. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 1999, 402:804-809.
12. Alcedo J., Kenyon C. Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 2004, 41:45-55.
13. Maier W., Adilov B., Regenass M., Alcedo J. A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol 2010, 8:e1000376.
14. Lee S.J., Kenyon C. Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Curr Biol 2009, 19:715-722.
15. Kuningas M., Magi R., Westendorp R.G., Slagboom P.E., Remm M., van Heemst D. Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. Eur J Hum Genet 2007, 15:294-301.
16. Willcox B.J., Donlon T.A., He Q., Chen R., Grove J.S., Yano K., Masaki K.H., Willcox D.C., Rodriguez B., Curb J.D. FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci USA 2008, 105:13987-13992.
17. Flachsbart F., Caliebe A., Kleindorp R., Blanche H., von Eller-Eberstein H., Nikolaus S., Schreiber S., Nebel A. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci USA 2009, 106:2700-2705.
18. Pawlikowska L., Hu D., Huntsman S., Sung A., Chu C., Chen J., Joyner A.H., Schork N.J., Hsueh W.C., Reiner A.P., et al. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 2009, 8:460-472.
19. Karpac J., Younger A., Jasper H. Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage. Dev Cell 2011, 20:841-854.
20. Garinis G.A., Uittenboogaard L.M., Stachelscheid H., Fousteri M., van Ijcken W., Breit T.M., van Steeg H., Mullenders L.H., van der Horst G.T., Bruning J.C., et al. Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nat Cell Biol 2009, 11:604-615.
21. Fabrizio P., Pozza F., Pletcher S.D., Gendron C.M., Longo V.D. Regulation of longevity and stress resistance by Sch9 in yeast. Science 2001, 292:288-290.
22. Kaeberlein M., Powers R.W., Steffen K.K., Westman E.A., Hu D., Dang N., Kerr E.O., Kirkland K.T., Fields S., Kennedy B.K. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 2005, 310:1193-1196.
23. Kenyon C., Chang J., Gensch E., Rudner A., Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 1993, 366:461-464.
24. Clancy D.J., Gems D., Harshman L.G., Oldham S., Stocker H., Hafen E., Leevers S.J., Partridge L. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 2001, 292:104-106.
25. Tatar M., Kopelman A., Epstein D., Tu M.P., Yin C.M., Garofalo R.S. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 2001, 292:107-110.
26. Holzenberger M., Dupont J., Ducos B., Leneuve P., Geloen A., Even P.C., Cervera P., Le Bouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003, 421:182-187.
27. Bluher M., Kahn B.B., Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003, 299:572-574.
28. Selman C., Lingard S., Choudhury A.I., Batterham R.L., Claret M., Clements M., Ramadani F., Okkenhaug K., Schuster E., Blanc E., et al. Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J 2008, 22:807-818.
29. Cohen E., Paulsson J.F., Blinder P., Burstyn-Cohen T., Du D., Estepa G., Adame A., Pham H.M., Holzenberger M., Kelly J.W., et al. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell 2009, 139:1157-1169.
30. Cohen E., Bieschke J., Perciavalle R.M., Kelly J.W., Dillin A. Opposing activities protect against age-onset proteotoxicity. Science 2006, 313:1604-1610.
31. Cornils A., Gloeck M., Chen Z., Zhang Y., Alcedo J. Specific insulin-like peptides encode sensory information to regulate distinct developmental processes. Development 2011, 138:1183-1193.
32. Gronke S., Clarke D-F., Broughton S., Andrews T.D., Partridge L. Molecular evolution and functional characterisation of Drosophila insulin-like peptides. PLoS Genet 2010, 6:e1000857.
33. Broughton S.J., Slack C., Alic N., Metaxakis A., Bass T.M., Driege Y., Partridge L. DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition. Aging Cell 2010, 9:336-346.
34. Alic N., Hoddinott M.P., Vinti G., Partridge L. Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. Aging Cell 2011, 10:137-147.
35. Conover C.A., Bale L.K. Loss of pregnancy-associated plasma protein A extends lifespan in mice. Aging Cell 2007, 6:727-729.
36. Slack C, Giannakou ME, Foley A, Goss M, Partridge L: dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell 2011, in press. doi:10.1111/j.1474-9726.2011.00707.x.
37. Yamamoto R., Tatar M. Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan. Aging Cell 2011, 10:729-732.
38. Alic N, Andrews TD, Giannakou ME, Papatheodorou I, Slack C, Hoddinott MP, Cochemé HM, Schuster EF, Thornton JM, Partridge L: Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Mol Syst Biol 2011, 7 Article number: 502 doi:10.1038/msb.2011.36.
39. Taguchi A., Wartschow L.M., White M.F. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 2007, 317:369-372.
40. Kwon E.S., Narasimhan S.D., Yen K., Tissenbaum H.A. A new DAF-16 isoform regulates longevity. Nature 2010, 466:498-502.
41. Giannakou M.E., Goss M., Junger M.A., Hafen E., Leevers S.J., Partridge L. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 2004, 305:361.
42. Hwangbo D.S., Gershman B., Tu M.P., Palmer M., Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2004, 429:562-566.
43. Demontis F., Perrimon N. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell 2010, 143:813-825.
44. Murphy C.T., Lee S.J., Kenyon C. Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci USA 2007, 104:19046-19050.
45. Biteau B., Karpac J., Supoyo S., DeGennaro M., Lehmann R., Jasper H. Lifespan extension by preserving proliferative homeostasis in Drosophila. PLoS Genet 2010, 6.
46. Fabrizio P., Liou L.L., Moy V.N., Diaspro A., Valentine J.S., Gralla E.B., Longo V.D. SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics 2003, 163:35-46.
47. Borras C., Monleon D., Lopez-Grueso R., Gambini J., Orlando L., Pallardo F.V., Santos E., Vina J., Font de Mora J. RasGrf1 deficiency delays aging in mice. Aging (Albany NY) 2011, 3:262-276.
48. Hansen M., Taubert S., Crawford D., Libina N., Lee S.J., Kenyon C. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 2007, 6:95-110.
49. Kapahi P., Zid B.M., Harper T., Koslover D., Sapin V., Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 2004, 14:885-890.
50. Harrison D.E., Strong R., Sharp Z.D., Nelson J.F., Astle C.M., Flurkey K., Nadon N.L., Wilkinson J.E., Frenkel K., Carter C.S., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460:392-395.
51. Bjedov I., Toivonen J.M., Kerr F., Slack C., Jacobson J., Foley A., Partridge L. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab 2010, 11:35-46.
52. Selman C., Tullet J.M., Wieser D., Irvine E., Lingard S.J., Choudhury A.I., Claret M., Al-Qassab H., Carmignac D., Ramadani F., et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009, 326:140-144.
53. Partridge L., Alic N., Bjedov I., Piper M.D. Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp Gerontol 2011, 46:376-381.
54. Zid B.M., Rogers A.N., Katewa S.D., Vargas M.A., Kolipinski M.C., Lu T.A., Benzer S. Kapahi P: 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 2009, 139:149-160.
55. Tatar M. The plate half-full: status of research on the mechanisms of dietary restriction in Drosophila melanogaster. Exp Gerontol 2011, 46:363-368.
56. Paik J.H., Kollipara R., Chu G., Ji H., Xiao Y., Ding Z., Miao L., Tothova Z., Horner J.W., Carrasco D.R., et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 2007, 128:309-323.
57. Bouchard C., Lee S., Paulus-Hock V., Loddenkemper C., Eilers M., Schmitt C.A. FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. Genes Dev 2007, 21:2775-2787.
58. Dansen T.B., Burgering B.M. Unravelling the tumor-suppressive functions of FOXO proteins. Trends Cell Biol 2008, 18:421-429.
59. Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature 2001, 411:355-365.
60. Serrano M., Blasco M.A. Cancer and ageing: convergent and divergent mechanisms. Nat Rev Mol Cell Biol 2007, 8:715-722.
61. Blagosklonny M.V., Hall M.N. Growth and aging: a common molecular mechanism. Aging (Albany NY) 2009, 1:357-362.
62. Matheu A., Maraver A., Collado M., Garcia-Cao I., Canamero M., Borras C., Flores J.M., Klatt P., Vina J., Serrano M. Anti-aging activity of the Ink4/Arf locus. Aging Cell 2009, 8:152-161.