메뉴 건너뛰기




Volumn 1, Issue 2, 2009, Pages 144-165

Prophylactic and therapeutic vaccination against hepatitis C virus (HCV): Developments and future perspectives

Author keywords

Immune responses; Immunotherapy; Neutralizing antibody; T cells; Vaccine

Indexed keywords


EID: 82355188723     PISSN: 19994915     EISSN: None     Source Type: Journal    
DOI: 10.3390/v1020144     Document Type: Review
Times cited : (9)

References (121)
  • 1
    • 11144246127 scopus 로고    scopus 로고
    • Novel insights into hepatitis C virus replication and persistence
    • Bartenschlager, R.; Frese, M.; Pietschmann, T. Novel insights into hepatitis C virus replication and persistence. Adv. Virus Res. 2004, 63, 71-180.
    • (2004) Adv. Virus Res. , vol.63 , pp. 71-180
    • Bartenschlager, R.1    Frese, M.2    Pietschmann, T.3
  • 4
    • 0034651580 scopus 로고    scopus 로고
    • Pathogenesis, natural history, treatment, and prevention of hepatitis C
    • Liang, T.J.; Rehermann, B.; Seeff, L.B.; Hoofnagle, J.H. Pathogenesis, natural history, treatment, and prevention of hepatitis C. Ann. Intern. Med. 2000, 132, 296-305.
    • (2000) Ann. Intern. Med. , vol.132 , pp. 296-305
    • Liang, T.J.1    Rehermann, B.2    Seeff, L.B.3    Hoofnagle, J.H.4
  • 5
    • 0036828783 scopus 로고    scopus 로고
    • Course and outcome of hepatitis C
    • Hoofnagle, J.H. Course and outcome of hepatitis C. Hepatology 2002, 36, S21-S29.
    • (2002) Hepatology , vol.36
    • Hoofnagle, J.H.1
  • 6
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • Manns, M.P.; McHutchison, J.G.; Gordon, S.C.; Rustgi, V.K.; Shiffman, M.; Reindollar, R.; Goodman, Z.D.; Koury, K.; Ling, M.; Albrecht, J.K. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001, 358, 958-965.
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    Rustgi, V.K.4    Shiffman, M.5    Reindollar, R.6    Goodman, Z.D.7    Koury, K.8    Ling, M.9    Albrecht, J.K.10
  • 9
    • 0028265186 scopus 로고
    • Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2
    • Mizushima, H.; Hijikata, M.; Tanji, Y.; Kimura, K.; Shimotohno, K. Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2. J. Virol. 1994, 68, 2731-2734.
    • (1994) J. Virol. , vol.68 , pp. 2731-2734
    • Mizushima, H.1    Hijikata, M.2    Tanji, Y.3    Kimura, K.4    Shimotohno, K.5
  • 10
    • 0026025737 scopus 로고
    • Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins
    • Weiner, A.J.; Brauer, M.J.; Rosenblatt, J.; Richman, K.H.; Tung, J.; Crawford, K.; Bonino, F.; Saracco, G.; Choo, Q.L.; Houghton, M. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology 1991, 180, 842-848.
    • (1991) Virology , vol.180 , pp. 842-848
    • Weiner, A.J.1    Brauer, M.J.2    Rosenblatt, J.3    Richman, K.H.4    Tung, J.5    Crawford, K.6    Bonino, F.7    Saracco, G.8    Choo, Q.L.9    Houghton, M.10
  • 11
    • 0028355846 scopus 로고
    • Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: Humoral immune response to hypervariable region 1
    • Sekiya, H.; Kato, N.; Ootsuyama, Y.; Nakazawa, T.; Yamauchi, K.; Shimotohno, K. Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: humoral immune response to hypervariable region 1. Int. J. Cancer 1994, 57, 664-670.
    • (1994) Int. J. Cancer , vol.57 , pp. 664-670
    • Sekiya, H.1    Kato, N.2    Ootsuyama, Y.3    Nakazawa, T.4    Yamauchi, K.5    Shimotohno, K.6
  • 12
    • 0030912338 scopus 로고    scopus 로고
    • The molecular virology of hepatitis C
    • Major, M.E.; Feinstone, S.M. The molecular virology of hepatitis C. Hepatology 1997, 25, 1527-1538.
    • (1997) Hepatology , vol.25 , pp. 1527-1538
    • Major, M.E.1    Feinstone, S.M.2
  • 13
    • 0027304173 scopus 로고
    • A structurally flexible and antigenically variable Nterminal domain of the hepatitis C virus E2/NS1 protein: Implication for an escape from antibody
    • Taniguchi, S.; Okamoto, H.; Sakamoto, M.; Kojima, M.; Tsuda, F.; Tanaka, T.; Munekata, E.; Muchmore, E.E.; Peterson, D.A.; Mishiro, S. A structurally flexible and antigenically variable Nterminal domain of the hepatitis C virus E2/NS1 protein: implication for an escape from antibody. Virology 1993, 195, 297-301.
    • (1993) Virology , vol.195 , pp. 297-301
    • Taniguchi, S.1    Okamoto, H.2    Sakamoto, M.3    Kojima, M.4    Tsuda, F.5    Tanaka, T.6    Munekata, E.7    Muchmore, E.E.8    Peterson, D.A.9    Mishiro, S.10
  • 14
    • 0034700083 scopus 로고    scopus 로고
    • Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees
    • Forns, X.; Thimme, R.; Govindarajan, S.; Emerson, S.U.; Purcell, R.H.; Chisari, F.V.; Bukh, J. Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees. Proc. Natl. Acad. Sci. USA 2000, 97, 13318-13323.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13318-13323
    • Forns, X.1    Thimme, R.2    Govindarajan, S.3    Emerson, S.U.4    Purcell, R.H.5    Chisari, F.V.6    Bukh, J.7
  • 17
    • 0027223705 scopus 로고
    • Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus
    • Kato, N.; Sekiya, H.; Ootsuyama, Y.; Nakazawa, T.; Hijikata, M.; Ohkoshi, S.; Shimotohno, K. Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus. J. Virol. 1993, 67, 3923-3930.
    • (1993) J. Virol. , vol.67 , pp. 3923-3930
    • Kato, N.1    Sekiya, H.2    Ootsuyama, Y.3    Nakazawa, T.4    Hijikata, M.5    Ohkoshi, S.6    Shimotohno, K.7
  • 18
    • 0028140138 scopus 로고
    • Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses
    • Shimizu, Y.K.; Hijikata, M.; Iwamoto, A.; Alter, H.J.; Purcell, R.H.; Yoshikura, H. Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses. J. Virol. 1994, 68, 1494-1500.
    • (1994) J. Virol. , vol.68 , pp. 1494-1500
    • Shimizu, Y.K.1    Hijikata, M.2    Iwamoto, A.3    Alter, H.J.4    Purcell, R.H.5    Yoshikura, H.6
  • 19
    • 0037057124 scopus 로고    scopus 로고
    • Genetic diversity and models of viral evolution for the hepatitis C virus
    • Stumpf, M.P.; Pybus, O.G. Genetic diversity and models of viral evolution for the hepatitis C virus. FEMS Microbiol. Lett. 2002, 214, 143-152.
    • (2002) FEMS Microbiol. Lett. , vol.214 , pp. 143-152
    • Stumpf, M.P.1    Pybus, O.G.2
  • 22
    • 22344448015 scopus 로고    scopus 로고
    • Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man
    • Bowen, D.G.; Walker, C.M. Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man. J. Exp. Med. 2005, 201, 1709-1714.
    • (2005) J. Exp. Med. , vol.201 , pp. 1709-1714
    • Bowen, D.G.1    Walker, C.M.2
  • 24
    • 33847015308 scopus 로고    scopus 로고
    • Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo
    • von Hahn, T.; Yoon, J.C.; Alter, H.; Rice, C.M.; Rehermann, B.; Balfe, P.; McKeating, J.A. Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo. Gastroenterology 2007, 132, 667-678.
    • (2007) Gastroenterology , vol.132 , pp. 667-678
    • von Hahn, T.1    Yoon, J.C.2    Alter, H.3    Rice, C.M.4    Rehermann, B.5    Balfe, P.6    McKeating, J.A.7
  • 28
    • 23844553059 scopus 로고    scopus 로고
    • Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein
    • Owsianka, A.; Tarr, A.W.; Juttla, V.S.; Lavillette, D.; Bartosch, B.; Cosset, F.L.; Ball, J.K.; Patel, A.H. Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein. J. Virol. 2005, 79, 11095-11104.
    • (2005) J. Virol. , vol.79 , pp. 11095-11104
    • Owsianka, A.1    Tarr, A.W.2    Juttla, V.S.3    Lavillette, D.4    Bartosch, B.5    Cosset, F.L.6    Ball, J.K.7    Patel, A.H.8
  • 31
    • 17144403776 scopus 로고    scopus 로고
    • Mathematical modeling of primary hepatitis C infection: Noncytolytic clearance and early blockage of virion production
    • Dahari, H.; Major, M.; Zhang, X.; Mihalik, K.; Rice, C.M.; Perelson, A.S.; Feinstone, S.M.; Neumann, A.U. Mathematical modeling of primary hepatitis C infection: noncytolytic clearance and early blockage of virion production. Gastroenterology 2005, 128, 1056-1066.
    • (2005) Gastroenterology , vol.128 , pp. 1056-1066
    • Dahari, H.1    Major, M.2    Zhang, X.3    Mihalik, K.4    Rice, C.M.5    Perelson, A.S.6    Feinstone, S.M.7    Neumann, A.U.8
  • 32
    • 2542577112 scopus 로고    scopus 로고
    • Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzees
    • Major, M.E.; Dahari, H.; Mihalik, K.; Puig, M.; Rice, C.M.; Neumann, A.U.; Feinstone, S.M. Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzees. Hepatology 2004, 39, 1709-1720.
    • (2004) Hepatology , vol.39 , pp. 1709-1720
    • Major, M.E.1    Dahari, H.2    Mihalik, K.3    Puig, M.4    Rice, C.M.5    Neumann, A.U.6    Feinstone, S.M.7
  • 38
    • 0034985916 scopus 로고    scopus 로고
    • Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection
    • Bassett, S.E.; Guerra, B.; Brasky, K.; Miskovsky, E.; Houghton, M.; Klimpel, G.R.; Lanford, R.E. Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection. Hepatology 2001, 33, 1479-1487.
    • (2001) Hepatology , vol.33 , pp. 1479-1487
    • Bassett, S.E.1    Guerra, B.2    Brasky, K.3    Miskovsky, E.4    Houghton, M.5    Klimpel, G.R.6    Lanford, R.E.7
  • 39
    • 0036284899 scopus 로고    scopus 로고
    • Previously infected and recovered chimpanzees exhibit rapid responses that control hepatitis C virus replication upon rechallenge
    • Major, M.E.; Mihalik, K.; Puig, M.; Rehermann, B.; Nascimbeni, M.; Rice, C.M.; Feinstone, S.M. Previously infected and recovered chimpanzees exhibit rapid responses that control hepatitis C virus replication upon rechallenge. J. Virol. 2002, 76, 6586-6595.
    • (2002) J. Virol. , vol.76 , pp. 6586-6595
    • Major, M.E.1    Mihalik, K.2    Puig, M.3    Rehermann, B.4    Nascimbeni, M.5    Rice, C.M.6    Feinstone, S.M.7
  • 41
    • 49149114141 scopus 로고    scopus 로고
    • Previously infected chimpanzees are not consistently protected against reinfection or persistent infection after reexposure to the identical hepatitis C virus strain
    • Bukh, J.; Thimme, R.; Meunier, J.C.; Faulk, K.; Spangenberg, H.C.; Chang, K.M.; Satterfield, W.; Chisari, F.V.; Purcell, R.H. Previously infected chimpanzees are not consistently protected against reinfection or persistent infection after reexposure to the identical hepatitis C virus strain. J. Virol. 2008, 82, 8183-8195.
    • (2008) J. Virol. , vol.82 , pp. 8183-8195
    • Bukh, J.1    Thimme, R.2    Meunier, J.C.3    Faulk, K.4    Spangenberg, H.C.5    Chang, K.M.6    Satterfield, W.7    Chisari, F.V.8    Purcell, R.H.9
  • 44
    • 0029151623 scopus 로고
    • Possible mechanism involving T-lymphocyte response to nonstructural protein 3 in viral clearance in acute hepatitis C virus infection
    • Diepolder, H.M.; Zachoval, R.; Hoffmann, R.M.; Wierenga, E.A.; Santantonio, T.; Jung, M.C.; Eichenlaub, D.; Pape, G.R. Possible mechanism involving T-lymphocyte response to nonstructural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 1995, 346, 1006-1007.
    • (1995) Lancet , vol.346 , pp. 1006-1007
    • Diepolder, H.M.1    Zachoval, R.2    Hoffmann, R.M.3    Wierenga, E.A.4    Santantonio, T.5    Jung, M.C.6    Eichenlaub, D.7    Pape, G.R.8
  • 47
    • 0037369712 scopus 로고    scopus 로고
    • Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection
    • Wertheimer, A.M.; Miner, C.; Lewinsohn, D.M.; Sasaki, A.W.; Kaufman, E.; Rosen, H.R. Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection. Hepatology 2003, 37, 577-589.
    • (2003) Hepatology , vol.37 , pp. 577-589
    • Wertheimer, A.M.1    Miner, C.2    Lewinsohn, D.M.3    Sasaki, A.W.4    Kaufman, E.5    Rosen, H.R.6
  • 49
    • 0035914925 scopus 로고    scopus 로고
    • Determinants of viral clearance and persistence during acute hepatitis C virus infection
    • Thimme, R.; Oldach, D.; Chang, K.M.; Steiger, C.; Ray, S.C.; Chisari, F.V. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J. Exp. Med. 2001, 194, 1395-1406.
    • (2001) J. Exp. Med. , vol.194 , pp. 1395-1406
    • Thimme, R.1    Oldach, D.2    Chang, K.M.3    Steiger, C.4    Ray, S.C.5    Chisari, F.V.6
  • 50
    • 23944467250 scopus 로고    scopus 로고
    • Adaptive immune responses in acute and chronic hepatitis C virus infection
    • Bowen, D.G.; Walker, C.M. Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 2005, 436, 946-952.
    • (2005) Nature , vol.436 , pp. 946-952
    • Bowen, D.G.1    Walker, C.M.2
  • 51
    • 0034030136 scopus 로고    scopus 로고
    • Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C
    • Takaki, A.; Wiese, M.; Maertens, G.; Depla, E.; Seifert, U.; Liebetrau, A.; Miller, J.L.; Manns, M.P.; Rehermann, B. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat. Med. 2000, 6, 578-582.
    • (2000) Nat. Med. , vol.6 , pp. 578-582
    • Takaki, A.1    Wiese, M.2    Maertens, G.3    Depla, E.4    Seifert, U.5    Liebetrau, A.6    Miller, J.L.7    Manns, M.P.8    Rehermann, B.9
  • 53
    • 0037383169 scopus 로고    scopus 로고
    • Kinetics of CD4+ and CD8+ memory T-cell responses during hepatitis C virus rechallenge of previously recovered chimpanzees
    • Nascimbeni, M.; Mizukoshi, E.; Bosmann, M.; Major, M.E.; Mihalik, K.; Rice, C.M.; Feinstone, S.M.; Rehermann, B. Kinetics of CD4+ and CD8+ memory T-cell responses during hepatitis C virus rechallenge of previously recovered chimpanzees. J. Virol. 2003, 77, 4781-4793.
    • (2003) J. Virol. , vol.77 , pp. 4781-4793
    • Nascimbeni, M.1    Mizukoshi, E.2    Bosmann, M.3    Major, M.E.4    Mihalik, K.5    Rice, C.M.6    Feinstone, S.M.7    Rehermann, B.8
  • 54
    • 0037416146 scopus 로고    scopus 로고
    • Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes
    • Bartosch, B.; Dubuisson, J.; Cosset, F.L. Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. J. Exp. Med. 2003, 197, 633-642.
    • (2003) J. Exp. Med. , vol.197 , pp. 633-642
    • Bartosch, B.1    Dubuisson, J.2    Cosset, F.L.3
  • 61
    • 56749131299 scopus 로고    scopus 로고
    • Highly efficient JFH1-based cell-culture system for hepatitis C virus genotype 5a: Failure of homologous neutralizing-antibody treatment to control infection
    • Jensen, T.B.; Gottwein, J.M.; Scheel, T.K.; Hoegh, A.M.; Eugen-Olsen, J.; Bukh, J. Highly efficient JFH1-based cell-culture system for hepatitis C virus genotype 5a: failure of homologous neutralizing-antibody treatment to control infection. J. Infect. Dis. 2008, 198, 1756-1765.
    • (2008) J. Infect. Dis. , vol.198 , pp. 1756-1765
    • Jensen, T.B.1    Gottwein, J.M.2    Scheel, T.K.3    Hoegh, A.M.4    Eugen-Olsen, J.5    Bukh, J.6
  • 64
    • 20944449916 scopus 로고    scopus 로고
    • Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection
    • Lavillette, D.; Morice, Y.; Germanidis, G.; Donot, P.; Soulier, A.; Pagkalos, E.; Sakellariou, G.; Intrator, L.; Bartosch, B.; Pawlotsky, J.M.; Cosset, F.L. Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection. J. Virol. 2005, 79, 6023-6034.
    • (2005) J. Virol. , vol.79 , pp. 6023-6034
    • Lavillette, D.1    Morice, Y.2    Germanidis, G.3    Donot, P.4    Soulier, A.5    Pagkalos, E.6    Sakellariou, G.7    Intrator, L.8    Bartosch, B.9    Pawlotsky, J.M.10    Cosset, F.L.11
  • 65
    • 66149119738 scopus 로고    scopus 로고
    • Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus
    • Dowd, K.A.; Netski, D.M.; Wang, X.H.; Cox, A.L.; Ray, S.C. Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus. Gastroenterology 2009, 136, 2377-2386.
    • (2009) Gastroenterology , vol.136 , pp. 2377-2386
    • Dowd, K.A.1    Netski, D.M.2    Wang, X.H.3    Cox, A.L.4    Ray, S.C.5
  • 70
    • 55249088800 scopus 로고    scopus 로고
    • Evidence for protection against chronic hepatitis C virus infection in chimpanzees by immunization with replicating recombinant vaccinia virus
    • Youn, J.W.; Hu, Y.W.; Tricoche, N.; Pfahler, W.; Shata, M.T.; Dreux, M.; Cosset, F.L.; Folgori, A.; Lee, D.H.; Brotman, B.; Prince, A.M. Evidence for protection against chronic hepatitis C virus infection in chimpanzees by immunization with replicating recombinant vaccinia virus. J. Virol. 2008, 82, 10896-10905.
    • (2008) J. Virol. , vol.82 , pp. 10896-10905
    • Youn, J.W.1    Hu, Y.W.2    Tricoche, N.3    Pfahler, W.4    Shata, M.T.5    Dreux, M.6    Cosset, F.L.7    Folgori, A.8    Lee, D.H.9    Brotman, B.10    Prince, A.M.11
  • 71
    • 63449109294 scopus 로고    scopus 로고
    • T-cell vaccines that elicit effective immune responses against HCV in chimpanzees may create greater immune pressure for viral mutation
    • Zubkova, I.; Choi, Y.H.; Chang, E.; Pirollo, K.; Uren, T.; Watanabe, H.; Wells, F.; Kachko, A.; Krawczynski, K.; Major, M.E. T-cell vaccines that elicit effective immune responses against HCV in chimpanzees may create greater immune pressure for viral mutation. Vaccine 2009, 27, 2594-2602.
    • (2009) Vaccine , vol.27 , pp. 2594-2602
    • Zubkova, I.1    Choi, Y.H.2    Chang, E.3    Pirollo, K.4    Uren, T.5    Watanabe, H.6    Wells, F.7    Kachko, A.8    Krawczynski, K.9    Major, M.E.10
  • 74
    • 0033848911 scopus 로고    scopus 로고
    • Vaccination of chimpanzees with plasmid DNA encoding the hepatitis C virus (HCV) envelope E2 protein modified the infection after challenge with homologous monoclonal HCV
    • Forns, X.; Payette, P.J.; Ma, X.; Satterfield, W.; Eder, G.; Mushahwar, I.K.; Govindarajan, S.; Davis, H.L.; Emerson, S.U.; Purcell, R.H.; Bukh, J. Vaccination of chimpanzees with plasmid DNA encoding the hepatitis C virus (HCV) envelope E2 protein modified the infection after challenge with homologous monoclonal HCV. Hepatology 2000, 32, 618-625.
    • (2000) Hepatology , vol.32 , pp. 618-625
    • Forns, X.1    Payette, P.J.2    Ma, X.3    Satterfield, W.4    Eder, G.5    Mushahwar, I.K.6    Govindarajan, S.7    Davis, H.L.8    Emerson, S.U.9    Purcell, R.H.10    Bukh, J.11
  • 76
    • 1242293129 scopus 로고    scopus 로고
    • Immunization of chimpanzees with an envelope protein-based vaccine enhances specific humoral and cellular immune responses that delay hepatitis C virus infection
    • Puig, M.; Major, M.E.; Mihalik, K.; Yu, M.Y.; Feinstone, S.M. Immunization of chimpanzees with an envelope protein-based vaccine enhances specific humoral and cellular immune responses that delay hepatitis C virus infection. Vaccine 2004, 22, 991-1000.
    • (2004) Vaccine , vol.22 , pp. 991-1000
    • Puig, M.1    Major, M.E.2    Mihalik, K.3    Yu, M.Y.4    Feinstone, S.M.5
  • 81
    • 0033981997 scopus 로고    scopus 로고
    • Approaches to improved influenza vaccination
    • Betts, R.F.; Treanor, J.J. Approaches to improved influenza vaccination. Vaccine 2000, 18, 1690-1695.
    • (2000) Vaccine , vol.18 , pp. 1690-1695
    • Betts, R.F.1    Treanor, J.J.2
  • 83
    • 0035180888 scopus 로고    scopus 로고
    • Performance characteristics of a transcription-mediated nucleic acid amplification assay for qualitative detection of hepatitis C virus RNA
    • Ross, R.S.; Viazov, S.O.; Hoffmann, S.; Roggendorf, M. Performance characteristics of a transcription-mediated nucleic acid amplification assay for qualitative detection of hepatitis C virus RNA. J. Clin. Lab Anal. 2001, 15, 308-313.
    • (2001) J. Clin. Lab Anal. , vol.15 , pp. 308-313
    • Ross, R.S.1    Viazov, S.O.2    Hoffmann, S.3    Roggendorf, M.4
  • 86
    • 0025248742 scopus 로고
    • Immunization against hepatitis B
    • Zuckerman, A.J. Immunization against hepatitis B. Br. Med. Bull. 1990, 46, 383-398.
    • (1990) Br. Med. Bull. , vol.46 , pp. 383-398
    • Zuckerman, A.J.1
  • 88
    • 0033932001 scopus 로고    scopus 로고
    • Recovery, persistence, and sequelae in hepatitis C virus infection: A perspective on long-term outcome
    • Alter, H.J.; Seeff, L.B. Recovery, persistence, and sequelae in hepatitis C virus infection: a perspective on long-term outcome. Semin. Liver Dis. 2000, 20, 17-35.
    • (2000) Semin. Liver Dis. , vol.20 , pp. 17-35
    • Alter, H.J.1    Seeff, L.B.2
  • 89
    • 0036829816 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis C
    • Seeff, L.B. Natural history of chronic hepatitis C. Hepatology 2002, 36, S35-S46.
    • (2002) Hepatology , vol.36
    • Seeff, L.B.1
  • 92
    • 0041381363 scopus 로고    scopus 로고
    • Similarities and differences in CD4+ and CD8+ effector and memory T cell generation
    • Seder, R.A.; Ahmed, R. Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat. Immunol. 2003, 4, 835-842.
    • (2003) Nat. Immunol. , vol.4 , pp. 835-842
    • Seder, R.A.1    Ahmed, R.2
  • 94
    • 67049160649 scopus 로고    scopus 로고
    • Strategies to overcome host immunity to adenovirus vectors in vaccine development
    • Thacker, E.E.; Timares, L.; Matthews, Q.L. Strategies to overcome host immunity to adenovirus vectors in vaccine development. Exp. Rev. Vaccines. 2009, 8, 761-777.
    • (2009) Exp. Rev. Vaccines. , vol.8 , pp. 761-777
    • Thacker, E.E.1    Timares, L.2    Matthews, Q.L.3
  • 97
    • 0036166630 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural protein 3-specific cellular immune responses following single or combined immunization with DNA or recombinant Semliki Forest virus particles
    • Brinster, C.; Chen, M.; Boucreux, D.; Paranhos-Baccala, G.; Liljestrom, P.; Lemmonier, F.; Inchauspe, G. Hepatitis C virus non-structural protein 3-specific cellular immune responses following single or combined immunization with DNA or recombinant Semliki Forest virus particles. J. Gen. Virol. 2002, 83, 369-381.
    • (2002) J. Gen. Virol. , vol.83 , pp. 369-381
    • Brinster, C.1    Chen, M.2    Boucreux, D.3    Paranhos-Baccala, G.4    Liljestrom, P.5    Lemmonier, F.6    Inchauspe, G.7
  • 98
    • 47749130475 scopus 로고    scopus 로고
    • Induction of broad CD4+ and CD8+ T-cell responses and crossneutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5
    • Lin, Y.; Kwon, T.; Polo, J.; Zhu, Y.F.; Coates, S.; Crawford, K.; Dong, C.; Wininger, M.; Hall, J.; Selby, M.; Coit, D.; Medina-Selby, A.; McCoin, C.; Ng, P.; Drane, D.; Chien, D.; Han, J.; Vajdy, M.; Houghton, M. Induction of broad CD4+ and CD8+ T-cell responses and crossneutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5. J. Virol. 2008, 82, 7492-7503.
    • (2008) J. Virol. , vol.82 , pp. 7492-7503
    • Lin, Y.1    Kwon, T.2    Polo, J.3    Zhu, Y.F.4    Coates, S.5    Crawford, K.6    Dong, C.7    Wininger, M.8    Hall, J.9    Selby, M.10    Coit, D.11    Medina-Selby, A.12    McCoin, C.13    Ng, P.14    Drane, D.15    Chien, D.16    Han, J.17    Vajdy, M.18    Houghton, M.19
  • 99
    • 0024514346 scopus 로고
    • Sindbis virus: An efficient, broad host range vector for gene expression in animal cells
    • Xiong, C.; Levis, R.; Shen, P.; Schlesinger, S.; Rice, C.M.; Huang, H.V. Sindbis virus: an efficient, broad host range vector for gene expression in animal cells. Science 1989, 243, 1188-1191.
    • (1989) Science , vol.243 , pp. 1188-1191
    • Xiong, C.1    Levis, R.2    Shen, P.3    Schlesinger, S.4    Rice, C.M.5    Huang, H.V.6
  • 102
    • 43049144208 scopus 로고    scopus 로고
    • A vectorbased minigene vaccine approach results in strong induction of T-cell responses specific of hepatitis C virus
    • Martin, P.; Simon, B.; Lone, Y.C.; Chatel, L.; Barry, R.; Inchauspe, G.; Fournillier, A. A vectorbased minigene vaccine approach results in strong induction of T-cell responses specific of hepatitis C virus. Vaccine 2008, 26, 2471-2481.
    • (2008) Vaccine , vol.26 , pp. 2471-2481
    • Martin, P.1    Simon, B.2    Lone, Y.C.3    Chatel, L.4    Barry, R.5    Inchauspe, G.6    Fournillier, A.7
  • 105
    • 0034623816 scopus 로고    scopus 로고
    • Efficient initiation of HCV RNA replication in cell culture
    • Blight, K.J.; Kolykhalov, A.A.; Rice, C.M. Efficient initiation of HCV RNA replication in cell culture. Science 2000, 290, 1972-1974.
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1    Kolykhalov, A.A.2    Rice, C.M.3
  • 106
    • 34748815771 scopus 로고    scopus 로고
    • Phase I clinical study of a personalized peptide vaccination for patients infected with hepatitis C virus (HCV) 1b who failed to respond to interferon-based therapy
    • Yutani, S.; Yamada, A.; Yoshida, K.; Takao, Y.; Tamura, M.; Komatsu, N.; Ide, T.; Tanaka, M.; Sata, M.; Itoh, K. Phase I clinical study of a personalized peptide vaccination for patients infected with hepatitis C virus (HCV) 1b who failed to respond to interferon-based therapy. Vaccine 2007, 25, 7429-7435.
    • (2007) Vaccine , vol.25 , pp. 7429-7435
    • Yutani, S.1    Yamada, A.2    Yoshida, K.3    Takao, Y.4    Tamura, M.5    Komatsu, N.6    Ide, T.7    Tanaka, M.8    Sata, M.9    Itoh, K.10
  • 111
    • 43149083669 scopus 로고    scopus 로고
    • Open-label trial of therapeutic immunization with oral V-5 Immunitor (V5) vaccine in patients with chronic hepatitis C
    • Batdelger, D.; Dandii, D.; Jirathitikal, V.; Bourinbaiar, A.S. Open-label trial of therapeutic immunization with oral V-5 Immunitor (V5) vaccine in patients with chronic hepatitis C. Vaccine 2008, 26, 2733-2737.
    • (2008) Vaccine , vol.26 , pp. 2733-2737
    • Batdelger, D.1    Dandii, D.2    Jirathitikal, V.3    Bourinbaiar, A.S.4
  • 113
    • 49749110778 scopus 로고    scopus 로고
    • A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection
    • Chua, B.Y.; Eriksson, E.M.; Brown, L.E.; Zeng, W.; Gowans, E.J.; Torresi, J.; Jackson, D.C. A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection. Vaccine 2008, 26, 4866-4875.
    • (2008) Vaccine , vol.26 , pp. 4866-4875
    • Chua, B.Y.1    Eriksson, E.M.2    Brown, L.E.3    Zeng, W.4    Gowans, E.J.5    Torresi, J.6    Jackson, D.C.7
  • 115
    • 3843137346 scopus 로고    scopus 로고
    • A candidate vaccine based on the hepatitis C E1 protein: Tolerability and immunogenicity in healthy volunteers
    • Leroux-Roels, G.; Depla, E.; Hulstaert, F.; Tobback, L.; Dincq, S.; Desmet, J.; Desombere, I.; Maertens, G. A candidate vaccine based on the hepatitis C E1 protein: tolerability and immunogenicity in healthy volunteers. Vaccine 2004, 22, 3080-3086.
    • (2004) Vaccine , vol.22 , pp. 3080-3086
    • Leroux-Roels, G.1    Depla, E.2    Hulstaert, F.3    Tobback, L.4    Dincq, S.5    Desmet, J.6    Desombere, I.7    Maertens, G.8
  • 116
    • 22144434860 scopus 로고    scopus 로고
    • Immunogenicity and tolerability of intradermal administration of an HCV E1-based vaccine candidate in healthy volunteers and patients with resolved or ongoing chronic HCV infection
    • Leroux-Roels, G.; Batens, A.H.; Desombere, I.; Van Den, S.B.; Vander, S.C.; Maertens, G.; Hulstaert, F. Immunogenicity and tolerability of intradermal administration of an HCV E1-based vaccine candidate in healthy volunteers and patients with resolved or ongoing chronic HCV infection. Hum. Vaccin. 2005, 1, 61-65.
    • (2005) Hum. Vaccin. , vol.1 , pp. 61-65
    • Leroux-Roels, G.1    Batens, A.H.2    Desombere, I.3    Van Den, S.B.4    Vander, S.C.5    Maertens, G.6    Hulstaert, F.7
  • 117
    • 0035284757 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine
    • Polakos, N.K.; Drane, D.; Cox, J.; Ng, P.; Selby, M.J.; Chien, D.; O'Hagan, D.T.; Houghton, M.; Paliard, X. Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine. J. Immunol. 2001, 166, 3589-3598.
    • (2001) J. Immunol. , vol.166 , pp. 3589-3598
    • Polakos, N.K.1    Drane, D.2    Cox, J.3    Ng, P.4    Selby, M.J.5    Chien, D.6    O'Hagan, D.T.7    Houghton, M.8    Paliard, X.9
  • 118
    • 9244230047 scopus 로고    scopus 로고
    • ISCOMATRIX adjuvant for antigen delivery
    • Pearse, M.J.; Drane, D. ISCOMATRIX adjuvant for antigen delivery. Adv. Drug Deliv. Rev. 2005, 57, 465-474.
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 465-474
    • Pearse, M.J.1    Drane, D.2
  • 120
    • 34748832365 scopus 로고    scopus 로고
    • An accelerated vaccine schedule with a poly-antigenic hepatitis C virus MVA-based candidate vaccine induces potent, long lasting and in vivo cross-reactive T cell responses
    • Fournillier, A.; Gerossier, E.; Evlashev, A.; Schmitt, D.; Simon, B.; Chatel, L.; Martin, P.; Silvestre, N.; Balloul, J.M.; Barry, R.; Inchauspe, G. An accelerated vaccine schedule with a poly-antigenic hepatitis C virus MVA-based candidate vaccine induces potent, long lasting and in vivo cross-reactive T cell responses. Vaccine 2007, 25, 7339-7353.
    • (2007) Vaccine , vol.25 , pp. 7339-7353
    • Fournillier, A.1    Gerossier, E.2    Evlashev, A.3    Schmitt, D.4    Simon, B.5    Chatel, L.6    Martin, P.7    Silvestre, N.8    Balloul, J.M.9    Barry, R.10    Inchauspe, G.11
  • 121
    • 35448967046 scopus 로고    scopus 로고
    • Vaccines and immunotherapies against hepatitis B and hepatitis C viruses
    • Inchauspe, G.; Michel, M.L. Vaccines and immunotherapies against hepatitis B and hepatitis C viruses. J. Viral Hepat. 2007, 14 Suppl. 1, 97-103.
    • (2007) J. Viral Hepat. , vol.14 , Issue.SUPPL. 1 , pp. 97-103
    • Inchauspe, G.1    Michel, M.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.