Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease

Journal of Biological Chemistry

Volumn 286, Issue 48, 2011, Pages 41647-41655

  Costa, Rita ^a   Speretta, Elena ^b,c   Crowther, Damian C ^b,c   Cardoso, Isabel ^a,d  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d POLYTECHNIC INSTITUTE OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION STATE; ALZHEIMER DISEASE; CASPASE-3 ACTIVATION; DOXYCYCLINE; DROSOPHILA MELANOGASTER; FIBRILLIZATION; IN-VITRO; IN-VIVO; LIFE SPAN; NEUROBLASTOMA CELL LINES; NEUROPROTECTIVE EFFECTS; PATHOGENIC AMYLOIDS; THERAPEUTIC POTENTIALS; THIOFLAVIN T; TRANSGENICS;

CELL CULTURE; DISEASE CONTROL; GLYCOPROTEINS; PEPTIDES; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY;

NEURODEGENERATIVE DISEASES;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; CASPASE 3; DOXYCYCLINE; GREEN FLUORESCENT PROTEIN; THIOFLAVINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE COURSE; DROSOPHILA MELANOGASTER; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; EYE DISEASE; HUMAN; HUMAN CELL; IN VIVO STUDY; LIFESPAN; LIGHT SCATTERING; LOCOMOTION; MOTOR DYSFUNCTION; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN VARIANT; TRANSGENIC ANIMAL; TRANSMISSION ELECTRON MICROSCOPY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTI-BACTERIAL AGENTS; CASPASE 3; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DOXYCYCLINE; DROSOPHILA MELANOGASTER; FLUORESCENT DYES; HUMANS; LONGEVITY; THIAZOLES;

EID: 82355164174     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.274548     Document Type: Article

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