-
1
-
-
33746468121
-
Acetyl-l-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease
-
Abdul H.M., Calabrese V., Calvani M., and Butterfield D.A. Acetyl-l-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. J. Neurosci. Res. 84 (2006) 398-408
-
(2006)
J. Neurosci. Res.
, vol.84
, pp. 398-408
-
-
Abdul, H.M.1
Calabrese, V.2
Calvani, M.3
Butterfield, D.A.4
-
2
-
-
18244384051
-
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease
-
Adlard P.A., Perreau V.M., Pop V., and Cotman C.W. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J. Neurosci. 25 (2005) 4217-4221
-
(2005)
J. Neurosci.
, vol.25
, pp. 4217-4221
-
-
Adlard, P.A.1
Perreau, V.M.2
Pop, V.3
Cotman, C.W.4
-
3
-
-
0032527045
-
Acetyl-l-carnitine modulates glucose metabolism and stimulates glycogen synthesis in rat brain
-
Aureli T., Di Cocco M.E., Puccetti C., Ricciolini R., Scalibastri M., Miccheli A., Manetti C., and Conti F. Acetyl-l-carnitine modulates glucose metabolism and stimulates glycogen synthesis in rat brain. Brain Res. 796 (1998) 75-81
-
(1998)
Brain Res.
, vol.796
, pp. 75-81
-
-
Aureli, T.1
Di Cocco, M.E.2
Puccetti, C.3
Ricciolini, R.4
Scalibastri, M.5
Miccheli, A.6
Manetti, C.7
Conti, F.8
-
4
-
-
0038238122
-
Effect of a new derivative of retinoic acid on proliferation and differentiation in human neuroblastoma cells
-
Bartolini G., Orlandi M., Ammar K., Magrini E., Ferreri A.M., and Rocchi P. Effect of a new derivative of retinoic acid on proliferation and differentiation in human neuroblastoma cells. Anticancer Res. 23 (2003) 1495-1499
-
(2003)
Anticancer Res.
, vol.23
, pp. 1495-1499
-
-
Bartolini, G.1
Orlandi, M.2
Ammar, K.3
Magrini, E.4
Ferreri, A.M.5
Rocchi, P.6
-
6
-
-
0037411794
-
Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain
-
Chauhan N.B., and Siegel G.J. Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain. Neurochem. Int. 43 (2003) 225-233
-
(2003)
Neurochem. Int.
, vol.43
, pp. 225-233
-
-
Chauhan, N.B.1
Siegel, G.J.2
-
7
-
-
0036042518
-
[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients
-
Colciaghi F., Borroni B., Pastorino L., Marcello E., Zimmermann M., Cattabeni F., Padovani A., and Di Luca M. [alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients. Mol. Med. 8 (2002) 67-74
-
(2002)
Mol. Med.
, vol.8
, pp. 67-74
-
-
Colciaghi, F.1
Borroni, B.2
Pastorino, L.3
Marcello, E.4
Zimmermann, M.5
Cattabeni, F.6
Padovani, A.7
Di Luca, M.8
-
8
-
-
0029661438
-
Amyloid alpha peptide formation in cell-free preparations. Regulation by protein kinase C, calmodulin, and calcineurin
-
Desdouits F., Buxbaum J.D., Desdouits-Magnen J., Nairn A.C., and Greengard P. Amyloid alpha peptide formation in cell-free preparations. Regulation by protein kinase C, calmodulin, and calcineurin. J. Biol. Chem. 271 (1996) 24670-24674
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24670-24674
-
-
Desdouits, F.1
Buxbaum, J.D.2
Desdouits-Magnen, J.3
Nairn, A.C.4
Greengard, P.5
-
9
-
-
0042630561
-
Secretases as targets for the treatment of Alzheimer's disease: the prospects
-
Dewachter I., and Van Leuven F. Secretases as targets for the treatment of Alzheimer's disease: the prospects. Lancet Neurol. 1 (2002) 409-416
-
(2002)
Lancet Neurol.
, vol.1
, pp. 409-416
-
-
Dewachter, I.1
Van Leuven, F.2
-
10
-
-
0029819924
-
Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome
-
Di Luca M., Pastorino L., Cattabeni F., Zanardi R., Scarone S., Racagni G., Smeraldi E., and Perez J. Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome. Arch. Neurol. 53 (1996) 1162-1166
-
(1996)
Arch. Neurol.
, vol.53
, pp. 1162-1166
-
-
Di Luca, M.1
Pastorino, L.2
Cattabeni, F.3
Zanardi, R.4
Scarone, S.5
Racagni, G.6
Smeraldi, E.7
Perez, J.8
-
11
-
-
0019796481
-
Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices
-
Dolezal V., and Tucek S. Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices. J. Neurochem. 36 (1981) 1323-1330
-
(1981)
J. Neurochem.
, vol.36
, pp. 1323-1330
-
-
Dolezal, V.1
Tucek, S.2
-
12
-
-
0032907788
-
Clinical benefits of a new piperidine-class AChE inhibitor
-
Doody R.S. Clinical benefits of a new piperidine-class AChE inhibitor. Eur. Neuropsychopharmacol. 9 Suppl 2 (1999) S69-77
-
(1999)
Eur. Neuropsychopharmacol.
, vol.9
, Issue.SUPPL. 2
-
-
Doody, R.S.1
-
13
-
-
0029148786
-
Clinical heterogeneity: responders to cholinergic therapy
-
Eagger S.A., and Harvey R.J. Clinical heterogeneity: responders to cholinergic therapy. Alzheimer Dis. Assoc. Disord. 9 Suppl 2 (1995) 37-42
-
(1995)
Alzheimer Dis. Assoc. Disord.
, vol.9
, Issue.SUPPL. 2
, pp. 37-42
-
-
Eagger, S.A.1
Harvey, R.J.2
-
14
-
-
0036993442
-
A clinical overview of cholinesterase inhibitors in Alzheimer's disease
-
Farlow M. A clinical overview of cholinesterase inhibitors in Alzheimer's disease. Int. Psychogeriatr. 14 Suppl 1 (2002) 93-126
-
(2002)
Int. Psychogeriatr.
, vol.14
, Issue.SUPPL. 1
, pp. 93-126
-
-
Farlow, M.1
-
15
-
-
0036458825
-
Lack of PSD-95 drives hippocampal neuronal cell death through activation of an alpha CaMKII transduction pathway
-
Gardoni F., Bellone C., Viviani B., Marinovich M., Meli E., Pellegrini-Giampietro D.E., Cattabeni F., and Di Luca M. Lack of PSD-95 drives hippocampal neuronal cell death through activation of an alpha CaMKII transduction pathway. Eur. J. Neurosci. 16 (2002) 777-786
-
(2002)
Eur. J. Neurosci.
, vol.16
, pp. 777-786
-
-
Gardoni, F.1
Bellone, C.2
Viviani, B.3
Marinovich, M.4
Meli, E.5
Pellegrini-Giampietro, D.E.6
Cattabeni, F.7
Di Luca, M.8
-
17
-
-
0031769321
-
Action of l-acetylcarnitine on different cerebral mitochondrial populations from cerebral cortex
-
Gorini A., D'Angelo A., and Villa R.F. Action of l-acetylcarnitine on different cerebral mitochondrial populations from cerebral cortex. Neurochem. Res. 23 (1998) 1485-1491
-
(1998)
Neurochem. Res.
, vol.23
, pp. 1485-1491
-
-
Gorini, A.1
D'Angelo, A.2
Villa, R.F.3
-
18
-
-
1442264828
-
Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
-
Haass C. Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. Embo J. 23 (2004) 483-488
-
(2004)
Embo J.
, vol.23
, pp. 483-488
-
-
Haass, C.1
-
19
-
-
0032482999
-
Acetyl-l-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity
-
Hagen T.M., Ingersoll R.T., Wehr C.M., Lykkesfeldt J., Vinarsky V., Bartholomew J.C., Song M.H., and Ames B.N. Acetyl-l-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 9562-9566
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 9562-9566
-
-
Hagen, T.M.1
Ingersoll, R.T.2
Wehr, C.M.3
Lykkesfeldt, J.4
Vinarsky, V.5
Bartholomew, J.C.6
Song, M.H.7
Ames, B.N.8
-
20
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz F., Tomita T., Hsieh H., Seabrook G., Borchelt D., Iwatsubo T., Sisodia S., and Malinow R. APP processing and synaptic function. Neuron 37 (2003) 925-937
-
(2003)
Neuron
, vol.37
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
Seabrook, G.4
Borchelt, D.5
Iwatsubo, T.6
Sisodia, S.7
Malinow, R.8
-
21
-
-
0035826909
-
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10
-
Kojro E., Gimpl G., Lammich S., Marz W., and Fahrenholz F. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 5815-5820
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 5815-5820
-
-
Kojro, E.1
Gimpl, G.2
Lammich, S.3
Marz, W.4
Fahrenholz, F.5
-
22
-
-
0142258009
-
Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells
-
Kraveka J.M., Li L., Bielawski J., Obeid L.M., and Ogretmen B. Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells. Arch. Biochem. Biophys. 419 (2003) 110-119
-
(2003)
Arch. Biochem. Biophys.
, vol.419
, pp. 110-119
-
-
Kraveka, J.M.1
Li, L.2
Bielawski, J.3
Obeid, L.M.4
Ogretmen, B.5
-
23
-
-
0032569990
-
The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells
-
Lahiri D.K., Farlow M.R., and Sambamurti K. The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells. Brain Res. Mol. Brain Res. 62 (1998) 131-140
-
(1998)
Brain Res. Mol. Brain Res.
, vol.62
, pp. 131-140
-
-
Lahiri, D.K.1
Farlow, M.R.2
Sambamurti, K.3
-
24
-
-
0037315878
-
A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease
-
Lahiri D.K., Farlow M.R., Sambamurti K., Greig N.H., Giacobini E., and Schneider L.S. A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease. Curr. Drug Targets 4 (2003) 97-112
-
(2003)
Curr. Drug Targets
, vol.4
, pp. 97-112
-
-
Lahiri, D.K.1
Farlow, M.R.2
Sambamurti, K.3
Greig, N.H.4
Giacobini, E.5
Schneider, L.S.6
-
25
-
-
0033616716
-
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
-
Lammich S., Kojro E., Postina R., Gilbert S., Pfeiffer R., Jasionowski M., Haass C., and Fahrenholz F. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 3922-3927
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 3922-3927
-
-
Lammich, S.1
Kojro, E.2
Postina, R.3
Gilbert, S.4
Pfeiffer, R.5
Jasionowski, M.6
Haass, C.7
Fahrenholz, F.8
-
26
-
-
11144353586
-
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
-
Lustbader J.W., Cirilli M., Lin C., Xu H.W., Takuma K., Wang N., Caspersen C., Chen X., Pollak S., Chaney M., Trinchese F., Liu S., Gunn-Moore F., Lue L.F., Walker D.G., Kuppusamy P., Zewier Z.L., Arancio O., Stern D., Yan S.S., and Wu H. ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304 (2004) 448-452
-
(2004)
Science
, vol.304
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
Xu, H.W.4
Takuma, K.5
Wang, N.6
Caspersen, C.7
Chen, X.8
Pollak, S.9
Chaney, M.10
Trinchese, F.11
Liu, S.12
Gunn-Moore, F.13
Lue, L.F.14
Walker, D.G.15
Kuppusamy, P.16
Zewier, Z.L.17
Arancio, O.18
Stern, D.19
Yan, S.S.20
Wu, H.21
more..
-
27
-
-
33847171931
-
Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity
-
Marcello E., Gardoni F., Mauceri D., Romorini S., Jeromin A., Epis R., Borroni B., Cattabeni F., Sala C., Padovani A., and Di Luca M. Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity. J. Neurosci. 27 (2007) 1682-1691
-
(2007)
J. Neurosci.
, vol.27
, pp. 1682-1691
-
-
Marcello, E.1
Gardoni, F.2
Mauceri, D.3
Romorini, S.4
Jeromin, A.5
Epis, R.6
Borroni, B.7
Cattabeni, F.8
Sala, C.9
Padovani, A.10
Di Luca, M.11
-
28
-
-
36849023935
-
Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders
-
Marks N., and Berg M.J. Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders. Neurochem. Int. 52 (2008) 184-215
-
(2008)
Neurochem. Int.
, vol.52
, pp. 184-215
-
-
Marks, N.1
Berg, M.J.2
-
29
-
-
0033012064
-
The effect of aging and acetyl-l-carnitine on the pyruvate transport and oxidation in rat heart mitochondria
-
Paradies G., Petrosillo G., Gadaleta M.N., and Ruggiero F.M. The effect of aging and acetyl-l-carnitine on the pyruvate transport and oxidation in rat heart mitochondria. FEBS Lett. 454 (1999) 207-209
-
(1999)
FEBS Lett.
, vol.454
, pp. 207-209
-
-
Paradies, G.1
Petrosillo, G.2
Gadaleta, M.N.3
Ruggiero, F.M.4
-
30
-
-
0028891690
-
Clinical and neurochemical effects of acetyl-l-carnitine in Alzheimer's disease
-
Pettegrew J.W., Klunk W.E., Panchalingam K., Kanfer J.N., and McClure R.J. Clinical and neurochemical effects of acetyl-l-carnitine in Alzheimer's disease. Neurobiol. Aging 16 (1995) 1-4
-
(1995)
Neurobiol. Aging
, vol.16
, pp. 1-4
-
-
Pettegrew, J.W.1
Klunk, W.E.2
Panchalingam, K.3
Kanfer, J.N.4
McClure, R.J.5
-
31
-
-
0033653231
-
Acetyl-l-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression
-
Pettegrew J.W., Levine J., and McClure R.J. Acetyl-l-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Mol. Psychiatry 5 (2000) 616-632
-
(2000)
Mol. Psychiatry
, vol.5
, pp. 616-632
-
-
Pettegrew, J.W.1
Levine, J.2
McClure, R.J.3
-
32
-
-
0037008737
-
Dynamic change of neural cell adhesion molecule polysialylation on human neuroblastoma (IMR-32) and rat pheochromocytoma (PC-12) cells during growth and differentiation
-
Poongodi G.L., Suresh N., Gopinath S.C., Chang T., Inoue S., and Inoue Y. Dynamic change of neural cell adhesion molecule polysialylation on human neuroblastoma (IMR-32) and rat pheochromocytoma (PC-12) cells during growth and differentiation. J. Biol. Chem. 277 (2002) 28200-28211
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 28200-28211
-
-
Poongodi, G.L.1
Suresh, N.2
Gopinath, S.C.3
Chang, T.4
Inoue, S.5
Inoue, Y.6
-
33
-
-
85047690140
-
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
-
Postina R., Schroeder A., Dewachter I., Bohl J., Schmitt U., Kojro E., Prinzen C., Endres K., Hiemke C., Blessing M., Flamez P., Dequenne A., Godaux E., van Leuven F., and Fahrenholz F. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J. Clin. Invest. 113 (2004) 1456-1464
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 1456-1464
-
-
Postina, R.1
Schroeder, A.2
Dewachter, I.3
Bohl, J.4
Schmitt, U.5
Kojro, E.6
Prinzen, C.7
Endres, K.8
Hiemke, C.9
Blessing, M.10
Flamez, P.11
Dequenne, A.12
Godaux, E.13
van Leuven, F.14
Fahrenholz, F.15
-
34
-
-
10244259208
-
The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial. The Donepezil Study Group
-
Rogers S.L., and Friedhoff L.T. The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial. The Donepezil Study Group. Dementia 7 (1996) 293-303
-
(1996)
Dementia
, vol.7
, pp. 293-303
-
-
Rogers, S.L.1
Friedhoff, L.T.2
-
35
-
-
0035066332
-
Alzheimer's disease: genes, proteins, and therapy
-
Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
36
-
-
0029789746
-
Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenic role in the formation of senile plaques and neurofibrillary tangles
-
Smith M.A., Sayre L.M., Monnier V.M., and Perry G. Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenic role in the formation of senile plaques and neurofibrillary tangles. Mol. Chem. Neuropathol. 28 (1996) 41-48
-
(1996)
Mol. Chem. Neuropathol.
, vol.28
, pp. 41-48
-
-
Smith, M.A.1
Sayre, L.M.2
Monnier, V.M.3
Perry, G.4
-
37
-
-
0026002366
-
Long-term acetyl-l-carnitine treatment in Alzheimer's disease
-
Spagnoli A., Lucca U., Menasce G., Bandera L., Cizza G., Forloni G., Tettamanti M., Frattura L., Tiraboschi P., Comelli M., et al. Long-term acetyl-l-carnitine treatment in Alzheimer's disease. Neurology 41 (1991) 1726-1732
-
(1991)
Neurology
, vol.41
, pp. 1726-1732
-
-
Spagnoli, A.1
Lucca, U.2
Menasce, G.3
Bandera, L.4
Cizza, G.5
Forloni, G.6
Tettamanti, M.7
Frattura, L.8
Tiraboschi, P.9
Comelli, M.10
-
38
-
-
9544240348
-
A 1-year multicenter placebo-controlled study of acetyl-l-carnitine in patients with Alzheimer's disease
-
Thal L.J., Carta A., Clarke W.R., Ferris S.H., Friedland R.P., Petersen R.C., Pettegrew J.W., Pfeiffer E., Raskind M.A., Sano M., Tuszynski M.H., and Woolson R.F. A 1-year multicenter placebo-controlled study of acetyl-l-carnitine in patients with Alzheimer's disease. Neurology 47 (1996) 705-711
-
(1996)
Neurology
, vol.47
, pp. 705-711
-
-
Thal, L.J.1
Carta, A.2
Clarke, W.R.3
Ferris, S.H.4
Friedland, R.P.5
Petersen, R.C.6
Pettegrew, J.W.7
Pfeiffer, E.8
Raskind, M.A.9
Sano, M.10
Tuszynski, M.H.11
Woolson, R.F.12
-
39
-
-
17444414627
-
Cholinesterase inhibitors influence APP metabolism in Alzheimer disease patients
-
Zimmermann M., Borroni B., Cattabeni F., Padovani A., and Di Luca M. Cholinesterase inhibitors influence APP metabolism in Alzheimer disease patients. Neurobiol. Dis. 19 (2005) 237-242
-
(2005)
Neurobiol. Dis.
, vol.19
, pp. 237-242
-
-
Zimmermann, M.1
Borroni, B.2
Cattabeni, F.3
Padovani, A.4
Di Luca, M.5
-
40
-
-
4544239545
-
Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines
-
Zimmermann M., Gardoni F., Marcello E., Colciaghi F., Borroni B., Padovani A., Cattabeni F., and Di Luca M. Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines. J. Neurochem. 90 (2004) 1489-1499
-
(2004)
J. Neurochem.
, vol.90
, pp. 1489-1499
-
-
Zimmermann, M.1
Gardoni, F.2
Marcello, E.3
Colciaghi, F.4
Borroni, B.5
Padovani, A.6
Cattabeni, F.7
Di Luca, M.8
|