Minireview: Stress-related psychiatric disorders with low cortisol levels: A metabolic hypothesis

Endocrinology

Volumn 152, Issue 12, 2011, Pages 4496-4503

  Yehuda, Rachel ^a   Seckl, Jonathan ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; CORTICOTROPIN; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE 1; STEROID 5BETA REDUCTASE;

ADAPTATION; AMYGDALOID NUCLEUS; BRAIN; BRAIN METABOLISM; DOWN REGULATION; EARLY LIFE STRESS; EPIGENETICS; GENE EXPRESSION; GLUCOSE METABOLISM; HIPPOCAMPUS; HOLOCAUST; HORMONE ACTION; HORMONE SENSITIVITY; HORMONE SYNTHESIS; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHESIS; KIDNEY; LEUKOCYTE; LIFE EVENT; LIVER; MENTAL DISEASE; MUSCLE; NEGATIVE FEEDBACK; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PREGNANCY; PRIORITY JOURNAL; PSYCHOTRAUMA; RECEPTOR DENSITY; SHORT SURVEY; STARVATION; STEROID METABOLISM; STRESS; UPREGULATION;

CHRONIC PAIN; FATIGUE; GLUCOCORTICOIDS; HYDROCORTISONE; LIVER; MENTAL DISORDERS; STRESS DISORDERS, TRAUMATIC;

EID: 82355163444     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1218     Document Type: Short Survey

References (70)

1. Carroll BJ 1982 The dexamethasone suppression test for melancholia. Br J Psychiatry 140:292-304 (Pubitemid 12184534)
2. Stetler C, Miller GE 2011 Depression and hypothalamic-pituitaryadrenal activation: a quantitative summary of four decades of research. Psychosom Med 73:114-126
3. Mason JW, Giller EL, Kosten TR, Ostroff RB, Podd L 1986 Urinary free-cortisol levels in posttraumatic-stress-disorder patients. J Nerv Ment Dis 174:145-149 (Pubitemid 16117404)
4. Yehuda R, Southwick SM, Nussbaum G, Wahby V, Giller Jr EL, Mason JW 1990 Low urinary cortisol excretion in patients with posttraumatic-stress-disorder. J Nerv Ment Dis 178:366-369 (Pubitemid 20203850)
5. Yehuda R 2002 Current concepts: post-traumatic stress disorder. N Engl J Med 346:108-114 (Pubitemid 34438902)
6. Yehuda R 2009 Status of glucocorticoid alterations in post-traumatic stress disorder. Ann NY Acad Sci 1179:56-69
7. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB 1995 Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 52:1048-1060
8. Heim C, Ehlert U, Hellhammer DH 2000 The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 25:1-35 (Pubitemid 29490865)
9. Crofford LJ, Pillemer SR, Kalogeras KT, Cash JM, Michelson D, Kling MA, Sternberg EM, Gold PW, Chrousos GP, Wilder RL 1994 Hypothalamic-pituitary- adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum 37:1583-1592 (Pubitemid 24345804)
10. Meewisse ML, Reitsma JB, de Vries GJ, Gersons BP, Olff M 2007 Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis. Br J Psychiatry 191:387-392 (Pubitemid 350069578)
11. Kumari M, Badrick E, Chandola T, Adam EK, Stafford M, Marmot MG, Kirschbaum C, Kivimaki M 2009 Cortisol secretion and fatigue: Associations in a community based cohort. Psychoneuroendocrinology 34:1476-1485
12. Yehuda R, Levengood RA, Schmeidler J, Wilson S, Guo LS, Gerber D1996 Increased pituitary activation following metyrapone administration in post-traumatic stress disorder. Psychoneuroendocrinology 21:1-16 (Pubitemid 26129275)
13. Yehuda R, Golier JA, Halligan SL, Meaney M, Bierer LM 2004 The ACTH response to dexamethasone in PTSD. Am J Psychiatry 161:1397-1403 (Pubitemid 38989092)
14. Kanter ED, Wilkinson CW, Radant AD, Petrie EC, Dobie DJ, McFall ME, Peskind ER, Raskind MA 2001 Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder. Biol Psychiatry 50:238-245 (Pubitemid 32778439)
15. Heim C, Ehlert U, Hanker JP, Hellhammer DH 1998 Abuse-related posttraumatic stress disorder and alterations of the hypothalamicpituitary- adrenal axis in women with chronic pelvic pain. Psychosom Med 60:309-318 (Pubitemid 28279975)
16. Rasmusson AM, Lipschitz DS, Wang S, Hu S, Vojvoda D, Bremner JD, Southwick SM, Charney DS 2001 Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder. Biolog Psychiatry 50:965-977 (Pubitemid 34066489)
17. de Kloet CS, Vermetten E, Geuze E, Kavelaars A, Heijnen CJ, Westenberg HGM 2006 Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J Psychiatr Res 40:550-567 (Pubitemid 44175408)
18. Bremner JD, Vythilingam M, Vermetten E, Adil J, Khan S, Nazeer A, Afzal N, McGlashan T, Elzinga B, Anderson GM, Heninger G, Southwick SM, Charney DS 2003 Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology 28:733-750 (Pubitemid 36695030)
19. Meijer OC, de Lange EC, Breimer DD, de Boer AG, Workel JO, de Kloet ER 1998 Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice. Endocrinology 139:1789-1793 (Pubitemid 28513838)
20. Yehuda R, Golier JA, Yang RK, Tischler L 2004 Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder. Biol Psychiatry 55:1110-1116 (Pubitemid 38680564)
21. Yehuda R, Boisoneau D, Mason JW, Giller EL 1993 Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders. Biol Psychiatry 34:18-25 (Pubitemid 23240018)
22. Gill J, Luckenbaugh D, Charney D, Vythilingam M 2010 Sustained elevation of serum interleukin-6 and relative insensitivity to hydrocortisone differentiates posttraumatic stress disorder with and without depression. Biol Psychiatry 68:999-1006
23. Golier JA, Schmeidler J, Legge J, Yehuda R 2006 Enhanced cortisol suppression to dexamethasone associated with Gulf War deployment. Psychoneuroendocrinology 31:1181-1189 (Pubitemid 44792367)
24. Yehuda R, Boisoneau D, Lowy MT, Giller Jr EL 1995 Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethaosne administration in combat veterans with and without posttraumatic stress disorder. Arch Gen Psychiatry 52:583-593
25. Grossman R, Yehuda R, Golier J, McEwen B, Harvey P, Maria NS 2006 Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects. In: Yehuda R, ed. Psychobiology of posttraumatic stress disorder: a decade of progress. Boston, Blackwell; 410-421 (Pubitemid 44126746)
26. Yehuda R, Harvey PD, Buchsbaum M, Tischler L, Schmeidler J 2007 Enhanced effects of cortisol administration on episodic and working memory in aging veterans with PTSD. Neuropsychopharmacology 32:2581-2591 (Pubitemid 350126833)
27. Yehuda R, Harvey PD, Golier JA, Newmark RE, Bowie CR, Wohltmann JJ, Grossman RA, Schmeidler J, Hazlett EA, Buchsbaum MS 2009 Changes in relative glucose metabolic rate following cortisol administration in aging veterans with posttraumatic stress disorder: an FDG-PET neuroimaging Study. J Neuropsychiatry Clin Neurosci 21:132-143
28. Seckl JR, Meaney MJ 2006 Glucocorticoid "programming" and PTSD risk. In: Yehuda R, ed. Psychobiology of posttraumatic stress disorder: a decade of progress. Boston, Blackwell; 351-378
29. McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ 2009 Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12:342-348
30. Seckl JR, Holmes MC 2007 Mechanisms of disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology. Nat Clin Pract Endocrinol Metab 3:479-488 (Pubitemid 46808745)
31. Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ 2004 Epigenetic programming by maternal behavior. Nat Neurosci 7:847-854 (Pubitemid 38989508)
32. Welberg LA, Seckl JR, Holmes MC 2001 Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophinreleasing hormone: possible implications for behaviour. Neuroscience 104:71-79 (Pubitemid 32322614)
33. Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, Macklin ML, Lasko NB, Cavanagh SR, Krangel TS, Orr SP, Pitman RK, Whalen PJ, Rauch SL 2005 A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry 62:273-281 (Pubitemid 40990972)
34. Kolber BJ, Roberts MS, Howell MP, Wozniak DF, Sands MS, Muglia LJ 2008 Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning. Proc Natl Acad Sci USA 105:12004-12009
35. Fenoglio KA, Brunson KL, Avishai-Eliner S, Stone BA, Kapadia BJ, Baram TZ 2005 Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor. Endocrinology 146:4090-4096 (Pubitemid 41175781)
36. Bazak N, Kozlovsky N, Kaplan Z, Matar M, Golan H, Zohar J, Richter-Levin G, Cohen H 2009 Pre-pubertal stress exposure affects adult behavioral response in association with changes in circulating corticosterone and brain-derived neurotrophic factor. Psychoneuroendocrinology 34:844-858
37. Walker BR, Seckl JR 2001 Cortisol metabolism. In: Björntorp P, ed. International textbook of obesity. Chichester, UK: John Wiley and Sons; 241-268
38. Stewart PM, Krozowski ZS 1999 11β-Hydroxysteroid dehydrogenase. Vitam Horm 57:249-324
39. Seckl JR, Walker BR 2001 11β-Hydroxysteroid dehydrogenase type 1: a tissue-specific amplifier of glucocorticoid action. Endocrinology 142:1371-1376 (Pubitemid 32299662)
40. Andrew R, Westerbacka J, Wahren J, Yki-Järvinen H, Walker BR 2005 The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans. Diabetes 54:1364-1370 (Pubitemid 40586665)
41. Basu R, Singh RJ, Basu A, Chittilapilly EG, Johnson CM, Toffolo G, Cobelli C, Rizza RA 2004 Splanchnic cortisol production occurs in humans: evidence for conversion of cortisone to cortisol via the 11-β- hydroxysteroid dehydrogenase (11β-HSD) type 1 pathway. Diabetes 53:2051-2059 (Pubitemid 38970754)
42. Kotelevtsev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR, Mullins JJ 1997 11ß-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid inducible responses and resist hyperglycaemia on obesity or stress. Proc Natl Acad Sci USA 94:14924-14929 (Pubitemid 28041476)
43. Moisan MP, Seckl JR, Edwards CR 1990 11β-Hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus and cortex. Endocrinology 127:1450-1455 (Pubitemid 20277632)
44. Harris HJ, Kotelevtsev Y, Mullins JJ, Seckl JR, Holmes MC 2001 11β-Hydroxysteroid dehydrogenase type 1 null mice have altered hypothalamic-pituitary-adrenal axis activity: a novel control of glucocorticoid feedback. Endocrinology 142:114-120
45. Rosenstock J, Banarer S, Fonseca VA, Inzucchi SE, Sun W, Yao W, Hollis G, Flores R, Levy R, Williams WV, Seckl JR, Huber R; INCB13739-202 Principal Investigators 2010 The 11-β-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy. Diabetes Care 33:1516-1522
46. Paterson JM, Holmes MC, Kenyon CJ, Carter R, Mullins JJ, Seckl JR 2007 Liver-selective transgene rescue of hypothalamic-pituitaryadrenal axis dysfunction in 11β-hydroxysteroid dehydrogenase type 1-deficient mice. Endocrinology 148:961-966
47. Yehuda R, Bierer LM, Andrew R, Schmeidler J, Seckl JR 2009 Enduring effects of severe developmental adversity, including nutritional deprivation, on cortisol metabolism in aging Holocaust survivors. J Psychiatr Res 43:877-883
48. Tang JI, Kenyon CJ, Seckl JR, Nyirenda MJ 2011 Prenatal overexposure to glucocorticoids programs renal 11β-hydroxysteroid dehydrogenase type 2 expression and salt-sensitive hypertension in the rat. J Hypertens 29:282-289
49. Alikhani-Koopaei R, Fouladkou F, Frey FJ, Frey BM 2004 Epigenetic regulation of 11β-hydroxysteroid dehydrogenase type 2 expression. J Clin Invest 114:1146-1157 (Pubitemid 39578704)
50. Baserga M, Kaur R, Hale MA, Bares A, Yu X, Callaway CW, McKnight RA, Lane RH 2010 Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11β-hydroxysteroid dehydrogenase type 2 in a sex-specific manner. Am J Physiol Regul Integr Comp Physiol 299:R334-R342
51. Yehuda R, Teicher MH, Seckl JR, Grossman RA, Morris A, Bierer LM 2007 Parental posttraumatic stress disorder as a vulnerability factor for low cortisol trait in offspring of holocaust survivors. Arch Gen Psychiatry 64:1040-1048 (Pubitemid 47360849)
52. Drake AJ, Walker BR, Seckl JR 2005 Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats. Am J Physiol Regul Integr Comp Physiol 288:R34-R38 (Pubitemid 40023908)
53. Bertram C, Khan O, Ohri S, Phillips DI, Matthews SG, Hanson MA 2008 Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function. J Physiol 586:2217-2229 (Pubitemid 351524573)
54. Yehuda R, Engel SM, Brand SR, Seckl J, Marcus SM, Berkowitz GS 2005 Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the world trade center attacks during pregnancy. J Clin Endocrinol Metab 90:4115-4118 (Pubitemid 41058182)
55. Yehuda R, Bierer LM, Sarapas C, Makotkine I, Andrew R, Seckl JR 2009 Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001. Psychoneuroendocrinology 34:1304-1313
56. Gustafsson JA, Stenberg A 1974 Irreversible androgenic programming at birth of microsomal and soluble rat liver enzymes active on 4-androstene-3,17- dione and 5α-androstane-3α,17β-diol. J Biol Chem 249:711-718
57. Gustafsson JA, Stenberg A 1974 Neonatal programming of androgen responsiveness of liver of adult rats. J Biol Chem 249:719-723
58. Stimson RH, Lobley GE, Maraki I, Morton NM, Andrew R, Walker BR 2010 Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats. Plos One 5:e8779
59. Tomlinson JW, Finney J, Gay C, Hughes BA, Hughes SV, Stewart PM 2008 Impaired glucose tolerance and insulin resistance are associated with increased adipose 11β-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5α-reductase activity. Diabetes 57:2652-2660
60. Dallman MF, Akana SF, Laugero KD, Gomez F, Manalo S, Bell ME, Bhatnagar S 2003 A spoonful of sugar: feedback signals of energy stores and corticosterone regulate responses to chronic stress. Physiol Behav 79:3-12 (Pubitemid 36734825)
61. la Fleur SE, Manalo SL, Roy M, Houshyar H, Dallman MF 2005 Hepatic vagotomy alters limbic and hypothalamic neuropeptide responses to insulin-dependent diabetes and voluntary lard ingestion. Eur J Neurosci 21:2733-2742 (Pubitemid 40835116)
62. Roozendaal B, McEwen BS, Chattarji S 2009 Stress, memory and the amygdala. Nat Rev Neurosci 10:423-433
63. Dedert EA, Calhoun PS, Watkins LL, Sherwood A, Beckham JC 2010 Posttraumatic stress disorder, cardiovascular, and metabolic disease: a review of the evidence. Ann Behav Med 39:61-78
64. de Quervain DJ, Margraf J 2008 Glucocorticoids for the treatment of post-traumatic stress disorder and phobias: a novel therapeutic approach. Eur J Pharmacol 583:365-371
65. Surís A, North C, Adinoff B, Powell CM, Greene R 2010 Effects of exogenous glucocorticoid on combat-related PTSD symptoms. Ann Clin Psychiatry 22:274-279
66. Zohar J, Yahalom H, Kozlovsky N, Cwikel-Hamzany S, Matar M, Kaplan Z, Yehuda R, Cohen H 8 July 2011 High dose hydrocortisone immediately after trauma may alter the trajectory of PTSD: Interplay between clinical and animal studies. Eur Neuropsychopharmacol 10.1016/j.euroneuro.2011.06.001
67. Yehuda R, Golier J 2009 Is there a rationale for cortisol-based treatments for PTSD? Expert Rev Neurother 9:1113-1115
68. Rasmusson AM, Pinna G, Paliwal P, Weisman D, Gottschalk C, Charney D, Krystal J, Guidotti A 2006 Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biol Psychiatry 60:704-713 (Pubitemid 44427765)
69. Pibiri F, Nelson M, Guidotti A, Costa E, Pinna G 2008 Decreased corticolimbic allopregnanolone expression during, social isolation enhances contextual fear: a model relevant for posttraumatic stress disorder. Proc Natl Acad Sci USA 105:5567-5572 (Pubitemid 351753903)
70. Melcangi RC, Celotti F, Ballabio M, Carnaghi R, Poletti A, Martini L 1989 Effect of postnatal starvation on the 5-α-reductase activity of the brain and of the isolated myelin membranes. Exp Clin Endocrinol 94:253-261 (Pubitemid 20072266)