Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 14, 2008, Pages 5567-5572

  Pibiri, Fabio ^a   Nelson, Marianela ^a   Guidotti, Alessandro ^a   Costa, Erminio ^a   Pinna, Graziano ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Fear conditioning; Selective brain steroidogenic stimulants

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; NORFLUOXETINE; SKF 10511; STEROID 5ALPHA REDUCTASE 1; STEROID 5ALPHA REDUCTASE INHIBITOR;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; BRAIN CORTEX; CONDITIONING; CONTROLLED STUDY; DOWN REGULATION; EMOTION; EXPERIMENTAL MODEL; FEAR; HORMONE RELEASE; LIMBIC SYSTEM; MALE; MOUSE; NEUROMODULATION; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; REINFORCEMENT; SEROTONIN UPTAKE; SOCIAL ISOLATION;

ANIMALS; BRAIN CHEMISTRY; CEREBRAL CORTEX; FEAR; FLUOXETINE; GENE EXPRESSION REGULATION; LIMBIC SYSTEM; MICE; MODELS, ANIMAL; PREGNANOLONE; RNA, MESSENGER; SEROTONIN UPTAKE INHIBITORS; SOCIAL ISOLATION; STRESS DISORDERS, POST-TRAUMATIC; TESTOSTERONE 5-ALPHA-REDUCTASE;

MUS;

EID: 44449155724     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801853105     Document Type: Article

References (44)

1. Valzelli L (1969) Aggressive behavior induced by isolation. Aggressive Behavior, eds Garattini S, Sigg SB (Excerpta Medica Foundation, Amsterdam), pp 70-76.
2. Pinna G, Dong E, Matsumoto K, Costa E, Guidotti A (2003) In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc Natl Acad Sci USA 100:2035-2040.
3. A receptor neurotransmission dysfunction in a mouse model of social isolation-induced stress: Possible insights into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders. Stress 10:3-12.
4. Matsumoto K, et al. (1999) Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss. Neuropharmacology 38:955-963.
5. A receptors. Neuron 4:759-765.
6. A receptor. Nat Rev Neurosci 6:565-575.
7. Dong E, et al. (2001) Brain 5α-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation. Proc Natl Acad Sci USA 98:2849-2854.
8. Agís-Balboa RC, et al. (2007) Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. Proc Natl Acad Sci USA 104:18736-18741.
9. Nelson RJ, Trainor BC (2007) Neural mechanisms of aggression. Nat Rev Neurosci 8:536-546.
10. McDonald AJ (1998) Cortical pathways to the mammalian amygdala. Prog Neurobiol 55:257-332.
11. A receptor agonist muscimol. Neuropharmacology 39:440-448.
12. Guidotti A, et al. (2001) The socially-isolated mouse: A model to study the putative role of allopregnanolone and 5α-dihydroprogesterone in psychiatric disorders. Brain Res Brain Res Rev 37:110-115.
13. Pinna G, Costa E, Guidotti A (2006) Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology (Berlin) 186:362-372.
14. Milad MR, et al. (2007) A role for the human dorsal anterior cingulate cortex in fear expression. Biol Psychiatry 62:1191-1194.
15. Rauch SL, Shin LM, Phelps EA (2006) Neurocircuitry models of posttraumatic stress disorder and extinction: Human neuroimaging research-past, present, and future. Biol Psychiatry 60:376-382.
16. Akirav I, Maroun M (2007) The role of the medial prefrontal cortex-amygdala circuit in stress effects on the extinction of fear. Neural Plast, 10.1155/2007/30873.
17. LeDoux JE (2000) Emotion circuits in the brain. Annu Rev Neurosci 23:155-184.
18. Orr SP, et al. (2000) De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. J Abnorm Psychol 109:290-298.
19. Koenigs M, et al. (2007) Focal brain damage protects against post-traumatic stress disorder in combat veterans. Nat Neurosci 11:232-237.
20. Rasmusson AM, et al. (2006) Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biol Psychiatry 60:704-713.
21. Pibiri F, Nelson M, Carboni G, Pinna G (2006) Neurosteroids regulate mouse aggression induced by anabolic androgenic steroids. Neuroreport 17:1537-1541.
22. Pinna G, Costa E, Guidotti A (2004) Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proc Natl Acad Sci USA 101:6222-6225.
23. Phillips RG, LeDoux JE (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106:274-285.
24. Myers KM, Davis M (2007) Mechanisms of fear extinction. Mol Psychiatry 12:120-150.
25. A receptors in the amygdala blocks the acquisition and expression of conditioned defeat in Syrian hamsters. Brain Res 920:142-150.
26. Rodríguez Manzanares PA, Isoardi NA, Carrer HF, Molina VA (2005) Previous stress facilitates fear memory, attenuates GABAergic inhibition, and increases synaptic plasticity in the rat basolateral amygdala. J Neurosci 25:8725-8734.
27. Li S, Murakami Y, Wang M, Maeda K, Matsumoto K (2006) The effects of chronic valproate and diazepam in a mouse model of posttraumatic stress disorder. Pharmacol Biochem Behav 85:324-331.
28. 5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear. Eur J Neurosci 20:1928-1936.
29. Daniels RN, Lindsley CW (2007) A new, non-SSRI mechanism of action for Prozac. Curr Top Med Chem 7:1039.
30. Rau V, DeCola JP, Fanselow MS (2005) Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder. Neurosci Biobehav Rev 29:1207-1223.
31. Morrow BA, Elsworth JD, Rasmusson AM, Roth RH (1999) The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat. Neuroscience 92:553-564.
32. Ameli R, Ip C, Grillon C (2001) Contextual fear-potentiated startle conditioning in humans: Replication and extension. Psychophysiology 38:383-390.
33. Grillon C, Morgan CA, III (1999) Fear-potentiated startle conditioning to explicit and contextual cues in Gulf War veterans with posttraumatic stress disorder. J Abnorm Psychol 108:134-142.
34. Davidson JR (2004) Use of benzodiazepines in social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. J Clin Psychiatry 65:29-33.
35. Gelpin E, Bonne O, Peri T, Brandes D, Shalev AY (1996) Treatment of recent trauma survivors with benzodiazepines: A prospective study. J Clin Psychiatry 57:390-394.
36. Viola J, et al. (1997) Pharmacological management of post-traumatic stress disorder: Clinical summary of a five-year retrospective study, 1990-1995. Mil Med 162:616-619.
37. A benzodiazepine receptor binding in veterans with post-traumatic stress disorder. Molecular Psychiatry 13:74-83.
38. Bremner JD, et al. (2000) Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder. Am J Psychiatry 157:1120-1126.
39. Pinna G, et al. (2006) Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Proc Natl Acad Sci USA 103:4275-4280.
40. Davidson JR, Landerman LR, Farfel GM, Clary CM (2002) Characterizing the effects of sertraline in post-traumatic stress disorder. Psychol Med 32:661-670.
41. Stein DJ, Seedat S, Van der Linden GJ, Zungu-Dirwayi N (2000) Selective serotonin reuptake inhibitors in the treatment of post-traumatic stress disorder: A meta-analysis of randomized controlled trials. Int Clin Psychopharmacol 15:S31-S39.
42. Blanchard RJ, Blanchard DC (1969) Passive and active reactions to fear-eliciting stimuli. J Comp Physiol Psychol 68:129-135.
43. Auta J, Chen Y, Ruzicka WB, Grayson DR (2006) in Handbook of Neurochemistry and Mol Neurobiol-Practical Neurochemistry Methods, eds Backer G, Dunn S, Holt A, Lajtha A (Springer, New York), 3rd Ed, pp 341-361.
44. Uzunov DP, Cooper TB, Costa E, Guidotti A (1996) Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proc Natl Acad Sci USA 93:12599-12604.