High dose hydrocortisone immediately after trauma may alter the trajectory of PTSD: Interplay between clinical and animal studies

European Neuropsychopharmacology

Volumn 21, Issue 11, 2011, Pages 796-809

  Zohar, Joseph ^a   Yahalom, Hila ^a   Kozlovsky, Nitsan ^b   Cwikel Hamzany, Shlomit ^a   Matar, Michael A ^b   Kaplan, Zeev ^b   Yehuda, Rachel ^c   Cohen, Hagit ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Animal model; Brain derived neurotrophic factor (BDNF); Dendritic arborization; Hydrocortisone; Postsynaptic density 95 (PSD 95); Posttraumatic stress disorder; Secondary prevention

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; HYDROCORTISONE; PLACEBO; POSTSYNAPTIC DENSITY PROTEIN 95; SIGMA; UNCLASSIFIED DRUG;

ACUTE STRESS; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DENDRITIC CELL; DENTATE GYRUS; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; FEMALE; HUMAN; ILLNESS TRAJECTORY; MALE; NONHUMAN; PILOT STUDY; POSTSYNAPTIC DENSITY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RAT;

ACOUSTIC STIMULATION; ADULT; ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANXIETY; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION; HUMANS; HYDROCORTISONE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAZE LEARNING; MEMBRANE PROTEINS; MIDDLE AGED; NEURONS; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SILVER STAINING; STARTLE REACTION; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL; TIME FACTORS; TRAUMA SEVERITY INDICES; TREATMENT OUTCOME; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 80053386486     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2011.06.001     Document Type: Article

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