Mitochondria as protean organelles: Membrane processes that influence mitochondrial shape in yeast

General Physiology and Biophysics

Volumn 30, Issue SPECIAL, 2011, Pages

  Abelovska, Lenka ^a  

^a Faculty of Natural Sciences   (Slovakia)

Author keywords

Mitochondria; Mitochondrial morphology; Tubulation; Yeast

Indexed keywords

ION; LIPID; MITOCHONDRIAL PROTEIN;

ARTICLE; BIOGENESIS; CELLULAR PARAMETERS; HOMEOSTASIS; HUMAN; INHERITANCE; LIPOGENESIS; MEMBRANE BIOLOGY; MITOCHONDRIA SHAPE; MITOCHONDRION; MORPHOGENESIS; NONHUMAN; PHENOTYPE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; YEAST; CYTOLOGY; METABOLISM; MITOCHONDRIAL MEMBRANE; ORGANELLE SHAPE; REVIEW; SACCHAROMYCES CEREVISIAE;

HOMEOSTASIS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; ORGANELLE SHAPE; SACCHAROMYCES CEREVISIAE;

EID: 82255166341     PISSN: 02315882     EISSN: 13384325     Source Type: Journal    
DOI: 10.4149/gpb_2011_si1_13     Document Type: Article

References (104)

1. Altmann K., Westermann B. (2005): Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Mol. Biol. Cell 16, 5410-5417 doi:10.1091/mbc.E05-07-0678 (Pubitemid 41566849)
2. Bauerschmitt H., Mick D. U., Deckers M., Vollmer C., Funes S., Kehrein K., Ott M., Rehling P., Herrmann J. M. (2010): Ribos-ome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. Mol. Biol. Cell 21, 1937-1944 doi:10.1091/mbc.E10-02-0101
3. Benard G., Bellance N., James D., Parrone P., Fernandez H., Letellier T., Rossignol R. (2007): Mitochondrial bioenergetics and struc-tural network organization. J. Cell Sci. 120, 838-848 doi:10.1242/jcs.03381 (Pubitemid 46523485)
4. Bereiter-Hahn J., Voth M. (1994): Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria. Microsc. Res. Tech. 27, 198-219 doi:10.1002/jemt 1070270303 (Pubitemid 24062014)
5. Berger K. H., Sogo L. F., YaffeM. P. (1997): Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J. Cell Biol. 136, 545-553 doi:10.1083/jcb.136.3.545 (Pubitemid 27083757)
6. Berger K. H., YaffeM. P. (1998): Prohibit in family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol. Cell. Biol. 18, 4043-4052
7. Birner R., Nebauer R., Schneiter R., Daum G. (2003): Synthetic lethal interaction of the mitochondrial phosphatidyleth-anolamine biosynthetic machinery with the prohibitin complex of Saccharomyces cerevisiae. Mol. Biol. Cell 14, 370-383 doi:10.1091/mbc.E02-05-0263 (Pubitemid 36237002)
8. Boldogh I. R., Yang H. C., Nowakowski W. D., Karmon S. L., Hays L. G., Yates J. R., 3rd, Pon L. A. (2001): Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast. Proc. Natl. Acad. Sci. U.S.A. 98, 3162-3167 doi:10.1073/pnas.051494698 (Pubitemid 32220816)
9. Boldogh I. R., Nowakowski D. W., Yang H. C., Chung H., Karmon S., Royes P., Pon L. A. (2003): A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery Mol. Biol. Cell 14, 4618-4627 doi:10.1091/mbc.E03-04-0225 (Pubitemid 37444660)
10. Boldogh I. R., Fehrenbacher K. L., Yang H. C., Pon L. A. (2005): Mitochondrial movement and inheritance in budding yeast. Gene 354, 28-36 doi:10.1016/j.gene.2005.03.049 (Pubitemid 41116678)
11. Boldogh I. R., Pon L. A. (2007): Mitochondria on the move. Trends Cell Biol. 17, 502-510 doi:10.1016/j.tcb.2007.07.008 (Pubitemid 47562767)
12. Borgese N., Brambillasca S., Soffientini P., Yabal M., Makarow M. (2003): Biogenesis of tail-anchored proteins. Biochem. Soc. Trans. 31, 1238-1242 doi:10.1042/BST0311238 (Pubitemid 38030946)
13. Brown G. C., Brand M. D. (1986): Changes in permeability to protons and other cations at high proton motive force in rat liver mitochondria. Biochem. J. 234, 75-81 (Pubitemid 16053659)
14. Cerveny K. L., Studer S. L., Jensen R. E., Sesaki H. (2007): Yeast mitochondrial division and distribution require the cortical num1 protein. Dev. Cell 12, 363-375 doi:10.1016/j.devcel.2007.01.017
15. Chan D. C. (2006): Mitochondria: dynamic organelles in disease, aging, and development. Cell 125, 1241-1252 doi:10.1016/j.cell.2006.06.010 (Pubitemid 43929096)
16. Chen H., Chomyn A., Chan D. C. (2005): Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J. Biol. Chem. 280, 26185-26192 doi:10.1074/jbc.M503062200 (Pubitemid 41022214)
17. Chen H., Chan D. C. (2009): Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Hum. Mol. Genet. 18, R169-176 doi:10.1093/hmg/ddp326
18. Chernomordik L. V., Zimmerberg J., Kozlov M. M. (2006): Mem-branes of the world unite! J. Cell Biol. 175, 201-207 doi:10.1083/jcb.200607083 (Pubitemid 44631414)
19. Detmer S. A., Chan D. C. (2007): Functions and dysfunctions of mi-tochondrial dynamics. Nat. Rev. Mol. Cell. Biol. 8, 870-879 doi:10.1038/nrm2275 (Pubitemid 47622562)
20. DeVay R. M., Dominguez-Ramirez L., Lackner L. L., Hoppins S., Stahlberg H., Nunnari J. (2009): Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner mem-brane fusion. J. Cell Biol. 186, 793-803 doi:10.1083/jcb.200906098
21. Dimmer K. S., Fritz S., Fuchs F., Messerschmitt M., Weinbach N., Neupert W., Westermann B. (2002): Genetic basis of mitochon-drial function and morphology in Saccharomyces cerevisiae. Mol. Biol. Cell 13, 847-853 doi:10.1091/mbc.01-12-0588 (Pubitemid 34250350)
22. Dimmer K. S., Jakobs S., Vogel F., Altmann K., Westermann B. (2005): Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast. J. Cell Biol. 168, 103-115 doi:10.1083/jcb.200410030 (Pubitemid 40111061)
23. Dimmer K. S., Navoni F., Casarin A., Trevisson E., Endele S., Winterpacht A., Salviati L., Scorrano L. (2008): LETM1, de-leted in Wolf Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability Hum. Mol. Genet. 17, 201-214 doi:10.1093/hmg/ddm297
24. Fehrenbacher K. L., Yang H. C., Gay A. C., Huckaba T. M., Pon L. A. (2004): Live cell imaging of mitochondrial movement along actin cables in budding yeast. Curr. Biol. 14, 1996-2004 doi:10.1016/j.cub.2004.11.004 (Pubitemid 39547954)
25. Fehrenbacher K. L., Boldogh I. R., Pon L. A. (2005): A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast. Mol. Biol. Cell 16, 5094-5102 doi:10.1091/mbc.E05-06-0590 (Pubitemid 41566823)
26. Fisk H. A., Yaffe M. P. (1997): Mutational analysis ofMdm1p function in nuclear and mitochondrial inheritance. J. Cell Biol. 138, 485-494 doi:10.1083/jcb.138.3.485 (Pubitemid 27349832)
27. Fratti R. A., Jun Y., Merz A. J., Margolis N., Wickner W. (2004): Interdependent assembly of specific regulatorylipids and mem-brane fusion proteins into the vertex ring domain of docked vacuoles. J. Cell Biol. 167, 1087-1098 doi:10.1083/jcb.200409068 (Pubitemid 40066624)
28. Frazier A. E., Taylor R. D., Mick D. U., Warscheid B., Stoepel N., Meyer H. E., Ryan M. T., Guiard B., Rehling P. (2006): Mdm38 interacts with ribosomes and is a component of the mitochon-drial protein export machinery J. Cell Biol. 172, 553-564 doi:10.1083/jcb.200505060 (Pubitemid 43243876)
29. Froschauer E., Nowikovsky K., Schweyen R. J. (2005): Elec-troneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim. Biophys. Acta 1711, 41-48 doi:10.1016/j.bbamem.2005.02.018 (Pubitemid 40726399)
30. Garcia-Rodriguez L. J., Gay A. C., Pon L. A. (2007): Puf3p, a Pumil-io family RNA binding protein, localizes to mitochondria and regulates mitochondrial biogenesis and motility in budding yeast. J. Cell Biol. 176, 197-207 doi:10.1083/jcb.200606054 (Pubitemid 46143260)
31. Garcia-Rodriguez L. J., Crider D. G., Gay A. C., Salanueva I. J., Boldogh I. R., Pon L. A. (2009): Mitochondrial inheritance is required for MEN-regulated cytokinesis in budding yeast. Curr. Biol. 19, 1730-1735 doi:10.1016/j.cub.2009.08.041
32. Garlid K. D., Dos Santos P., Xie Z. J., Costa A. D., Paucek P. (2003): Mitochondrial potassium transport: the role of the mitochon-drial ATP-sensitive K(+) channel in cardiac function and cardioprotection. Biochim. Biophys. Acta 1606, 1-21 doi:10.1016/S0005-2728(03)00109-9 (Pubitemid 37267867)
33. Garlid K. D., Paucek P. (2003): Mitochondrial potassium transport: the K(+) cycle. Biochim. Biophys. Acta 1606, 23-41 doi:10.1016/S0005-2728(03)00108-7 (Pubitemid 37267868)
34. Graham T. R., Kozlov M. M. (2010): Interplay of proteins and lipids in generating membrane curvature. Curr. Opin. Cell Biol. 22, 430-436 doi:10.1016/j.ceb.2010.05.002
35. Gregan J., Bui D. M., Pillich R., Fink M., Zsurka G., Schweyen R. J. (2001): Te mitochondrial inner membrane protein Lpe10p, a homologue of Mrs2p, is essential for magnesium homeostasis and group II intron splicing in yeast. Mol. Gen. Genet. 264, 773-781 doi:10.1007/s004380000366
36. Griparic L., van der Bliek A. M. (2001): Te many shapes ofmito-chondrial membranes. Traffic 2, 235-244 doi:10.1034/j.1600-0854.2001.1r008.x (Pubitemid 32487553)
37. Guan K., Farh L., Marshall T. K., Deschenes R. J. (1993): Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene. Curr. Genet. 24, 141-148 doi:10.1007/BF00324678 (Pubitemid 23240904)
38. Hamel P., Saint-Georges Y., de Pinto B., Lachacinski N., Altamura N., Dujardin G. (2004): Redundancy in the function of mito-chondrial phosphate transport in Saccharomyces cerevisiae and Arabidopsis thaliana. Mol. Microbiol. 51, 307-317 doi:10.1046/j.1365-2958.2003.03810.x (Pubitemid 38142122)
39. Hanekamp T., Torsness M. K., Rebbapragada I., Fisher E. M., Seebart C., Darland M. R., Coxbill J. A., Updike D. L., Tors-ness P. E. (2002): Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Sac-charomyces cerevisiae. Genetics 162, 1147-1156 (Pubitemid 35417508)
40. Herlan M., Vogel F., Bornhovd C., Neupert W., Reichert A. S. (2003): Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial mor-phology and of mitochondrial DNA. J. Biol. Chem. 278, 27781-27788 doi:10.1074/jbc.M211311200 (Pubitemid 36899969)
41. Herlan M., Bornhovd C., Hell K., Neupert W., Reichert A. S. (2004): Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor J. Cell Biol. 165, 167-173 doi:10.1083/jcb.200403022 (Pubitemid 38544519)
42. Hobbs A. E., Srinivasan M., McCaffery J. M., Jensen R. E. (2001): Mmm1p, a mitochondrial outer membrane protein, is connect-ed to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability J. Cell Biol. 152, 401-410 doi:10.1083/jcb.152.2.401 (Pubitemid 34285608)
43. Hoffmann H. P., Avers C. J. (1973): Mitochondrion ofyeast: ultrastructural evidence for one giant, branched organelle per cell. Science 181, 749-751 doi:10.1126/science.181.4101.749
44. Itoh T., Watabe A., Toh E. A., Matsui Y. (2002): Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae. Mol. Cell. Biol. 22, 7744-7757 doi:10.1128/MCB.22.22.7744-7757.2002 (Pubitemid 35217286)
45. Itoh T., Toh E. A., Matsui Y. (2004): Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast. EMBO J. 23, 2520-2530 doi:10.1038/sj.emboj.7600271 (Pubitemid 38988224)
46. Jensen R. E. (2005): Control of mitochondrial shape. Curr. Opin. Cell Biol. 17, 384-388 doi:10.1016/j.ceb.2005.06.011 (Pubitemid 40968068)
47. Jezek P., Plecita-Hlavata L. (2009): Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia. Int. J. Biochem. Cell Biol. 41, 1790-1804 doi:10.1016/j.biocel.2009.02.014
48. Jiang D., Zhao L., Clapham D. E. (2009): Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Sci-ence 326, 144-147 doi:10.1126/science.1175145
49. Kaasik A., SafiulinaD.,ZharkovskyA.,VekslerV. (2007): Regulation of mitochondrial matrix volume. Am. J. Physiol. Cell Physiol. 292, C157-163 doi:10.1152/ajpcell.00272.2006 (Pubitemid 46127307)
50. Kato M., Wickner W. (2001): Ergosterol is required for the Sec18/ATP-dependent priming step of homotypic vacuole fusion. EMBO J. 20, 4035-4040 doi:10.1093/emboj/20.15.4035 (Pubitemid 32751820)
51. Kemper C., Habib S. J., Engl G., Heckmeyer P., Dimmer K. S., Ra-paport D. (2008): Integration of tail-anchored proteins into the mitochondrial outer membrane does not require any known import components. J. Cell Sci. 121, 1990-1998 doi:10.1242/jcs.024034 (Pubitemid 352015196)
52. Kolisek M., Zsurka G., Samaj J., Weghuber J., Schweyen R. J., Schweigel M. (2003): Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria. EMBO J. 22, 1235-1244 doi:10.1093/emboj/cdg122 (Pubitemid 36362687)
53. Kornmann B., Currie E., Collins S. R., Schuldiner M., Nunnari J., Weiss-man J. S., Walter P. (2009): An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325, 477-481 doi:10.1126/science.1175088
54. Kovac L., Bohmerova E., Butko P. (1982): Ionophores and intact cells. I. Valinomycin and nigericin act preferentially on mito-chondria and not on the plasma membrane of Saccharomyces cerevisiae. Biochim. Biophys. Acta 721, 341-348 doi:10.1016/0167-4889(82)90088-X (Pubitemid 13141265)
55. Kovac L., Klobucnikova V. (1983): Some ionophores act pref-erentially on mitochondria in intact cells of Saccharomyces cerevisiae and induce respiration-deficient mutants. In: Mito-chondria. (Eds. K. R. J. Schweyen, K. Wolf and F. Kaudewitz), pp. 65-68, Walter de Gruyter, Berlin, New York
56. Kozlov M. M., McMahon H. T., Chernomordik L. V. (2010): Protein-driven membrane stresses in fusion and fission. Trends Biochem. Sci. 35, 699-706 doi:10.1016/j.tibs.2010.1006.1003 doi:10.1016/j.tibs.2010.06.003
57. Kucejova B., Kucej M., Petrezselyova S., Abelovska L., Tomaska L. (2005): A screen for nigericin-resistant yeast mutants revealed genes controlling mitochondrial volume and mitochondrial cation homeostasis. Genetics 171, 517-526 doi:10.1534/genetics.105.046540 (Pubitemid 43156443)
58. Kuznetsov A. V., Margreiter R. (2009): Heterogeneity of mitochon-dria and mitochondrial function within cells as another level of mitochondrial complexity Int. J. Mol. Sci. 10, 1911-1929 doi:10.3390/ijms10041911
59. Liesa M., Palacin M., Zorzano A. (2009): Mitochondrial dynamics in mammalian health and disease. Physiol. Rev. 89, 799-845 doi:10.1152/physrev. 00030.2008
60. McConnell S. J., Stewart L. C., Talin A., Yaffe M. P. (1990): Temperature-sensitive yeast mutants defective in mitochondrial inheritance. J. Cell Biol. 111, 967-976 doi:10.1083/jcb.111.3.967 (Pubitemid 20263779)
61. McQuibban G. A., Saurya S., Freeman M. (2003): Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. Nature 423, 537-541 doi:10.1038/nature01633 (Pubitemid 36648577)
62. Meeusen S., Nunnari J. (2003): Evidence for a two membrane-spanning autonomous mitochondrial DNA replisome. J. Cell Biol. 163, 503-510 doi:10.1083/jcb.200304040 (Pubitemid 37429864)
63. Meeusen S., DeVay R., Block J., Cassidy-Stone A., Wayson S., McCaffery J. M., Nunnari J. (2006): Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1. Cell 127, 383-395 doi:10.1016/j.cell.2006.09.021 (Pubitemid 44572371)
64. Meisinger C., Pfannschmidt S., Rissler M., Milenkovic D., Becker T., Stojanovski D., Youngman M. J., Jensen R. E., Chacinska A., Guiard B., Pfanner N., Wiedemann N. (2007): Te morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J. 26, 2229-2239 doi:10.1038/sj.emboj.7601673 (Pubitemid 46685856)
65. Meisinger C., Rissler M., Chacinska A., Szklarz L. K., Milenkovic D., Kozjak V., Schonfisch B., Lohaus C., Meyer H. E., Yaffe M. P., Guiard B., Wiedemann N., Pfanner N. (2004): Te mito-chondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev. Cell 7, 61-71 doi:10.1016/j.devcel.2004.06.003 (Pubitemid 39172688)
66. Meisinger C., Wiedemann N., Rissler M., Strub A., Milenkovic D., Schonfisch B., Muller H., Kozjak V., Pfanner N. (2006): Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10. J. Biol. Chem. 281, 22819-22826 doi:10.1074/jbc.M602679200
67. Mozdy A. D., McCaffery J. M., Shaw J. M. (2000): Dnm1p GT-Pase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J. Cell Biol. 151, 367-380 doi:10.1083/jcb.151.2.367
68. Muhlenhoff U., Stadler J. A., Richhardt N., Seubert A., Eickhorst T., Schweyen R. J., Lill R., Wiesenberger G. (2003): A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions. J. Biol. Chem. 278, 40612-40620 doi:10.1074/jbc. M307847200 (Pubitemid 37280874)
69. Nicholls D. G., Ferguson S. J. (2001): Ion transport across energy-conserving membranes, In: Bioenergetics 3. Academic Press, San Diego
70. Nijtmans L. G., de Jong L., Artal Sanz M., Coates P. J., Berden J. A., Back J. W., Muijsers A. O., van der Spek H., Grivell L. A. (2000): Prohibitins act as a membrane-bound chaperone for the stabi-lization of mitochondrial proteins. EMBO J. 19, 2444-2451 doi:10.1093/emboj/19.11.2444 (Pubitemid 30323534)
71. Nowikovsky K., Froschauer E. M., Zsurka G., Samaj J., Reipert S., Kolisek M., Wiesenberger G., Schweyen R. J. (2004): Te LETM1/YOL027 gene family encodes a factor of the mito-chondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J. Biol. Chem. 279, 30307-30315 doi:10.1074/jbc. M403607200 (Pubitemid 38937958)
72. Nowikovsky K., Reipert S., Devenish R. J., Schweyen R. J. (2007): Mdm38 protein depletion causes loss of mitochondrial K+/H+ exchange activity, osmotic swelling and mitophagy. Cell Death Differ. 14, 1647-1656 doi:10.1038/sj.cdd. 4402167 (Pubitemid 47278850)
73. Okamoto K., Shaw J. M. (2005): Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Annu. Rev. Genet. 39, 503-536 doi:10.1146/annurev.genet.38.072902.093019 (Pubitemid 43011125)
74. Osman C., Haag M., Potting C., Rodenfels J., Dip P. V., Wieland F. T., Brugger B., Westermann B., Langer T. (2009): Te genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J. Cell Biol. 184, 583-596 doi:10.1083/jcb.200810189
75. Paschen S. A., Neupert W., Rapaport D. (2005): Biogenesis of beta-barrel membrane proteins of mitochondria. Trends Biochem. Sci. 30, 575-582 doi:10.1016/j.tibs.2005.08.009 (Pubitemid 41356496)
76. Petrezselyova S., Lalakova J., Abelovska L., Klobucnikova V., To-maska L. (2007): A collection of yeast mutants selectively resist-ant to ionophores acting on mitochondrial inner membrane. Mitochondrion 8, 117-129 doi:10.1016/j.mito.2007.10.003 (Pubitemid 351325751)
77. Pfanner N., Wiedemann N., Meisinger C., Lithgow T. (2004): As-sembling the mitochondrial outer membrane. Nat. Struct. Mol. Biol. 11, 1044-1048 doi:10.1038/nsmb852 (Pubitemid 39453331)
78. Potting C., Wilmes C., Engmann T., Osman C., Langer T. (2010): Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35. EMBO J. 29, 2888-2898 doi:10.1038/emboj.2010.169
79. Ren G., Vajjhala P., Lee J. S., Winsor B., Munn A. L. (2006): Te BAR domain proteins: molding membranes in fission, fusion, and phagy. Microbiol. Mol. Biol. Rev. 70, 37-120 doi:10.1128/MMBR.70.1.37-120.2006
80. Rujiviphat J., Meglei G., Rubinstein J. L., McQuibban G. A. (2009): Phospholipid association is essential for dynamin-related pro-tein Mgm1 to function in mitochondrial membrane fusion. J. Biol. Chem. 284, 28682-28686 doi:10.1074/jbc.M109.044933
81. Safiulina D., Veksler V., Zharkovsky A., Kaasik A. (2006): Loss of mitochondrial membrane potential is associated with increase in mitochondrial volume: physiological role in neurones. J. Cell. Physiol. 206, 347-353 doi:10.1002/jcp.20476 (Pubitemid 43062802)
82. Schauss A. C., McBride H. M. (2007): Mitochondrial fission: a non-nuclear role for Num1p. Curr. Biol. 17, R467-470 doi:10.1016/j.cub.2007.04.018 (Pubitemid 46899523)
83. Schindl R., Weghuber J., Romanin C., Schweyen R. J. (2007): Mrs2p forms a high conductance Mg2+ selective channel in mitochondria. Biophys. J. 93, 3872-3883 doi:10.1529/biophysj.107.112318 (Pubitemid 350223805)
84. Sesaki H., Dunn C. D., Iijima M., Shepard K. A., Yaffe M. P., Ma-chamer C. E., Jensen R. E. (2006): Ups1p, a conserved inter-membrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. J. Cell Biol. 173, 651-658 doi:10.1083/jcb.200603092 (Pubitemid 46165573)
85. Shepard K. A., Yaffe M. P. (1999): Te yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance. J. Cell Biol. 144, 711-720 doi:10.1083/jcb.144.4.711 (Pubitemid 29234549)
86. Shibata Y., Hu J., Kozlov M. M., Rapoport T. A. (2009): Mechanisms shaping the membranes of cellular organelles. Annu. Rev. Cell Dev. Biol. 25, 329-354 doi:10.1146/annurev.cellbio.042308.113324
87. Simon V. R., Karmon S. L., Pon L. A. (1997): Mitochondrial in-heritance: cell cycle and actin cable dependence of polarized mitochondrial movements in Saccharomyces cerevisiae. Cell Motil. Cytoskeleton 37, 199-210 doi:10.1002/(SICI)1097-0169(1997)37:3<199::AID-CM2>3.0.CO;2-2 (Pubitemid 27287680)
88. Sogo L. F., Yaffe M. P. (1994): Regulation ofmitochondrialmorphol-ogy and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J. Cell Biol. 126, 1361-1373 doi:10.1083/jcb.126.6.1361 (Pubitemid 24284603)
89. Steglich G., Neupert W., Langer T. (1999): Prohibitins regulate membrane protein degradation by the m-AAA protease in mitochondria. Mol. Cell. Biol. 19, 3435-3442 (Pubitemid 29193803)
90. Stewart L. C., Yaffe M. P. (1991): A role for unsaturated fatty acids in mitochondrial movement and inheritance. J. Cell Biol. 115, 1249-1257 doi:10.1083/jcb.115.5.1249 (Pubitemid 21909970)
91. Stukey J. E., McDonough V. M., Martin C. E. (1990): Te OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene. J. Biol. Chem. 265, 20144-20149 (Pubitemid 120013987)
92. Tamura Y., Endo T., Iijima M., Sesaki H. (2009): Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochon-dria. J. Cell Biol. 185, 1029-1045 doi:10.1083/jcb.200812018
93. Wattenberg B., Lithgow T. (2001): Targeting of C-terminal (tail)-anchored proteins: understanding how cytoplasmic activities are anchored to intracellular membranes. Traffic 2, 66-71 doi:10.1034/j.1600-0854.2001.20108.x (Pubitemid 32219858)
94. Welihinda A. A., Trumbly R. J., Garlid K. D., Beavis A. D. (1993): On the regulation of Na+/H+ and K+/H+ antiport in yeast mitochondria: evidence for the absence of an Na(+)-selective Na+/H+ antiporter. Biochim. Biophys. Acta 1144, 367-373 doi:10.1016/0005-2728(93)90122-V (Pubitemid 23290265)
95. Wiesenberger G., Waldherr M., Schweyen R. J. (1992): Tenuclear gene MRS2 is essential for the excision of group II introns from yeast mitochondrial transcripts in vivo. J. Biol. Chem. 267, 6963-6969
96. Wong E. D., Wagner J. A., Scott S. V, Okreglak V, Holewinske T. J., Cas-sidy-Stone A, Nunnari J. (2003): Teintramitochondrialdynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion. J. Cell Biol. 160, 303-311 doi:10.1083/jcb.200209015 (Pubitemid 36182721)
97. Yamano K., Tanaka-Yamano S., Endo T. (2010): Mdm10 as a dy-namic constituent of the TOB/SAM complex directs coordi-nated assembly of Tom40. EMBO Rep. 11, 187-193 doi:10.1038/embor.2009.283
98. Youngman M. J., Hobbs A. E., Burgess S. M., Srinivasan M., Jensen R. E. (2004): Mmm2p, a mitochondrial outer membrane pro-tein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids. J. Cell Biol. 164, 677-688 doi:10.1083/jcb.200308012 (Pubitemid 38282952)
99. Yu J. W., Lemmon M. A. (2001): All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphati-dylinositol 3-phosphate. J. Biol. Chem. 276, 44179-44184 doi:10.1074/jbc.M108811200
100. Zhang Y., Chan D. C. (2007): Structural basis for recruitment of mitochondrial fission complexes by Fis1. Proc. Natl. Acad. Sci. U.S.A 104, 18526-18530 doi:10.1073/pnas.0706441104 (Pubitemid 350210730)
101. Zheng Y. Z., Berg K. B., Foster L. J. (2009): Mitochondria do not contain lipid rafs, and lipid rafs do not contain mitochondrial proteins. J. Lipid Res. 50, 988-998 doi:10.1194/jlr.M800658-JLR200
102. Zinser E., Paltauf F., Daum G. (1993): Sterol composition of yeast organelle membranes and subcellular distribution of enzymes involved in sterol metabolism. J. Bacteriol. 175, 2853-2858 (Pubitemid 23148716)
103. Zorzano A., Liesa M., Sebastian D., Segales J., Palacin M. (2010): Mitochondrial fusion proteins: dual regulators of morphology and metabolism. Semin. Cell Dev. Biol. 21, 566-574 doi:10.1016/j.semcdb.2010.01.002
104. Zotova L., Aleschko M., Sponder G., Baumgartner R., Reipert S., Prinz M., Schweyen R. J., Nowikovsky K. (2010): Novel compo-nents of an active mitochondrial K(+)/H(+) exchange. J. Biol. Chem. 285, 14399-14414 doi:10.1074/jbc.M109.059956