Targeting of C-terminal (tail)-anchored proteins: Understanding how cytoplasmic activities are anchored to intracellular membranes

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Volumn 2, Issue 1, 2001, Pages 66-71

  Wattenberg, Binks ^a   Lithgow, Trevor ^b  

^a HANSON INSTITUTE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Endoplasmic reticulum; Membrane; Membrane protein; Mitochondria; Protein targeting; Tail anchored protein; Transmembrane segment

Indexed keywords

AMINO ACID; APOPTOSIS INDUCING FACTOR; APOPTOSIS INHIBITOR; MEMBRANE PROTEIN; PHOSPHOLIPID; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; CELL MEMBRANE; CELL ORGANELLE; CELL SPECIFICITY; CELL SURFACE; CYTOPLASM; CYTOSOL; ENDOPLASMIC RETICULUM; EUKARYOTIC CELL; HYDROPHOBICITY; INTRACELLULAR MEMBRANE; MEMBRANE BINDING; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN TARGETING; SIGNAL DETECTION; SIGNAL PROCESSOR; YEAST CELL;

ENDOPLASMIC RETICULUM; INTRACELLULAR MEMBRANES; KINETICS; MEMBRANE PROTEINS; MITOCHONDRIA; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT;

EID: 0035102443     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2001.20108.x     Document Type: Article

References (31)

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2. Transmembrane domain-dependent sorting of proteins to the endoplasmic reticulum and plasma membrane in yeast
3. 5 in the endoplasmic reticulum is transmembrane and lumenal domain-dependent
4. Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein
5. The Bcl-2 family of proteins
6. Co-translational protein folding
7. Recombination of protein domains facilitated by co-translational folding in eukaryotes
8. Co-translational folding
9. Movement of Bax from the cytosol to mitochondria during apoptosis
10. Regulated targeting of Bax to mitochondria
11. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
12. 5 is contained within the carboxyl-terminal region
13. The mitochondrial targeting signal of rat liver monoamine oxidase B is located at its carboxy terminus
14. Assembly of Bcl-2 into microsomal and outer mitochondrial membranes
15. Targeting of tail-anchored proteins to yeast mitochondria in vivo
16. 5 in yeast and characterization of mutants of the membrane-anchoring domain
17. A 12-residue-long polyleucine tail is sufficient to anchor synaptobrevin to the endoplasmic reticulum membrane
18. A splice-isoform of vesicle-associated membrane protein-1 (Vamp-1) contains a mitochondrial targeting signal
19. 5
20. Identification of the endoplasmic reticulum signal in vesicle associated membrane proteins
21. 5 suggests novel targeting pathways
22. Protein import into mitochondria
23. Signal anchor sequence insertion into the outer mitochondrial membrane
24. Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: Evidence for the 'acid chain' hypothesis
25. Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein
26. Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20
27. The DNA helicase, Hmi1p, is transported into mitochondria by a C-terminal cleavable targeting signal
28. Mitochondrial targeting of carboxy-terminally anchored proteins is specific and saturable, but independent of ATP and cytosolic factors
29. The alpha and the beta: The unusual solution for protein translocation across mitochondrial and plastid outer membranes
30. Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
31. The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane