Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eiF2a-mediated decrease in type 2 deiodinase synthesis

Molecular Endocrinology

Volumn 25, Issue 12, 2011, Pages 2065-2075

  e Drigo, Rafael Arrojo ^a   Fonseca, Tatiana L ^a   Castillo, Melany ^a   Salathe, Matthias ^a   Simovic, Gordana ^a   Mohácsik, Petra ^b   Gereben, Balazs ^b   Bianco, Antonio C ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Ligands; Thyroid hormone

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHAPERONE; DEIODINASE TYPE 2; ENZYME; MESSENGER RNA; THAPSIGARGIN; THYROID HORMONE; TUNICAMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN; CONTROLLED STUDY; CYSTIC FIBROSIS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; KIDNEY CELL; LUNG ALVEOLUS CELL; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CYSTIC FIBROSIS; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL CELLS; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION; HUMANS; IODIDE PEROXIDASE; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; PROTEOLYSIS; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; THAPSIGARGIN; THYROXINE; TRANSCRIPTION FACTOR CHOP; TRIIODOTHYRONINE; TUNICAMYCIN;

EID: 82055194436     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2011-1061     Document Type: Article

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