Ubc6p and Ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase

Molecular Endocrinology

Volumn 16, Issue 9, 2002, Pages 1999-2007

  Botero, Diego ^c   Gereben, Balazs ^b   Goncalves, Carla ^c   De Jesus, Lucia A ^a   Harney, John W ^a   Bianco, Antonio C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c Harvard Institutes of Medicine Building ^*

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE; LACTACYSTIN; LACTONE DERIVATIVE; LIOTHYRONINE; PROTEASOME; PROTEIN UBC6P; PROTEIN UBC7P; SELENOPROTEIN; THYROID HORMONE; THYROXINE; THYROXINE DEIODINASE; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; DEIODINATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME SUBSTRATE; GENE MUTATION; GENETIC CODE; HALF LIFE TIME; HORMONE ACTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SACCHAROMYCES CEREVISIAE; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE; CYSTEINE ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; GALACTOSE; GENE DELETION; HALF-LIFE; HUMANS; IODIDE PEROXIDASE; KINETICS; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; THYROXINE; TRIIODOTHYRONINE; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; VERTEBRATA;

EID: 0036715341     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2002-0135     Document Type: Article

References (35)

1. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases
2. Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy
3. The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line
4. Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes
5. Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center
6. Selective proteolysis of human type 2 deiodinase: A novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation
7. Cerebral cortex responds rapidly to thyroid hormones
8. m (type II) iodothyronine 5′-deiodinase in cultured NB41A3 mouse neuroblastoma cells
9. Catabolite inactivation of fructose-1,6-bisphosphatase of Saccharomyces cerevisiae. Degradation occurs via the ubiquitin pathway
10. Proteins of newly isolated mutants and the amino-terminal proline are essential for ubiquitin-proteasome-catalyzed catabolite degradation of fructose-1,6-bisphosphatase of Saccharomyces cerevisiae
11. Ubiquitin and the control of protein fate in the secretory and endocytic pathways
12. Endoplasmic reticulum-associated protein degradation
13. The ubiquitin-conjugation system
14. The ubiquitin system
15. Retrograde protein translocation: Eradication of secretory proteins in health and disease
16. A regulatory link between ER-associated protein degradation and the unfolded-protein response
17. Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system
18. HRD gene dependence of endoplasmic reticulum-associated degradation
19. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation
20. A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation
21. Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway
22. ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
23. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase
24. Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome
25. 'ER degradation' of a mutant yeast plasma membrane protein by the ubiquitin-proteasome pathway
26. A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum
27. Role of Cue1p in ubiquitination and degradation at the ER surface
28. Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins
29. UBC1 encodes a novel member of an essential subfamily of yeast ubiquitin-conjugating enzymes involved in protein degradation
30. Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae
31. In vivo expression of rat liver c-erbA β thyroid hormone receptor in yeast (Saccharomyces cerevisiae)
32. A rapid and reliable DNA preparation method for screening a large number of yeast clones by polymerase chain reaction
33. The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase
34. The measurement of ubiquitin and ubiquitinated proteins
35. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding