-
1
-
-
3042665929
-
The biology of epidermal growth factor receptor in lung cancer
-
Scagliotti GV, Selvaggi G, Novello S et al. The biology of epidermal growth factor receptor in lung cancer. Clin Cancer Res 2004; 10: 4227s-32s.
-
(2004)
Clin Cancer Res
, vol.10
-
-
Scagliotti, G.V.1
Selvaggi, G.2
Novello, S.3
-
2
-
-
0033561522
-
Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis and radiosensitivity in squamous cell carcinomas of head and neck
-
Huang SM, Bock JM, Harari PM. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis and radiosensitivity in squamous cell carcinomas of head and neck. Cancer Res 1999; 59: 1935-40.
-
(1999)
Cancer Res
, vol.59
, pp. 1935-1940
-
-
Huang, S.M.1
Bock, J.M.2
Harari, P.M.3
-
3
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of head and neck
-
Bonner JA, Harari PM, Giralt J et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of head and neck. N Engl J Med 2006; 354: 567-78.
-
(2006)
N Engl J Med
, vol.354
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
4
-
-
0037270588
-
Epidermal growth factor family receptors and inhibitors: radiation response modulators
-
Sartor CI. Epidermal growth factor family receptors and inhibitors: radiation response modulators. Semin Radiat Oncol 2003; 13: 22-30.
-
(2003)
Semin Radiat Oncol
, vol.13
, pp. 22-30
-
-
Sartor, C.I.1
-
5
-
-
0035860147
-
Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
-
Giatromanolaki A, Koukourakis MI, Sivridis E et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 2001; 85: 881-90.
-
(2001)
Br J Cancer
, vol.85
, pp. 881-890
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Sivridis, E.3
-
6
-
-
3042816190
-
Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways
-
Swinson DE, Jones JL, Cox G et al. Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. Int J Cancer 2004; 111: 43-50.
-
(2004)
Int J Cancer
, vol.111
, pp. 43-50
-
-
Swinson, D.E.1
Jones, J.L.2
Cox, G.3
-
7
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Cairns RA, Fontana L et al. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006; 3: 187-97.
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
-
8
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006; 3: 177-85.
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
-
9
-
-
0036710591
-
Signal transduction to hypoxia-inducible factor 1
-
Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 2002; 64: 993-8.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 993-998
-
-
Semenza, G.1
-
10
-
-
0023518452
-
Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical
-
Ignarro LJ, Byrns RE, Buga GM et al. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ Res 1987; 61: 866-79.
-
(1987)
Circ Res
, vol.61
, pp. 866-879
-
-
Ignarro, L.J.1
Byrns, R.E.2
Buga, G.M.3
-
11
-
-
0023198721
-
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
-
Palmer RM, Ferrige A, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-6.
-
(1987)
Nature
, vol.327
, pp. 524-526
-
-
Palmer, R.M.1
Ferrige, A.2
Moncada, S.3
-
12
-
-
0031660334
-
Ionizing radiation potentiates the induction of nitric oxide synthase by IFN-gamma and/or LPS in murine macrophage cell lines: role of TNF-alpha
-
McKinney LC, Aquilla EM, Coffin D et al. Ionizing radiation potentiates the induction of nitric oxide synthase by IFN-gamma and/or LPS in murine macrophage cell lines: role of TNF-alpha. J Leukoc Biol 1998; 64: 459-66.
-
(1998)
J Leukoc Biol
, vol.64
, pp. 459-466
-
-
McKinney, L.C.1
Aquilla, E.M.2
Coffin, D.3
-
13
-
-
28044464985
-
Reversible inhibition of cytochrome c oxidase, the terminalenzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases
-
Cleeter MW, Cooper JM, Darley-Usmar VM et al. Reversible inhibition of cytochrome c oxidase, the terminalenzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett 1994; 345: 50-4.
-
(1994)
FEBS Lett
, vol.345
, pp. 50-54
-
-
Cleeter, M.W.1
Cooper, J.M.2
Darley-Usmar, V.M.3
-
14
-
-
0348134741
-
Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha
-
Hagen T, Taylor CT, Lam F et al. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science 2003; 302: 1975-8.
-
(2003)
Science
, vol.302
, pp. 1975-1978
-
-
Hagen, T.1
Taylor, C.T.2
Lam, F.3
-
15
-
-
0028134892
-
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen atcytochrome oxidase
-
Brown GC, Cooper CE. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen atcytochrome oxidase. FEBS Lett 1994; 356: 295-8.
-
(1994)
FEBS Lett
, vol.356
, pp. 295-298
-
-
Brown, G.C.1
Cooper, C.E.2
-
16
-
-
0028145462
-
Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes
-
Bolanos JP, Peuchen S, Heales SJ et al. Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J Neurochem 1994; 63: 910-6.
-
(1994)
J Neurochem
, vol.63
, pp. 910-916
-
-
Bolanos, J.P.1
Peuchen, S.2
Heales, S.J.3
-
17
-
-
4143132198
-
Nitroprusside stimulates mitochondrial aconitase gene expression through the cyclic adenosine 3',5'-monosphosphate signal transduction pathway in human prostate carcinoma cells
-
Juang HH. Nitroprusside stimulates mitochondrial aconitase gene expression through the cyclic adenosine 3', 5'-monosphosphate signal transduction pathway in human prostate carcinoma cells. Prostate 2004; 61: 92-102.
-
(2004)
Prostate
, vol.61
, pp. 92-102
-
-
Juang, H.H.1
-
18
-
-
0026758210
-
Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen
-
Laderoute KR, Grant TD, Murphy BJ et al. Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen. Int J Cancer 1992; 52: 428-32.
-
(1992)
Int J Cancer
, vol.52
, pp. 428-432
-
-
Laderoute, K.R.1
Grant, T.D.2
Murphy, B.J.3
-
19
-
-
0036468259
-
Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia
-
Nishi H, Nishi KH, Johnson AC. Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia. Cancer Res 2002; 62: 827-34.
-
(2002)
Cancer Res
, vol.62
, pp. 827-834
-
-
Nishi, H.1
Nishi, K.H.2
Johnson, A.C.3
-
20
-
-
20444423286
-
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway
-
Lo HW, Hsu SC, Ali-Seyed M et al. Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell 2005; 7: 575-89.
-
(2005)
Cancer Cell
, vol.7
, pp. 575-589
-
-
Lo, H.W.1
Hsu, S.C.2
Ali-Seyed, M.3
-
21
-
-
0035864361
-
Accumulation of HIF-1alpha under the influence of nitric oxide
-
Sandau KB, Fandrey J, Brüne B. Accumulation of HIF-1alpha under the influence of nitric oxide. Blood 2001; 97: 1009-15.
-
(2001)
Blood
, vol.97
, pp. 1009-1015
-
-
Sandau, K.B.1
Fandrey, J.2
Brüne, B.3
-
22
-
-
31544473721
-
Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation
-
Quintero M, Brennan PA, Thomas GJ et al. Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation. Cancer Res 2006; 66: 770-4.
-
(2006)
Cancer Res
, vol.66
, pp. 770-774
-
-
Quintero, M.1
Brennan, P.A.2
Thomas, G.J.3
-
23
-
-
69749117834
-
HIF-1 prevents the overproduction of mitochondrial ROS after cytokine stimulation through induction of PDK-1
-
Kirito K, Hu Y, Komatsu N. HIF-1 prevents the overproduction of mitochondrial ROS after cytokine stimulation through induction of PDK-1. Cell Cycle 2009; 8: 2844-9.
-
(2009)
Cell Cycle
, vol.8
, pp. 2844-2849
-
-
Kirito, K.1
Hu, Y.2
Komatsu, N.3
-
25
-
-
0036838358
-
Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species
-
Schroedl C, McClintock DS, Budinger GR et al. Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 2002; 283: 922-31.
-
(2002)
Am J Physiol Lung Cell Mol Physiol
, vol.283
, pp. 922-931
-
-
Schroedl, C.1
McClintock, D.S.2
Budinger, G.R.3
-
26
-
-
24144493814
-
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
-
Guzy RD, Hoyos B, Robin E et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 2005; 1: 401-8.
-
(2005)
Cell Metab
, vol.1
, pp. 401-408
-
-
Guzy, R.D.1
Hoyos, B.2
Robin, E.3
-
27
-
-
29144460223
-
Inducible nitric oxide synthase inhibitors reduce urinary markers of systemic oxidant stress in murine proliferative lupus nephritis
-
Njoku CJ, Patrick KS, Ruiz P Jr et al. Inducible nitric oxide synthase inhibitors reduce urinary markers of systemic oxidant stress in murine proliferative lupus nephritis. J Investig Med 2005; 53: 347-52.
-
(2005)
J Investig Med
, vol.53
, pp. 347-352
-
-
Njoku, C.J.1
Patrick, K.S.2
Ruiz Jr., P.3
-
28
-
-
0036121596
-
Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia
-
Pearlstein DP, Ali MH, Mungai PT et al. Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia. Arterioscler Thromb Vasc Biol 2002; 22: 566-73.
-
(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 566-573
-
-
Pearlstein, D.P.1
Ali, M.H.2
Mungai, P.T.3
-
29
-
-
2442664117
-
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase
-
Palacios-Callender M, Quintero M, Hollis VS et al. Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase. Proc Natl Acad Sci USA 2004; 101: 7630-5.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 7630-7635
-
-
Palacios-Callender, M.1
Quintero, M.2
Hollis, V.S.3
-
30
-
-
0035282782
-
Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase
-
Brown GC. Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim Biophys Acta 2001; 1504: 46-57.
-
(2001)
Biochim Biophys Acta
, vol.1504
, pp. 46-57
-
-
Brown, G.C.1
-
31
-
-
0036162636
-
Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector?
-
Cooper CE. Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector? Trends Biochem Sci 2002; 27: 33-9.
-
(2002)
Trends Biochem Sci
, vol.27
, pp. 33-39
-
-
Cooper, C.E.1
-
32
-
-
0034012313
-
Caspase activation and cytochrome c release during HL-60 cell apoptosis induced by a nitric oxide donor
-
Yabuki M, Tsutsui K, Horton AA et al. Caspase activation and cytochrome c release during HL-60 cell apoptosis induced by a nitric oxide donor. Free Radic Res 2000; 32: 507-14.
-
(2000)
Free Radic Res
, vol.32
, pp. 507-514
-
-
Yabuki, M.1
Tsutsui, K.2
Horton, A.A.3
-
33
-
-
0034634441
-
Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells
-
Moriya R, Uehara T, Nomura Y. Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells. FEBS Lett 2000; 484: 253-60.
-
(2000)
FEBS Lett
, vol.484
, pp. 253-260
-
-
Moriya, R.1
Uehara, T.2
Nomura, Y.3
-
34
-
-
0033546165
-
Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes
-
Li J, Bombeck CA, Yang S et al. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. J Biol Chem 1999; 274: 17325-33.
-
(1999)
J Biol Chem
, vol.274
, pp. 17325-17333
-
-
Li, J.1
Bombeck, C.A.2
Yang, S.3
-
35
-
-
41949096676
-
CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constant
-
Levesque MC, Ghosh DK, Beasley BE et al. CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constant. Leuk Res 2008; 32: 1061-70.
-
(2008)
Leuk Res
, vol.32
, pp. 1061-1070
-
-
Levesque, M.C.1
Ghosh, D.K.2
Beasley, B.E.3
-
36
-
-
0002766414
-
Does apoptosis contribute to tumor cell sensitivity to anticancer agents?
-
Hickman JA, Dive C, eds. Totowa, NJ, USA: Humana Press
-
Brown JM, Wouters BG. Does apoptosis contribute to tumor cell sensitivity to anticancer agents? In: Hickman JA, Dive C, eds. Apoptosis and Cancer Chemotherapy. Totowa, NJ, USA: Humana Press, 1999; 1-20.
-
(1999)
Apoptosis and Cancer Chemotherapy
, pp. 1-20
-
-
Brown, J.M.1
Wouters, B.G.2
-
37
-
-
0030842655
-
Cell-cycle arrest versus cell death in cancer therapy
-
Waldman T, Zhang Y, Dillehay L et al. Cell-cycle arrest versus cell death in cancer therapy. Nat Med 1997; 3: 1034-6.
-
(1997)
Nat Med
, vol.3
, pp. 1034-1036
-
-
Waldman, T.1
Zhang, Y.2
Dillehay, L.3
-
38
-
-
0033755468
-
Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin
-
Viktorsson K, Heiden T, Molin M, Akusjärvi G, Linder S, Shoshan MC. Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin. Apoptosis 2000; 5: 355-67.
-
(2000)
Apoptosis
, vol.5
, pp. 355-367
-
-
Viktorsson, K.1
Heiden, T.2
Molin, M.3
Akusjärvi, G.4
Linder, S.5
Shoshan, M.C.6
-
39
-
-
33244491058
-
Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer
-
Swinson DE, O'Byrne KJ. Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer. Clin Lung Cancer 2006; 7: 250-6.
-
(2006)
Clin Lung Cancer
, vol.7
, pp. 250-256
-
-
Swinson, D.E.1
O'Byrne, K.J.2
-
40
-
-
5644293135
-
Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255
-
Tracy S, Mukohara T, Hansen M et al. Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255. Cancer Res 2004; 64: 7241-4.
-
(2004)
Cancer Res
, vol.64
, pp. 7241-7244
-
-
Tracy, S.1
Mukohara, T.2
Hansen, M.3
-
41
-
-
4644269625
-
Radiation-induced activation of a common variant of EGFR confers enhanced radioresistance
-
Lammering G, Valerie K, Lin PS et al. Radiation-induced activation of a common variant of EGFR confers enhanced radioresistance. Radiother Oncol 2004; 72: 267-73.
-
(2004)
Radiother Oncol
, vol.72
, pp. 267-273
-
-
Lammering, G.1
Valerie, K.2
Lin, P.S.3
-
42
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S, Boggon TJ, Dayaram T et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005; 352: 786-92.
-
(2005)
N Engl J Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
-
43
-
-
2342624080
-
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
-
Paez JG, Jänne PA, Lee JC et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497-500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Jänne, P.A.2
Lee, J.C.3
-
44
-
-
0041629450
-
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
-
Mendelsohon J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 2003; 21: 2787-99.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2787-2799
-
-
Mendelsohon, J.1
Baselga, J.2
-
45
-
-
0025321157
-
Epidermal growth factor
-
Carpenter G, Cohen S. Epidermal growth factor. J Biol Chem 1990; 265: 7709-12.
-
(1990)
J Biol Chem
, vol.265
, pp. 7709-7712
-
-
Carpenter, G.1
Cohen, S.2
|