Radiation-induced activation of a common variant of EGFR confers enhanced radioresistance

Radiotherapy and Oncology

Volumn 72, Issue 3, 2004, Pages 267-273

  Lammering, Guido ^a,b   Valerie, Kristoffer ^a   Lin, Peck Sun ^a   Hewit, Theodore H ^a   Schmidt Ullrich, Rupert K ^a  

^a UNIVERSITY OF RICHMOND   (United States)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

EGFR; EGFRvIII; Human carcinoma; Malignant glioma; Radioresistance

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ASTROCYTOMA CELL; BREAST ADENOCARCINOMA; CELL LINE; COLONY FORMING UNIT; CONFERENCE PAPER; FEMALE; GLIOMA CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIATION DOSE; RADIOSENSITIVITY; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; HUMANS; MICE; NEOPLASM TRANSPLANTATION; PHOSPHORYLATION; RADIATION TOLERANCE; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; TYROSINE;

EID: 4644269625     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2004.07.004     Document Type: Conference Paper

References (29)

1. M.A. Antonyak, D.K. Moscatello, and A.J. Wong Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor J Biol Chem 273 1998 2817 2822
2. S.K. Batra, S. Castelino-Prabhu, and C.J. Wikstrand Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene Cell Growth Differ 6 1995 1251 1259
3. G. Bowers, D. Reardon, and T. Hewitt The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells Oncogene 20 2001 1388 1397
4. D. Brust, J. Feden, J. Farnsworth, C. Amir, W.C. Broaddus, and K. Valerie Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion Cancer Gene Ther 7 2000 778 788
5. J.N. Contessa, D.B. Reardon, and D. Todd The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells Clin Cancer Res 5 1999 405 411
6. J.N. Contessa, J. Hampton, and G. Lammering Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells Oncogene 21 2002 4032 4041
7. P. Dent, D.B. Reardon, and J.S. Park Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death Mol Biol Cell 10 1999 2493 2506
8. H.S. Huang, M. Nagane, and C.K. Klingbeil The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling J Biol Chem 272 1997 2927 2935
9. P.A. Humphrey, A.J. Wong, and B. Vogelstein Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma Proc Natl Acad Sci USA 87 1990 4207 4211
10. G. Lammering, T.H. Hewit, and W. Hawkins Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization J Natl Cancer Inst 93 2001 921 929
11. G. Lammering, T. Hewit, and K. Valerie EGFRvIII-mediated radioresistance through a strong cytoprotective response Oncogene 22 2003 5545 5553
12. G. Lammering, K. Valerie, and P.S. Lin Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor Clin Cancer Res 7 2001 682 690
13. G. Lammering, P.S. Lin, J.N. Contessa, J.L. Hampton, K. Valerie, and R.K. Schmidt-Ullrich Adenovirus-mediated overexpression of dominant negative epidermal growth factor receptor-CD533 as a gene therapeutic approach radiosensitizes human carcinoma and malignant glioma cells Int J Radiat Oncol Biol Phys 51 2001 775 784
14. I. Lee, J.H. Kim, S.H. Levitt, and C.W. Song Increases in tumor response by pentoxyfylline alone or in combination with nicotinamide Int J Radiat Oncol Biol Phys 22 1992 425 429
15. R.B. Montgomery, D.K. Moscatello, A.J. Wong, J.A. Cooper, and W.L. Stahl Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor J Biol Chem 270 1995 30562 30566
16. D.K. Moscatello, R.B. Montgomery, P. Sundareshan, H. McDanel, M.Y. Wong, and A.J. Wong Transformational and altered signal transduction by a naturally occurring mutant EGF receptor Oncogene 13 1996 85 96
17. D.K. Moscatello, M. Holgado-Madruga, and A.K. Godwin Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors Cancer Res 55 1995 5536 5539
18. D.K. Moscatello, M. Holgado-Madruga, D.R. Emlet, R.B. Montgomery, and A.J. Wong Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor J Biol Chem 273 1998 200 206
19. R. Nishikawa, X.D. Ji, and R.C. Harmon A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity Proc Natl Acad Sci USA 91 1994 7727 7731
20. D.M. O'Rourke, E.J. Nute, and J.G.I. Davis Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: implications for subdomain contributions to receptor assembly Oncogene 16 1998 1197 1207
21. D.B. Reardon, J.N. Contessa, and R.B. Mikkelsen Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells Oncogene 18 1999 4756 4766
22. R.K. Schmidt-Ullrich, P. Dent, S. Grant, R.B. Mikkelsen, and K. Valerie Signal transduction and cellular radiation responses Radiat Res 153 2000 245 257
23. R.K. Schmidt-Ullrich, R.B. Mikkelsen, and P. Dent Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation Oncogene 15 1997 1191 1197
24. R. Schmidt-Ullrich, J. Contessa, G. Lammering, and G. Amorino Receptor tyrosine kinases and cellular responses to ionizing radiation Oncog Rev 22 2003 5855 5865
25. R.K. Schmidt-Ullrich, J.N. Contessa, and P. Dent Molecular mechanisms of radiation-induced accelerated repopulation Radiat Oncol Investig 7 1999 321 330
26. K. Valerie, D. Brust, and J. Farnsworth Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant herpes simplex virus-thymidine kinase in combination with acyclovir Cancer Gene Ther 7 2000 879 884
27. K. Valerie, W. Hawkins, and J. Farnsworth Substantially improved in vivo radiosensitization of rat glioma with mutant HSV-TK and acyclovir Cancer Gene Ther 8 2001 3 8
28. A.J. Wong, J.M. Ruppert, and S.H. Bigner Structural alterations of the epidermal growth factor receptor gene in human gliomas Proc Natl Acad Sci USA 89 1992 2965 2969
29. H. Yamazaki, Y. Ohba, N. Tamaoki, and M. Shibuya A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors Jpn J Cancer Res 81 1990 773 779