p,p′-DDE induces testicular apoptosis in prepubertal rats via the Fas/FasL pathway

Toxicology Letters

Volumn 193, Issue 1, 2010, Pages 79-85

  Shi, Yu Qin ^a   Wang, Yu Ping ^a   Song, Yang ^a   Li, Hao Wen ^a   Liu, Chang Jiang ^a   Wu, Zhi Gang ^a   Yang, Ke Di ^a  

^a Institute of Environmental Medicine   (China)

Author keywords

Apoptosis; Caspase; Fas FasL; NF B; p,p DDE; Testis

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; CASPASE 3; CASPASE 8; FAS LIGAND; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; MESSENGER RNA; PROCASPASE 8; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; INSECTICIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION; GERM CELL; LIPID PEROXIDATION; MALE; NONHUMAN; ORGAN WEIGHT; PREPUBERTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPRODUCTIVE TOXICITY; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; METABOLISM; NICK END LABELING; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEXUAL MATURATION; SIGNAL TRANSDUCTION; SPERMATOGENESIS; SPRAGUE DAWLEY RAT; TESTIS; WESTERN BLOTTING;

ANIMALIA; RATTUS;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BODY WEIGHT; CASPASE 3; CASPASE 8; DICHLORODIPHENYL DICHLOROETHYLENE; FAS LIGAND PROTEIN; GLUTATHIONE PEROXIDASE; IN SITU NICK-END LABELING; INSECTICIDES; MALE; MALONDIALDEHYDE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEXUAL MATURATION; SIGNAL TRANSDUCTION; SPERMATOGENESIS; SUPEROXIDE DISMUTASE; TESTIS;

EID: 75949128582     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.12.008     Document Type: Article

References (54)

1. Allan D.J., Harmon B.V., and Roberts S.A. Spermatogonial apoptosis has 3 morphologically recognizable phases and shows no circadian-rhythm during normal spermatogenesis in the rat. Cell Proliferation 25 (1992) 241-250
2. Alvarez-Pedrerol M., Ribas-Fito N., Torrent M., Carrizo D., Grimalt J.O., and Sunyer J. Effects of PCBs, p,p′-DDT, p,p′-DDE, HCB and beta-HCH on thyroid function in preschool children. Occupational and Environmental Medicine 65 (2008) 452-457
3. Ashby J., and Lefevre P.A. The weanling male rat as an assay for endocrine disruption: preliminary observations. Regulatory Toxicology and Pharmacology 26 (1997) 330-337
4. Aulakh R.S., Bedi J.S., Gill J.P.S., Joia B.S., Pooni P.A., and Sharma J.K. Occurrence of DDT and HCH insecticide residues in human biopsy adipose tissues in Punjab, India. Bulletin of Environmental Contamination and Toxicology 78 (2007) 330-334
5. Barkett M., and Gilmore T.D. Control of apoptosis by Rel/NF-kappa B transcription factors. Oncogene 18 (1999) 6910-6924
6. Bauer M.K.A., Vogt M., Los M., Siegel J., Wessellborg S., and Schulze-Osthoff K. Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression. Journal of Biological Chemistry 273 (1998) 8048-8055
7. Ben Rhouma K., Tebourbi O., Krichah R., and Sakly M. Reproductive toxicity of DDT in adult male rats. Human & Experimental Toxicology 20 (2001) 393-397
8. Billig H., Furuta I., Rivier C., Tapanainen J., Parvinen M., and Hsueh A.J.W. Apoptosis in testis germ-cells-developmental-changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology 136 (1995) 5-12
9. D'Alessio A., Riccioli A., Lauretti P., Padula F., Muciaccia B., De Cesaris P., Filippini A., Nagata S., and Ziparo E. Testicular FasL is expressed by sperm cells. Proceedings of the National Academy of Sciences of the United States of America 98 (2001) 3316-3321
10. Dalgaard M., Nellemann C., Lam H.R., Sorensen I.K., and Ladefoged O. The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats. Toxicology Letters 122 (2001) 69-79
11. Daxenberger A. Pollutants with androgen-disrupting potency. European Journal of Lipid Science and Technology 104 (2002) 124-130
12. DeMaria R., Lenti L., Malisan F., dAgostino F., Tomassini B., Zeuner A., Rippo M.R., and Testi R. Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. Science 277 (1997) 1652-1655
13. El-Gohary M., Awara W.M., Nassar S., and Hawas S. Deltamethrin-induced testicular apoptosis in rats: the protective effect of nitric oxide synthase inhibitor. Toxicology 132 (1999) 1-8
14. Feng H.P., Zeng Y., Graner M.W., Whitesell L., and Katsanis E. Evidence for a novel, caspase-8-independent, fas death domain-mediated apoptotic pathway. Journal of Biomedicine and Biotechnology (2004) 41-51
15. Feng Y.X., Shi Z.M., Fang X.M., Xu M.Q., and Dai J.Y. Perfluorononanoic acid induces apoptosis involving the Fas death receptor signaling pathway in rat testis. Toxicology Letters 190 (2009) 224-230
16. Gray L.E., and Kelce W.R. Latent effects of pesticides and toxic substances on sexual differentiation of rodents. Toxicology and Industrial Health 12 (1996) 515-531
17. Hofmann M.A., Lalla E., Lu Y., Gleason M.R., Wolf B.M., Tanji N., Ferran L.J., Kohl B., Rao V., Kisiel W., Stern D.M., and Schmidt A.M. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. Journal of Clinical Investigation 107 (2001) 675-683
18. Hughes P.J., McLellan H., Lowes D.A., Khan S.Z., Bilmen J.G., Tovey S.C., Godfrey R.E., Michell R.H., Kirk C.J., and Michelangeli F. Estrogenic alkylphenols induce cell death by inhibiting testis endoplasmic reticulum Ca2+ pumps. Biochemical and Biophysical Research Communications 277 (2000) 568-574
19. Kelce W.R., Stone C.R., Laws S.C., Gray L.E., Kemppainen J.A., and Wilson E.M. Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 375 (1995) 581-585
20. Khan S.M., Dauffenbach L.M., and Yeh J. Mitochondria and caspases in induced apoptosis in human luteinized granulosa cells. Biochemical and Biophysical Research Communications 269 (2000) 542-545
21. Kreuz S., Siegmund D., Rumpf J.J., Samel D., Leverkus M., Janssen O., Hacker G., Dittrich-Breiholz O., Kracht M., Scheurich P., and Wajant H. NF kappa B activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. Journal of Cell Biology 166 (2004) 369-380
22. Kucharczak J., Simmons M.J., Fan Y.J., and Gelinas C. To be, or not to be: NF-kappa B is the answer-role of Rel/NF-kappa B in the regulation of apoptosis. Oncogene 22 (2003) 8961-8982
23. Lin W.W., Lamb D.J., Wheeler T.M., Lipshultz L.I., and Kim E.D. In situ end-labeling of human testicular tissue demonstrates increased apoptosis in conditions of abnormal spermatogenesis. Fertility and Sterility 68 (1997) 1065-1069
24. LopezCarrillo L., TorresArreola L., TorresSanchez L., EspinosaTorres F., Jimenez C., Cebrian M., Waliszewski S., and Saldate O. Is DDT use a public health problem in Mexico?. Environmental Health Perspectives 104 (1996) 584-588
25. Makita Y., Omura M., Tanaka A., and Kiyohara C. Effects of concurrent exposure to tributyltin and 1,1-dichloro-2,2 bis(p-chlorophenyl) ethylene (p,p′-DDE) on immature male Wistar rats. Basic & Clinical Pharmacology & Toxicology 97 (2005) 364-368
26. Malewicz M., Zeller N., Yilmaz Z.B., and Weih F. NF kappa B controls the balance between fas and tumor necrosis factor cell death pathways during T cell receptor-induced apoptosis via the expression of its target gene A20. Journal of Biological Chemistry 278 (2003) 32825-32833
27. Muguruma M., Yamazaki M., Okamura M., Moto M., Kashida Y., and Mitsumori K. Molecular mechanism on the testicular toxicity of 1,3-dinitrobenzene in Sprague-Dawley rats: preliminary study. Archives of Toxicology 79 (2005) 729-736
28. Nagata S. Apoptosis by death factor. Cell 88 (1997) 355-365
29. Nagata S., and Golstein P. The fas death factor. Science 267 (1995) 1449-1456
30. Nair R., and Shaha C. Diethylstilbestrol induces rat spermatogenic cell apoptosis in vivo through increased expression of spermatogenic cell Fas/FasL system. Journal of Biological Chemistry 278 (2003) 6470-6481
31. O'Connor J.C., Frame S.R., Davis L.G., and Cook J.C. Detection of the environmental antiandrogen p,p′-DDE in CD and Long-Evans rats using a Tier I screening battery and a Hershberger assay. Toxicological Sciences 51 (1999) 44-53
32. Ogi S., Tanji N., Yokoyama M., Takeuchi M., and Terada N. Involvement of Fas in the apoptosis of mouse germ cells induced by experimental cryptorchidism. Urological Research 26 (1998) 17-21
33. Onorato T.M., Brown P.W., and Morris P.L. Mono-(2-ethylhexyl) phthalate increases spermatocyte mitochondrial peroxiredoxin 3 and cyclooxygenase 2. Journal of Andrology 29 (2008) 293-303
34. Paasch, U., Grunewald, S., Wuendrich, K., Glander, H.J., 2001. Caspases are associated with apoptosis in human ejaculated spermatozoa and in spermatogenesis. Andrology in the 21st Century, Short Communications, pp. 59-64.
35. Pentikainen V., Suomalainen L., Erkkila K., Martelin E., Parvinen M., Pentikainen M.O., and Dunkel L. Nuclear factor-kappa B activation in human testicular apoptosis. American Journal of Pathology 160 (2002) 205-218
36. Philchenkov A. Caspases: potential targets for regulating cell death. Journal of Cellular and Molecular Medicine 8 (2004) 432-444
37. Ratcliffe D.A. Decrease in eggshell weight in certain birds of prey. Nature 215 (1967) 208-210
38. RiveroRodriguez L., BorjaAburto V.H., SantosBurgoa C., Waliszewskiy S., Rios C., and Cruz V. Exposure assessment for workers applying DDT to control malaria in Veracruz, Mexico. Environmental Health Perspectives 105 (1997) 98-101
39. Rogan W.J., and Chen A.M. Health risks and benefits of bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT). Lancet 366 (2005) 763-773
40. Said T.M., Paasch U., Glander H.J., and Agarwal A. Role of caspases in male infertility. Human Reproduction Update 10 (2004) 39-51
41. Saradha B., Vaithinathan S., and Mathur P.P. Lindane induces testicular apoptosis in adult Wistar rats through the involvement of Fas-FasL and mitochondria-dependent pathways. Toxicology 255 (2009) 131-139
42. Shalini S., and Bansal M.P. Alterations in selenium status influences reproductive potential of male mice by modulation of transcription factor NF kappa B. Biometals 20 (2007) 49-59
43. Shi Y.Q., Song Y., Wang Y.N., Liang X.M., Hu Y.F., Guan X., Cheng J., and Yang K. p,p′-DDE induces apoptosis of rat Sertoli cells via a FasL-dependent pathway. Journal of Biomedicine and Biotechnology (2009)
44. Shin J.H., Mori C., and Shiota K. Involvement of germ cell apoptosis in the induction of testicular toxicity following hydroxyurea treatment. Toxicology and Applied Pharmacology 155 (1999) 139-149
45. Shinoda K., Mitsumori K., Yasuhara K., Uneyama C., Onodera H., Takegawa K., Takahashi M., and Umemura T. Involvement of apoptosis in the rat germ cell degeneration induced by nitrobenzene. Archives of Toxicology 72 (1998) 296-302
46. Song Y., Liang X.M., Hu Y.F., Wang Y.N., Yu H.G., and Yang K.D. p,p′-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells. Toxicology 253 (2008) 53-61
47. Tebourbi O., Rhouma K.B., and Sakly M. DDT induces apoptosis in rat thymocytes. Bulletin of Environmental Contamination and Toxicology 61 (1998) 216-223
48. Valeron P.F., Pestano J.J., Luzardo O.P., Zumbado M.L., Almeida M., and Boada L.D. Differential effects exerted on human mammary epithelial cells by environmentally relevant organochlorine pesticides either individually or in combination. Chemico-Biological Interactions 180 (2009) 485-491
49. Wang J.L., Kannan S., Li H., and Khan M.F. Cytokine gene expression and activation of NF-kappa B in aniline-induced splenic toxicity. Toxicology and Applied Pharmacology 203 (2005) 36-44
50. Williams K., Frayne J., McLaughlin E.A., and Hall L. Expression of extracellular superoxide dismutase in the human male reproductive tract, detected using antisera raised against a recombinant protein. Molecular Human Reproduction 4 (1998) 235-242
51. Xiong X.Z., Wang A.G., Liu G.H., Liu H.K., Wang C., Xia T., Chen X.M., and Yang K.D. Effects of p,p′-dichorodiphenyldichloroethylene on the expressions of transferrin and androgen-binding protein in rat Sertoli cells. Environmental Research 101 (2006) 334-339
52. Xu L.C., Sun H., Chen J.F., Bian Q., Song L., and Wang X.R. Androgen receptor activities of p,p′-DDE, fenvalerate and phoxim detected by androgen receptor reporter gene assay. Toxicology Letters 160 (2006) 151-157
53. Yamasaki K., Okuda H., Takeuchi T., and Minobe Y. Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p′-DDE in Sprague-Dawley rats. Toxicology Letters 189 (2009) 14-20
54. You L., Casanova M., Archibeque-Engle S., Sar M., Fan L.Q., and Heck H.D. Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p′-DDE. Toxicological Sciences 45 (1998) 162-173