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Volumn 39, Issue 6, 2011, Pages 1659-1666

Angiogenesis regulation by TGFβ signalling: Clues from an inherited vascular disease

Author keywords

Activin receptor like kinase 1 (ACVRL1); Angiogenesis; Endoglin; Hereditary haemorrhagic telangiectasia (HHT); Transforming growth factor (TGF ); Vascular disease

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; BONE MORPHOGENETIC PROTEIN 9; ENDOGLIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN C JUN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

EID: 81855169461     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20110664     Document Type: Conference Paper
Times cited : (46)

References (69)
  • 1
    • 77955880114 scopus 로고    scopus 로고
    • Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment
    • Shovlin, C.L. (2010) Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment. Blood Rev. 24, 203-219
    • (2010) Blood Rev. , vol.24 , pp. 203-219
    • Shovlin, C.L.1
  • 2
    • 0025129826 scopus 로고
    • Ultrastructure and three-dimensional organization of the telangiectases of hereditary hemmorhagic telangiectasia
    • Braverman, I.M., Keh, A. and Jacobson, B.S. (1990) Ultrastructure and three-dimensional organization of the telangiectases of hereditary hemorrhagic telangiectasia. J. Invest. Dermatol. 95, 422-427 (Pubitemid 20331987)
    • (1990) Journal of Investigative Dermatology , vol.95 , Issue.4 , pp. 422-427
    • Braverman, I.M.1    Keh, A.2    Jacobson, B.S.3
  • 3
    • 35448991324 scopus 로고    scopus 로고
    • Extracellular control of TGFβ signalling in vascular development and disease
    • ten Dijke, P. and Arthur, H.M. (2007) Extracellular control of TGFβ signalling in vascular development and disease. Nat. Rev. 8, 857-869
    • (2007) Nat. Rev. , vol.8 , pp. 857-869
    • Ten Dijke, P.1    Arthur, H.M.2
  • 6
    • 12144286738 scopus 로고    scopus 로고
    • A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4)
    • DOI 10.1016/S0140-6736(04)15732-2, PII S0140673604157322
    • Gallione, C.J., Repetto, G.M., Legius, E., Rustgi, A.K., Schelley, S.L., Tejpar, S., Mitchell, G., Drouin, E., Westermann, C.J. and Marchuk, D.A. (2004) A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4). Lancet 363, 852-859 (Pubitemid 38368834)
    • (2004) Lancet , vol.363 , Issue.9412 , pp. 852-859
    • Gallione, C.J.1    Repetto, G.M.2    Legius, E.3    Rustgi, A.K.4    Schelley, S.L.5    Tejpar, S.6    Mitchell, G.7    Drouin, E.8    Westermann, C.J.J.9    Marchuk, D.A.10
  • 7
    • 0025310515 scopus 로고
    • Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells
    • Gougos, A. and Letarte, M. (1990) Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. J. Biol. Chem. 265, 8361-8364
    • (1990) J. Biol. Chem. , vol.265 , pp. 8361-8364
    • Gougos, A.1    Letarte, M.2
  • 8
    • 33845616815 scopus 로고    scopus 로고
    • Structural Model of Human Endoglin, a Transmembrane Receptor Responsible for Hereditary Hemorrhagic Telangiectasia
    • DOI 10.1016/j.jmb.2006.10.015, PII S0022283606013544
    • Llorca, O., Trujillo, A., Blanco, F.J. and Bernabeu, C. (2007) Structural model of human endoglin, a transmembrane receptor responsible for hereditary hemorrhagic telangiectasia. J. Mol. Biol. 365, 694-705 (Pubitemid 44960353)
    • (2007) Journal of Molecular Biology , vol.365 , Issue.3 , pp. 694-705
    • Llorca, O.1    Trujillo, A.2    Blanco, F.J.3    Bernabeu, C.4
  • 9
    • 79955120788 scopus 로고    scopus 로고
    • Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-β binding
    • Lin, S.J., Hu, Y., Zhu, J., Woodruff, T.K. and Jardetzky, T.S. (2011) Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-β binding. Proc. Natl. Acad. Sci. U.S.A. 108, 5232-5236
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 5232-5236
    • Lin, S.J.1    Hu, Y.2    Zhu, J.3    Woodruff, T.K.4    Jardetzky, T.S.5
  • 10
    • 57749084578 scopus 로고    scopus 로고
    • Endoglin promotes transforming growth factor β-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC
    • Lee, N.Y., Ray, B., How, T. and Blobe, G.C. (2008) Endoglin promotes transforming growth factor β-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. J. Biol. Chem. 283, 32527-32533
    • (2008) J. Biol. Chem. , vol.283 , pp. 32527-32533
    • Lee, N.Y.1    Ray, B.2    How, T.3    Blobe, G.C.4
  • 11
    • 0028170145 scopus 로고
    • Phosphorylation of the human-transforming-growth-factor-β-binding protein endoglin
    • Lastres, P., Martin-Perez, J., Langa, C. and Bernabeu, C. (1994) Phosphorylation of the human-transforming-growth-factor-β-binding protein endoglin. Biochem. J. 301, 765-768
    • (1994) Biochem. J. , vol.301 , pp. 765-768
    • Lastres, P.1    Martin-Perez, J.2    Langa, C.3    Bernabeu, C.4
  • 12
    • 33748749625 scopus 로고    scopus 로고
    • Endoglin structure and function: Determinants of endoglin phosphorylation by transforming growth factor-β receptors
    • DOI 10.1074/jbc.M601288200
    • Koleva, R.I., Conley, B.A., Romero, D., Riley, K.S., Marto, J.A., Lux, A. and Vary, C.P. (2006) Endoglin structure and function: determinants of endoglin phosphorylation by transforming growth factor-β receptors. J. Biol. Chem. 281, 25110-25123 (Pubitemid 44401898)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.35 , pp. 25110-25123
    • Koleva, R.I.1    Conley, B.A.2    Romero, D.3    Riley, K.S.4    Marto, J.A.5    Lux, A.6    Vary, C.P.H.7
  • 13
    • 77950880642 scopus 로고    scopus 로고
    • ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration
    • Ray, B.N., Lee, N.Y., How, T. and Blobe, G.C. (2010) ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration. Carcinogenesis 31, 435-441
    • (2010) Carcinogenesis , vol.31 , pp. 435-441
    • Ray, B.N.1    Lee, N.Y.2    How, T.3    Blobe, G.C.4
  • 14
    • 3042589327 scopus 로고    scopus 로고
    • Endoglin controls cell migration and composition of focal adhesions: Function of the cytosolic domain
    • DOI 10.1074/jbc.M312561200
    • Conley, B.A., Koleva, R., Smith, J.D., Kacer, D., Zhang, D., Bernabeu, C. and Vary, C.P. (2004) Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain. J. Biol. Chem. 279, 27440-27449 (Pubitemid 38812583)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.26 , pp. 27440-27449
    • Conley, B.A.1    Koleva, R.2    Smith, J.D.3    Kacer, D.4    Zhang, D.5    Bernabeu, C.6    Vary, C.P.H.7
  • 15
  • 17
    • 34547111838 scopus 로고    scopus 로고
    • The interaction of endoglin with β-arrestin2 regulates transforming growth factor-β-mediated ERK activation and migration in endothelial cells
    • DOI 10.1074/jbc.M700176200
    • Lee, N.Y. and Blobe, G.C. (2007) The interaction of endoglin with β-arrestin2 regulates transforming growth factor-β-mediated ERK activation and migration in endothelial cells. J. Biol. Chem. 282, 21507-21517 (Pubitemid 47099970)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.29 , pp. 21507-21517
    • Lee, N.Y.1    Blobe, G.C.2
  • 18
  • 20
    • 0001421509 scopus 로고    scopus 로고
    • CD105 antagonizes the inhibitory signaling of transforming growth factor β1 on human vascular endothelial cells
    • Li, C., Hampson, I.N., Hampson, L., Kumar, P., Bernabeu, C. and Kumar, S. (2000) CD105 antagonizes the inhibitory signaling of transforming growth factor β1 on human vascular endothelial cells. FASEB J. 14, 55-64 (Pubitemid 30051523)
    • (2000) FASEB Journal , vol.14 , Issue.1 , pp. 55-64
    • Chenggang, L.1    Hampson, I.N.2    Hampson, L.3    Kumar, P.4    Bernabeu, C.5    Kumar, S.6
  • 22
    • 80052821904 scopus 로고    scopus 로고
    • Alternative splicing factor or splicing factor-2 plays a key role in intron retention of the endoglin gene during endothelial senescence
    • Blanco, F.J. and Bernabeu, C. (2011) Alternative splicing factor or splicing factor-2 plays a key role in intron retention of the endoglin gene during endothelial senescence. Aging Cell 10, 896-907
    • (2011) Aging Cell , vol.10 , pp. 896-907
    • Blanco, F.J.1    Bernabeu, C.2
  • 25
    • 1642473157 scopus 로고    scopus 로고
    • The transforming growth factor-β superfamily of receptors
    • de Caestecker, M. (2004) The transforming growth factor-β superfamily of receptors. Cytokine Growth Factor Rev. 15, 1-11
    • (2004) Cytokine Growth Factor Rev. , vol.15 , pp. 1-11
    • De Caestecker, M.1
  • 26
    • 61749097816 scopus 로고    scopus 로고
    • Tgf-β superfamily signaling in embryonic development and homeostasis
    • Wu, M.Y. and Hill, C.S. (2009) Tgf-β superfamily signaling in embryonic development and homeostasis. Dev. Cell 16, 329-343
    • (2009) Dev. Cell , vol.16 , pp. 329-343
    • Wu, M.Y.1    Hill, C.S.2
  • 27
    • 77956187467 scopus 로고    scopus 로고
    • Signaling by members of the TGF-β family in vascular morphogenesis and disease
    • Pardali, E., Goumans, M.J. and ten Dijke, P. (2010) Signaling by members of the TGF-β family in vascular morphogenesis and disease. Trends Cell Biol. 20, 556-567
    • (2010) Trends Cell Biol. , vol.20 , pp. 556-567
    • Pardali, E.1    Goumans, M.J.2    Ten Dijke, P.3
  • 28
    • 33847716712 scopus 로고    scopus 로고
    • Negative regulation of TGF-β receptor/Smad signal transduction
    • DOI 10.1016/j.ceb.2007.02.015, PII S0955067407000294
    • Itoh, S. and ten Dijke, P. (2007) Negative regulation of TGF-β receptor/Smad signal transduction. Curr. Opin. Cell Biol. 19, 176-184 (Pubitemid 46386411)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.2 , pp. 176-184
    • Itoh, S.1    Ten, D.P.2
  • 29
    • 0037007226 scopus 로고    scopus 로고
    • Balancing the activation state of the endothelium via two distinct TGF-β type I receptors
    • DOI 10.1093/emboj/21.7.1743
    • Goumans, M.J., Valdimarsdottir, G., Itoh, S., Rosendahl, A., Sideras, P. and ten Dijke, P. (2002) Balancing the activation state of the endothelium via two distinct TGF-β type I receptors. EMBO J. 21, 1743-1753 (Pubitemid 34614630)
    • (2002) EMBO Journal , vol.21 , Issue.7 , pp. 1743-1753
    • Goumans, M.-J.1    Valdimarsdottir, G.2    Itoh, S.3    Rosendahl, A.4    Sideras, P.5    Ten, D.P.6
  • 30
    • 0242330126 scopus 로고    scopus 로고
    • Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFβ/ALK5 signaling
    • DOI 10.1016/S1097-2765(03)00386-1
    • Goumans, M.J., Valdimarsdottir, G., Itoh, S., Lebrin, F., Larsson, J., Mummery, C., Karlsson, S. and ten Dijke, P. (2003) Activin receptor-like kinase (ALK) 1 is an antagonistic mediator of lateral TGFβ/ALK5 signaling. Mol. Cell 12, 817-828 (Pubitemid 37352776)
    • (2003) Molecular Cell , vol.12 , Issue.4 , pp. 817-828
    • Goumans, M.-J.1    Valdimarsdottir, G.2    Itoh, S.3    Lebrin, F.4    Larsson, J.5    Mummery, C.6    Karlsson, S.7    Ten, D.P.8
  • 32
    • 33847369980 scopus 로고    scopus 로고
    • Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
    • DOI 10.1182/blood-2006-07-034124
    • David, L., Mallet, C., Mazerbourg, S., Feige, J.J. and Bailly, S. (2007) Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood 109, 1953-1961 (Pubitemid 46348192)
    • (2007) Blood , vol.109 , Issue.5 , pp. 1953-1961
    • David, L.1    Mallet, C.2    Mazerbourg, S.3    Feige, J.-J.4    Bailly, S.5
  • 34
    • 0037114702 scopus 로고    scopus 로고
    • Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis
    • DOI 10.1182/blood.V100.13.4495
    • Lamouille, S., Mallet, C., Feige, J.J. and Bailly, S. (2002) Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis. Blood 100, 4495-4501 (Pubitemid 35429690)
    • (2002) Blood , vol.100 , Issue.13 , pp. 4495-4501
    • Lamouille, S.1    Mallet, C.2    Felge, J.-J.3    Bailly, S.4
  • 36
    • 67650188576 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells
    • Upton, P.D., Davies, R.J., Trembath, R.C. and Morrell, N.W. (2009) Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. J. Biol. Chem. 284, 15794-15804
    • (2009) J. Biol. Chem. , vol.284 , pp. 15794-15804
    • Upton, P.D.1    Davies, R.J.2    Trembath, R.C.3    Morrell, N.W.4
  • 38
    • 0033534572 scopus 로고    scopus 로고
    • Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-β superfamily
    • Barbara, N.P., Wrana, J.L. and Letarte, M. (1999) Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-β superfamily. J. Biol. Chem. 274, 584-594
    • (1999) J. Biol. Chem. , vol.274 , pp. 584-594
    • Barbara, N.P.1    Wrana, J.L.2    Letarte, M.3
  • 42
    • 33646713486 scopus 로고    scopus 로고
    • The TGFβ activated kinase TAK1 regulates vascular development in vivo
    • DOI 10.1242/dev.02333
    • Jadrich, J.L., O'Connor, M.B. and Coucouvanis, E. (2006) The TGFβ activated kinase TAK1 regulates vascular development in vivo. Development 133, 1529-1541 (Pubitemid 43732966)
    • (2006) Development , vol.133 , Issue.8 , pp. 1529-1541
    • Jadrich, J.L.1    O'Connor, M.B.2    Coucouvanis, E.3
  • 43
    • 34848842778 scopus 로고    scopus 로고
    • Activin receptor-like kinase 1 inhibits human microvascular endothelial cell migration: Potential roles for JNK and ERK
    • DOI 10.1002/jcp.21126
    • David, L., Mallet, C., Vailhe, B., Lamouille, S., Feige, J.J. and Bailly, S. (2007) Activin receptor-like kinase 1 inhibits human microvascular endothelial cell migration: potential roles for JNK and ERK. J. Cell. Physiol. 213, 484-489 (Pubitemid 47509730)
    • (2007) Journal of Cellular Physiology , vol.213 , Issue.2 , pp. 484-489
    • David, L.1    Mallet, C.2    Vailhe, B.3    Lamouille, S.4    Feige, J.-J.5    Bailly, S.6
  • 44
    • 0030795214 scopus 로고    scopus 로고
    • Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and anglogenesis in early mouse development
    • DOI 10.1002/(SICI)1097-0177(199708)209:4<418::AID-AJA9>3.0.CO;2-L
    • Roelen, B.A., van Rooijen, M.A. and Mummery, C.L. (1997) Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development. Dev. Dyn. 209, 418-430 (Pubitemid 27328468)
    • (1997) Developmental Dynamics , vol.209 , Issue.4 , pp. 418-430
    • Roelen, B.A.J.1    Van Rooijen, M.A.2    Mummery, C.L.3
  • 45
    • 0035666199 scopus 로고    scopus 로고
    • Endoglin expression in early development is associated with vasculogenesis and angiogenesis
    • Jonker, L. and Arthur, H.M. (2002) Endoglin expression in early development is associated with vasculogenesis and angiogenesis. Mech. Dev. 110, 193-196
    • (2002) Mech. Dev. , vol.110 , pp. 193-196
    • Jonker, L.1    Arthur, H.M.2
  • 46
    • 77949898210 scopus 로고    scopus 로고
    • ALK1 signaling regulates early postnatal lymphatic vessel development
    • Niessen, K., Zhang, G., Ridgway, J.B., Chen, H. and Yan, M. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood 115, 1654-1661
    • (2010) Blood , vol.115 , pp. 1654-1661
    • Niessen, K.1    Zhang, G.2    Ridgway, J.B.3    Chen, H.4    Yan, M.5
  • 47
    • 58149112610 scopus 로고    scopus 로고
    • Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: Implications for two familial vascular dysplasias, HHT and PAH
    • Mahmoud, M., Borthwick, G.M., Hislop, A.A. and Arthur, H.M. (2009) Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH. Lab. Invest. 89, 15-25
    • (2009) Lab. Invest. , vol.89 , pp. 15-25
    • Mahmoud, M.1    Borthwick, G.M.2    Hislop, A.A.3    Arthur, H.M.4
  • 48
    • 0032908133 scopus 로고    scopus 로고
    • Elevated expression of endoglin, a component of the TGF-β-receptor complex, correlates with proliferation of tumor endothelial cells
    • DOI 10.1002/(SICI)1097-0215(19990517)81:4<568::AID-IJC11>3.0.CO;2-X
    • Miller, D.W., Graulich, W., Kargas, B., Stahl, S., Ernst, M., Ramaswamy, A., Sadlacek, H.H., Muller, R. and Adamkiewicz, J. (1999) Elevated expression of endoglin, a component of the TGF-β-receptor complex, correlates with proliferation of tumour endothelial cells. Int. J. Cancer 81, 568-572 (Pubitemid 29203054)
    • (1999) International Journal of Cancer , vol.81 , Issue.4 , pp. 568-572
    • Miller, D.W.1    Graulich, W.2    Karges, B.3    Stahl, S.4    Ernst, M.5    Ramaswamy, A.6    Sedlacek, H.-H.7    Muller, R.8    Adamkiewicz, J.9
  • 49
    • 0036733053 scopus 로고    scopus 로고
    • Inducible expression of human endoglin during inflammation and wound healing in vivo
    • Torsney, E., Charlton, R., Parums, D., Collis, M. and Arthur, H.M. (2002) Inducible expression of human endoglin during inflammation and wound healing in vivo. Inflamm. Res. 51, 464-470 (Pubitemid 35034452)
    • (2002) Inflammation Research , vol.51 , Issue.9 , pp. 464-470
    • Torsney, E.1    Charlton, R.2    Parums, D.3    Collis, M.4    Arthur, H.M.5
  • 50
    • 0141752813 scopus 로고    scopus 로고
    • Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling
    • DOI 10.1161/01.RES.0000095246.40391.3B
    • Seki, T., Yun, J. and Oh, S.P. (2003) Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circ. Res. 93, 682-689 (Pubitemid 37222165)
    • (2003) Circulation Research , vol.93 , Issue.7 , pp. 682-689
    • Seki, T.1    Yun, J.2    Oh, S.P.3
  • 55
    • 44449175091 scopus 로고    scopus 로고
    • ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes
    • DOI 10.1359/jbmr.080209
    • Finnson, K.W., Parker, W.L., ten Dijke, P., Thorikay, M. and Philip, A. (2008) ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes. J. Bone Miner. Res. 23, 896-906 (Pubitemid 351768808)
    • (2008) Journal of Bone and Mineral Research , vol.23 , Issue.6 , pp. 896-906
    • Finnson, K.W.1    Parker, W.L.2    Ten, D.P.3    Thorikay, M.4    Philip, A.5
  • 56
    • 0032720393 scopus 로고    scopus 로고
    • A murine model of hereditary hemorrhagic telangiectasia
    • Bourdeau, A., Dumont, D.J. and Letarte, M. (1999) A murine model of hereditary hemorrhagic telangiectasia. J. Clin. Invest. 104, 1343-1351
    • (1999) J. Clin. Invest. , vol.104 , pp. 1343-1351
    • Bourdeau, A.1    Dumont, D.J.2    Letarte, M.3
  • 58
  • 59
    • 12344255297 scopus 로고    scopus 로고
    • Defective paracrine signalling by TGFβ in yolk sac vasculature of endoglin mutant mice: A paradigm for hereditary haemorrhagic telangiectasia
    • DOI 10.1242/dev.01529
    • Carvalho, R.L., Jonker, L., Goumans, M.J., Larsson, J., Bouwman, P., Karlsson, S., Dijke, P.T., Arthur, H.M. and Mummery, C.L. (2004) Defective paracrine signalling by TGFβ in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia. Development 131, 6237-6247 (Pubitemid 40123935)
    • (2004) Development , vol.131 , Issue.24 , pp. 6237-6247
    • Carvalho, R.L.C.1    Jonker, L.2    Goumans, M.-J.3    Larsson, J.4    Bouwman, P.5    Karlsson, S.6    Ten, D.P.7    Arthur, H.M.8    Mummery, C.L.9
  • 60
    • 0037380583 scopus 로고    scopus 로고
    • Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality
    • DOI 10.1161/01.CIR.0000058170.92267.00
    • Torsney, E., Charlton, R., Diamond, A.G., Burn, J., Soames, J.V. and Arthur, H.M. (2003) Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality. Circulation 107, 1653-1657 (Pubitemid 36397335)
    • (2003) Circulation , vol.107 , Issue.12 , pp. 1653-1657
    • Torsney, E.1    Charlton, R.2    Diamond, A.G.3    Burn, J.4    Soames, J.V.5    Arthur, H.M.6
  • 64
    • 79955448391 scopus 로고    scopus 로고
    • Interaction between alk1 and blood flow in the development of arteriovenous malformations
    • Corti, P., Young, S., Chen, C.Y., Patrick, M.J., Rochon, E.R., Pekkan, K. and Roman, B.L. (2011) Interaction between alk1 and blood flow in the development of arteriovenous malformations. Development 138, 1573-1582
    • (2011) Development , vol.138 , pp. 1573-1582
    • Corti, P.1    Young, S.2    Chen, C.Y.3    Patrick, M.J.4    Rochon, E.R.5    Pekkan, K.6    Roman, B.L.7
  • 68
    • 84864288370 scopus 로고    scopus 로고
    • Plasma endoglin as a marker to predict cardiovascular events in patients with chronic coronary artery diseases
    • doi:10.1007/s00380-011-0163-z
    • Ikemoto, T., Hojo, Y., Kondo, H., Takahashi, N., Hirose, M., Nishimura, Y., Katsuki, T., Shimada, K. and Kario, K. (2011) Plasma endoglin as a marker to predict cardiovascular events in patients with chronic coronary artery diseases. Heart Vessels, doi:10.1007/s00380-011-0163-z
    • (2011) Heart Vessels
    • Ikemoto, T.1    Hojo, Y.2    Kondo, H.3    Takahashi, N.4    Hirose, M.5    Nishimura, Y.6    Katsuki, T.7    Shimada, K.8    Kario, K.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.