CD105 antagonizes the inhibitory signaling of transforming growth factor β1 on human vascular endothelial cells

FASEB Journal

Volumn 14, Issue 1, 2000, Pages 55-64

  Chenggang, Li ^a   Hampson, Ian N ^b   Hampson, Lynn ^c   Kumar, Pat ^a   Bernabeu, Carmelo ^a,d   Kumar, Shant ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d CSIC   (Spain)

Author keywords

Angiogenesis; HUVEC; TGF 1

Indexed keywords

ENDOGLIN; TRANSFORMING GROWTH FACTOR BETA1;

ANGIOGENESIS; ARTICLE; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

EID: 0001421509     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.1.55     Document Type: Article

References (40)

1. Battegay, E. J. (1995) Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects. J. Mol. Med. 73, 333-346
2. Folkman, J. (1997) Angiogenesis and angiogenesis inhibition: an overview. EXS 79, 1-8
3. Pepper, M.S. (1997) Transforming growth factor-β: vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev. 8, 21-43
4. Kingsley, D. M. (1994) The TGFβ superfamily: new members, new receptors and new genetic tests of function in different organisms. Genes Dev. 8, 133-146
5. Miyazono, K. (1997) TGF-β receptors and signal transduction. Int. J. Hematol. 65, 97-104
6. Roberts, A. B. (1998) Molecular and cell biology of TGFβ. Miner. Elertrol. Metab. 24, 111-119
7. Abdollah, S., Macias, S. M., Tsukazaki, T., Hayashi, H., Attisano, L., and Wrana, J. L. (1997) TβRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J. Biol. Chem. 272, 27678-27685
8. Heldin, C. H., Miyazono, K., and ten Dijke, P. (1997) TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature (London) 390, 465-471
9. Lopez-Casillas, F., Payne, H. M., Andres, J. L., and Massague, J. (1994) Betaglycan can act as a dual modulator of TGF-β access to signaling receptors: mapping of ligand binding and GAG attachment sites. J. Cell Biol. 124, 557-568
10. Cheifetz, S., Bellon, T., Cales, C., Vera, S., Bernabeu, C., Massague, J., and Letarte, M. (1992) Endoglin is a component of the transforming growth factor-β receptor system in human endothelial cells. J. Biol. Chem. 267, 19027-19030
11. Fernandez, R. E., Saint, J. S., Bellon, T., Letarte, M., and Bernabeu, C. (1993) Assignment of the human endoglin gene (END) to 9q34->qter. Cytogenet. Cell Genet. 64, 204-207
12. McAllister, K. A., Grogg, K. M., Johnson, D. W., Gallione, C. J., Baldwin, M. A., Jackson, C. E., Helmbold, E. A., Markel, D. S., McKinnon, W. C., Murrell J., et al. (1994) Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat. Genet. 8, 345-351
13. Burrows, F. J., Derbyshire, E. J., Tazzari, P. L., Amlot, P., Gazdar, A. F., King, S. W., Letarte, M., Vitella, E. S., and Thorpe P. E. (1995) Up-regulation of endoglin on vascular endothelial cells in human solid tumours: implications for diagnosis and therapy. Clin. Cancer Res. 1, 1623-1634
14. Rulo, H. F., Westphal, J. R., van de Kerkhof, P., De, W. R., van, V. I., and Ruiter, D. J. (1995) Expression of endoglin in psoriatic involved and uninvolved skin. J. Dermatol. Sci. 10, 103-109
15. Szekanecz, Z., Haines, G. K., Harlow, L. A., Shah, M. R., Fong, T. W., Fu, R., Lin, S. J., Rayan, G., and Koch, A. E. (1995) Increased synovial expression of transforming growth factor (TGF)-β receptor endoglin and TGF-β1 in rheumatoid arthritis: possible interactions in the pathogenesis of the disease. Clin. Immunol. Immunopathol. 76, 187-194
16. Krupinski, J., Kumar, P., Kumar, S., and Kaluza, J. (1996) Increased expression of TGF-β1 in brain tissue after ischemic stroke in humans. Stroke 27, 852-857
17. Kumar, S., Wang, J. M., and Bernabeu, C. (1996) CD 105 and angiogenesis. J. Pathol. 178, 363-366
18. Bodey, B., Bodey, B., Jr., Siegel, S. E., and Kaiser, H. E. (1998) Upregulalion of endoglin (CD105) expression during childhood brain tumour-related angiogenesis. Anti-angiogenic therapy. Anticancer Res. 18, 1485-1500
19. Matsuno, K., Haruta, Y., Kondo, M., Tsai, H., Barcos, M., and Seon, B. K. (1999) Induction of lasting complete regression of preformed distinct solid tumors by targeting the tumor vasculature using two new anti-endoglin monoclonal antibodies. Clin. Cancer Res. 5, 371-382
20. Kumar, S., Ghellal, A., Li, C. G., Byrne, G., Haboni, N., Wang, J. M., and Bundred, N. (1999) Breast carcinoma: vascular density determined using CD105 antibody correlates with tumour prognosis. Cancer Res. 59, 856-861
21. Li, C. G., Wang, J. M., Wilson, P. B., Levine, E., Hunter, R., and Kumar, S. (1998) Role of transforming growth factor β3 in lymphatic metastasis in breast cancer. Int. J. Cancer 79, 455-459
22. Letamendia, A., Lastres, P., Botella, L. M., Raab, U., Langa, C., Velasco, B., Attisano, L., and Bernabeu, C. (1998) Role of endoglin in cellular responses to transforming growth factor-β. J. Biol. Chem. 273, 33011-33019
23. Li, D. Y., Sorensen, L. K., Brook, B. S., Urness, L. D., Davis, E. C., Taylor, D. G., Boak, B. B., and Wendel, D. P. (1999) Defective angiogenesis in mice lacking endoglin. Science 284, 1534-1537
24. Wang, J. M., Kumar, S., van, A. A., Kumar, P., Pye, D., and Hunter, R. D. (1995) Irradiation induces up-regulation of E9 protein (CD105) in human vascular endothelial cells. Int. J. Cancer 62, 791-796
25. Li, C. G., Kumar, S., Ponting, J. M., Carette, M., and Allan, E. (1997) Glucosaminylmuramyl dipeptide (GMDP) modulates endothelial cell activities in vitro but no effects on angiogenesis in vivo. Inflamm. Res. 46, 348-353
26. Chomczynski, P., and Sacchi, N. (1987) Single-step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem 162, 156-109
27. Lehrach, H., Diamond, D., Wozney, J. M., and Boedtker, H. (1977) RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry 16, 4743-4751
28. Lauder, H., Frost, K. E., Hiley, C. R., and Fan, T. P. (1998) Quantification of the repair process involved in the repair of a cell monolayer using an in vitro model of mechanical injury. Angiogenesis 2, 67-80
29. Sutton, A. B., Canfield, A. E., Schor, S. L., Grant, M. E., and Schor, A. M. (1991) The response of endothelial cells to TGFβ1 is dependent upon cell shape, proliferative state and the nature of the substratum. J. Cell Sci. 99, 777-787
30. Klein-Soyer, C., Archipoff, G., Beretz, A., and Cazenave, J. P. (1992) Opposing effects of heparin with TGF-β or aFGF during repair of a mechanical wound of human endothelium. Biol. Cell 75, 155-162
31. Takashima, S., and Klagsbrun, M. (1996) Inhibition of endothelial cell growth by macrophage-like U-937 cell-derived oncostatin M, leukemia inhibitory factor, and transforming growth factor β1. J. Biol. Chem. 271, 24901-24906
32. Yang, E. Y., and Moses, H. L. (1990) Transforming growth factor β1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane. J. Cell Biol. 111, 731-741
33. Li, C. G., Wilson, P. B., Levine, E., Barber, J., and Kumar, S. (1999) TGFβ1 levels in pretreatment plasma identify patients at risk of developing breast fibrosis post-radiotherapy. Int. J. Cancer 84, 155-159
34. Imamura, T., Takase, M., Nishihara, A., Oeda, E., Hanai, J., Kawabata, M., and Miyazono, K. (1997) Smad6 inhibits signaling by the TGF-β superfamily. Nature (London) 389, 622-626
35. Sankar, S., Mahooti, B. N., Bensen, L., McCarthy, T. L., Centrella, M., and Madri, J. A. (1996) Modulation of transforming growth factor β receptor levels on microvascular endothelial cells during in vitro angiogenesis. J. Clin. Invest. 97, 1436-1446
36. Kanzawa, S., Endo, H., and Shioya, N. (1993) Improved in vitro angiogenesis model by collagen density reduction and the use of type III collagen. Ann. Plast. Surg. 30, 244-251
37. Tada, K., Fukunaga, T., Wakabayashi, Y., Masumi, S., Sato, Y., Izumi, H., Kohno, K., and Kuwano, M. (1994) Inhibition of tubular morphogenesis in human microvascular endothelial cells by co-culture with chondrocytes and involvement of transforming growth factor-β: a model for avascularity in human cartilage. Biochim. Biophys. Acta 1201, 135-142
38. Yamashita, H., Ichijo, H., Grimsby, S., Moren, A., ten Dijke, P., and Miyazono, K. (1994) Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-β. J. Biol Chem. 269, 1995-2001
39. Lastres, P., Martin, P. J., Langa, C., and Bernabeu, C. (1994) Phosphorylation of the human-transforming-growth-faclor-β-binding protein endoglin. Biochem. J. 301, 765-768
40. Lastres, P., Letamendia, A., Zhang, H., Rius, C., Almendro, N., Raab, U., Lopez, L. A., Langa, C., Fabra, A., Letarte, M., and Bernabeu, C. (1996) Endoglin modulates cellular responses to TGF-β1. J. Cell Biol. 133, 1109-1121