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Volumn 6, Issue 11, 2011, Pages

Synergy analysis reveals association between insulin signaling and desmoplakin expression in palmitate treated HepG2 cells

Author keywords

[No Author keywords available]

Indexed keywords

DESMOPLAKIN; INSULIN; PALMITIC ACID; PALMITIC ACID DERIVATIVE;

EID: 81755171963     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028138     Document Type: Article
Times cited : (7)

References (84)
  • 1
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, et al. (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115: 1343-1351.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5
  • 2
    • 34547491854 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease
    • Angulo P, (2007) Obesity and nonalcoholic fatty liver disease. Nutr Rev 65: S57-63.
    • (2007) Nutr Rev , vol.65
    • Angulo, P.1
  • 3
    • 0037382071 scopus 로고    scopus 로고
    • Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
    • Musso G, Gambino R, De Michieli F, Cassader M, Rizzetto M, et al. (2003) Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology 37: 909-916.
    • (2003) Hepatology , vol.37 , pp. 909-916
    • Musso, G.1    Gambino, R.2    De Michieli, F.3    Cassader, M.4    Rizzetto, M.5
  • 4
    • 34848830434 scopus 로고    scopus 로고
    • Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study
    • Zelber-Sagi S, Nitzan-Kaluski D, Goldsmith R, Webb M, Blendis L, et al. (2007) Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study. J Hepatol 47: 711-717.
    • (2007) J Hepatol , vol.47 , pp. 711-717
    • Zelber-Sagi, S.1    Nitzan-Kaluski, D.2    Goldsmith, R.3    Webb, M.4    Blendis, L.5
  • 5
    • 57649214103 scopus 로고    scopus 로고
    • Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    • Musso G, Gambino R, Cassader M, (2009) Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid Res 48: 1-26.
    • (2009) Prog Lipid Res , vol.48 , pp. 1-26
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 6
    • 34447270785 scopus 로고    scopus 로고
    • A Three Stage Integrative Pathway Search (TIPS) framework to identify toxicity relevant genes and pathways
    • Li Z, Srivastava S, Mittal S, Yang X, Sheng L, et al. (2007) A Three Stage Integrative Pathway Search (TIPS) framework to identify toxicity relevant genes and pathways. BMC Bioinformatics 8: 202.
    • (2007) BMC Bioinformatics , vol.8 , pp. 202
    • Li, Z.1    Srivastava, S.2    Mittal, S.3    Yang, X.4    Sheng, L.5
  • 7
    • 38149052956 scopus 로고    scopus 로고
    • A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells
    • Li Z, Srivastava S, Yang X, Mittal S, Norton P, et al. (2007) A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells. BMC Syst Biol 1: 21.
    • (2007) BMC Syst Biol , vol.1 , pp. 21
    • Li, Z.1    Srivastava, S.2    Yang, X.3    Mittal, S.4    Norton, P.5
  • 8
    • 36949021371 scopus 로고    scopus 로고
    • Identification of genes that regulate multiple cellular processes/responses in the context of lipotoxicity to hepatoma cells
    • Srivastava S, Li Z, Yang X, Yedwabnick M, Shaw S, et al. (2007) Identification of genes that regulate multiple cellular processes/responses in the context of lipotoxicity to hepatoma cells. BMC Genomics 8: 364.
    • (2007) BMC Genomics , vol.8 , pp. 364
    • Srivastava, S.1    Li, Z.2    Yang, X.3    Yedwabnick, M.4    Shaw, S.5
  • 9
    • 69949134573 scopus 로고    scopus 로고
    • Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorization
    • Yang X, Zhou Y, Jin R, Chan C, (2009) Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorization. Bioinformatics 25: 2236-2243.
    • (2009) Bioinformatics , vol.25 , pp. 2236-2243
    • Yang, X.1    Zhou, Y.2    Jin, R.3    Chan, C.4
  • 10
    • 38949218422 scopus 로고    scopus 로고
    • Using dynamic gene module map analysis to identify targets that modulate free fatty acid induced cytotoxicity
    • Li Z, Srivastava S, Findlan R, Chan C, (2008) Using dynamic gene module map analysis to identify targets that modulate free fatty acid induced cytotoxicity. Biotechnol Prog 24: 29-37.
    • (2008) Biotechnol Prog , vol.24 , pp. 29-37
    • Li, Z.1    Srivastava, S.2    Findlan, R.3    Chan, C.4
  • 12
    • 38449101948 scopus 로고    scopus 로고
    • Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line
    • Srivastava S, Chan C, (2008) Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line. Biotechnol Bioeng 99: 399-410.
    • (2008) Biotechnol Bioeng , vol.99 , pp. 399-410
    • Srivastava, S.1    Chan, C.2
  • 13
    • 33847015674 scopus 로고    scopus 로고
    • Computational analysis of the synergy among multiple interacting genes
    • Anastassiou D, (2007) Computational analysis of the synergy among multiple interacting genes. Mol Syst Biol 3: 83.
    • (2007) Mol Syst Biol , vol.3 , pp. 83
    • Anastassiou, D.1
  • 14
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: a metabolic pathway to chronic liver disease
    • Bugianesi E, McCullough AJ, Marchesini G, (2005) Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42: 987-1000.
    • (2005) Hepatology , vol.42 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 15
    • 55349100928 scopus 로고    scopus 로고
    • Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling
    • Ruddock MW, Stein A, Landaker E, Park J, Cooksey RC, et al. (2008) Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling. J Biochem 144: 599-607.
    • (2008) J Biochem , vol.144 , pp. 599-607
    • Ruddock, M.W.1    Stein, A.2    Landaker, E.3    Park, J.4    Cooksey, R.C.5
  • 16
    • 1842733459 scopus 로고    scopus 로고
    • Working out the strength and flexibility of desmosomes
    • Getsios S, Huen AC, Green KJ, (2004) Working out the strength and flexibility of desmosomes. Nat Rev Mol Cell Biol 5: 271-281.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 271-281
    • Getsios, S.1    Huen, A.C.2    Green, K.J.3
  • 17
    • 18644363134 scopus 로고    scopus 로고
    • Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy
    • Rampazzo A, Nava A, Malacrida S, Beffagna G, Bauce B, et al. (2002) Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet 71: 1200-1206.
    • (2002) Am J Hum Genet , vol.71 , pp. 1200-1206
    • Rampazzo, A.1    Nava, A.2    Malacrida, S.3    Beffagna, G.4    Bauce, B.5
  • 18
  • 19
    • 34548809689 scopus 로고    scopus 로고
    • Alteration of adhesion molecule expression and cellular polarity in hepatocellular carcinoma
    • Cao Y, Chang H, Li L, Cheng RC, Fan XN, (2007) Alteration of adhesion molecule expression and cellular polarity in hepatocellular carcinoma. Histopathology 51: 528-538.
    • (2007) Histopathology , vol.51 , pp. 528-538
    • Cao, Y.1    Chang, H.2    Li, L.3    Cheng, R.C.4    Fan, X.N.5
  • 21
    • 81755178612 scopus 로고    scopus 로고
    • Construction of the gene network by synergy analysis of the genes related to palmitate-induced cytotoxicity
    • In: Jayaraman A, Hahn J, editors, Artech House Publishers
    • Yang X, Wang X, Wu M, Dalkic E, Chan C, (2009) Construction of the gene network by synergy analysis of the genes related to palmitate-induced cytotoxicity. In: Jayaraman A, Hahn J, editors. Methods in Bioengineering in Systems Analysis of Biological Networks: Artech House Publishers pp. 75-93.
    • (2009) Methods in Bioengineering in Systems Analysis of Biological Networks , pp. 75-93
    • Yang, X.1    Wang, X.2    Wu, M.3    Dalkic, E.4    Chan, C.5
  • 22
    • 40149090339 scopus 로고    scopus 로고
    • Identification of gene interactions associated with disease from gene expression data using synergy networks
    • Watkinson J, Wang X, Zheng T, Anastassiou D, (2008) Identification of gene interactions associated with disease from gene expression data using synergy networks. BMC Syst Biol 2: 10.
    • (2008) BMC Syst Biol , vol.2 , pp. 10
    • Watkinson, J.1    Wang, X.2    Zheng, T.3    Anastassiou, D.4
  • 25
    • 48349142136 scopus 로고    scopus 로고
    • Class-specific correlations of gene expressions: identification and their effects on clustering analyses
    • Zhang J, Li J, Deng H, (2008) Class-specific correlations of gene expressions: identification and their effects on clustering analyses. Am J Hum Genet 83: 269-277.
    • (2008) Am J Hum Genet , vol.83 , pp. 269-277
    • Zhang, J.1    Li, J.2    Deng, H.3
  • 26
    • 34548058037 scopus 로고    scopus 로고
    • Searching for differentially expressed gene combinations
    • Dettling M, Gabrielson E, Parmigiani G, (2005) Searching for differentially expressed gene combinations. Genome Biol 6: R88.
    • (2005) Genome Biol , vol.6
    • Dettling, M.1    Gabrielson, E.2    Parmigiani, G.3
  • 27
    • 34547617328 scopus 로고    scopus 로고
    • Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes
    • Guo W, Wong S, Xie W, Lei T, Luo Z, (2007) Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes. Am J Physiol Endocrinol Metab 293: E576-586.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Guo, W.1    Wong, S.2    Xie, W.3    Lei, T.4    Luo, Z.5
  • 28
    • 36348984507 scopus 로고    scopus 로고
    • Evidence for adipose-muscle cross talk: opposing regulation of muscle proteolysis by adiponectin and Fatty acids
    • Zhou Q, Du J, Hu Z, Walsh K, Wang XH, (2007) Evidence for adipose-muscle cross talk: opposing regulation of muscle proteolysis by adiponectin and Fatty acids. Endocrinology 148: 5696-5705.
    • (2007) Endocrinology , vol.148 , pp. 5696-5705
    • Zhou, Q.1    Du, J.2    Hu, Z.3    Walsh, K.4    Wang, X.H.5
  • 29
    • 34548400259 scopus 로고    scopus 로고
    • A systems biology approach for pathway level analysis
    • Draghici S, Khatri P, Tarca AL, Amin K, Done A, et al. (2007) A systems biology approach for pathway level analysis. Genome Res 17: 1537-1545.
    • (2007) Genome Res , vol.17 , pp. 1537-1545
    • Draghici, S.1    Khatri, P.2    Tarca, A.L.3    Amin, K.4    Done, A.5
  • 30
    • 13444287857 scopus 로고    scopus 로고
    • Expression analysis of a human hepatic cell line in response to palmitate
    • Swagell CD, Henly DC, Morris CP, (2005) Expression analysis of a human hepatic cell line in response to palmitate. Biochem Biophys Res Commun 328: 432-441.
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 432-441
    • Swagell, C.D.1    Henly, D.C.2    Morris, C.P.3
  • 31
    • 1642587872 scopus 로고    scopus 로고
    • Palmitate increases nitric oxide synthase activity that is involved in palmitate-induced cell death in cardiomyocytes
    • Tsang MY, Cowie SE, Rabkin SW, (2004) Palmitate increases nitric oxide synthase activity that is involved in palmitate-induced cell death in cardiomyocytes. Nitric Oxide 10: 11-19.
    • (2004) Nitric Oxide , vol.10 , pp. 11-19
    • Tsang, M.Y.1    Cowie, S.E.2    Rabkin, S.W.3
  • 32
    • 77958048585 scopus 로고    scopus 로고
    • The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells
    • Yang X, Nath A, Opperman MJ, Chan C, (2010) The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells. Mol Biol Cell 21: 3449-3458.
    • (2010) Mol Biol Cell , vol.21 , pp. 3449-3458
    • Yang, X.1    Nath, A.2    Opperman, M.J.3    Chan, C.4
  • 33
    • 77953913791 scopus 로고    scopus 로고
    • From 'differential expression' to 'differential networking' - identification of dysfunctional regulatory networks in diseases
    • de la Fuente A, (2010) From 'differential expression' to 'differential networking'- identification of dysfunctional regulatory networks in diseases. Trends Genet 26: 326-333.
    • (2010) Trends Genet , vol.26 , pp. 326-333
    • de la Fuente, A.1
  • 34
    • 34249931654 scopus 로고    scopus 로고
    • Transcriptional responses to fatty acid are coordinated by combinatorial control
    • Smith JJ, Ramsey SA, Marelli M, Marzolf B, Hwang D, et al. (2007) Transcriptional responses to fatty acid are coordinated by combinatorial control. Mol Syst Biol 3: 115.
    • (2007) Mol Syst Biol , vol.3 , pp. 115
    • Smith, J.J.1    Ramsey, S.A.2    Marelli, M.3    Marzolf, B.4    Hwang, D.5
  • 35
    • 34250173805 scopus 로고    scopus 로고
    • Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8
    • Sumi K, Tanaka T, Uchida A, Magoori K, Urashima Y, et al. (2007) Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8. Mol Cell Biol 27: 4248-4260.
    • (2007) Mol Cell Biol , vol.27 , pp. 4248-4260
    • Sumi, K.1    Tanaka, T.2    Uchida, A.3    Magoori, K.4    Urashima, Y.5
  • 36
    • 0036291635 scopus 로고    scopus 로고
    • Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription
    • Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, et al. (2002) Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription. Mol Cell Biol 22: 5114-5127.
    • (2002) Mol Cell Biol , vol.22 , pp. 5114-5127
    • Tan, N.S.1    Shaw, N.S.2    Vinckenbosch, N.3    Liu, P.4    Yasmin, R.5
  • 37
    • 33646806826 scopus 로고    scopus 로고
    • Lipotoxicity, overnutrition and energy metabolism in aging
    • Slawik M, Vidal-Puig AJ, (2006) Lipotoxicity, overnutrition and energy metabolism in aging. Ageing Res Rev 5: 144-164.
    • (2006) Ageing Res Rev , vol.5 , pp. 144-164
    • Slawik, M.1    Vidal-Puig, A.J.2
  • 38
    • 27144542809 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47
    • Amemiya-Kudo M, Oka J, Ide T, Matsuzaka T, Sone H, et al. (2005) Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47. J Biol Chem 280: 34577-34589.
    • (2005) J Biol Chem , vol.280 , pp. 34577-34589
    • Amemiya-Kudo, M.1    Oka, J.2    Ide, T.3    Matsuzaka, T.4    Sone, H.5
  • 39
    • 53349153430 scopus 로고    scopus 로고
    • Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease
    • Higuchi N, Kato M, Shundo Y, Tajiri H, Tanaka M, et al. (2008) Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res 38: 1122-1129.
    • (2008) Hepatol Res , vol.38 , pp. 1122-1129
    • Higuchi, N.1    Kato, M.2    Shundo, Y.3    Tajiri, H.4    Tanaka, M.5
  • 40
    • 48249123867 scopus 로고    scopus 로고
    • Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes
    • Reed BD, Charos AE, Szekely AM, Weissman SM, Snyder M, (2008) Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes. PLoS Genet 4: e1000133.
    • (2008) PLoS Genet , vol.4
    • Reed, B.D.1    Charos, A.E.2    Szekely, A.M.3    Weissman, S.M.4    Snyder, M.5
  • 41
    • 53049096061 scopus 로고    scopus 로고
    • Gene module level analysis: identification to networks and dynamics
    • Wang X, Dalkic E, Wu M, Chan C, (2008) Gene module level analysis: identification to networks and dynamics. Curr Opin Biotechnol 19: 482-491.
    • (2008) Curr Opin Biotechnol , vol.19 , pp. 482-491
    • Wang, X.1    Dalkic, E.2    Wu, M.3    Chan, C.4
  • 42
    • 26444467171 scopus 로고    scopus 로고
    • Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome
    • discussion 618-620
    • Mattar SG, Velcu LM, Rabinovitz M, Demetris AJ, Krasinskas AM, et al. (2005) Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome. Ann Surg 242: 610-617; discussion 618-620.
    • (2005) Ann Surg , vol.242 , pp. 610-617
    • Mattar, S.G.1    Velcu, L.M.2    Rabinovitz, M.3    Demetris, A.J.4    Krasinskas, A.M.5
  • 43
    • 38949123691 scopus 로고    scopus 로고
    • [Photosynthesis and active-oxygen-scavenging enzyme activities in rice varieties with different phosphorus efficiency under phosphorus stress]
    • Han SF, Deng RL, Xu HR, Cao YF, Wang XY, et al. (2007) [Photosynthesis and active-oxygen-scavenging enzyme activities in rice varieties with different phosphorus efficiency under phosphorus stress]. Ying Yong Sheng Tai Xue Bao 18: 2462-2467.
    • (2007) Ying Yong Sheng Tai Xue Bao , vol.18 , pp. 2462-2467
    • Han, S.F.1    Deng, R.L.2    Xu, H.R.3    Cao, Y.F.4    Wang, X.Y.5
  • 44
    • 4344680669 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells
    • Lorch JH, Klessner J, Park JK, Getsios S, Wu YL, et al. (2004) Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells. J Biol Chem 279: 37191-37200.
    • (2004) J Biol Chem , vol.279 , pp. 37191-37200
    • Lorch, J.H.1    Klessner, J.2    Park, J.K.3    Getsios, S.4    Wu, Y.L.5
  • 45
  • 46
    • 34250365241 scopus 로고    scopus 로고
    • Desmosomes: a role in cancer?
    • Chidgey M, Dawson C, (2007) Desmosomes: a role in cancer? Br J Cancer 96: 1783-1787.
    • (2007) Br J Cancer , vol.96 , pp. 1783-1787
    • Chidgey, M.1    Dawson, C.2
  • 47
    • 0036178690 scopus 로고    scopus 로고
    • Compound heterozygosity for non-sense and mis-sense mutations in desmoplakin underlies skin fragility/woolly hair syndrome
    • Whittock NV, Wan H, Morley SM, Garzon MC, Kristal L, et al. (2002) Compound heterozygosity for non-sense and mis-sense mutations in desmoplakin underlies skin fragility/woolly hair syndrome. J Invest Dermatol 118: 232-238.
    • (2002) J Invest Dermatol , vol.118 , pp. 232-238
    • Whittock, N.V.1    Wan, H.2    Morley, S.M.3    Garzon, M.C.4    Kristal, L.5
  • 48
    • 33748741625 scopus 로고    scopus 로고
    • Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy
    • Yang Z, Bowles NE, Scherer SE, Taylor MD, Kearney DL, et al. (2006) Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res 99: 646-655.
    • (2006) Circ Res , vol.99 , pp. 646-655
    • Yang, Z.1    Bowles, N.E.2    Scherer, S.E.3    Taylor, M.D.4    Kearney, D.L.5
  • 50
    • 33646558843 scopus 로고    scopus 로고
    • Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome
    • Uzumcu A, Norgett EE, Dindar A, Uyguner O, Nisli K, et al. (2006) Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome. J Med Genet 43: e5.
    • (2006) J Med Genet , vol.43
    • Uzumcu, A.1    Norgett, E.E.2    Dindar, A.3    Uyguner, O.4    Nisli, K.5
  • 51
    • 53549112749 scopus 로고    scopus 로고
    • Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?
    • Targher G, Marra F, Marchesini G, (2008) Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia 51: 1947-1953.
    • (2008) Diabetologia , vol.51 , pp. 1947-1953
    • Targher, G.1    Marra, F.2    Marchesini, G.3
  • 52
    • 77956266803 scopus 로고    scopus 로고
    • Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type 1 diabetes
    • Targher G, Bertolini L, Padovani R, Rodella S, Zoppini G, et al. (2010) Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type 1 diabetes. J Hepatol 53: 713-718.
    • (2010) J Hepatol , vol.53 , pp. 713-718
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4    Zoppini, G.5
  • 53
    • 67651173053 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease is associated with cardiovascular disease risk markers
    • Edens MA, Kuipers F, Stolk RP, (2009) Non-alcoholic fatty liver disease is associated with cardiovascular disease risk markers. Obes Rev 10: 412-419.
    • (2009) Obes Rev , vol.10 , pp. 412-419
    • Edens, M.A.1    Kuipers, F.2    Stolk, R.P.3
  • 54
    • 0032733910 scopus 로고    scopus 로고
    • Free PKC catalytic subunits (PKM) phosphorylate tau via a pathway distinct from that utilized by intact PKC
    • Ekinci FJ, Shea TB, (1999) Free PKC catalytic subunits (PKM) phosphorylate tau via a pathway distinct from that utilized by intact PKC. Brain Res 850: 207-216.
    • (1999) Brain Res , vol.850 , pp. 207-216
    • Ekinci, F.J.1    Shea, T.B.2
  • 56
    • 79954468679 scopus 로고    scopus 로고
    • The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKC{alpha} signaling
    • Hobbs RP, Amargo EV, Somasundaram A, Simpson CL, Prakriya M, et al. (2010) The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKC{alpha} signaling. FASEB J.
    • (2010) FASEB J
    • Hobbs, R.P.1    Amargo, E.V.2    Somasundaram, A.3    Simpson, C.L.4    Prakriya, M.5
  • 57
    • 44149127750 scopus 로고    scopus 로고
    • Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly
    • Bass-Zubek AE, Hobbs RP, Amargo EV, Garcia NJ, Hsieh SN, et al. (2008) Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly. J Cell Biol 181: 605-613.
    • (2008) J Cell Biol , vol.181 , pp. 605-613
    • Bass-Zubek, A.E.1    Hobbs, R.P.2    Amargo, E.V.3    Garcia, N.J.4    Hsieh, S.N.5
  • 58
    • 33745848407 scopus 로고    scopus 로고
    • Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy
    • Garcia-Gras E, Lombardi R, Giocondo MJ, Willerson JT, Schneider MD, et al. (2006) Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest 116: 2012-2021.
    • (2006) J Clin Invest , vol.116 , pp. 2012-2021
    • Garcia-Gras, E.1    Lombardi, R.2    Giocondo, M.J.3    Willerson, J.T.4    Schneider, M.D.5
  • 59
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis P, (2000) Wnt signaling and cancer. Genes Dev 14: 1837-1851.
    • (2000) Genes Dev , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 60
    • 77954036677 scopus 로고    scopus 로고
    • Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells
    • Abiola M, Favier M, Christodoulou-Vafeiadou E, Pichard AL, Martelly I, et al. (2009) Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells. PLoS One 4: e8509.
    • (2009) PLoS One , vol.4
    • Abiola, M.1    Favier, M.2    Christodoulou-Vafeiadou, E.3    Pichard, A.L.4    Martelly, I.5
  • 61
    • 77954851049 scopus 로고    scopus 로고
    • Wnt signaling regulates mitochondrial physiology and insulin sensitivity
    • Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, et al. (2010) Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev 24: 1507-1518.
    • (2010) Genes Dev , vol.24 , pp. 1507-1518
    • Yoon, J.C.1    Ng, A.2    Kim, B.H.3    Bianco, A.4    Xavier, R.J.5
  • 62
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, et al. (2004) Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40: 1387-1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3    Nuremberg, P.4    Horton, J.D.5
  • 64
    • 40849083460 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: the mist gradually clears
    • de Alwis NM, Day CP, (2008) Non-alcoholic fatty liver disease: the mist gradually clears. J Hepatol 48 (Suppl 1): S104-112.
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 1
    • de Alwis, N.M.1    Day, C.P.2
  • 65
    • 46649101669 scopus 로고    scopus 로고
    • Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake
    • Smith J, Su X, El-Maghrabi R, Stahl PD, Abumrad NA, (2008) Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake. J Biol Chem 283: 13578-13585.
    • (2008) J Biol Chem , vol.283 , pp. 13578-13585
    • Smith, J.1    Su, X.2    El-Maghrabi, R.3    Stahl, P.D.4    Abumrad, N.A.5
  • 66
    • 77956921023 scopus 로고    scopus 로고
    • The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways
    • Gao D, Nong S, Huang X, Lu Y, Zhao H, et al. (2010) The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. J Biol Chem 285: 29965-29973.
    • (2010) J Biol Chem , vol.285 , pp. 29965-29973
    • Gao, D.1    Nong, S.2    Huang, X.3    Lu, Y.4    Zhao, H.5
  • 70
    • 77955845426 scopus 로고    scopus 로고
    • Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription
    • Huang L, Yan M, Kirschke CP, (2010) Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription. Exp Cell Res.
    • (2010) Exp Cell Res
    • Huang, L.1    Yan, M.2    Kirschke, C.P.3
  • 71
    • 70349113136 scopus 로고    scopus 로고
    • Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants
    • Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, et al. (2009) Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes 58: 2070-2083.
    • (2009) Diabetes , vol.58 , pp. 2070-2083
    • Nicolson, T.J.1    Bellomo, E.A.2    Wijesekara, N.3    Loder, M.K.4    Baldwin, J.M.5
  • 72
    • 66249127252 scopus 로고    scopus 로고
    • SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress
    • Smidt K, Jessen N, Petersen AB, Larsen A, Magnusson N, et al. (2009) SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress. PLoS One 4: e5684.
    • (2009) PLoS One , vol.4
    • Smidt, K.1    Jessen, N.2    Petersen, A.B.3    Larsen, A.4    Magnusson, N.5
  • 73
    • 40849134067 scopus 로고    scopus 로고
    • ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells
    • Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M, (2008) ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells. Eur J Cell Biol 87: 197-209.
    • (2008) Eur J Cell Biol , vol.87 , pp. 197-209
    • Buffa, L.1    Fuchs, E.2    Pietropaolo, M.3    Barr, F.4    Solimena, M.5
  • 74
    • 70350589654 scopus 로고    scopus 로고
    • Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt
    • Anderson AA, Helmering J, Juan T, Li CM, McCormick J, et al. (2009) Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt. Pathogenetics 2: 1.
    • (2009) Pathogenetics , vol.2 , pp. 1
    • Anderson, A.A.1    Helmering, J.2    Juan, T.3    Li, C.M.4    McCormick, J.5
  • 75
    • 73249148728 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice
    • Prada PO, Ropelle ER, Mourao RH, de Souza CT, Pauli JR, et al. (2009) EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice. Diabetes 58: 2910-2919.
    • (2009) Diabetes , vol.58 , pp. 2910-2919
    • Prada, P.O.1    Ropelle, E.R.2    Mourao, R.H.3    de Souza, C.T.4    Pauli, J.R.5
  • 76
    • 6044260216 scopus 로고    scopus 로고
    • Insulin potentiates EGFR activation and signaling in fibroblasts
    • Chong MP, Barritt GJ, Crouch MF, (2004) Insulin potentiates EGFR activation and signaling in fibroblasts. Biochem Biophys Res Commun 322: 535-541.
    • (2004) Biochem Biophys Res Commun , vol.322 , pp. 535-541
    • Chong, M.P.1    Barritt, G.J.2    Crouch, M.F.3
  • 77
    • 2342483173 scopus 로고    scopus 로고
    • Differential expression of Homer family proteins in the developing mouse brain
    • Shiraishi Y, Mizutani A, Yuasa S, Mikoshiba K, Furuichi T, (2004) Differential expression of Homer family proteins in the developing mouse brain. J Comp Neurol 473: 582-599.
    • (2004) J Comp Neurol , vol.473 , pp. 582-599
    • Shiraishi, Y.1    Mizutani, A.2    Yuasa, S.3    Mikoshiba, K.4    Furuichi, T.5
  • 78
    • 0242353156 scopus 로고    scopus 로고
    • PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis
    • Rong R, Ahn JY, Huang H, Nagata E, Kalman D, et al. (2003) PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci 6: 1153-1161.
    • (2003) Nat Neurosci , vol.6 , pp. 1153-1161
    • Rong, R.1    Ahn, J.Y.2    Huang, H.3    Nagata, E.4    Kalman, D.5
  • 79
    • 0028915206 scopus 로고
    • Localization of short/branched chain acyl-CoA dehydrogenase (ACADSB) to human chromosome 10
    • Arden KC, Viars CS, Fu K, Rozen R, (1995) Localization of short/branched chain acyl-CoA dehydrogenase (ACADSB) to human chromosome 10. Genomics 25: 743-745.
    • (1995) Genomics , vol.25 , pp. 743-745
    • Arden, K.C.1    Viars, C.S.2    Fu, K.3    Rozen, R.4
  • 80
    • 30044448374 scopus 로고    scopus 로고
    • Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis
    • Ceddia RB, (2005) Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis. Int J Obes (Lond) 29: 1175-1183.
    • (2005) Int J Obes (Lond) , vol.29 , pp. 1175-1183
    • Ceddia, R.B.1
  • 81
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    • Kahn BB, Alquier T, Carling D, Hardie DG, (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1: 15-25.
    • (2005) Cell Metab , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 82
    • 0034823750 scopus 로고    scopus 로고
    • Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle
    • Dyck DJ, Steinberg G, Bonen A, (2001) Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle. Am J Physiol Endocrinol Metab 281: E600-607.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Dyck, D.J.1    Steinberg, G.2    Bonen, A.3
  • 83
    • 0015250464 scopus 로고
    • The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterification, lipogenesis and carbohydrate metabolism
    • Topping DL, Mayes PA, (1972) The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterification, lipogenesis and carbohydrate metabolism. Biochem J 126: 295-311.
    • (1972) Biochem J , vol.126 , pp. 295-311
    • Topping, D.L.1    Mayes, P.A.2
  • 84
    • 0002697987 scopus 로고    scopus 로고
    • Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake
    • Storz P, Doppler H, Wernig A, Pfizenmaier K, Muller G, (1999) Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake. Eur J Biochem 266: 17-25.
    • (1999) Eur J Biochem , vol.266 , pp. 17-25
    • Storz, P.1    Doppler, H.2    Wernig, A.3    Pfizenmaier, K.4    Muller, G.5


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