SLC30A3 responds to glucose- and zinc variations in β-cells and is critical for insulin production and in vivo glucose-metabolism during β-cell stress

PLoS ONE

Volumn 4, Issue 5, 2009, Pages

  Smidt, Kamille ^a   Jessen, Niels ^b   Petersen, Andreas Brønden ^a   Larsen, Agnete ^a   Magnusson, Nils ^a   Jeppesen, Johanne Bruun ^a   Stoltenberg, Meredin ^a   Culvenor, Janetta G ^c   Tsatsanis, Andrew ^d   Brock, Birgitte ^a   Schmitz, Ole ^a,b   Wogensen, Lise ^b   Bush, Ashley I ^c,d   Rungby, Jørgen ^a,b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; PROTEIN SLC30A3; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ZINC; ZINC TRANSPORTER; ZINC TRANSPORTER 3; ZINC TRANSPORTER 5; ZINC TRANSPORTER 8; CARRIER PROTEIN; CATION TRANSPORT PROTEIN; CHELATING AGENT; INSULIN; MEMBRANE PROTEIN; SLC30A3 PROTEIN, MOUSE; STREPTOZOCIN; ZINC TRANSPORTER ZNT8, MOUSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELLULAR STRESS RESPONSE; CHELATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSDUCTION; GLUCOSE METABOLISM; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; INSULIN SYNTHESIS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; STREPTOZOCIN DIABETES; WESTERN BLOTTING; ZINC METABOLISM; ANIMAL; BLOOD; CELL LINE; CYTOLOGY; DIET RESTRICTION; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; METABOLISM; MOUSE MUTANT; PHYSIOLOGICAL STRESS; SECRETION;

ANIMALIA; MUS;

ANIMALS; BLOOD GLUCOSE; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CELL DEATH; CELL LINE; CHELATING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FASTING; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; RATS; STREPTOZOCIN; STRESS, PHYSIOLOGICAL; ZINC;

EID: 66249127252     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005684     Document Type: Article

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