-
1
-
-
8144220730
-
Genetic engineering and molecular technology
-
Ed.: G. Krinke. Academic Press, London
-
Bolon, B., E. Galbreath, L. Sargent & J. Weiss: Genetic engineering and molecular technology. In: The laboratory rat. Ed.: G. Krinke. Academic Press, London, 2000, pp. 603-634.
-
(2000)
The Laboratory Rat
, pp. 603-634
-
-
Bolon, B.1
Galbreath, E.2
Sargent, L.3
Weiss, J.4
-
2
-
-
0036212445
-
Use of genetically engineered mice in drug discovery and development: Wielding Occam's razor to prune the product portfolio
-
Bolon, B. & E. J. Galbreath: Use of genetically engineered mice in drug discovery and development: Wielding Occam's razor to prune the product portfolio. Int. J. Toxicol. 2002, 21, 55-64.
-
(2002)
Int. J. Toxicol.
, vol.21
, pp. 55-64
-
-
Bolon, B.1
Galbreath, E.J.2
-
3
-
-
2542492032
-
The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing nerve dysfunction
-
Bolon, B., S. Jing, F. Asuncion, S. Scully, M. Pisegna, G. Van, Z. Hu, Y. B. Yu, H. Min, K. Wild, R. D. Rosenfeld, J. Tarpley, J. Carnahan, D. Duryea, D. Hill, S. Kaufman, X.-Q. Yan, T. Juan, K. Christensen, J. McCabe & W. S. Simonet: The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing nerve dysfunction. Toxicol. Pathol. 2004, 32, 275-294.
-
(2004)
Toxicol. Pathol.
, vol.32
, pp. 275-294
-
-
Bolon, B.1
Jing, S.2
Asuncion, F.3
Scully, S.4
Pisegna, M.5
Van, G.6
Hu, Z.7
Yu, Y.B.8
Min, H.9
Wild, K.10
Rosenfeld, R.D.11
Tarpley, J.12
Carnahan, J.13
Duryea, D.14
Hill, D.15
Kaufman, S.16
Yan, X.-Q.17
Juan, T.18
Christensen, K.19
McCabe, J.20
Simonet, W.S.21
more..
-
4
-
-
0036898425
-
Osteoprotegerin (OPG): An endogenous anti-osteoclast factor for protecting bone in rheumatoid arthritis
-
Bolon, B., V. Shalhoub, P. J. Kostenuik, G. Campagnuolo, S. Morony, W. J. Boyle, D. Zack & U. Feige: Osteoprotegerin (OPG): an endogenous anti-osteoclast factor for protecting bone in rheumatoid arthritis. Arthritis Rheum. 2002, 46, 3121-3135.
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 3121-3135
-
-
Bolon, B.1
Shalhoub, V.2
Kostenuik, P.J.3
Campagnuolo, G.4
Morony, S.5
Boyle, W.J.6
Zack, D.7
Feige, U.8
-
5
-
-
0031713845
-
Transgenic models to study the actions of cytokines in the central nervous system
-
Campbell, I. L., A. K. Stalder, Y. Akwa, A. Pagenstecher & V. C. Asensio: Transgenic models to study the actions of cytokines in the central nervous system. Neuroimmunomodulation 1998, 5, 126-135.
-
(1998)
Neuroimmunomodulation
, vol.5
, pp. 126-135
-
-
Campbell, I.L.1
Stalder, A.K.2
Akwa, Y.3
Pagenstecher, A.4
Asensio, V.C.5
-
6
-
-
0030197964
-
Transgenesis in rats: Technical aspects and models
-
Charreau, B., L. Tesson, J. P. Soulillou, C. Pourcel & I. Anegon: Transgenesis in rats: technical aspects and models. Transgenic Res. 1996, 5, 223-234.
-
(1996)
Transgenic Res.
, vol.5
, pp. 223-234
-
-
Charreau, B.1
Tesson, L.2
Soulillou, J.P.3
Pourcel, C.4
Anegon, I.5
-
7
-
-
0031977883
-
In vivo transgenic bioassays and assessment of the carcinogenic potential of pharmaceuticals
-
Contrera, J. F. & J. J. DeGeorge: In vivo transgenic bioassays and assessment of the carcinogenic potential of pharmaceuticals. Env. Health Perspect. 1998, 106, 71-80.
-
(1998)
Env. Health Perspect.
, vol.106
, pp. 71-80
-
-
Contrera, J.F.1
DeGeorge, J.J.2
-
8
-
-
0024443942
-
Transgenic mice as future tools in risk assessment
-
Cordaro, C. J.: Transgenic mice as future tools in risk assessment. Risk Analysis 1989, 9, 157-168.
-
(1989)
Risk Analysis
, vol.9
, pp. 157-168
-
-
Cordaro, C.J.1
-
9
-
-
0034613927
-
Differential mutation of transgenic and endogenous loci in vivo
-
Cosentino, L. & J. A. Heddle: Differential mutation of transgenic and endogenous loci in vivo. Mut. Res. 2000, 454, 1-10.
-
(2000)
Mut. Res.
, vol.454
, pp. 1-10
-
-
Cosentino, L.1
Heddle, J.A.2
-
10
-
-
0029922452
-
Age dependent selection against HPRT-deficient T lymphocytes in the HPRT+/- heterozygous mouse
-
Deubel, W., I. Bassukas, W. Schlereth, R. Lorenz & K. Hempel: Age dependent selection against HPRT-deficient T lymphocytes in the HPRT+/- heterozygous mouse. Mut. Res. 1996, 351, 67-77.
-
(1996)
Mut. Res.
, vol.351
, pp. 67-77
-
-
Deubel, W.1
Bassukas, I.2
Schlereth, W.3
Lorenz, R.4
Hempel, K.5
-
11
-
-
0032939061
-
Interpretation of phenotype in genetically engineered mice
-
Doetschman, T.: Interpretation of phenotype in genetically engineered mice. Lab. Animal Sci. 1999, 49, 137-143.
-
(1999)
Lab. Animal Sci.
, vol.49
, pp. 137-143
-
-
Doetschman, T.1
-
12
-
-
10744225196
-
Tg.Ac genetically altered mouse: Assay working group overview of available data
-
Eastin, W. C., J. H. Mennear, R. W. Tennant, R. E. Stoll, D. G. Branstetter, J. R. Bucher, B. McCullough, R. L. Binder, J. W. Spalding & J. F. Mahler: Tg.Ac genetically altered mouse: Assay working group overview of available data. Toxicol. Pathol. 2001, 29 (Suppl.), 60-80.
-
(2001)
Toxicol. Pathol.
, vol.29
, Issue.SUPPL.
, pp. 60-80
-
-
Eastin, W.C.1
Mennear, J.H.2
Tennant, R.W.3
Stoll, R.E.4
Branstetter, D.G.5
Bucher, J.R.6
McCullough, B.7
Binder, R.L.8
Spalding, J.W.9
Mahler, J.F.10
-
13
-
-
0034751175
-
The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens
-
French, J., R. D. Storer & L. A. Donehower: The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens. Toxicol. Pathol. 2001, 29 (Suppl.), 24-29.
-
(2001)
Toxicol. Pathol.
, vol.29
, Issue.SUPPL.
, pp. 24-29
-
-
French, J.1
Storer, R.D.2
Donehower, L.A.3
-
14
-
-
0032102885
-
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 2
-
Friedberg, E. C., L. B. Meira & D. L. Cheo: Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 2. Mut. Res. 1998, 407, 217-226.
-
(1998)
Mut. Res.
, vol.407
, pp. 217-226
-
-
Friedberg, E.C.1
Meira, L.B.2
Cheo, D.L.3
-
15
-
-
0033969701
-
The broken mouse: The role of development, plasticity and environment in the interpretation of phenotypic changes in knockout mice
-
Gingrich, J. A. & R. Hen: The broken mouse: the role of development, plasticity and environment in the interpretation of phenotypic changes in knockout mice. Curr. Opin. Neurobiol. 2000, 10, 146-152.
-
(2000)
Curr. Opin. Neurobiol.
, vol.10
, pp. 146-152
-
-
Gingrich, J.A.1
Hen, R.2
-
16
-
-
0031992613
-
Neuropathologic findings associated with seizures in FVB mice
-
Goelz, M. F., J. Mahler, J. Harry, P. Myers, J. Clark, J. E. Thigpen & D. B. Forsythe: Neuropathologic findings associated with seizures in FVB mice. Lab. Animal Sci. 1998, 48, 34-37.
-
(1998)
Lab. Animal Sci.
, vol.48
, pp. 34-37
-
-
Goelz, M.F.1
Mahler, J.2
Harry, J.3
Myers, P.4
Clark, J.5
Thigpen, J.E.6
Forsythe, D.B.7
-
17
-
-
0028295634
-
Transgenic animals in toxicology
-
Goldsworthy, T. L., L. Recio, K. Brown, L. A. Donehower, J. C. Mirsalis, R. W. Tennant & I. F. H. Purchase: Transgenic animals in toxicology. Fundam. Appl. Toxicol. 1994, 22, 8-19.
-
(1994)
Fundam. Appl. Toxicol.
, vol.22
, pp. 8-19
-
-
Goldsworthy, T.L.1
Recio, L.2
Brown, K.3
Donehower, L.A.4
Mirsalis, J.C.5
Tennant, R.W.6
Purchase, I.F.H.7
-
18
-
-
0035977838
-
The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis
-
Gonzalez, F. J.: The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis. Toxicol. Lett. 2001, 120, 199-208.
-
(2001)
Toxicol. Lett.
, vol.120
, pp. 199-208
-
-
Gonzalez, F.J.1
-
19
-
-
0030483288
-
The role of the aryl hydrocarbon receptor in animal development, physiological homeostasis and toxicity of TCDD
-
Gonzalez, F. J., P. Fernandez-Salguero & J. M. Ward: The role of the aryl hydrocarbon receptor in animal development, physiological homeostasis and toxicity of TCDD. J. Toxicol. Sci. 1996, 21, 273-277.
-
(1996)
J. Toxicol. Sci.
, vol.21
, pp. 273-277
-
-
Gonzalez, F.J.1
Fernandez-Salguero, P.2
Ward, J.M.3
-
20
-
-
8144220898
-
Validation issues for the use of transgenic mouse mutation assays in risk assessment
-
Gorelick, N. J., J. A. O'Kelly, V. E. Walker, J. G. DeBoer & B. W. Glickman: Validation issues for the use of transgenic mouse mutation assays in risk assessment. Toxicol. Pathol. 1995, 23, 823-824.
-
(1995)
Toxicol. Pathol.
, vol.23
, pp. 823-824
-
-
Gorelick, N.J.1
O'Kelly, J.A.2
Walker, V.E.3
DeBoer, J.G.4
Glickman, B.W.5
-
21
-
-
20244384686
-
Use of transgenic animals for carcinogenicity testing: Considerations and implications for risk assessment
-
Gulezian, D., D. Jacobson-Kram, C. B. McCullough, H. Olson, L. Redo, D. Robinson, R. Storer, R. Tennant, J. M. Ward & D. A. Neumann: Use of transgenic animals for carcinogenicity testing: Considerations and implications for risk assessment. Toxicol. Pathol. 2000, 28, 482-499.
-
(2000)
Toxicol. Pathol.
, vol.28
, pp. 482-499
-
-
Gulezian, D.1
Jacobson-Kram, D.2
McCullough, C.B.3
Olson, H.4
Redo, L.5
Robinson, D.6
Storer, R.7
Tennant, R.8
Ward, J.M.9
Neumann, D.A.10
-
23
-
-
0029695833
-
Estrogen receptor gene disruption: Molecular characterization and experimental and clinical phenotypes
-
discussion, 186-188
-
Korach, K. S., J. F. Couse, S. W. Curtis, T. F. Washburn, J. Lindzey, K. S. Kimbro, E. M. Eddy, S. Migliaccio, S. M. Snedeker, D. B. Lubahn, D. W. Schomberg & E. P. Smith: Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes. Recent Progr. Harm. Res. 1996, 51, 159-186 [discussion, 186-188].
-
(1996)
Recent Progr. Harm. Res.
, vol.51
, pp. 159-186
-
-
Korach, K.S.1
Couse, J.F.2
Curtis, S.W.3
Washburn, T.F.4
Lindzey, J.5
Kimbro, K.S.6
Eddy, E.M.7
Migliaccio, S.8
Snedeker, S.M.9
Lubahn, D.B.10
Schomberg, D.W.11
Smith, E.P.12
-
24
-
-
0028997684
-
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
-
Lee, S. S., T. Pineau, J. Drago, E. J. Lee, J. W. Owens, D. L. Kroetz, P. M. Fernandez Salgeuro, H. Westphal & F. J. Gonzalez: Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 1995, 15, 3102-3022.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 3102-3022
-
-
Lee, S.S.1
Pineau, T.2
Drago, J.3
Lee, E.J.4
Owens, J.W.5
Kroetz, D.L.6
Fernandez Salgeuro, P.M.7
Westphal, H.8
Gonzalez, F.J.9
-
25
-
-
0029867020
-
-/-) null mutant mice develop normally but show deficient drug metabolism
-
-/-) null mutant mice develop normally but show deficient drug metabolism. Proc. Nat. Acad. Sci. USA 1996, 93, 1671-1676.
-
(1996)
Proc. Nat. Acad. Sci. USA
, vol.93
, pp. 1671-1676
-
-
Liang, H.C.1
Li, H.2
McKinnon, R.A.3
Duffy, J.J.4
Potter, S.S.5
Puga, A.6
Nebert, D.W.7
-
26
-
-
0026671764
-
Transgenic animals in the evaluation of compound efficacy and toxicity: Will they be as useful as they are novel?
-
Liggitt, H. D. & G. M. Reddington: Transgenic animals in the evaluation of compound efficacy and toxicity: will they be as useful as they are novel? Xenobiotica 1992, 22, 1043-1054.
-
(1992)
Xenobiotica
, vol.22
, pp. 1043-1054
-
-
Liggitt, H.D.1
Reddington, G.M.2
-
27
-
-
0035348633
-
The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases
-
Linder, C. C.: The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases. Lab. Animal. 2001, 30, 34-39.
-
(2001)
Lab. Animal.
, vol.30
, pp. 34-39
-
-
Linder, C.C.1
-
28
-
-
0026378593
-
Tests of genetic allelism between four inbred mouse strains with absent corpus callosum
-
Livy, D. J. & D. Wahlsten: Tests of genetic allelism between four inbred mouse strains with absent corpus callosum. J. Heredity 1991, 82, 459-464.
-
(1991)
J. Heredity
, vol.82
, pp. 459-464
-
-
Livy, D.J.1
Wahlsten, D.2
-
29
-
-
0042334543
-
BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time
-
Luo, Y., B. Bolon, M. A. Damore, D. Fitzpatrick, H. T. Liu, J. H. Zhang, Q. Yan, R. Vassar & M. Citron: BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time. Neurobiol. Disease 2003, 14, 81-88.
-
(2003)
Neurobiol. Disease
, vol.14
, pp. 81-88
-
-
Luo, Y.1
Bolon, B.2
Damore, M.A.3
Fitzpatrick, D.4
Liu, H.T.5
Zhang, J.H.6
Yan, Q.7
Vassar, R.8
Citron, M.9
-
30
-
-
0035116273
-
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation
-
Luo, Y., B. Bolon, S. Kahn, B. D. Bennett, S. Babu-Khan, P. Denis, W. Fan, H. Kha, J. Zhang, Y. Gong, L. Martin, J.-C. Louis, Q. Yan, W. G. Richards, M. Citron & R. Vassar: Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation. Nature Neurosci. 2001, 4, 213-232.
-
(2001)
Nature Neurosci.
, vol.4
, pp. 213-232
-
-
Luo, Y.1
Bolon, B.2
Kahn, S.3
Bennett, B.D.4
Babu-Khan, S.5
Denis, P.6
Fan, W.7
Kha, H.8
Zhang, J.9
Gong, Y.10
Martin, L.11
Louis, J.-C.12
Yan, Q.13
Richards, W.G.14
Citron, M.15
Vassar, R.16
-
31
-
-
0030463716
-
Spontaneous lesions in aging FVB/N mice
-
Mahler, J. F., W. Stokes, P. C. Mann, M. Takaoka & R. R. Maronpot: Spontaneous lesions in aging FVB/N mice. Toxicol. Pathol. 1996, 24, 710-716.
-
(1996)
Toxicol. Pathol.
, vol.24
, pp. 710-716
-
-
Mahler, J.F.1
Stokes, W.2
Mann, P.C.3
Takaoka, M.4
Maronpot, R.R.5
-
32
-
-
0034085671
-
The use of genetically modified animals in carcinogenicity bioassays
-
Maronpot, R. R.: The use of genetically modified animals in carcinogenicity bioassays. Toxicol. Pathol. 2000, 28, 450-453.
-
(2000)
Toxicol. Pathol.
, vol.28
, pp. 450-453
-
-
Maronpot, R.R.1
-
34
-
-
0033711707
-
"Gene-swap knock-in" cassette in mice to study allelic differences in human genes
-
Nebert, D. W., T. P. Dalton, G. W. Stuart & M. J. Carvan 3rd: "Gene-swap knock-in" cassette in mice to study allelic differences in human genes. Ann. NY Acad. Sci. 2000, 919, 148-170.
-
(2000)
Ann. NY Acad. Sci.
, vol.919
, pp. 148-170
-
-
Nebert, D.W.1
Dalton, T.P.2
Stuart, G.W.3
Carvan III, M.J.4
-
35
-
-
0031054440
-
How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress
-
Nebert, D. W. & J. J. Duffy: How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress. Biochem. Pharmacol. 1997, 53, 249-254.
-
(1997)
Biochem. Pharmacol.
, vol.53
, pp. 249-254
-
-
Nebert, D.W.1
Duffy, J.J.2
-
36
-
-
0031717427
-
Transgenic mice in drug dependence research
-
Pich, E. M. & M. P. Epping-Jordan: Transgenic mice in drug dependence research. Ann. Med. 1998, 30, 390-396.
-
(1998)
Ann. Med.
, vol.30
, pp. 390-396
-
-
Pich, E.M.1
Epping-Jordan, M.P.2
-
37
-
-
0029071846
-
Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 CYP1A2
-
Pineau, T., P. Fernandez Salgeuro, S. S. T. Lee, T. McPhail, J. M. Ward & F. J. Gonzalez: Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 CYP1A2. Proc. Nat. Acad. Sci. USA 1995, 92, 5134-5138.
-
(1995)
Proc. Nat. Acad. Sci. USA
, vol.92
, pp. 5134-5138
-
-
Pineau, T.1
Fernandez Salgeuro, P.2
Lee, S.S.T.3
McPhail, T.4
Ward, J.M.5
Gonzalez, F.J.6
-
38
-
-
0033172826
-
Characterization of drug specificity by pharmacokinetic analysis in gene knockout mice
-
Piwnica-Worms, D. & M. Marmion: Characterization of drug specificity by pharmacokinetic analysis in gene knockout mice. J. Clin. Pharmacol. 1999, Suppl., 30S-33S.
-
(1999)
J. Clin. Pharmacol.
, Issue.SUPPL.
-
-
Piwnica-Worms, D.1
Marmion, M.2
-
39
-
-
0027288339
-
Transgenic systems for in vivo mutation analysis
-
Provost, G. S., P. L. Kretz, R. T. Hamner, C. D. Matthews, B. J. Rogers, K. S. Lundberg, M. J. Dycaico & J. M. Short: Transgenic systems for in vivo mutation analysis. Mut. Res. 1993, 288, 133-149.
-
(1993)
Mut. Res.
, vol.288
, pp. 133-149
-
-
Provost, G.S.1
Kretz, P.L.2
Hamner, R.T.3
Matthews, C.D.4
Rogers, B.J.5
Lundberg, K.S.6
Dycaico, M.J.7
Short, J.M.8
-
40
-
-
0345517953
-
Genetically modified animals in pharmacological research: Future trends
-
Rudolph, U. & H. Moehler: Genetically modified animals in pharmacological research: future trends. Eur. J. Pharmacol. 1999, 375, 327-337.
-
(1999)
Eur. J. Pharmacol.
, vol.375
, pp. 327-337
-
-
Rudolph, U.1
Moehler, H.2
-
41
-
-
0030887195
-
Impact of knockout mice in toxicology
-
Ryffel, B.: Impact of knockout mice in toxicology. Crit. Rev. Toxicol. 1997, 27, 135-154.
-
(1997)
Crit. Rev. Toxicol.
, vol.27
, pp. 135-154
-
-
Ryffel, B.1
-
42
-
-
2642625666
-
Temporally and spatially regulated somatic mutagenesis in mice
-
Schwenk, F., R. Kühn, P. O. Angrand, K. Rajewsky & A. F. Stewart: Temporally and spatially regulated somatic mutagenesis in mice. Nucleic Acids Res. 1998, 26, 1427-1432.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 1427-1432
-
-
Schwenk, F.1
Kühn, R.2
Angrand, P.O.3
Rajewsky, K.4
Stewart, A.F.5
-
43
-
-
8144222638
-
Mutant mouse resources
-
Eds.: J. M. Ward, J. F. Mahler, R. R. Maronpot, J. P. Sundberg and R. M. Frederickson. Iowa State University Press, Ames, IA
-
Sharp, J. J., L. E. Mobraaten & H. G. Bedigian: Mutant mouse resources. In: Pathology of genetically engineered mice. Eds.: J. M. Ward, J. F. Mahler, R. R. Maronpot, J. P. Sundberg and R. M. Frederickson. Iowa State University Press, Ames, IA, 2000, pp. 3-9.
-
(2000)
Pathology of Genetically Engineered Mice
, pp. 3-9
-
-
Sharp, J.J.1
Mobraaten, L.E.2
Bedigian, H.G.3
-
44
-
-
0031906231
-
Gene disruption in mice: Models of development and disease
-
Shastry, B. S.: Gene disruption in mice: Models of development and disease. Mol. Cell. Biochem. 1998, 181, 163-179.
-
(1998)
Mol. Cell. Biochem.
, vol.181
, pp. 163-179
-
-
Shastry, B.S.1
-
45
-
-
0030902872
-
Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice
-
Simpson, E. M., C. C. Linder, E. E. Sargent, M. T. Davisson, L. E. Mobraaten & J. J. Sharp: Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nature Gen. 1997, 16, 19-27.
-
(1997)
Nature Gen.
, vol.16
, pp. 19-27
-
-
Simpson, E.M.1
Linder, C.C.2
Sargent, E.E.3
Davisson, M.T.4
Mobraaten, L.E.5
Sharp, J.J.6
-
46
-
-
17944374237
-
p53 +/- hemizygous knockout mouse: Overview of available data
-
Storer, R. D., J. E. French, J. Haseman, G. Hajian, E. K. LeGrand, G. G. Long, L. A. Mixson, R. Ochoa, J. E. Sagartz & K. A. Soper: p53 +/- hemizygous knockout mouse: Overview of available data. Toxicol. Pathol. 2001, 29 (Suppl.), 30-50.
-
(2001)
Toxicol. Pathol.
, vol.29
, Issue.SUPPL.
, pp. 30-50
-
-
Storer, R.D.1
French, J.E.2
Haseman, J.3
Hajian, G.4
LeGrand, E.K.5
Long, G.G.6
Mixson, L.A.7
Ochoa, R.8
Sagartz, J.E.9
Soper, K.A.10
-
47
-
-
0024434991
-
Activated oncogenes in human tumors
-
Suarez, H. G.: Activated oncogenes in human tumors. Anticancer Res. 1989, 9, 1331-1343.
-
(1989)
Anticancer Res.
, vol.9
, pp. 1331-1343
-
-
Suarez, H.G.1
-
48
-
-
0028198725
-
Initial experiences and future directions for transgenic mouse mutation assays
-
Suzuki, T., M. Hayashi & T. Sofuni: Initial experiences and future directions for transgenic mouse mutation assays. Mut. Res. 1994, 307, 489-494.
-
(1994)
Mut. Res.
, vol.307
, pp. 489-494
-
-
Suzuki, T.1
Hayashi, M.2
Sofuni, T.3
-
49
-
-
0034751732
-
The rasH2 transgenic mouse: Nature of the model and mechanistic studies on tumorigenesis
-
Tamaoki, N.: The rasH2 transgenic mouse: Nature of the model and mechanistic studies on tumorigenesis. Toxicol. Pathol. 2001, 29 (Suppl.), 81-89.
-
(2001)
Toxicol. Pathol.
, vol.29
, Issue.SUPPL.
, pp. 81-89
-
-
Tamaoki, N.1
-
50
-
-
0028892461
-
Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models
-
Tennant, R. W., J. E. French & J. W. Spalding: Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models. Env. Health Perspect. 1995, 103, 942-950.
-
(1995)
Env. Health Perspect.
, vol.103
, pp. 942-950
-
-
Tennant, R.W.1
French, J.E.2
Spalding, J.W.3
-
51
-
-
0034749117
-
The Tg.Ac (v-Ha-ras) transgenic mouse: Nature of the model
-
Tennant, R. W., S. Stasiewicz, W. C. Eastin, J. H. Mennear & J. W. Spalding: The Tg.Ac (v-Ha-ras) transgenic mouse: nature of the model. Toxicol. Pathol. 2001, 29 (Suppl.), 51-59.
-
(2001)
Toxicol. Pathol.
, vol.29
, Issue.SUPPL.
, pp. 51-59
-
-
Tennant, R.W.1
Stasiewicz, S.2
Eastin, W.C.3
Mennear, J.H.4
Spalding, J.W.5
-
52
-
-
0034752066
-
CB6F1-rasH2 mouse: Overview of available data
-
Usui, T., M. Mutai, S. Hisada, M. Takoaka, K. A. Soper, B. McCullough & C. Alden: CB6F1-rasH2 mouse: Overview of available data. Toxicol. Pathol. 2001, 29 (Suppl.), 90-108.
-
(2001)
Toxicol. Pathol.
, vol.29
, Issue.SUPPL.
, pp. 90-108
-
-
Usui, T.1
Mutai, M.2
Hisada, S.3
Takoaka, M.4
Soper, K.A.5
McCullough, B.6
Alden, C.7
-
53
-
-
0030296583
-
Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression
-
Valentine, J. L., S. S. Lee, M. J. Seaton, B. Asgharian, G. Farris, J. C. Corton, F. J. Gonzalez & M. A. Medinsky: Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol. Appl. Pharmacol. 1996, 141, 205-213.
-
(1996)
Toxicol. Appl. Pharmacol.
, vol.141
, pp. 205-213
-
-
Valentine, J.L.1
Lee, S.S.2
Seaton, M.J.3
Asgharian, B.4
Farris, G.5
Corton, J.C.6
Gonzalez, F.J.7
Medinsky, M.A.8
-
54
-
-
0034749932
-
+/- knockout mice: Overview of available data
-
+/- knockout mice: Overview of available data. Toxicol. Pathol. 2001, 29 (Suppl.), 117-127.
-
(2001)
Toxicol. Pathol.
, vol.29
, Issue.SUPPL.
, pp. 117-127
-
-
Van Kreijl, C.F.1
McAnulty, P.A.2
Beems, R.B.3
Vynckier, A.4
Van Steeg, H.5
Fransson-Steen, R.6
Alden, C.L.7
Forster, R.8
Van Der Laan, J.-W.9
Vandenberghe, J.10
-
55
-
-
0032212152
-
Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice
-
Van Sloun, P. P., S. W. Wijnhoven, H. J. Kool, R. Slater, G. Weeda, A. A. van Zeeland, P. H. Lohman & H. Vrieling: Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice. Nucleic Acids Res. 1998, 26, 4888-4894.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 4888-4894
-
-
Van Sloun, P.P.1
Wijnhoven, S.W.2
Kool, H.J.3
Slater, R.4
Weeda, G.5
Van Zeeland, A.A.6
Lohman, P.H.7
Vrieling, H.8
-
56
-
-
0034749118
-
DNA repair-deficient Xpa and Xpa/ p53+/- knock-out mice: Nature of the models
-
van Steeg, H., A. de Vries, C. T. van Oostrom, J. van Benthem, R. B. Beems & C. F. van Kreijl: DNA repair-deficient Xpa and Xpa/ p53+/- knock-out mice: nature of the models. Toxicol. Pathol. 2001, 29 (Suppl), 109-116.
-
(2001)
Toxicol. Pathol.
, vol.29
, Issue.SUPPL.
, pp. 109-116
-
-
Van Steeg, H.1
De Vries, A.2
Van Oostrom, C.T.3
Van Benthem, J.4
Beems, R.B.5
Van Kreijl, C.F.6
-
57
-
-
0033623415
-
Aβ-generating enzymes: Recent advances in β- and γ-secretase research
-
Vassar, R. & M. Citron: Aβ-generating enzymes: recent advances in β- and γ-secretase research. Neuron 2000, 27, 419-422.
-
(2000)
Neuron
, vol.27
, pp. 419-422
-
-
Vassar, R.1
Citron, M.2
-
58
-
-
0032699143
-
Detection of cyclophosphamide-induced mutations at the Hprt but not the lacI locus in splenic lymphocytes of exposed mice
-
Walker, V. E., J. L. Andrews, P. B. Upton, T. R. Skopek, J. G. deBoer, D. M. Walker, X. Shi, H. E. Sussman & N. J. Gorelick: Detection of cyclophosphamide-induced mutations at the Hprt but not the lacI locus in splenic lymphocytes of exposed mice. Environ. Mol. Mutagen. 1999, 34, 167-181.
-
(1999)
Environ. Mol. Mutagen.
, vol.34
, pp. 167-181
-
-
Walker, V.E.1
Andrews, J.L.2
Upton, P.B.3
Skopek, T.R.4
DeBoer, J.G.5
Walker, D.M.6
Shi, X.7
Sussman, H.E.8
Gorelick, N.J.9
-
59
-
-
0037255214
-
Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge base
-
Waters, M., G. Doorman, P. Bushel, M. Cunningham, R. Irwin, A. Merrick, K. Olden, R. Paules, J. Selkirk, S. Stasiewicz, B. Weis, B. Van Houten, N. Walker & R. Tennant: Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge base. Env. Health Perspect. Toxicogen. 2003, 111, 15-28.
-
(2003)
Env. Health Perspect. Toxicogen.
, vol.111
, pp. 15-28
-
-
Waters, M.1
Doorman, G.2
Bushel, P.3
Cunningham, M.4
Irwin, R.5
Merrick, A.6
Olden, K.7
Paules, R.8
Selkirk, J.9
Stasiewicz, S.10
Weis, B.11
Van Houten, B.12
Walker, N.13
Tennant, R.14
-
60
-
-
0031821919
-
An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. I. Evidence for a confounding nonresponder phenotype
-
Weaver, J. L., J. F. Contrera, B. A. Rosenzweig, K. L. Thompson, P. J. Faustino, J. M. Strong, C. D. Ellison, L. W. Anderson, H. R. Prasanna, P. E. Long-Bradley, K. K. Lin, J. Zhang & F. D. Sistare: An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. I. Evidence for a confounding nonresponder phenotype. Toxicol. Pathol. 1998, 26, 532-540.
-
(1998)
Toxicol. Pathol.
, vol.26
, pp. 532-540
-
-
Weaver, J.L.1
Contrera, J.F.2
Rosenzweig, B.A.3
Thompson, K.L.4
Faustino, P.J.5
Strong, J.M.6
Ellison, C.D.7
Anderson, L.W.8
Prasanna, H.R.9
Long-Bradley, P.E.10
Lin, K.K.11
Zhang, J.12
Sistare, F.D.13
-
61
-
-
0030915848
-
Transgenic animals as new approaches in pharmacological studies
-
Wei, L.-N.: Transgenic animals as new approaches in pharmacological studies. Ann. Rev. Pharmacol. Toxicol. 1997, 37, 119-141.
-
(1997)
Ann. Rev. Pharmacol. Toxicol.
, vol.37
, pp. 119-141
-
-
Wei, L.-N.1
-
62
-
-
0032506032
-
Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse
-
Wijnhoven, S. W., P. P. Van Sloun, H. J. Kool, G. Weeda, R. Slater, P. H. Lohman, A. A. van Zeeland & H. Vrieling: Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse. Proc. Nat. Acad. Sci. USA 1998, 95, 13759-13764.
-
(1998)
Proc. Nat. Acad. Sci. USA
, vol.95
, pp. 13759-13764
-
-
Wijnhoven, S.W.1
Van Sloun, P.P.2
Kool, H.J.3
Weeda, G.4
Slater, R.5
Lohman, P.H.6
Van Zeeland, A.A.7
Vrieling, H.8
-
63
-
-
0242331212
-
Transgenic and knockout mice for DNA repair functions in carcinogenesis and mutagenesis
-
Wijnhoven, S. W. & H. van Steeg: Transgenic and knockout mice for DNA repair functions in carcinogenesis and mutagenesis. Toxicology 2003, 193, 171-187.
-
(2003)
Toxicology
, vol.193
, pp. 171-187
-
-
Wijnhoven, S.W.1
Van Steeg, H.2
-
64
-
-
0031835013
-
Use of trangenic animals in understanding molecular mechanisms of toxicity
-
Wolf, C. R. & C. J. Henderson: Use of trangenic animals in understanding molecular mechanisms of toxicity. J. Pharm. Pharmacol. 1998, 50, 567-574.
-
(1998)
J. Pharm. Pharmacol.
, vol.50
, pp. 567-574
-
-
Wolf, C.R.1
Henderson, C.J.2
-
65
-
-
0034721159
-
Humanized xenobiotic response in mice expressing nuclear receptor SXR
-
Xie, W., J. L. Barwick, M. Dowries, B. Blumberg, C. M. Simon, M. C. Nelson, B. A. Neuschwander-Tetri, E. M. Brunt, P. S. Guzelian & R. M. Evans: Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 2000, 406, 435-439.
-
(2000)
Nature
, vol.406
, pp. 435-439
-
-
Xie, W.1
Barwick, J.L.2
Dowries, M.3
Blumberg, B.4
Simon, C.M.5
Nelson, M.C.6
Neuschwander-Tetri, B.A.7
Brunt, E.M.8
Guzelian, P.S.9
Evans, R.M.10
-
66
-
-
0037267313
-
Knockouts model the 100 best-selling drugs - Will they model the next 100?
-
Zambrowicz, B. P. & A. T. Sands: Knockouts model the 100 best-selling drugs - will they model the next 100? Nature Rev. Drug Discovery 2003, 2, 38-51.
-
(2003)
Nature Rev. Drug Discovery
, vol.2
, pp. 38-51
-
-
Zambrowicz, B.P.1
Sands, A.T.2
-
67
-
-
0029133857
-
Factors affecting somatic mutation frequencies in vivo
-
Zhang, X. B., C. Urlando, K. S. Tao & J. A. Heddle: Factors affecting somatic mutation frequencies in vivo. Mut. Res. 1995, 338, 189-201.
-
(1995)
Mut. Res.
, vol.338
, pp. 189-201
-
-
Zhang, X.B.1
Urlando, C.2
Tao, K.S.3
Heddle, J.A.4
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