Differential mutation of transgenic and endogenous loci in vivo

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 454, Issue 1-2, 2000, Pages 1-10

  Cosentino, Lidia ^a   Heddle, John A ^a  

^a YORK UNIVERSITY   (Canada)

Author keywords

Dlb 1; DNA repair; hprt; lacZ; Somatic mutation

Indexed keywords

BENZO[A]PYRENE; DNA; ETHYLNITROSOUREA;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; DNA REPAIR; GENE LOCUS; GENE MUTATION; LONG TERM EXPOSURE; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; SOMATIC MUTATION; TRANSGENE; TRANSGENIC MOUSE;

ANIMAL; BACTERIAL PROTEINS; BENZO(A)PYRENE; CHROMOSOME MAPPING; ETHYLNITROSOUREA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LAC OPERON; MICE; MICE, TRANSGENIC; MUTATION; REPRESSOR PROTEINS; SUPPORT, NON-U.S. GOV'T;

EID: 0034613927     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(00)00125-1     Document Type: Article

References (23)

1. Cosentino L., Heddle J.A. A test for neutrality of mutations of the lacZ transgene. Environ. Mol. Mutagen. 28:1996;313-316.
2. Tao K.S., Urlando C., Heddle J.A. Comparison of somatic mutation in a transgenic versus host locus. Proc. Natl. Acad. Sci. U.S.A. 90:1993;10681-10685.
3. Douglas G.R., Jiao J., Gingerich L.M., Soper J.A., Gossen J.A. Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice. Environ. Mol. Mutagen. 28:1996;317-324.
4. Skopek T.R., Kort K.L., Marino D.R. Relative sensitivity of the endogenous hprt gene and the lacI transgene in ENU-treated Big Blue B6C3F1 mice. Environ. Mol. Mutagen. 26:1995;9-15.
5. L. Cosentino, J.A. Heddle, A comparison of the effects of diverse mutagens at the lacZ and Dlb-1 loci in vivo, Mutagenenesis 14, 113-119.
6. Shaver-Walker P.M., Urlando C., Tao K.S., Zhang X.B., Heddle J.A. Enhanced somatic mutation-rates induced in stem-cells of mice by low chronic exposure to ethylnitrosourea. Proc. Natl. Acad. Sci. U.S.A. 92:1995;11470-11474.
7. Chiu S., Oleinick N., Friedman L., Stambrook P.J. Hypersensitivity of DNA in transcriptionally active chromatin to ionizing radiation. Biochem. Biophys. Acta. 699:1982;15-21.
8. Oleinick N., Chiu S., Friedman L. Gamma radiation as a probe of chromatin structure: damage to and repair of active chromatin in the metaphase chromosome. Radiat. Res. 3:1984;629-641.
9. Boulikas T. Evolutionary consequences of nonrandom damage and repair of chromatin domains. J. Evol. 2:1992;156-180.
10. Lopez-Larraza D., Bianchi N. DNA response to bleomycin in mammalian cells with variable degrees of chromatin condensation. Environ. Mol. Mutagen. 21:1993;258-264.
11. Bohr V.A., Smith C.A., Okumoto D.S., Hanawalt P.C. DNA repair in an active gene: removal of pyrimidne dimers from the DHFR gene of CHO cells is much more efficient that in the genome overall. Cell. 40:1985;359-369.
12. Mellon I., Hanawalt P.C. Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand. Nature. 342:1989;95-98.
13. Ho L., Hanawalt P.C. Gene-specific DNA repair in terminally differentiating rat myoblasts. Mut. Res. 255:1991;123-141.
14. Lommel L., Carsell-Crumpton C., Hanawalt P.C. Preferential repair of the transcribed DNA strand in the dihydrofolate reductase gene throughout the cell cycle in UV-irradiated human cells. Mut. Res. 336:1995;181-192.
15. Winton D.J., Blount M.A., Ponder B.A.J. A clonal marker induced by mutation in mouse intestinal epithelium. Nature. 333:1988;463-466.
16. Cosentino L., Shaver-Walker P.M., Heddle J.A. The relationship among stem cells crypts, and villi in the small intestine of mice as determined by mutation-tagging. Dev. Dyn. 207:1996;420-428.
17. Gossen J.A., Molijn A.C., Douglas G.R., Vijg J. Application of galactose-sensitive E. coli strains as selective hosts for lacZ-plasmids. Nucleic Acids Res. 20:1992;3254.
18. Jones I.M., Burkhart-Schultz K., Strout C.L., Crippen T.L. Factors that affect the frequency of thioguanine-resistant lymphocytes in mice following exposure to ethylnitrosourea. Environ. Mol. Mutagen. 9:1987;317-329.
19. Skopek T.R., Kort K.L., Marino D.R., Mittal L.V., Umbenhauer D.R., Laws G.M., Adams S.P. Mutagenic response of the endogenous hprt gene and lacI transgene in benzo(a)pyrene-treated Big Blue B6C3F1 mice. Environ. Mol. Mutagen. 28:1996;384.
20. Zhang X.B., Felton J., Tucker J.D., Urlando C., Heddle J.A. Intestinal mutagenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) and amino carboline in transgenic mice. Carcinogenesis. 17:1996;2259-2265.
21. 6-ethylguanine in transcribed and nontranscribed genes of the rat. J. Biol. Chem. 269:1994;1681-1686.
22. 6-methylguanine lesion. Mol. Cell. Biol. 18:1998;1660-1669.
23. Cosentino L., Heddle J.A. Effects of extended chronic exposures on endogenous and transgenic loci: implications for low dose extrapolations. Environ. Mol. Mutagen. 34:1999;208-215.