Deciphering the Arginine-Binding preferences at the Substrate-Binding groove of Ser/Thr kinases by computational surface mapping

PLoS Computational Biology

Volumn 7, Issue 11, 2011, Pages

  Ben Shimon, Avraham ^a   Niv, Masha Y ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; ENZYMES; MAPPING; SUBSTRATES; X RAY CRYSTALLOGRAPHY;

ACIDIC RESIDUES; AMINO-ACIDS; CATALYSE; COMPUTATIONAL APPROACH; MOLECULAR FEATURE; PROTEIN KINASE; SIDE-CHAINS; SUBSTRATE-BINDING; SURFACE MAPPING; Γ-PHOSPHATE;

ARGININE;

ARGININE; SERINE; THREONINE; PROTEIN; PROTEIN SERINE THREONINE KINASE;

ACCURACY; ALGORITHM; AMINO ACID COMPOSITION; ARTICLE; BINDING SITE; CALCULATION; COMPUTATIONAL SURFACE MAPPING; CONTROLLED STUDY; MUTATION; PREDICTION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ENZYME SPECIFICITY; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PROTEIN ANALYSIS; PROTEIN CONFORMATION; REPRODUCIBILITY; THERMODYNAMICS;

ALGORITHMS; AMINO ACID SEQUENCE; ARGININE; BINDING SITES; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; REPRODUCIBILITY OF RESULTS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 81355150680     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002288     Document Type: Article

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