A single pair of acidic residues in the kinase major groove mediates strong substrate preference for P-2 or P-5 arginine in the AGC, CAMK, and STE kinases families

Journal of Biological Chemistry

Volumn 280, Issue 43, 2005, Pages 36372-36379

  Zhu, Guozhi ^a   Fujii, Koichi ^a,c   Liu, Yin ^a   Codrea, Vlad ^a   Herrero, Juan ^b   Shaw, Stephen ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b AxCell Biosciences   (United States)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; ENZYMES; GENETIC ENGINEERING; MUTAGENESIS; SUBSTRATES;

ACIDIC RESIDUES; ARGININE; KINASES; PEPTIDE LIBRARIES;

ENZYME KINETICS;

ARGININE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; PEPTIDE LIBRARY; PHOSPHOTRANSFERASE; PROTEIN KINASE C; PROTEIN P21; SERINE; THREONINE;

AMINO ACID SUBSTITUTION; ARTICLE; AUTOPHOSPHORYLATION; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME SUBSTRATE; GENE MUTATION; MOLECULAR RECOGNITION; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESIDUE ANALYSIS; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; BIOTINYLATION; BLOTTING, WESTERN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CHROMATOGRAPHY; HUMANS; ISOENZYMES; KINETICS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASE C; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 27744593477     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M505031200     Document Type: Article

References (46)

1. Pinna, L. A., and Ruzzene, M. (1996) Biochim. Biophys. Acta 1314, 191-225
2. Kemp, B. E., Bylund, D. B., Huang, T. S., and Krebs, E. G. (1975) Proc. Natl. Acad. Sci. U. S. A. 72, 3448-3452
3. Kemp, B. E., Graves, D. J., Benjamini, E., and Krebs, E. G. (1977) J. Biol. Chem. 252, 4888-4894
4. O'Brian, C. A., Lawrence, D. S., Kaiser, E. T., and Weinstein, I. B. (1984) Biochem. Biophys. Res. Commun. 124, 296-302
5. Turner, R. S., Kemp, B. E., Su, H. D., and Kuo, J. F. (1985) J. Biol. Chem. 260, 11503-11507
6. House, C., Wettenhall, R. E., and Kemp, B. E. (1987) J. Biol Chem. 262, 772-777
7. Kemp, B. E., and Pearson, R. B. (1990) Trends Biochem. Sci. 15, 342-346
8. Fujii, K., Zhu, G., Liu, Y., Hallam, J., Chen, L., Herrero, J., and Shaw, S. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 13744-13749
9. Yaffe, M. B., Leparc, G. G., Lai, J., Obata, T., Volinia, S., and Cantley, L. C. (2001) Nat. Biotechnol. 19, 348-353
10. Madhavan, R., and Jarrett, H. W. (1999) Biochim. Biophys. Acta 1434, 260-274
11. Mochizuki, T., Kitanaka, C., Noguchi, K., Muramatsu, T., Asai, A., and Kuchino, Y. (1999) J. Biol. Chem. 274, 18659-18666
12. Bokoch, G. M., Wang, Y., Bohl, B. P., Sells, M. A., Quilliam, L. A., and Knaus, U. G. (1996) J. Biol. Chem. 271, 25746-25749
13. Qian, Z., Lin, C., Espinosa, R., LeBeau, M., and Rosner, M. R. (2001) J. Biol. Chem. 276, 22439-22445
14. He, X., Liu, Y., Sharma, V., Dirksen, R. T., Waugh, R., Sheu, S. S., and Min, W. (2003) Am. J. Pathol. 163, 243-251
15. Kreegipuu, A., Blom, N., Brunak, S., and Jarv, J. (1998) FEBS Lett. 430, 45-50
16. Songyang, Z., Blechner, S., Hoagland, N., Hoekstra, M. F., Piwnica-Worms, H., and Cantley, L. C. (1994) Curr. Biol. 4, 973-982
17. Leighton, I. A., Dalby, K. N., Caudwell, F. B., Cohen, P. T., and Cohen, P. (1995) FEBS Lett. 375, 289-293
18. Nishikawa, K., Toker, A., Johannes, F. J., Songyang, Z., and Cantley, L. C. (1997) J. Biol. Chem. 272, 952-960
19. Yang, J., Cron, P., Good, V. M., Thompson, V., Hemmings, B. A., and Barford, D. (2002) Nat. Struct. Biol. 9, 940-944
20. Dale, S., Wilson, W. A., Edelman, A. M., and Hardie, D. G. (1995) FEBS Lett. 361, 191-195
21. Pearson, R. B., Woodgett, J. R., Cohen, P., and Kemp, B. E. (1985) J. Biol. Chem. 260, 14471-14476
22. Songyang, Z., Lu, K. P., Kwon, Y. T., Tsai, L. H., Filhol, O., Cochet, C., Brickey, D. A., Soderling, T. R., Bartleson, C., Graves, D. J., DeMaggio, A. J., Hoekstra, M. F., Blenis, J., Hunter, T., and Cantley, L. C. (1996) Mol. Cell. Biol. 16, 6486-6493
23. White, R. R., Kwon, Y. G., Taing, M., Lawrence, D. S., and Edelman, A. M. (1998) J. Biol. Chem. 273, 3166-3172
24. Seubert, P., Mawal-Dewan, M., Barbour, R., Jakes, R., Goedert, M., Johnson, G. V., Litersky, J. M., Schenk, D., Lieberburg, I., Trojanowski, J. Q., and Lee, V. M.-Y. (1995) J. Biol. Chem. 270, 18917-18922
25. Ebneth, A., Drewes, G., Mandelkow, E. M., and Mandelkow, E. (1999) Cell Motil. Cytoskeleton 44, 209-224
26. Stokoe, D., Caudwell, B., Cohen, P. T., and Cohen, P. (1993) Biochem. J. 296, 843-849
27. O'Neill, T., Giarratani, L., Chen, P., Iyer, L., Lee, C. H., Bobiak, M., Kanal, F., Zhou, B. B., Chung, J. H., and Rathbun, G. A. (2002) J. Biol Chem. 277, 16102-16115
28. Hutchins, J. R., Hughes, M., and Clarke, P. R. (2000) FEBS Lett. 466, 91-95
29. Velentza, A. V., Schumacher, A. M., Weiss, C., Egli, M., and Watterson, D. M. (2001) J. Biol. Chem. 276, 38956-38965
30. Burch, L. R., Scott, M., Pohler, E., Meek, D., and Hupp, T. (2004) J. Mol. Biol. 337, 115-128
31. Huang, C. Y., Yuan, C. J., Blumenthal, D. K., and Graves, D. J. (1995) J. Biol. Chem. 270, 7183-7188
32. Palaty, C. K., Clark-Lewis, I., Leung, D., and Pelech, S. L. (1997) Biochem. Cell Biol. 75, 153-162
33. Friedmann, M., Nissen, M. S., Hoover, D. S., Reeves, R., and Magnuson, N. S. (1992) Arch. Biochem. Biophys. 298, 594-601
34. Hutti, J. E., Jarrell, E. T., Chang, J. D., Abbott, D. W., Storz, P., Toker, A., Cantley, L. C., and Turk, B. E. (2004) Nat. Methods 1, 27-29
35. Gibbs, C. S., and Zoller, M. J. (1991) Biochemistry 30, 5329-5334
36. Batkin, M., Schvartz, I., and Shaltiel, S. (2000) Biochemistry 39, 5366-5373
37. Nolen, B., Ngo, J., Chakrabarti, S., Vu, D., Adams, J. A., and Ghosh, G. (2003) Biochemistry 42, 9575-9585
38. Zhu, G., Liu, Y., and Shaw, S. (2005) Cell Cycle 4, 52-56
39. Manser, E., Huang, H. Y., Loo, T. H., Chen, X. Q., Dong, J. M., Leung, T., and Lim, L. (1997) Mol. Cell. Biol. 17, 1129-1143
40. Zenke, F. T., King, C. C., Bohl, B. P., and Bokoch, G. M. (1999) J. Biol. Chem. 274, 32565-32573
41. Benner, G. E., Dennis, P. B., and Masaracchia, R. A. (1995) J. Biol. Chem. 270, 21121-21128
42. Xu, Z. B., Chaudhary, D., Olland, S., Wolfrom, S., Czerwinski, R., Malakian, K., Lin, L., Stahl, M. L., Joseph-McCarthy, D., Benander, C., Fitz, L., Greco, R., Somers, W. S., and Mosyak, L. (2004) J. Biol. Chem. 279, 50401-50409
43. Brinkworth, R. I., Breinl, R. A., and Kobe, B. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 74-79
44. Tuazon, P. T., Spanos, W. C., Gump, E. L., Monnig, C. A., and Traugh, J. A. (1997) Biochemistry 36, 16059-16064
45. Manning, G., Whyte, D. B., Martinez, R., Hunter, T., and Sudarsanam, S. (2002) Science 298, 1912-1934
46. Cheek, S., Zhang, H., and Grishin, N. V. (2002) J. Mol. Biol. 320, 855-881