메뉴 건너뛰기




Volumn 138, Issue 2, 2011, Pages 616-623

Acalypha wilkesiana extracts induce apoptosis by causing single strand and double strand DNA breaks

Author keywords

Acalypha wilkesiana; Antiproliferative effect; Apoptosis; DNA damage; Human glioma; Human lung carcinoma

Indexed keywords

ACALYPHA WILKESIANA EXTRACT; ACETIC ACID ETHYL ESTER; ALCOHOL; ANTINEOPLASTIC AGENT; HEXANE; PLANT EXTRACT; UNCLASSIFIED DRUG;

EID: 81255208503     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.10.005     Document Type: Article
Times cited : (37)

References (77)
  • 4
    • 79251528906 scopus 로고    scopus 로고
    • Antimicrobial screening of Terminalia avicennoides and Acalypha wilkesiana
    • O.O. Akpomie, and S. Olorungbon Antimicrobial screening of Terminalia avicennoides and Acalypha wilkesiana African Journal of Biotechnology 10 2010 180 182
    • (2010) African Journal of Biotechnology , vol.10 , pp. 180-182
    • Akpomie, O.O.1    Olorungbon, S.2
  • 5
    • 0027295948 scopus 로고
    • Antimicrobial activities of crude leaf extracts of Acalypha wilkesiana
    • P.I. Alade, and O.N. Irobi Antimicrobial activities of crude leaf extracts of Acalypha wilkesiana Journal of Ethnopharmacology 39 1993 171 174 (Pubitemid 23272433)
    • (1993) Journal of Ethnopharmacology , vol.39 , Issue.3 , pp. 171-174
    • Alade, P.I.1    Irobi, O.N.2
  • 6
    • 79951777954 scopus 로고    scopus 로고
    • Physiological study on the effect of Acalypha wilkesiana leaves extracts on Streptozotocin-induced experimental diabetes in male mice
    • A.M. Al-Attar Physiological study on the effect of Acalypha wilkesiana leaves extracts on Streptozotocin-induced experimental diabetes in male mice American Medical Journal 1 2010 51 58
    • (2010) American Medical Journal , vol.1 , pp. 51-58
    • Al-Attar, A.M.1
  • 7
    • 0037444271 scopus 로고    scopus 로고
    • Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein
    • J.D. Allen, S.C.V. Dort, M. Buitelaar, O.V. Tellingen, and A.H. Schinkel Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but epotoside oral availability is limited primarily by p-glycoprotein Cancer Research 63 2005 1339 1344 (Pubitemid 36348714)
    • (2003) Cancer Research , vol.63 , Issue.6 , pp. 1339-1344
    • Allen, J.D.1    Van Dort, S.C.2    Buitelaar, M.3    Van Tellingen, O.4    Schinkel, A.H.5
  • 9
    • 0032923360 scopus 로고    scopus 로고
    • P53/p21 (WAFI/CIPI) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells
    • A. Bhagavathi, Narayanana, Otto Geoffroya, M.C. Willinghama, G.G. Reb, and D.W. Nixona p53/p21 (WAFI/CIPI) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells Cancer Letters 136 1999 215 221
    • (1999) Cancer Letters , vol.136 , pp. 215-221
    • Bhagavathi, A.1    Narayanana2    Geoffroya, O.3    Willinghama, M.C.4    Reb, G.G.5    Nixona, D.W.6
  • 10
    • 0034807826 scopus 로고    scopus 로고
    • Dietary agents in cancer prevention: Flavonoids and isoflavonoids
    • DOI 10.1016/S0163-7258(01)00137-1, PII S0163725801001371
    • D.F. Birt, S. Hendrich, and W. Wang Dietary agents in cancer prevention: flavonoids and isoflavonoids Pharmacological Therapy 90 2001 157 177 (Pubitemid 32913477)
    • (2001) Pharmacology and Therapeutics , vol.90 , Issue.2-3 , pp. 157-177
    • Birt, D.F.1    Hendrich, S.2    Wang, W.3
  • 12
    • 14044267753 scopus 로고    scopus 로고
    • Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity
    • DOI 10.1074/jbc.M408177200
    • K. Brusselmans, R. Vrolix, G. Verhoeven, and J.V. Swinnen Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity Journal of Biological Chemistry 280 2005 5636 5645 (Pubitemid 40280043)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.7 , pp. 5636-5645
    • Brusselmans, K.1    Vrolix, R.2    Verhoeven, G.3    Swinnen, J.V.4
  • 14
    • 0344867879 scopus 로고    scopus 로고
    • Apoptosis-associated generation of reactive oxygen intermediates and release of pro-inflammatory cytokines in human lymphocytes and granulocytes by extracts from the seeds of Acalypha wilkesiana
    • DOI 10.1016/S0378-8741(98)00227-X, PII S037887419800227X
    • A. Büssing, G.M. Stein, I. Herterich-Akinpelu, and U. Pfüller Apoptosis-associated generation of reactive oxygen intermediates and release of pro-inflammatory cytokines in human lymphocytes and granulocytes by extracts from the seeds of Acalypha wilkesiana Journal of Ethnopharmacology 66 1999 301 309 (Pubitemid 29287199)
    • (1999) Journal of Ethnopharmacology , vol.66 , Issue.3 , pp. 301-309
    • Bussing, A.1    Stein, G.M.2    Herterich-Akinpelu, I.3    Pfuller, U.4
  • 16
    • 0035874028 scopus 로고    scopus 로고
    • Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: Regulation of cyclin-dependent kinases CDK2 and CDK1
    • DOI 10.1016/S0006-2952(01)00583-4, PII S0006295201005834
    • F. Casagrande, and J.M. Darbon Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1 Biochemical Pharmacology 61 2001 1205 1215 (Pubitemid 32375112)
    • (2001) Biochemical Pharmacology , vol.61 , Issue.10 , pp. 1205-1215
    • Casagrande, F.1    Darbon, J.-M.2
  • 17
    • 77954813506 scopus 로고    scopus 로고
    • Circumvetion of multi-drug resistance of cancer cells by Chinese herbal medicines
    • S. Chai, K.K.W. To, and G. Lin Circumvetion of multi-drug resistance of cancer cells by Chinese herbal medicines Chinese Medicine 5 2010 26
    • (2010) Chinese Medicine , vol.5 , pp. 26
    • Chai, S.1    To, K.K.W.2    Lin, G.3
  • 18
    • 36349008662 scopus 로고    scopus 로고
    • Combination of topotecan and etoposide as a salvage treatment for patients with recurrent small cell lung cancer following irinotecan and platinum first-line chemotherapy
    • DOI 10.1007/s00280-007-0505-9
    • H.J. Choi, B.C. Cho, S.J. Shin, S.H. Cheon, J.Y. Jung, J. Chang, S.K. Kim, J.H. Sohn, and J.H. Kim Combination of topotecan and etoposide as a salvage treatment for patients with recurrent small cell lung cancer following irinotecan and platinum first-line chemotherapy Cancer Chemotherapy and Pharmacology 61 2008 309 313 (Pubitemid 350160329)
    • (2008) Cancer Chemotherapy and Pharmacology , vol.61 , Issue.2 , pp. 309-313
    • Choi, H.J.1    Cho, B.C.2    Shin, S.J.3    Cheon, S.H.4    Jung, J.Y.5    Chang, J.6    Kim, S.K.7    Sohn, J.H.8    Kim, J.H.9
  • 20
    • 0036711591 scopus 로고    scopus 로고
    • Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I
    • DOI 10.1042/BJ20020098
    • A.R. Chowdhury, S. Sharma, S. Mandal, A. Goswami, S. Mukhopadhyay, and H.K. Majumder Luteolin, an emerging anti-cancer flavonoids, poisons eukaryotic DNA topoisomerase I Biochemistry Journal 366 2002 653 661 (Pubitemid 35001710)
    • (2002) Biochemical Journal , vol.366 , Issue.2 , pp. 653-661
    • Chowdhury, A.R.1    Sharma, S.2    Mandal, S.3    Goswami, A.4    Mukhopadhyay, S.5    Majumder, H.K.6
  • 22
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • S.P. Davies, H. Reddy, M. Caivano, and P. Cohen Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochemistry Journal 351 2000 95 105
    • (2000) Biochemistry Journal , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 25
    • 0029263089 scopus 로고
    • Letter to the editor: Necrotic DNA degradation mimics apoptotic nucleosomal fragmentation comet tail length
    • D.W. Fairbairn, and K.L. O'Neill Letter to the editor: Necrotic DNA degradation mimics apoptotic nucleosomal fragmentation comet tail length In Vitro Cell Development Biology 31 1995 171 173
    • (1995) Vitro Cell Development Biology , vol.31 , pp. 171-173
    • Fairbairn, D.W.1    O'Neill, K.L.2
  • 26
    • 0030317595 scopus 로고    scopus 로고
    • Key morphologic changes and DNA strand breaks in human lymphoid cells: Discriminating apoptosis from necrosis
    • D.W. Fairbairn, D.K. Walburger, J.J. Fairbairn, and K.L. O'Neill Key morphologic changes and DNA strand breaks in human lymphoid cells: discriminating apoptosis from necrosis Journal of Scanning Microscopies 18 1996 407 416
    • (1996) Journal of Scanning Microscopies , vol.18 , pp. 407-416
    • Fairbairn, D.W.1    Walburger, D.K.2    Fairbairn, J.J.3    O'Neill, K.L.4
  • 27
    • 33645312043 scopus 로고    scopus 로고
    • Stressing out over survival: Glutamine as an apoptotic modulator
    • B.C. Fuchs, and B.P. Bode Stressing out over survival: glutamine as an apoptotic modulator Journal of Surgical Research 128 2005
    • (2005) Journal of Surgical Research , vol.128
    • Fuchs, B.C.1    Bode, B.P.2
  • 28
    • 1942485966 scopus 로고    scopus 로고
    • Antibacterial Activity of Hydrolyzable Tannins Derived from Medicinal Plants against Helicobacter pylori
    • K. Funatogawa, S. Hayashi, H. Shimomura, T. Yoshida, T. Hatano, H. Ito, and Y. Iría Antibacterial activity of hydrolysable tannins derived from medicinal plants against helicobacter pylori Microbiology Immunology 48 2004 251 261 (Pubitemid 38508665)
    • (2004) Microbiology and Immunology , vol.48 , Issue.4 , pp. 251-261
    • Funatogawa, K.1    Hayashi, S.2    Shimomura, H.3    Yoshida, T.4    Hatano, T.5    Ito, H.6    Hirai, Y.7
  • 29
    • 81255154999 scopus 로고    scopus 로고
    • Antibacterial activity of ethanolic extracts of Acalypha wilkesiana leaves growing in Jos, Plateau State, Nigeria
    • J.G. Gotep, G.O.A. Agada, D.S. Gbise, and S. Chollom Antibacterial activity of ethanolic extracts of Acalypha wilkesiana leaves growing in Jos, Plateau State, Nigeria Malaysian Journal of Microbiology 6 2010 69 74
    • (2010) Malaysian Journal of Microbiology , vol.6 , pp. 69-74
    • Gotep, J.G.1    Agada, G.O.A.2    Gbise, D.S.3    Chollom, S.4
  • 30
    • 0028789425 scopus 로고
    • The killer and the executioner: How apoptosis controls malignancy
    • D.R. Green, and S.J. Scott The killer and the executioner: how apoptosis controls malignancy Current Opinion in Immunology 7 1995 694 703
    • (1995) Current Opinion in Immunology , vol.7 , pp. 694-703
    • Green, D.R.1    Scott, S.J.2
  • 33
    • 0028670379 scopus 로고
    • Lymphocyte apoptosis-mechanisms and implications in disease
    • S.E.M. Howie, D.J. Harrison, and A.H. Wyllie Lymphocyte apoptosis-mechanisms and implications in disease Immunological Reviews 142 1994 141 156
    • (1994) Immunological Reviews , vol.142 , pp. 141-156
    • Howie, S.E.M.1    Harrison, D.J.2    Wyllie, A.H.3
  • 34
    • 4444317848 scopus 로고    scopus 로고
    • Regulation of Vinca alkaloid-induced apoptosis by NF-κB/IκB pathway in human tumor cells
    • Y. Huang, Y. Fang, J. Wu, J.M. Dziadyk, X. Zhu, M. Sui, and W. Fan Regulation of Vinca alkaloid-induced apoptosis by NF-κB/IκB pathways in human tumour cells Molecular Cancer Therapy 3 2004 271 277 (Pubitemid 39193702)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.3 , pp. 271-277
    • Huang, Y.1    Fang, Y.2    Wu, J.3    Dziadyk, J.4    Zhu, X.5    Sui, M.6    Fan, W.7
  • 35
    • 30644457199 scopus 로고    scopus 로고
    • The comet assay to determine the mode of cell death for the ultrasonic delivery of doxorubicin to human leukemia (HL-60 Cells) from pluronic P105 micelles
    • G.A. Husseini, K.L. O'Neill, and W.G. Pitt The comet assay to determine the mode of cell death for the ultrasonic delivery of Doxorubicin to human leukaemia (HL-60 cells) from Pluronic P105 Micelles Technological Cancer Research Treatment 4 2005 707 711 (Pubitemid 43084804)
    • (2005) Technology in Cancer Research and Treatment , vol.4 , Issue.6 , pp. 707-711
    • Husseini, G.A.1    O'Neill, K.L.2    Pitt, W.G.3
  • 36
    • 37549046017 scopus 로고    scopus 로고
    • Effect of Acalypha wilkesiana Muell Arg on plasma sodium and potassium concentration of normal rabbits
    • J.C. Ikewuchi, and A. Anyadiegwu Effect of Acalypha wilkesiana Muell Arg on plasma sodium and potassium concentration of normal rabbits Pakistan Journal of Nutrition 7 2008 130 132
    • (2008) Pakistan Journal of Nutrition , vol.7 , pp. 130-132
    • Ikewuchi, J.C.1    Anyadiegwu, A.2
  • 37
    • 36849068505 scopus 로고    scopus 로고
    • Overweight/obesity and cancer genesis: More than a biological link
    • DOI 10.1016/j.biopha.2007.10.008, PII S0753332207002363
    • P. Irigaray, J.A. Newby, S. Lacomme, and D. Belpomme Overweight/obesity and cancer genesis: more than a biological link Biomedical Pharmacotherapy 61 2007 665 678 (Pubitemid 350236686)
    • (2007) Biomedicine and Pharmacotherapy , vol.61 , Issue.10 , pp. 665-678
    • Irigaray, P.1    Newby, J.A.2    Lacomme, S.3    Belpomme, D.4
  • 38
    • 14244269334 scopus 로고    scopus 로고
    • Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks
    • DOI 10.1074/jbc.M411588200
    • I.H. Ismail, S. Nystrom, J. Nygren, and O. Hammarsten Activation of Ataxia Telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks Journal of Biological Chemistry 280 2005 4649 4655 (Pubitemid 40288634)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.6 , pp. 4649-4655
    • Ismail, I.H.1    Nystrom, S.2    Nygren, J.3    Hammarsten, O.4
  • 40
    • 0004216453 scopus 로고    scopus 로고
    • sixth ed. Elsevier Saunders pp. 492-493
    • P. Kumar, and M. Clark sixth ed. Clinical Medicine vol. 9 2005 Elsevier Saunders pp. 492-493
    • (2005) Clinical Medicine , vol.9
    • Kumar, P.1    Clark, M.2
  • 42
    • 34247342227 scopus 로고    scopus 로고
    • Molecular pharmacokinetics of Catharanthus (vinca) alkaloids
    • DOI 10.1177/0091270007299430
    • D. Leveque, and F. Jehl Molecular pharmacokinetics of Catharanthus (vinca) alkaloids Journal of Clinical Pharmacology 47 2007 579 588 (Pubitemid 46632154)
    • (2007) Journal of Clinical Pharmacology , vol.47 , Issue.5 , pp. 579-588
    • Leveque, D.1    Jehl, F.2
  • 43
    • 81255126052 scopus 로고    scopus 로고
    • Lignans from the bark of Machilus thunbergii and their DNA topoisomerases i and II inhibition and cytotoxicity
    • PMID:15256759
    • G. Li, C.S. Lee, M.H. Woo, S.H. Lee, H.W. Chang, and J.K. Son Lignans from the bark of Machilus thunbergii and their DNA topoisomerases I and II inhibition and cytotoxicity PubMed 2004 PMID:15256759
    • (2004) PubMed
    • Li, G.1    Lee, C.S.2    Woo, M.H.3    Lee, S.H.4    Chang, H.W.5    Son, J.K.6
  • 45
    • 23844481408 scopus 로고    scopus 로고
    • Mechanisms of drug resistance in cancer chemotherapy
    • DOI 10.1159/000081921
    • Y.A. Luqmani Mechanism of drug resistance in cancer chemotherapy Medical Principles and Practice 14 2005 35 48 (Pubitemid 41161048)
    • (2005) Medical Principles and Practice , vol.14 , Issue.SUPPL. 1 , pp. 35-48
    • Luqmani, Y.A.1
  • 46
    • 81255126051 scopus 로고    scopus 로고
    • Phytochemical and Elemental analysis of Acalypha wilkesiana leaf
    • H.A. Madziga, S. Sanni, and U.K. Sandabe Phytochemical and Elemental analysis of Acalypha wilkesiana leaf Journal of American Science 6 2010 510 514
    • (2010) Journal of American Science , vol.6 , pp. 510-514
    • Madziga, H.A.1    Sanni, S.2    Sandabe, U.K.3
  • 47
    • 34447109108 scopus 로고    scopus 로고
    • Expression of deacetylvindoline-4-O-acetyltransferase in Catharanthus roseus hairy roots
    • DOI 10.1016/j.phytochem.2007.04.037, PII S0031942207002981
    • M. Magnotta, J. Murata, J. Chen, and V. De Luca Expression of deacethylvindoline-4-O-acethyltransferase in Catharanthus roseus hairy roots Phytochemistry 68 2007 1922 1931 (Pubitemid 47030621)
    • (2007) Phytochemistry , vol.68 , Issue.14 , pp. 1922-1931
    • Magnotta, M.1    Murata, J.2    Chen, J.3    De Luca, V.4
  • 48
    • 0027411586 scopus 로고
    • Apoptosis: Suicide, execution or murder?
    • S.J. Martin Apoptosis: suicide, execution or murder? Trends in cell Biology 3 1993 141 144 (Pubitemid 23115193)
    • (1993) Trends in Cell Biology , vol.3 , Issue.5 , pp. 141-144
    • Martin, S.J.1
  • 49
    • 39549088303 scopus 로고    scopus 로고
    • Sanguinarine causes DNA damage and p53-independent cell death in human colon cancer cell line
    • S.S. Matkar, L.A. Wrischnik, and U. Hellmann-Blumberg Sanguinarine causes DNA damage and p53-independent cell death in human colon cancer cell line Chemico-Biological Interactions 172 2008 63 71
    • (2008) Chemico-Biological Interactions , vol.172 , pp. 63-71
    • Matkar, S.S.1    Wrischnik, L.A.2    Hellmann-Blumberg, U.3
  • 53
    • 0036489186 scopus 로고    scopus 로고
    • Flavonoids increase the intracellular glutathione level by transactivation of the γ-glutamylcysteine synthetase catalytical subunit promoter
    • DOI 10.1016/S0891-5849(01)00812-7, PII S0891584901008127
    • M.C. Myhrstad, H. Carlsen, O. Nordstrom, R. Blomhoff, and J.O. Moskaug Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthase catalytical subunit promoter Free Radical Biology and Medicine 32 2002 386 393 (Pubitemid 34178348)
    • (2002) Free Radical Biology and Medicine , vol.32 , Issue.5 , pp. 386-393
    • Myhrstad, M.C.W.1    Carlsen, H.2    Nordstrom, O.3    Blomhoff, R.4    Moskaug, J.O.5
  • 54
    • 79955791095 scopus 로고    scopus 로고
    • National Cancer Institute Retrieved on 19th October 2010.
    • National Cancer Institute, 2010. Common Cancer Types. Retrieved on 19th October 2010.
    • (2010) Common Cancer Types
  • 55
    • 81255181421 scopus 로고    scopus 로고
    • National Cancer Institute. Retrieved on 23rd June 2011.
    • National Cancer Institute, 2011. Metastatic Cancer. Retrieved on 23rd June 2011.
    • (2011) Metastatic Cancer
  • 56
    • 60549113087 scopus 로고    scopus 로고
    • From Greens into Medicine: Taking a Lead from Nature
    • OAU Press Limited, lle-lfe Nigeria pp. 12-15
    • A.O. Ogundaini From Greens into Medicine: Taking a Lead from Nature Inaugural Lecture Series vol. 176 2005 OAU Press Limited, lle-lfe Nigeria pp. 12-15
    • (2005) Inaugural Lecture Series , vol.176
    • Ogundaini, A.O.1
  • 57
    • 81255126046 scopus 로고    scopus 로고
    • Effect of concentration on the rate of killing of some microorganisms and haemolytic activity of two varieties of Acalypha wilkesiana
    • M.K. Oladunmoye Effect of concentration on the rate of killing of some microorganisms and haemolytic activity of two varieties of Acalypha wilkesiana International Journal of Tropical Medicine 1 2006 130 133
    • (2006) International Journal of Tropical Medicine , vol.1 , pp. 130-133
    • Oladunmoye, M.K.1
  • 63
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: Bioavailability, metabolic effects, and safety
    • DOI 10.1146/annurev.nutr.22.111401.144957
    • J.A. Ross, and C.M. Kasum Dietary flavonoids: bioavailability, metabolic effects, and safety Annual Review Nutrition 22 2002 19 34 (Pubitemid 35221452)
    • (2002) Annual Review of Nutrition , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 65
    • 33744924191 scopus 로고    scopus 로고
    • Pollen morphology and ultrastructure of Acalypha (Euphorbiaceae)
    • DOI 10.1016/j.revpalbo.2006.03.005, PII S003466670600056X
    • V.G. Sagun, G.A. Levin, and R.W.J.M. van der Ham Pollen morphology and ultrastructure of Acalypha (Euphorbiaceae) Review of Palaeobotany and Palynology 140 2006 123 143 (Pubitemid 43842054)
    • (2006) Review of Palaeobotany and Palynology , vol.140 , Issue.1-2 , pp. 123-143
    • Sagun, V.G.1    Levin, G.A.2    Van Der Ham, R.W.J.M.3
  • 66
    • 0027333347 scopus 로고
    • Programmed cell death, apoptosis and killer genes
    • L.M. Schwartz, and B.A. Osborn Programmed cell death, apoptosis and killer genes Immunology Today 14 1993 582 590
    • (1993) Immunology Today , vol.14 , pp. 582-590
    • Schwartz, L.M.1    Osborn, B.A.2
  • 68
    • 81255181422 scopus 로고    scopus 로고
    • Brain cancer overview, causes, risk, and symptoms
    • Retrieved on 29 August
    • Swierzewski, S.J., 2007. Brain cancer overview, causes, risk, and symptoms. Oncology Channel. Retrieved on 29 August 2008.
    • (2007) Oncology Channel
    • Swierzewski, S.J.1
  • 70
    • 0035805052 scopus 로고    scopus 로고
    • The ratio of single-to double-strand DNA breaks and their absolute values determine cell death pathway
    • DOI 10.1054/bjoc.2001.1786
    • O. Tounekti, A. Kenani, N. Foray, S. Orlowski, and L.M. Mir The ratio of single-to double-strand DNA breaks and their absolute values determine cell death pathway British Journal of Cancer 84 2001 1272 1279 (Pubitemid 32511347)
    • (2001) British Journal of Cancer , vol.84 , Issue.9 , pp. 1272-1279
    • Tounekti, O.1    Kenani, A.2    Foray, N.3    Orlowski, S.4    Mir, L.M.5
  • 71
    • 0030660603 scopus 로고    scopus 로고
    • Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids
    • DOI 10.1016/S0304-3835(97)00311-X, PII S030438359700311X
    • Y. Uda, K.R. Price, G. Williamson, and M.J. Rhodes Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids Cancer Letters 120 1997 213 216 (Pubitemid 27496819)
    • (1997) Cancer Letters , vol.120 , Issue.2 , pp. 213-216
    • Uda, Y.1    Price, K.R.2    Williamson, G.3    Rhodes, M.J.C.4
  • 72
    • 73749084269 scopus 로고    scopus 로고
    • Analgesic and antimalarial activities of crude leaf extract and fractions of Acalypha wilkesiana
    • J.A. Udobang, P.A. Nwafor, and J.E. Okokon Analgesic and antimalarial activities of crude leaf extract and fractions of Acalypha wilkesiana Journal of Ethnopharmacology 127 2010 373 378
    • (2010) Journal of Ethnopharmacology , vol.127 , pp. 373-378
    • Udobang, J.A.1    Nwafor, P.A.2    Okokon, J.E.3
  • 73
    • 33646243794 scopus 로고    scopus 로고
    • Isolation, DNA topoisomerase-II inhibition, and cytotoxicity of three new terpenoids from the bark of Macaranga tanarius
    • S. Wada, and R. Tanaka Isolation, DNA topoisomerase-II inhibition, and cytotoxicity of three new terpenoids from the bark of Macaranga tanarius Chemical Biodiversity 3 2006 473 479
    • (2006) Chemical Biodiversity , vol.3 , pp. 473-479
    • Wada, S.1    Tanaka, R.2
  • 75
    • 0033622114 scopus 로고    scopus 로고
    • 1, the macrocyclic hydrolysable tannin induced apoptosis in HL-60 cell line
    • 1, the macrocyclic hydrolysable tannin induced apoptosis in HL-60 cell line Cancer Letters 149 2000 77 83
    • (2000) Cancer Letters , vol.149 , pp. 77-83
    • Wang, C.C.1    Chen, L.G.2    Yang, L.L.3
  • 76
    • 0002210465 scopus 로고
    • Synopsis of the genera and suprageneric taxa of Euphorbiaceae
    • G.L. Webster Synopsis of the genera and suprageneric taxa of Euphorbiaceae Annals of the Missouri Botanical Garden 81 1994 33 144
    • (1994) Annals of the Missouri Botanical Garden , vol.81 , pp. 33-144
    • Webster, G.L.1
  • 77
    • 0034739334 scopus 로고    scopus 로고
    • Induction of apoptosis by hydrolysable tannins from Eugenia jambos L. on human leukaemia cells
    • L.L. Yang, C.Y. Lee, and K.Y. Yen Induction of apoptosis by hydrolysable tannins from Eugenia jambos L. on human leukaemia cells Cancer Letters 157 2000 65 75
    • (2000) Cancer Letters , vol.157 , pp. 65-75
    • Yang, L.L.1    Lee, C.Y.2    Yen, K.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.