The ratio of single-to double-strand DNA breaks and their absolute values determine cell death pathway

British Journal of Cancer

Volumn 84, Issue 9, 2001, Pages 1272-1279

  Tounekti, O ^a,b   Kenani, A ^a,c   Foray, N ^d   Orlowski, S ^e   Mir, L M ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b UNIVERSITY OF CARTHAGE   (Tunisia)

^c UNIVERSITY OF MONASTIR   (Tunisia)

^d INSTITUT CURIE   (France)

^e CNRS   (France)

Author keywords

Apoptosis; Bleomycin; Deglyco bleomycin A2; Electrochemotherapy; Electroporation; Mitotic cell death

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; BLEOMYCIN DERIVATIVE; DOUBLE STRANDED DNA; SINGLE STRANDED DNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; DNA STRAND BREAKAGE; ELECTROPORATION; FIBROBLAST CULTURE; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BLEOMYCIN; CRICETINAE; CRICETULUS; DNA DAMAGE; DNA, SINGLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; MITOSIS;

EID: 0035805052     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.1786     Document Type: Article

References (27)

1. Analogue versus digital recognition of DNA by bleomycin: An effect of the carbohydrate moiety
2. How does radiation kill the cells?
3. CHO cell repair of single strand and double strand breaks induced by gamma and alpha radiations
4. Mechanisms of cell injury
5. Extrachromosomal chromatin: Novel target for bleomycin cleavage in cells and solid tumors
6. Dose-rate effect on radiation-induced DNA double strand breaks in the human fibroblast HF19 cell line
7. The initial physical damage produced by ionizing radiations
8. Measurement of bleomycin, neocarzinostatin, and auromomycin cleavage of cell-free and intracellular simian virus 40 DNA and chromatin
9. The role of the gulose-mannose part of bleomycin in inactivation of iron-molecular oxygen complex
10. 2
11. The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation
12. Bleomycin: Revival of an old drug
13. Deglyco-bleomycin Degradation of DNA and formation of a structurally unique Fe(II)-Co complex
14. Cell electropermeabilization: A new tool for biochemical and pharmacological studies
15. Transient electropermeabilization of cells in culture. Increase of the cytotoxicity of anticancer drugs
16. The apoptosis endonucleases: Cleaning up after cell death?
17. Very high cytotoxicity of bleomycin introduced into the cytosol of cells in culture
18. DNA double-strand breaks and alkali-labile bonds produced by bleomycin
19. Structure of bleomycin-induced DNA double-strand breaks: Predominance of blunt ends and single-base 5′ extensions
20. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
21. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
22. DNA strand scission by bleomycin: Catalytic cleavage and strand selectivity
23. Apoptosis: A program for death or survival?
24. Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending on the number of molecules internalized
25. Relationships between DNA fragmentation, chromatin condensation and changes in flow cytometry profiles detected during apoptosis
26. Life, death, and the pursuit of apoptosis
27. DNA damage and cell killing by camptothecin and its derivative in human leukemia HL-60 cells