Dna topoisomerase II inhibition by peroxisomicine A1 and its radical metabolite induces apoptotic cell death of HL-60 and HL-60/mx2 human leukemia cells

Chemical Research in Toxicology

Volumn 14, Issue 1, 2001, Pages 16-24

  Lansiaux, Amélie ^a   Laine, William ^a   Baldeyrou, Brigitte ^a   Mahieu, Christine ^a   Wattez, Nicole ^a   Vezin, Hervé ^b   Martinez, Francisco J ^c   Piñeyro, Alfredo ^c   Bailly, Christian ^a  

^a INSERM   (France)

^b Ecole Nationale Superieure de Chimie de Lille   (France)

^c UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACENE DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE 3; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DRUG METABOLITE; ETOPOSIDE; KARWINSKIA HUMBOLDTIANA EXTRACT; MITOXANTRONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXISOMICINE A; T 510R; T 514; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CYTOTOXICITY; DRUG DNA INTERACTION; ELECTRON SPIN RESONANCE; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MASS SPECTROMETRY;

ANTHRACENES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CASPASES; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA, NEOPLASM; DNA, SUPERHELICAL; DRUG RESISTANCE, NEOPLASM; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ACTIVATION; ENZYME INHIBITORS; FREE RADICALS; HL-60 CELLS; HUMANS; KINETICS; MITOXANTRONE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 0035156645     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000145j     Document Type: Article

References (7)

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