Apoptosis-associated generation of reactive oxygen intermediates and release of pro-inflammatory cytokines in human lymphocytes and granulocytes by extracts from the seeds of Acalypha wilkesiana

Journal of Ethnopharmacology

Volumn 66, Issue 3, 1999, Pages 301-309

  Bussing A ^a   Stein, G M ^a   Herterich Akinpelu, I ^b   Pfuller U ^b  

^a Krebsforschung Herdecke   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

Acalypha wilkesiana; Apoptosis; Cytokines; Granulocytes; Lymphocytes; Oxidative burst; Reactive oxygen intermediates

Indexed keywords

ACALYPHA WILKESIANA EXTRACT; GAMMA INTERFERON; INTERLEUKIN 5; INTERLEUKIN 6; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CYTOKINE RELEASE; CYTOTOXICITY; DRUG ACTIVITY; GRANULOCYTE; IMMUNOMODULATION; LYMPHOCYTE; PHAGOCYTOSIS; RESPIRATORY BURST;

APOPTOSIS; CELLS, CULTURED; CYTOKINES; ESCHERICHIA COLI; EUPHORBIACEAE; FLUORESCENT DYES; GRANULOCYTES; HUMANS; INTERFERON TYPE II; INTERLEUKIN-5; INTERLEUKIN-6; LYMPHOCYTES; MEDICINE, TRADITIONAL; NIGERIA; OXIDATION-REDUCTION; PHAGOCYTOSIS; PHENANTHRIDINES; PHYTOTHERAPY; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; RESPIRATORY BURST; TIME FACTORS;

EID: 0344867879     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(98)00227-X     Document Type: Article

References (25)

1. Akinpelu, S., 1994. Untersuchung afrikanischer Phytotherapeutika auf antineoplastische Aktivität. Thesis at the Institute of Immunology, University Witten/Herdecke, Germany.
2. Alade P.I., Irobi O.N. Antimicrobial activities of crude leaf extracts of Acalypha wilkesiana. Journal of Ethnopharmacology. 39:1993;171-174.
3. Arends M.J., McGregor A.H., Wyllie A.H. Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes. American Journal of Pathology. 144:1994;1045-1057.
4. Burkill H.M. 2nd ed The Useful Plants of West Tropical Africa. 2:1994;25. Families E-I Royal Botany Gardens, Kew.
5. Büssing A., Schweizer K. Effects of a phytopreparation from Helleborus niger on immunocompetent cells in vitro. Journal of Ethnopharmacology. 59:1998;139-146.
6. Büssing, A., Schaller, G., Pfüller, U., 1998a. Generation of reactive oxygen intermediates by the thionins from Viscum album L. Anticancer Research 18, 4291-4296.
7. lo) by the N-acetyl-D-galactosamine-specific lectin from Viscum album L. Cell Death and Differentiation. 5:1998;231-240.
8. Chapuis J.C., Sordat B., Hostettman K. Screening of cytotoxic plants used in traditional medicine. Journal of Ethnopharmacology. 23:1988;273-284.
9. Chavali S.R., Francis T., Campbell J.B. An in vitro study of immunomodulatory effects of some saponins. International Journal of Immunopharmacology. 9:1987;675-683.
10. Green D.R., Scott S.J. The killer and the executioner: how apoptosis controls malignancy. Current Opinion in Immunology. 7:1995;694-703.
11. Gruiz K. Fungitoxic activity of saponins: practical use and fundamental principles. Advances in Experimental Medicine Biology. 404:1996;527-534.
12. Howie S.E.M., Harrison D.J., Wyllie A.H. Lymphocyte apoptosis-mechanisms and implications in disease. Immunological Reviews. 142:1994;141-156.
13. Kroemer G., Zamzami N., Susin S.A. Mitochondrial control of apoptosis. Immunology Today. 18:1997;44-51.
14. Martin, S.J. 1993. Apoptosis: suicide, execution or murder? Trends in Cell Biology, 3, 141-144.
15. Mountz J.D, Zhou T., Wu J., Wang W., Su X., Cheng J. Regulation of apoptosis in immune cells. Journal of Clinical Immunology. 15:1995;1-16.
16. Mosman T.R., Coffman R.L. Heterogeneity of cytokine secretion patterns and function of helper T-cells. Advances in Immunology. 46:1989;111-114.
17. Mosman T.R., Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunology Today. 17:1996;138-146.
18. Odebiyi O.O., Sofowora E.A. Phytochemical screening of Nigerian medical plants II. Llydia. 41:1978;234-246.
19. Overbeeke R., Steffens-Nakken H., Vermes I., Reutingsperger C., Haanen C. Early features of apoptosis detected by four different flow cytometric assays. Apoptosis. 3:1998;115-121.
20. Rao A.V., Sung M.K. Saponins as anticarcinogens. Journal of Nutrition. 125:1995;717S-724S.
21. Romagnani S. The Th1/Th2 Paradigm in Disease. 1997;Springer, New York.
22. Schwartz L.M., Osborn B.A. Programmed cell death, apoptosis and killer genes. Immunology Today. 14:1993;582-590.
23. Stein G.M., Meink H., Durst J., Berg P.A. The release of cytokines by a fermented lectin-1 (ML-1) free mistletoe extract reflects differences in the reactivity of PBMC in healthy and allergic individuals and tumour patients. European Journal of Clinical Pharmacology. 51:1996;247-252.
24. Stein, G.M., Schaller, G., Pfüller, U., Wagner, M., Wagner, B., Schietzel, M., Büssing, M., 1998. Characterisation of granulocyte stimulation by thionins from European mistletoe and from wheat. Biochimica et Biophysica Acta (in press).
25. Wagner H., Bladt S., Zgainski E.M. Drogenanalyse. 1983;225-305 Springer, Berlin.