A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes

BMC Medicine

Volumn 9, Issue , 2011, Pages

  Wiebe, Natasha ^a   Padwal, Raj ^a   Field, Catherine ^a   Marks, Seth ^a   Jacobs, Rene ^a   Tonelli, Marcello ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACESULFAME; ASPARTAME; CARBOHYDRATE; CYCLAMATE SODIUM; FRUCTOSE; FRUCTOSE OLIGOSACCHARIDE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; LIPID; MALTITOL; PALATINOSE; SACCHARIN; SORBITOL; SUCRALOSE; SUCROSE; SWEETENING AGENT; TAGATOSE; TREHALOSE; CHOLESTEROL;

ARTICLE; BODY MASS; BODY WEIGHT; CALORIC INTAKE; DIET RESTRICTION; GLUCOSE BLOOD LEVEL; GLYCEMIC RESPONSE; HONEY; HUMAN; INSULIN RESISTANCE; LIPID BLOOD LEVEL; METABOLIC REGULATION; SYSTEMATIC REVIEW; BLOOD; DIET; META ANALYSIS; METHODOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; TREATMENT OUTCOME;

BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; DIET; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SWEETENING AGENTS; TREATMENT OUTCOME;

EID: 81155127536     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-9-123     Document Type: Article

References (92)

1. Parker KJ. Alternatives to sugar. The search for an ideal non-nutritive sweetener is almost a century old. Nature 1978, 271:493-495.
2. The straight facts on sweeteners. , http://www.thecoca-colacompany.com/ourcompany/pdf/sweetener_fact_sheet.pdf
3. Sugar substitutes. , http://www.pepsiproductfacts.com/sugarsub.php
4. Lipson E. Chapter 1: Executive Summary. Trends in the US market for sugar, sugar substitutes, and sweeteners 2008, 1-26. Packaged Facts.
5. Freedonia Freedonia focus on food and beverage additives 2010, The Freedonia Group I, Freedonia.
6. Sievenpiper JL, Carleton AJ, Chatha S, Jiang HY, de Souza RJ, Beyene J, Kendall CW, Jenkins DJ. Heterogeneous effects of fructose on blood lipids in individuals with type 2 diabetes: systematic review and meta-analysis of experimental trials in humans. Diabetes Care 2009, 32:1930-1937.
7. Vermunt SH, Pasman WJ, Schaafsma G, Kardinaal AF. Effects of sugar intake on body weight: a review. Obes Rev 2003, 4:91-99.
8. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M, . Finnish Diabetes Prevention Study Group Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001, 344:1343-1350. Finnish Diabetes Prevention Study Group.
9. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002, 346:393-403.
10. Gougeon R, Spidel M, Lee K, Field CJ. Canadian Diabetes Association National Nutrition Committee Technical Review: Non-nutritive intense sweeteners in diabetes management. Canadian Journal of Diabetes 2004, 28:385-399.
11. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009, 339:b2535.
12. Jadad AR, Moore RA, Carrol D, Jenkinson C, Reynolds JM, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: Is blinding necessary?. Control Clin Trials 1996, 17:1-12.
13. Schulze KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. JAMA 1995, 273:408-412.
14. Cho MK, Bero LA. The quality of drug studies published in symposium proceedings. Ann Intern Med 1996, 124:485-489.
15. Wiebe N, Vandermeer B, Platt RW, Klassen TP, Moher D, Barrowman NJ. A systematic review identifies a lack of standardization in methods for handling missing variance data. J Clin Epidemiol 2006, 59:342-353.
16. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
17. Renwick AG, Molinary SV. Sweet-taste receptors, low-energy sweeteners, glucose absorption and insulin release. Br J Nutr 2010, 104:1415-1420.
18. Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Chapter 16: Identifying and quantifying heterogeneity. Introduction to Meta-Analysis 2009, 123:-124. Wiley.
19. Lu G, Ades AE. Combination of direct and indirect evidence in mixed treatment comparisons. Stat Med 2004, 23:3105-3124.
20. Introduction to mixed treatment comparisons. , https://www.bris.ac.uk/cobm/docs/intro%20to%20mtc.doc
21. Dias S, Welton NJ, Caldwell DM, Ades AE. Checking consistency in mixed treatment comparison meta-analysis. Stat Med 2010, 29:932-944.
22. Prat-Larquemin L, Oppert JM, Bellisle F, Guy-Grand B. Sweet taste of aspartame and sucrose: effects on diet-induced thermogenesis. Appetite 2000, 34:245-251.
23. Melchior JC, Rigaud D, Colas-Linhart N, Petiet A, Girard A, Apfelbaum M. Immunoreactive beta-endorphin increases after an aspartame chocolate drink in healthy human subjects. PhysiolBehav 1991, 50:941-944.
24. Gonzalez-Ortiz M, Ramos-Zavala MG, Gonzalez-Lopez RC, Robles-Cervantes JA, Martinez-Abundis E, Gonzalez-Ortiz M, Ramos-Zavala MG, Gonzalez-Lopez RC, Robles-Cervantes JA, Martinez-Abundis E. Effect of 2 liquid nutritional supplements for diabetes patients on postprandial glucose, insulin secretion, and insulin sensitivity in healthy individuals. JPEN J Parenter Enteral Nutr 2009, 33:67-70.
25. Horwitz DL, McLane M, Kobe P. Response to single dose of aspartame or saccharin by NIDDM patients. Diabetes Care 1988, 11:230-234.
26. Nguyen NU, Dumoulin G, Henriet MT, Berthelay S, Regnard J. Carbohydrate metabolism and urinary excretion of calcium and oxalate after ingestion of polyol sweeteners. J Clin Endocrinol Metab 1993, 77:388-392.
27. Hassinger W, Sauer G, Cordes U, Krause U, Beyer J, Baessler KH. The effects of equal caloric amounts of xylitol, sucrose and starch on insulin requirements and blood glucose levels in insulin-dependent diabetics. Diabetologia 1981, 21:37-40.
28. Rizkalla SW, Luo J, Wils D, Bruzzo F, Slama G. Glycaemic and insulinaemic responses to a new hydrogenated starch hydrolysate in healthy and type 2 diabetic subjects. Diabetes Metab 2002, 28(5):385-390.
29. Wheeler ML, Fineberg SE, Gibson R, Fineberg N. Metabolic response to oral challenge of hydrogenated starch hydrolysate versus glucose in diabetes.[see comment]. Diabetes Care 1990, 13:733-740.
30. Maki KC, Kanter M, Rains TM, Hess SP, Geohas J. Acute effects of low insulinemic sweeteners on postprandial insulin and glucose concentrations in obese men. Int J Food Sci Nutr 2009, 60(SUPPL 3):48-55.
31. Teff KL, Grudziak J, Townsend RR, Dunn TN, Grant RW, Adams SH, Keim NL, Cummings BP, Stanhope KL, Havel PJ. Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab 2009, 94:1562-1569.
32. Bowen J, Noakes M, Clifton PM. Appetite hormones and energy intake in obese men after consumption of fructose, glucose and whey protein beverages. Int J Obes 2007, 31:1696-1703.
33. Chong MF, Fielding BA, Frayn KN, Chong MFF, Fielding BA, Frayn KN. Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr 2007, 85:1511-1520.
34. Visvanathan R, Chen R, Garcia M, Horowitz M, Chapman I. The effects of drinks made from simple sugars on blood pressure in healthy older people.[see comment]. Br J Nutr 2005, 93:575-579.
35. Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio D, Havel PJ. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 2004, 89:2963-2972.
36. Vozzo R, Baker B, Wittert GA, Wishart JM, Morris H, Horowitz M, Chapman I. Glycemic, hormone, and appetite responses to monosaccharide ingestion in patients with type 2 diabetes. Metabolism 2002, 51:949-957.
37. Spiller GA, Moynihan S, Butterfield G. Effects of sun-dried raisins on serum glucose: support for a convenient, plant-based snack food. Vegetarian Nutr 1998, 2:93-95.
38. Stewart SL, Black RM, Wolever TMS, Anderson GH. The relationship between glycaemic response to breakfast cereals and subjective appetite and food intake. Nutr Res 1997, 17:1249-1260.
39. Blaak EE, Saris WHM. Postprandial thermogenesis and substrate utilization after ingestion of different dietary carbohydrates. Metabolism 1996, 45:1235-1242.
40. Fukagawa NK, Veirs H, Langeloh G. Acute effects of fructose and glucose ingestion with and without caffeine in young and old humans. Metabolism 1995, 44:630-638.
41. Schwarz JM, Schutz Y, Piolino V, Schneider H, Felber JP, Jequier E. Thermogenesis in obese women: effect of fructose vs. glucose added to a meal. Am J Physiol 1992, 262:E394-E401.
42. Bukar J, Mezitis NH, Saitas V, Pi-Sunyer FX. Frozen desserts and glycemic response in well-controlled NIDDM patients. Diabetes Care 1990, 13:382-385.
43. Georgakopoulos K, Katsilambros N, Fragaki M, Poulopoulou Z, Kimbouris J, Sfikakis P, Raptis S. Recovery from insulin-induced hypoglycemia after saccharose or glucose administration. Clin Physiol Biochem 1990, 8:267-272.
44. Schwarz JM, Schutz Y, Froidevaux F, Acheson KJ, Jeanpretre N, Schneider H, Felber JP, Jequier E. Thermogenesis in men and women induced by fructose vs glucose added to a meal. Am J Clin Nutr 1989, 49:667-674.
45. Simonson DC, Tappy L, Jequier E, Felber JP, DeFronzo RA. Normalization of carbohydrate-induced thermogenesis by fructose in insulin-resistant states. Am J Physiol 1988, 254:E201-E207.
46. Jansen RW, Penterman BJ, van Lier HJ, Hoefnagels WH. Blood pressure reduction after oral glucose loading and its relation to age, blood pressure and insulin. Am J Cardiol 1987, 60:1087-1091.
47. Tappy L, Randin JP, Felber JP, Chiolero R, Simonson DC, Jequier E, DeFronzo RA. Comparison of thermogenic effect of fructose and glucose in normal humans. Am J Physiol 1986, 250:E718-724.
48. Samanta A, Burden AC, Jones GR. Plasma glucose responses to glucose, sucrose, and honey in patients with diabetes mellitus: an analysis of glycaemic and peak incremental indices. Diabet Med 1985, 2:371-373.
49. Bantle JP, Laine DC, Castle GW, Thomas JW, Hoogwerf BJ, Goetz FC. Postprandial glucose and insulin responses to meals containing different carbohydrates in normal and diabetic subjects. N Engl J Med 1983, 309:7-12.
50. Crapo PA, Scarlett JA, Kolterman OG. Comparison of the metabolic responses to fructose and sucrose sweetened foods. Am J Clin Nutr 1982, 36:256-261.
51. Mann JI, Truswell AS, Pimstone BL. The different effects of oral sucrose and glucose on alimentary lipaemia. Clin Sci 1971, 41:123-129.
52. Van Can JGP, Ijzerman TH, Van Loon LJC, Brouns F, Blaak EE. Reduced glycaemic and insulinaemic responses following isomaltulose ingestion: Implications for postprandial substrate use. Br J Nutr 2009, 102:1408-1413.
53. Qin LQ, Li J, Wang Y, Wang PY, Sato A, Kaneko T. Effect of repeated intake of disaccharides on glucose metabolism and insulin secretion in healthy adults - Comparison between sucrose and maltose. J Health Sci 2003, 49:226-228.
54. Stanhope KL, Griffen SC, Bair BR, Swarbrick MM, Keim NL, Havel PJ. Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals. Am J Clin Nutr 2008, 87:1194-1203.
55. Melanson KJ, Zukley L, Lowndes J, Nguyen V, Angelopoulos TJ, Rippe JM. Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women. Nutrition 2007, 23:103-112.
56. Kawai K, Yoshikawa H, Murayama Y, Okuda Y, Yamashita K. Usefulness of palatinose as a caloric sweetener for diabetic patients. Horm Metab Res 1989, 21:338-340.
57. Erkelens DW, Stofkooper A, Van DBE, Van D. Glycaemic effect of mono-, di- and polysaccharides in a mixed meal in diabetic patients. Neth J Med 1985, 28:157-163.
58. Grysman A, Carlson T, Wolever TM, Wolever TMS. Effects of sucromalt on postprandial responses in human subjects. Eur J Clin Nutr 2008, 62:1364-1371.
59. Munstedt K, Sheybani B, Hauenschild A, Bruggmann D, Bretzel RG, Winter D. Effects of basswood honey, honey-comparable glucose-fructose solution, and oral glucose tolerance test solution on serum insulin, glucose, and C-peptide concentrations in healthy subjects. J Med Food 2008, 11:424-428.
60. Bowker SL, Majumdar SR, Johnson JA. Systematic review of indicators and measurements used in controlled studies of quality improvement for type 2 diabetes. Can J Diabetes 2005, 29:230-238.
61. Reid M, Hammersley R, Hill AJ, Skidmore P. Long-term dietary compensation for added sugar: effects of supplementary sucrose drinks over a 4-week period. Br J Nutr 2007, 97:193-203.
62. Chantelau EA, Gosseringer G, Sonnenberg GE, Berger M. Moderate intake of sucrose does not impair metabolic control in pump-treated diabetic out-patients. Diabetologia 1985, 28:204-207.
63. Raben A, Vasilaras TH, Moller AC, Astrup A. Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects. Am J Clin Nutr 2002, 76:721-729.
64. Ngo Sock ET, Le KA, Ith M, Kreis R, Boesch C, Tappy L. Effects of a short-term overfeeding with fructose or glucose in healthy young males. Br J Nutr 2010, 103:939-943.
65. Bantle JP, Raatz SK, Thomas W, Georgopoulos A. Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 2000, 72:1128-1134.
66. Macdonald I, Taylor J. Differences in body weight loss on diets containing either sucrose or glucose syrup. Guys Hosp Rep 1973, 122:155-159.
67. Bantle JP, Laine DC, Thomas JW. Metabolic effects of dietary fructose and sucrose in types I and II diabetic subjects. JAMA 1986, 256:3241-3246.
68. Okuno M, Kim MK, Mizu M, Mori M, Mori H, Yamori Y. Palatinose-blended sugar compared with sucrose: different effects on insulin sensitivity after 12 weeks supplementation in sedentary adults. Int J Food Sci Nutr 2010, 61:643-651.
69. Yaghoobi N, Al-Waili N, Ghayour-Mobarhan M, Parizadeh SM, Abasalti Z, Yaghoobi Z, Yaghoobi F, Esmaeili H, Kazemi-Bajestani SM, Aghasizadeh R, Saloom KY, Ferns GA. Natural honey and cardiovascular risk factors; effects on blood glucose, cholesterol, triacylglycerole, CRP, and body weight compared with sucrose. ScientificWorldJournal 2008, 8:463-469.
70. Boesch C, Ith M, Jung B, Bruegger K, Erban S, Diamantis I, Kreis R, Bar A. Effect of oral D-tagatose on liver volume and hepatic glycogen accumulation in healthy male volunteers. Regul Toxicol Pharmacol 2001, 33:257-267.
71. Luo J, Van Yperselle M, Rizkalla SW, Rossi F, Bornet FR, Slama G. Chronic consumption of short-chain fructooligosaccharides does not affect basal hepatic glucose production or insulin resistance in type 2 diabetics. J Nutr 2000, 130:1572-1577.
72. Luo J, Rizkalla SW, Alamowitch C, Boussairi A, Blayo A, Barry JL, Laffitte A, Guyon F, Bornet FR, Slama G. Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism. Am j clin nutr 1996, 63:939-945.
73. Alles MS, de Roos NM, Bakx JC, van de Lisdonk E, Zock PL, Hautvast GA. Consumption of fructooligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes. Am J Clin Nutr 1999, 69:64-69.
74. Pearson ES. The application of statistical methods to industrial standardization and quality controls. 1960, London, UK: B.S. 600, British Standards Institution.
75. Bellisle F, Drewnowski A. Intense sweeteners, energy intake and the control of body weight. Eur J Clin Nutr 2007, 61:691-700.
76. Smeets PA, de Graaf C, Stafleu A, van Osch MJ, van der Grond J. Functional magnetic resonance imaging of human hypothalamic responses to sweet taste and calories. Am J Clin Nutr 2005, 82:1011-1016.
77. Tam J, Fukumura D, Jain RK. A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight. Cell Metab 2009, 9:52-63.
78. Sullivan EL, Cameron JL. A rapidly occurring compensatory decrease in physical activity counteracts diet-induced weight loss in female monkeys. Am J Physiol Regul Integr Comp Physiol 2010, 298:R1068-1074.
79. Erlanson-Albertsson C. How palatable food disrupts appetite regulation. Basic Clin Pharamcol Toxicol 2005, 97:61-73.
80. Black RM, Leiter LA, Anderson GH. Consuming aspartame with and without taste: differential effects on appetite and food intake of young adult males. Physiol Behav 1993, 53:459-466.
81. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, Schoelles K. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004, 292:1724-1737.
82. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009, 9:88.
83. Gougeon R, Spidel M, Lee K, Field CJ. Canadian Diabetes Association National Nutrition Committee Technical Review: Non-nutritive Intense Sweeteners in Diabetes Management. Can J Diabetes 2004, 28:385-399.
84. Wolever T, Barbeau M, Charron S, Harrigan K, Leung S, Madrick B, Taillefer T, Seto C. Guidelines for the nutritional management of diabetes mellitus in the new millennium: A position statement by the Canadian Diabetes Association. Can J Diabetes Care 1999, 23:56-69.
85. Calorie Control Council. , http://www.caloriecontrol.org/sweeteners-and-lite
86. Powers MA, Crapo PA. The fructose story. Diabetes Educ 1982, 7:22-25.
87. Lycasin maltitol syrups. , http://www.roquette-food.com/delia-CMS/search_product/topic_id-1720/article_id-3653/product_id-1208/
88. Glucerna 1.2 Cal Monograph. , http://abbottnutrition.com/Downloads/Gluc-1_2-Cal.pdf
89. Sweeteners. , http://www.elmhurst.edu/~chm/vchembook/549sweet.html
90. Carbohydrates and the sweeteners of honey. , http://www.honey.com/nhb/technical/technical-reference/
91. PALATINOSE™ -The functional carbohydrate providing better energy. , http://www.beneo-palatinit.com/en/Food_Ingredients/Isomaltulose/What_is_Isomaltulose/Palatinose-Brochure_EN_1.pdf
92. Trehalose. , http://www.caloriecontrol.org/sweeteners-and-lite/sugar-substitutes/other-sweeteners/trehalose