Sweet-taste receptors, low-energy sweeteners, glucose absorption and insulin release

British Journal of Nutrition

Volumn 104, Issue 10, 2010, Pages 1415-1420

  Renwick, Andrew G ^a   Molinary, Samuel V ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b Scientific and Regulatory Affairs   (United States)

Author keywords

Appetite; Food intake; Glucose absorption; Glucose homeostasis; Insulin release; Low energy sweeteners; Sweet taste receptors

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INCRETIN; INSULIN; RECEPTOR PROTEIN; SWEETENING AGENT;

APPETITE; BEVERAGE; BLOOD PRESSURE; BODY WEIGHT; CELL STIMULATION; CLINICAL STUDY; ENTEROENDOCRINE CELL; FOOD INTAKE; GLUCOSE ABSORPTION; HORMONE RELEASE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INGESTION; INSULIN RELEASE; MOLECULAR BIOLOGY; NONHUMAN; NUTRIENT; PROTEIN SECRETION; REVIEW; SWEETNESS; TASTE BUD;

ANIMALS; GLUCOSE; HUMANS; INSULIN; RECEPTORS, CELL SURFACE; SWEETENING AGENTS; TASTE;

ANIMALIA; MUS;

EID: 78650023940     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510002540     Document Type: Review

References (33)

1. Sclafani A (2007) Sweet taste signaling in the gut. Proc Natl Acad Sci U S A 104, 14887-14888.
2. Danilova V, Damak S, Margolskee RF, et al. (2006) Taste responses to sweet stimuli in α-gustducin knockout and wild-type mice. Chem Senses 31, 573-580.
3. Kellett GL & Helliwell PA (2000) The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane. Biochem J 350, 155-162.
4. Dyer J, Vayrol S, King TP, et al. (2003) Glucose sensing in the intestinal epithelium. Eur J Biochem (FEBS) 270, 3377-3388.
5. Mace OJ, Affleck J, Patel N, et al. (2007) Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol 582, 379-392.
6. Kellett GL (2007) Stress and intestinal sugar absorption. Am J Physiol Regul Integr Comp Physiol 292, R860-R861.
7. Hofer D, Puschel B & Drenckhahn D (1996) Taste receptor-like cells in the rat gut identified by expression of α-gustducin. Proc Natl Acad Sci U S A 93, 6631-6634.
8. +-glucose cotransporter 1. Proc Natl Acad Sci U S A 104, 15075-15080.
9. Egan JM & Margolskee RE (2008) Taste cells of the gut and gastrointestinal chemosensation. Mol Interv 8, 78-81.
10. Grieve DJ, Cassidy RS & Green BD (2009) Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: Potential therapeutic benefits beyond glycaemic control? Br J Pharmacol 157, 1340-1351.
11. Jang H-J, Kokrashvili Z, Theodorakis MJ, et al. (2007) Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 104, 15069-15074.
12. Li X, Staszewski L, Xu H, et al. (2002) Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A 99, 4692-4696.
13. Fujita Y, Wideman RD, Speck M, et al. (2009) Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. Am J Physiol Endocrinol Metab 296, E473-E479.
14. Blundell JE & Hill AJ (1986) Paradoxical effects of an intense sweetener (aspartame) on appetite. Lancet i, 1092-1093.
15. Teff KL, Mattes RD & Engelman K (1991) Cephalic phase insulin release in normal weight males: Verification and reliability. Am J Physiol Endocrinol Metab 261, E430-E436.
16. Renwick AG (1994) Intense sweeteners, food intake and the weight of a body of evidence. Physiol Behav 55, 139-143.
17. Just T, Pau HW, Engel U, et al. (2008) Cephalic phase insulin release in healthy humans after taste stimulation? Appetite 51, 622-627.
18. Teff KL, Devine J & Engelman K (1995) Sweet taste: Effect on cephalic phase insulin release in men. Physiol Behav 57, 1089-1095.
19. Abdallah L, Chabert M & Louis-Sylvestre J (1997) Cephalic phase responses to sweet taste. Am J Clin Nutr 65, 737-743.
20. Härtel B, Graubaum HL & Schneider B (1993) The influence of sweetener solutions on the secretion of insulin and the blood glucose level. Ernährungsumschau 40, 152-155.
21. Mezitis NHE, Maggio CA, Koch P, et al. (1996) Glycemic effect of a single high oral dose of the novel sweetener sucralose in patients with diabetes. Diabetes Care 19, 1004-1005.
22. Roberts A (1999) Sucralose and diabetes. Food Food Ingred Jpn 182, 49-55.
23. Grotz LV, Henry RF, McGill JB, et al. (2003) Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes. J Am Diet Assoc 103, 1607-1612.
24. Ma J, Bellon M, Wishart JM, et al. (2009) Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormaone release in healthy subjects. Am J Physiol - Gastrointest Liver Physiol 296, G735-G739.
25. Nauck MA, Niedereichholz U, Ettler R, et al. (1997) Glucagonlike peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 273, E981-E988.
26. Brown RJ, Walter M & Rother KI (2009) Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion. Diabetes Care 32, 2184-2186.
27. Chaikomin R, Doran S, Jones KL, et al. (2005) Initially more rapid small intestinal glucose delivery increases plasma insulin, GIP, and GLP-1 but does not improve overall glycemia in healthy subjects. Am J Physiol Endocrinol Metab 289, E504-E507.
28. Little TJ, Pilichiewicz AN, Russo A, et al. (2006) Effects of intravenous glucagon-like peptide-1 on gastric emptying and intragastric distribution in healthy subjects: Relationships with postprandial glycemic and insulinemic responses. J Clin Endocrinol Metab 91, 1916-1923.
29. WHO (2009) Evaluation of Certain Food Additives. Sixty-Ninth Report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series no. 952. Geneva: WHO.
30. Blackburn GL (2002) Evaluation of appetite, food intake, and usefulness of aspartame in weight control. Regul Toxicol Pharmacol 35, S83-S87.
31. de la Hunty A, Gibson S & Ashwell M (2006) A review of the effectiveness of aspartame in helping weight control. Nutr Bull 31, 115-128.
32. Bellisle F & Drewnowski A (2007) Intense sweeteners, energy intake and the control of body weight. Eur J Clin Nutr 61, 691-700.
33. Anton SD, Martin CK, Han H, et al. (2010) Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite (Epublication ahead of print version 18 March 2010).