Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependence

Neuropsychopharmacology

Volumn 36, Issue 13, 2011, Pages 2762-2773

  Kufahl, Peter R ^a,b   Martin Fardon, Rémi ^a   Weiss, Friedbert ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

dependence; ethanol; glutamate; mGluR2 3; reinstatement; withdrawal

Indexed keywords

4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; ALCOHOL; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3;

ALCOHOL INTOXICATION; ALCOHOL WITHDRAWAL; ALCOHOLISM; AMYGDALOID NUCLEUS; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG EFFECT; DRUG SELF ADMINISTRATION; FUNCTIONAL STATUS; LOW DRUG DOSE; MOTOR DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION; STRIA TERMINALIS;

ALCOHOLISM; AMINO ACIDS; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONDITIONING (PSYCHOLOGY); ETHANOL; MALE; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; SELF ADMINISTRATION;

EID: 80855137965     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.174     Document Type: Article

References (69)

1. Adams CL, Short JL, Lawrence AJ (2010). Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabo-tropic glutamate 5 receptors. Br J Pharmacol 159: 534-542.
2. Backstrom P, Bachteler D, Koch S, Hyytia P, Spanagel R (2004). mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29: 921-928. (Pubitemid 38526792)
3. Backstrom P, Hyytia P (2005). Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG. Eur J Pharmacol 528: 110-118. (Pubitemid 41773660)
4. Baptista MA, Martin-Fardon R, Weiss F (2004). Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. J Neurosci 24: 4723-4727. (Pubitemid 38668196)
5. Becker HC (2000). Animal models of alcohol withdrawal. Alcohol Res Health 24: 105-113.
6. Becker HC, Hale RL (1993). Repeated episodes of ethanol withdrawal potentiate the severity of subsequent withdrawal seizures: an animal model of alcohol withdrawal "kindling". Alcohol Clin Exp Res 17: 94-98. (Pubitemid 23080973)
7. Benarroch EE (2008). Metabotropic glutamate receptors: synaptic modulators and therapeutic targets for neurologic disease. Neurology 70: 964-968. (Pubitemid 351430745)
8. Beresford IJ, Harvey FJ, Hall DA, Giles H (1998). Pharmacological characterisation of melatonin mt1 receptor-mediated stimulation of [35S]-GTPgammaS binding. Biochem Pharmacol 56: 1167-1174. (Pubitemid 28511239)
9. Besheer J, Grondin J, Cannady R, Sharko A, Faccidomo S, Hodge C (2010). Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake. Biol Psychiatry 67: 812-822.
10. Blednov YA, Harris RA (2008). Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions. Int J Neuropsychopharmacol 11: 775-793.
11. Bossert JM, Busch RF, Gray SM (2005). The novel mGluR2/3 agonist LY379268 attenuates cue-induced reinstatement of heroin seeking. NeuroReport 16: 1013-1016. (Pubitemid 40904757)
12. Bossert JM, Poles GC, Sheffler-Collins SI, Ghitza UE (2006). The mGluR2/3 agonist LY379268 attenuates context-and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats. Behav Brain Res 173: 148-152. (Pubitemid 44604263)
13. Bowers MS, Hopf FW, Chou JK, Guillory AM, Chang SJ, Janak PH et al (2008). Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma. Proc Natl Acad Sci USA 105: 12533-12538.
14. Brown G, Jackson A, Stephens DN (1998). Effects of repeated withdrawal from chronic ethanol on oral self-administration of ethanol on a progressive ratio schedule. Behav Pharmacol 9: 149-161. (Pubitemid 28186511)
15. Brown SA, Vik PW, Patterson TL, Grant I, Schuckit MA (1995). Stress, vulnerability and adult alcohol relapse. J Stud Alcohol 56: 538-545.
16. Carboni E, Silvagni A, Rolando MT, Di Chiara G (2000). Stimulation of in vivo dopamine transmission in the bed nucleus of stria terminalis by reinforcing drugs. J Neurosci 20: RC102.
17. Cartmell J, Monn JA, Schoepp DD (1999). The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats. J Pharmacol Exp Ther 291: 161-170. (Pubitemid 29451586)
18. Cartmell J, Monn JA, Schoepp DD (2000). The mGlu(2/3) receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing. Eur J Pharmacol 400: 221-224. (Pubitemid 30438730)
19. Ciccocioppo R, Fedeli A, Economidou D, Policani F, Weiss F, Massi M (2003a). The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ. J Neurosci 23: 9445-9451. (Pubitemid 37323046)
20. Ciccocioppo R, Lin D, Martin-Fardon R, Weiss F (2003b). Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone. Psychopharmacology (Berl) 168: 208-215. (Pubitemid 36851181)
21. Clemmesen L, Hemmingsen R (1984). Physical dependence on ethanol during multiple intoxication and withdrawal episodes in the rat: evidence of a potentiation. Acta Pharmacol Toxicol (Copenh) 55: 345-350. (Pubitemid 15179473)
22. Dayas CV, Liu X, Simms JA, Weiss F (2007). Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone. Biol Psychiatry 61: 979-989. (Pubitemid 46482461)
23. Dumont EC, Mark GP, Mader S, Williams JT (2005). Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis. Nat Neurosci 8: 413-414. (Pubitemid 41007555)
24. Eiler II WJ, Hardy III L, Goergen J, Seyoum R, Mensah-Zoe B, June HL (2007). Responding for brain stimulation reward in the bed nucleus of the stria terminalis in alcohol-preferring rats following alcohol and amphetamine pretreatments. Synapse 61: 912-924. (Pubitemid 47464087)
25. Epping-Jordan MP, Markou A, Koob GF (1998). The dopamine D-1 receptor antagonist SCH 23390 injected into the dorsolateral bed nucleus of the stria terminalis decreased cocaine reinforcement in the rat. Brain Res 784: 105-115. (Pubitemid 28137854)
26. Ferraguti F, Shigemoto R (2006). Metabotropic glutamate receptors. Cell Tissue Res 326: 483-504. (Pubitemid 44435821)
27. Fox HC, Bergquist KL, Hong KI, Sinha R (2007). Stress-induced and alcohol cue-induced craving in recently abstinent alcohol-dependent individuals. Alcohol Clin Exp Res 31: 395-403. (Pubitemid 46239271)
28. Fox HC, Hong K-IA, Siedlarz K, Sinha R (2008). Enhanced sensitivity to stress and drug/alcohol craving in abstinent cocaine-dependent individuals compared to social drinkers. Neuropsychopharmacology 33: 796-805. (Pubitemid 351252705)
29. Fox HC, Talih M, Malison R, Anderson GM, Kreek MJ, Sinha R (2005). Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues. Psychoneuroendocrinology 30: 880-891. (Pubitemid 40977910)
30. Fuchs RA, Evans KA, Ledford CC, Parker MP, Case JM, Mehta RH et al (2005). The role of the dorsomedial prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats. Neuropsychopharma-cology 30: 296-309. (Pubitemid 40129481)
31. Gass JT, Olive MF (2009). Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell. Psychopharmacology (Berl) 204: 587-597.
32. Ghasemzadeh MB, Mueller C, Vasudevan P (2009). Behavioral sensitization to cocaine is associated with increased glutamate receptor trafficking to the postsynaptic density after extended withdrawal period. Neuroscience 159: 414-426.
33. Hao Y, Martin-Fardon R, Weiss F (2010). Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependence. Biol Psychiatry 68: 240-248.
34. Harrison C, Traynor JR (2003). The [35S]GTPgammaS binding assay: approaches and applications in pharmacology. Life Sci 74: 489-508. (Pubitemid 37377904)
35. Harwood HJ, Fountain D, Fountain G (1999). Economic cost of alcohol and drug abuse in the United States, 1992: a report. Addiction 94: 631-635.
36. Heilig M, Egli M (2006). Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol Ther 111: 855-876. (Pubitemid 44118437)
37. Helton DR, Tizzano JP, Monn JA, Schoepp DD, Kallman MJ (1998). Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J Pharmacol Exp Ther 284: 651-660. (Pubitemid 28086655)
38. Heyser CJ, Roberts AJ, Schulteis G, Koob GF (1999). Central administration of an opiate antagonist decreases oral ethanol self-administration in rats. Alcohol Clin Exp Res 23: 1468-1476. (Pubitemid 29468443)
39. Holland PC, Bouton ME (1999). Hippocampus and context in classical conditioning. Curr Opin Neurobiol 9: 195-202. (Pubitemid 29201792)
40. Hyytia P, Koob GF (1995). GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol 283: 151-159.
41. Kenny PJ, Markou A (2004). The ups and downs of addiction: role of metabotropic glutamate receptors. Trends Pharmacol Sci 25: 265-272. (Pubitemid 38553829)
42. Knopfel T, Kuhn R, Allgeier H (1995). Metabotropic glutamate receptors: novel targets for drug development. J Med Chem 38: 1417-1426.
43. Koob GF (2003). Neuroadaptive mechanisms of addiction: studies on the extended amygdala. Eur Neuropsychopharmacol 13: 442-452. (Pubitemid 37433964)
44. Koob GF, Volkow ND (2009). Neurocircuitry of addiction. Neuropsychopharmacology 35: 217-238.
45. Kreek MJ, Koob GF (1998). Drug dependence: stress and dysregulation of brain reward pathways. Drug Alcohol Depend 51: 23-47. (Pubitemid 28353754)
46. Liechti ME, Lhuillier L, Kaupmann K, Markou A (2007). Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence. J Neurosci 27: 9077-9085. (Pubitemid 47312061)
47. Liu X, Weiss F (2002a). Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms. J Neurosci 22: 7856-7861. (Pubitemid 35379090)
48. Liu X, Weiss F (2002b). Reversal of ethanol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously ethanol-dependent versus nondependent rats. J Pharmacol Exp Ther 300: 882-889.
49. Moller C, Wiklund L, Sommer W, Thorsell A, Heilig M (1997). Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions. Brain Res 760: 94-101. (Pubitemid 27304141)
50. Olive MF, McGeehan AJ, Kinder JR, McMahon T, Hodge CW, Janak PH et al (2005). The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism. Mol Pharmacol 67: 349-355. (Pubitemid 40216726)
51. Paxinos G, Watson C (1998). The Rat Brain in Stereotaxic Coordinates, 4th edn. Academic Press: San Diego, CA.
52. Pinheiro PS, Mulle C (2008). Presynaptic glutamate receptors: physiological functions and mechanisms of action. Nat Rev Neurosci 9: 423-436.
53. Roberts AJ, Cole M, Koob GF (1996). Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats. Alcohol Clin Exp Res 20: 1289-1298. (Pubitemid 26357034)
54. Roberts AJ, Heyser CJ, Cole M, Griffin P, Koob GF (2000). Excessive ethanol drinking following a history of dependence: animal model of allostasis. Neuropsychopharmacology 22: 581-594. (Pubitemid 30219402)
55. Rodd ZA, McKinzie DL, Bell RL, McQueen VK, Murphy JM, Schoepp DD et al (2006). The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats. Behav Brain Res 171: 207-215. (Pubitemid 43946492)
56. Schoepp DD (2001). Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther 299: 12-20. (Pubitemid 32905113)
57. Schroeder JP, Spanos M, Stevenson JR, Besheer J, Salling M, Hodge CW (2008). Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP. Neuropharmacology 55: 546-554.
58. Sidhpura N, Weiss F, Martin-Fardon R (2010). Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence. Biol Psychiatry 67: 804-811.
59. Sinha R (ed) (2000). Stress, craving, and relapse to drug use. National Institute on Drug Abuse (NIDA) Symposium: The Intersection of Stress, Drug Abuse, and Development. Bethesda, MD.
60. Sinha R (2001). How does stress increase risk of drug abuse and relapse? Psychopharmacology (Berl) 158: 343-359. (Pubitemid 33141310)
61. Sinha R, Fox HC, Hong KA, Bergquist K, Bhagwagar Z, Siedlarz KM (2009). Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsycho-pharmacology 34: 1198-1208.
62. Sinha R, Talih M, Malison R, Cooney N, Anderson GM, Kreek MJ (2003). Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states. Psychopharmacology (Berl) 170: 62-72. (Pubitemid 37372479)
63. Swanson CJ, Bures M, Johnson MP, Linden AM, Monn JA, Schoepp DD (2005). Metabotropic glutamate receptors as novel targets for anxiety and stress disorders. Nat Rev Drug Discov 4: 131-144. (Pubitemid 40277494)
64. Topple AN, Hunt GE, McGregor IS (1998). Possible neural substrates of beer-craving in rats. Neurosci Lett 252: 99-102. (Pubitemid 28384502)
65. Tzschentke TM, Schmidt WJ (2003). Glutamatergic mechanisms in addiction. Mol Psychiatry 8: 373-382. (Pubitemid 36609661)
66. Walker BM, Koob GF (2008). Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence. Neuropsychopharmacology 33: 643-652.
67. Wurtz RH, Olds J (1963). Amygdaloid stimulation and operant reinforcement in the rat. J Comp Physiol Psychol 56: 941-949.
68. Xi ZX, Ramamoorthy S, Baker DA, Shen H, Samuvel DJ, Kalivas PW (2002). Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. J Pharmacol Exp Ther 303: 608-615. (Pubitemid 35231232)
69. Zhao Y, Dayas CV, Aujla H, Baptista MA, Martin-Fardon R, Weiss F (2006). Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala. J Neurosci 26: 9967-9974. (Pubitemid 44477158)