-
1
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL, (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
2
-
-
22244440847
-
Proline hydroxylation and gene expression
-
Kaelin WG, (2005) Proline hydroxylation and gene expression. Annu Rev Biochem 74: 115-128.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 115-128
-
-
Kaelin, W.G.1
-
4
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
-
Tanimoto K, Makino Y, Pereira T, Poellinger L, (2000) Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J 19: 4298-4309.
-
(2000)
EMBO J
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
Makino, Y.2
Pereira, T.3
Poellinger, L.4
-
5
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL, (2001) HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21: 3995-4004.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
6
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
-
Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van Obberghen E, (2002) Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 277: 27975-27981.
-
(2002)
J Biol Chem
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
Van Obberghen, E.5
-
7
-
-
37549037125
-
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha
-
Galban S, Kuwano Y, Pullmann R Jr, Martindale JL, Kim HH, et al. (2008) RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol 28: 93-107.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 93-107
-
-
Galban, S.1
Kuwano, Y.2
Pullmann Jr., R.3
Martindale, J.L.4
Kim, H.H.5
-
8
-
-
64649086259
-
Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia
-
Yang J, Ahmed A, Poon E, Perusinghe N, de Haven Brandon A, et al. (2009) Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia. Mol Cell Biol 29: 2243-2253.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2243-2253
-
-
Yang, J.1
Ahmed, A.2
Poon, E.3
Perusinghe, N.4
de Haven Brandon, A.5
-
9
-
-
62449203027
-
Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression
-
Zhu K, Chan W, Heymach J, Wilkinson M, McConkey DJ, (2009) Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression. Cancer Res 69: 1836-1843.
-
(2009)
Cancer Res
, vol.69
, pp. 1836-1843
-
-
Zhu, K.1
Chan, W.2
Heymach, J.3
Wilkinson, M.4
McConkey, D.J.5
-
10
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, et al. (2002) Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J Biol Chem 277: 29936-29944.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
-
11
-
-
0036569704
-
Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells
-
Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, et al. (2002) Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res 62: 2478-2482.
-
(2002)
Cancer Res
, vol.62
, pp. 2478-2482
-
-
Mabjeesh, N.J.1
Post, D.E.2
Willard, M.T.3
Kaur, B.4
Van Meir, E.G.5
-
12
-
-
0042029755
-
The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism
-
Tang TT, Lasky LA, (2003) The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism. J Biol Chem 278: 30125-30135.
-
(2003)
J Biol Chem
, vol.278
, pp. 30125-30135
-
-
Tang, T.T.1
Lasky, L.A.2
-
13
-
-
33846254999
-
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
-
Liu YV, Baek JH, Zhang H, Diez R, Cole RN, et al. (2007) RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell 25: 207-217.
-
(2007)
Mol Cell
, vol.25
, pp. 207-217
-
-
Liu, Y.V.1
Baek, J.H.2
Zhang, H.3
Diez, R.4
Cole, R.N.5
-
14
-
-
56149089262
-
Hypoxia-inducible factor 1 and cancer pathogenesis
-
Semenza GL, (2008) Hypoxia-inducible factor 1 and cancer pathogenesis. IUBMB Life 60: 591-597.
-
(2008)
IUBMB Life
, vol.60
, pp. 591-597
-
-
Semenza, G.L.1
-
15
-
-
54549089738
-
Hypoxia signalling through mTOR and the unfolded protein response in cancer
-
Wouters BG, Koritzinsky M, (2008) Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 8: 851-864.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 851-864
-
-
Wouters, B.G.1
Koritzinsky, M.2
-
16
-
-
60549083256
-
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
-
Semenza GL, (2009) Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol 19: 12-16.
-
(2009)
Semin Cancer Biol
, vol.19
, pp. 12-16
-
-
Semenza, G.L.1
-
17
-
-
22744447648
-
HIF-1alpha and p53: the ODD couple?
-
Fels DR, Koumenis C, (2005) HIF-1alpha and p53: the ODD couple? Trends Biochem Sci 30: 426-429.
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 426-429
-
-
Fels, D.R.1
Koumenis, C.2
-
18
-
-
34447565882
-
The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts
-
Harada H, Kizaka-Kondoh S, Itasaka S, Shibuya K, Morinibu A, et al. (2007) The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts. Biochem Biophys Res Commun 360: 791-796.
-
(2007)
Biochem Biophys Res Commun
, vol.360
, pp. 791-796
-
-
Harada, H.1
Kizaka-Kondoh, S.2
Itasaka, S.3
Shibuya, K.4
Morinibu, A.5
-
19
-
-
0036531825
-
Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells
-
Harada H, Hiraoka M, Kizaka-Kondoh S, (2002) Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells. Cancer Res 62: 2013-2018.
-
(2002)
Cancer Res
, vol.62
, pp. 2013-2018
-
-
Harada, H.1
Hiraoka, M.2
Kizaka-Kondoh, S.3
-
20
-
-
33947362062
-
In vivo pathology: seeing with molecular specificity and cellular resolution in the living body
-
Contag CH, (2007) In vivo pathology: seeing with molecular specificity and cellular resolution in the living body. Annu Rev Pathol 2: 277-305.
-
(2007)
Annu Rev Pathol
, vol.2
, pp. 277-305
-
-
Contag, C.H.1
-
21
-
-
0036363666
-
Imaging of light emission from the expression of luciferases in living cells and organisms: a review
-
Greer LF 3rd, Szalay AA, (2002) Imaging of light emission from the expression of luciferases in living cells and organisms: a review. Luminescence 17: 43-74.
-
(2002)
Luminescence
, vol.17
, pp. 43-74
-
-
Greer 3rd, L.F.1
Szalay, A.A.2
-
22
-
-
0025121594
-
Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes
-
Saitoh A, Kimura M, Takahashi R, Yokoyama M, Nomura T, et al. (1990) Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene 5: 1195-1200.
-
(1990)
Oncogene
, vol.5
, pp. 1195-1200
-
-
Saitoh, A.1
Kimura, M.2
Takahashi, R.3
Yokoyama, M.4
Nomura, T.5
-
23
-
-
10544239531
-
Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice
-
Yamamoto S, Mitsumori K, Kodama Y, Matsunuma N, Manabe S, et al. (1996) Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice. Carcinogenesis 17: 2455-2461.
-
(1996)
Carcinogenesis
, vol.17
, pp. 2455-2461
-
-
Yamamoto, S.1
Mitsumori, K.2
Kodama, Y.3
Matsunuma, N.4
Manabe, S.5
-
24
-
-
0031977910
-
Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing
-
Yamamoto S, Urano K, Koizumi H, Wakana S, Hioki K, et al. (1998) Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. Environ Health Perspect 106 (Suppl 1): 57-69.
-
(1998)
Environ Health Perspect
, vol.106
, Issue.SUPPL. 1
, pp. 57-69
-
-
Yamamoto, S.1
Urano, K.2
Koizumi, H.3
Wakana, S.4
Hioki, K.5
-
25
-
-
33749327178
-
Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1alpha containing Pro564
-
Harada H, Kizaka-Kondoh S, Hiraoka M, (2006) Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1alpha containing Pro564. FEBS Lett 580: 5718-5722.
-
(2006)
FEBS Lett
, vol.580
, pp. 5718-5722
-
-
Harada, H.1
Kizaka-Kondoh, S.2
Hiraoka, M.3
-
26
-
-
41649116838
-
n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems
-
Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, et al. (2008) n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems. Biochem J 411: 97-105.
-
(2008)
Biochem J
, vol.411
, pp. 97-105
-
-
Kimura, M.1
Takabuchi, S.2
Tanaka, T.3
Murata, M.4
Nishi, K.5
-
27
-
-
0032211174
-
Erythropoietin mRNA expression in human fetal and neonatal tissue
-
Dame C, Fahnenstich H, Freitag P, Hofmann D, Abdul-Nour T, et al. (1998) Erythropoietin mRNA expression in human fetal and neonatal tissue. Blood 92: 3218-3225.
-
(1998)
Blood
, vol.92
, pp. 3218-3225
-
-
Dame, C.1
Fahnenstich, H.2
Freitag, P.3
Hofmann, D.4
Abdul-Nour, T.5
-
28
-
-
0031868228
-
Developmental biology of erythropoiesis
-
Palis J, Segel GB, (1998) Developmental biology of erythropoiesis. Blood Rev 12: 106-114.
-
(1998)
Blood Rev
, vol.12
, pp. 106-114
-
-
Palis, J.1
Segel, G.B.2
-
30
-
-
30444445382
-
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production
-
Safran M, Kim WY, O'Connell F, Flippin L, Gunzler V, et al. (2006) Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. Proc Natl Acad Sci U S A 103: 105-110.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 105-110
-
-
Safran, M.1
Kim, W.Y.2
O'Connell, F.3
Flippin, L.4
Gunzler, V.5
-
31
-
-
10744226756
-
The utility of genetically modified mouse assays for identifying human carcinogens: a basic understanding and path forward. The Alternatives to Carcinogenicity Testing Committee ILSI HESI
-
MacDonald J, French JE, Gerson RJ, Goodman J, Inoue T, et al. (2004) The utility of genetically modified mouse assays for identifying human carcinogens: a basic understanding and path forward. The Alternatives to Carcinogenicity Testing Committee ILSI HESI. Toxicol Sci 77: 188-194.
-
(2004)
Toxicol Sci
, vol.77
, pp. 188-194
-
-
MacDonald, J.1
French, J.E.2
Gerson, R.J.3
Goodman, J.4
Inoue, T.5
-
32
-
-
77952314409
-
Alternative mouse models for carcinogenicity assessment: industry use and issues with pathology interpretation
-
Long GG, Morton D, Peters T, Short B, Skydsgaard M, (2010) Alternative mouse models for carcinogenicity assessment: industry use and issues with pathology interpretation. Toxicol Pathol 38: 43-50.
-
(2010)
Toxicol Pathol
, vol.38
, pp. 43-50
-
-
Long, G.G.1
Morton, D.2
Peters, T.3
Short, B.4
Skydsgaard, M.5
-
33
-
-
77952306315
-
An industry perspective on the utility of short-term carcinogenicity testing in transgenic mice in pharmaceutical development
-
Storer RD, Sistare FD, Reddy MV, DeGeorge JJ, (2010) An industry perspective on the utility of short-term carcinogenicity testing in transgenic mice in pharmaceutical development. Toxicol Pathol 38: 51-61.
-
(2010)
Toxicol Pathol
, vol.38
, pp. 51-61
-
-
Storer, R.D.1
Sistare, F.D.2
Reddy, M.V.3
DeGeorge, J.J.4
-
34
-
-
78650824227
-
In vivo imaging of HIF-active tumors by an oxygen-dependent degradation protein probe with an interchangeable labeling system
-
Kuchimaru T, Kadonosono T, Tanaka S, Ushiki T, Hiraoka M, et al. (2010) In vivo imaging of HIF-active tumors by an oxygen-dependent degradation protein probe with an interchangeable labeling system. PLoS One 5: e15736.
-
(2010)
PLoS One
, vol.5
-
-
Kuchimaru, T.1
Kadonosono, T.2
Tanaka, S.3
Ushiki, T.4
Hiraoka, M.5
-
35
-
-
66149164442
-
Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer
-
Kizaka-Kondoh S, Itasaka S, Zeng L, Tanaka S, Zhao T, et al. (2009) Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer. Clin Cancer Res 15: 3433-3441.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3433-3441
-
-
Kizaka-Kondoh, S.1
Itasaka, S.2
Zeng, L.3
Tanaka, S.4
Zhao, T.5
|