DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells

British Journal of Cancer

Volumn 88, Issue 4, 2003, Pages 599-605

  Trapani, V ^a   Patel, V ^b   Leong, C O ^a   Ciolino, H P ^c   Yeh, G C ^c   Hose, C ^c   Trepel, J B ^e   Stevens, M F G ^a   Sausville, E A ^d   Loaiza Perez A I ^d  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Natl Institutes Dent/C   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e NONE

Author keywords

2 (4 aminophenyl)benzothiazoles; Aryl hydrocarbon receptor; CYP1A1; DNA damage; MCF 7; S phase arrest

Indexed keywords

2 (4 AMINO 3 METHYLPHENYL) 5 FLUOROBENZOTHIAZOLE; 5 FLUORO 2 (4 LYSYLAMINO 3 METHYLPHENYL)BENZOTHIAZOLE; 5F 203; AMIDE; ANTINEOPLASTIC AGENT; AROMATIC HYDROCARBON RECEPTOR; BENZOTHIAZOLE DERIVATIVE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; ETHOXYRESORUFIN DEETHYLASE; LYSINE DERIVATIVE; NSC 703786; NSC 710305; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DNA PROTEIN COMPLEX; DNA RESPONSIVE ELEMENT; DRUG CYTOTOXICITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TRANSCRIPTION INITIATION; XENOBIOTIC RESPONSIVE ELEMENT;

ARYL HYDROCARBON HYDROXYLASES; CELL CYCLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A1; DNA ADDUCTS; DNA DAMAGE; ENZYME INDUCTION; HUMANS; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0037463319     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600722     Document Type: Article

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