Mechanism of action of E7010, an orally active sulfonamide antitumor agent: Inhibition of mitosis by binding to the colchicine site of tubulin

Cancer Research

Volumn 57, Issue 15, 1997, Pages 3208-3213

  Yoshimatsu, Kentaro ^a   Yamaguchi, Atsumi ^a   Yoshino, Hiroshi ^a   Koyanagi, Nozomu ^a   Kitoh, Kyosuke ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CISPLATIN; COLCHICINE; DOXORUBICIN; FLUOROURACIL; GLYCOPROTEIN; MITOMYCIN C; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PIRIDINYL] 4 METHOXYBENZENESULFONAMIDE; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; PACLITAXEL; PODOPHYLLOTOXIN; SULFONAMIDE; TUBULIN; UNCLASSIFIED DRUG; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS RESISTANCE; DRUG ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MITOSIS INDEX; MITOSIS INHIBITION; MULTIDRUG RESISTANCE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN ANALYSIS;

AMINOPHENOLS; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CELL CYCLE; COLCHICINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; HUMANS; LEUKEMIA; LUNG NEOPLASMS; MICE; MICROTUBULES; MITOSIS; SULFONAMIDES; TUBULIN; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 0030756156     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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