Nuclear factor-κb signaling in endothelium

Endothelial Biomedicine

Volumn , Issue , 2007, Pages 784-795

  Bijli, Kaiser M ^a   Rahman, Arshad ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80655127436     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511546198.087     Document Type: Chapter

References (70)

1. Bonizzi G, Karin M. The two NF-êB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004;25:280–288.
2. Hayden MS, Ghosh S. Signaling to NF-êB. Genes Dev. 2004;18: 2195–2224.
3. Senftleben U, Cao Y, Xiao G, et al. Activation of IKKá of a second, evolutionary conserved, NF-êB signaling pathway Science. 2001; 293:1495–1499.
4. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell. 1986;46:705–716.
5. Haskill S, Beg A, Tompkins S, et al. Characterization of an immediate early gene induced in adherent monocytes that encodes an IêB-like activity. Cell. 1991;65:1281–1289.
6. Huxford T, Huang DB, Malek S, et al. The crystal structure of IêBá/NF-êB complex reveals mechanisms of NF-êB inactivation. Cell. 1998;95:759–770.
7. Ghosh S, Karin M. Missing pieces in the NF-êB puzzle. Cell. 2002;109:S81–S86.
8. Li Q, Van Antwerp D, Mercurio F, et al. Severe liver degeneration in mice lacking the IKK2 gene. Science. 1999;284:321–325.
9. Tanaka M, Fuentes ME, Yamaguchi K, et al. Embryonic lethality, liver degeneration, and impaired NF-êB activation in IKKâ-deficient mice. Immunity. 1999;10:421–429.
10. Regnier CH, Song HY, Gao X, et al. Identification and characterization of an IêB kinase. Cell. 1997;90:357–383.
11. Xiao G, Fong A, Sun SC. Induction of p100 processing by NIK involves docking IKKá to p100 and IKKá-mediated phosphorylation. J Biol Chem. 2004;279:30099–30105.
12. Kato T Jr., Delhase M, Hoffmann A, et al. CK2 is a C-terminal IKK responsible for NF-êB activation during the UV response. Mol Cell. 2003;12:829–839.
13. Bouwmwester T, Bauch A, Ruffner H, et al. A physical and functionalmapof thehumanTNFá/NF-êBsignal transduction pathway. Nat Cell Biol. 2004;6:97–105.
14. Chen LF, GreeneWC. Shaping the nuclear activation of NF-êB. Nat Mol Cell Biol. 2004;5:392–401.
15. Viatour P, Merville MP, Bours V, et al. Phosphorylation of NF-êB and IêB proteins: implications in cancer and inflammation. Trends Biochem Sci. 2005;30:43–52.
16. Ryo A, Suizu F, Yoshida Y. Regulation of NF-êB signaling by PIN 1-dependent prolyl isomerization and ubiquitination-mediated proteolysis of p65/RelA. Mol Cell. 2003;12:1413–1426.
17. Chen L, Fischle W, Verdin E, et al. Duration of nuclear NF-êB action regulated by reversible acetylation. Science. 2001;293: 1653–1657.
18. Imhof A, Wolffe AP. Transcription: gene controlled by targeted histone acetylation. Curr Biol. 1998;8:R422–R424.
19. Saccani S, Pantano S, Natoli G. Two waves of NF-êB recruitment to target promoters. J Exp Med. 2001;193:1351–1359.
20. Chen LF, Greene WC. Regulation of distinct biological activities of the NF-êB transcription factor complex by acetylation. J Mol Med. 2003;81:549–557.
21. Rahman I, Marwick J, Kirkham P. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-êB and pro-inflammatory gene expression. Biochem Pharmacol. 2004;68:1255–1267.
22. Almawi WY, Melemedjian OK. Negative regulation of NF-êB activation and function by glucocorticoids. J Mol Endocrinol. 2002;28:69–78.
23. Yamamoto Y, Verma UN, Prajapati S, et al.Histone H3 phosphorylation byIKKá is critical for cytokine-induced gene expression. Nature. 2003;423:655–659.
24. Anest V, Hanson JL, Cogswell PC, et al. A nucleosomal function for IKKá in NF-êB dependent gene expression. Nature. 2003; 423:659–663.
25. Saccani S, Pantano S, Natoli G. p38-dependent marking of inflammatory genes for increased NF-êB recruitment. Nature Immunol. 2002;3:69–75.
26. Aird WC. Endothelium as an organ system. Crit Care Med. 2004; 32:S271–S279.
27. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76: 301–314.
28. Brown EJ. Adhesive interactions in the immune system. Trends Cell Biol. 1997;7:289–295.
29. Rahman A, Anwar KN, Uddin S, et al. PKC-ä regulates thrombininduced ICAM-gene expression in ECs via activation of p38 mitogen-activated protein kinase. Mol Cell Biol. 2001;21:5554– 5565.
30. Minami T, Abid MR, Zhang J, et al. Thrombin stimulation of vascular adhesion molecule-in ECs is mediated by PKC-ä-NF-êB and PKC-æ-GATA signaling pathways. J Biol Chem. 2003;278: 6976–6984.
31. Collins T, Read MA, Neish AS, et al. Transcriptional regulation of EC adhesion molecules: NF-êB and cytokine-inducible enhancers. FASEB J. 1995;9:899–909.
32. Rahman A, Roebuck KA, Malik AB. Transcriptional regulation of endothelial adhesion molecule gene expression by oxidants and cytokines. In: Weir EK, Archer SL, Reeves JT, eds. Nitric Oxide and Radicals in the Pulmonary Vasculature. Armonk, New York: Futura Publishing Company, Inc.; 1996:63–85.
33. Rahman A, Anwar KN, True AL, et al. Thrombin-induced p65 homodimer binding to downstream NF-êB site of the promoter mediates endothelial ICAM-expression and neutrophil adhesion. J Immunol. 1999;162:5466–5476.
34. Minami T, Aird WC. Thrombin stimulation of the vascular cell adhesion molecule-promoter in ECs is mediated by tandem NF-êB and GATA motifs. J Biol Chem. 2001;276:47632–47641.
35. Pan J, Xia L, Yao L, et al. TNFá or lipopolysaccharide-induced expression of themurine P-selectin gene in ECs involves novel êB sites and a variant activating transcription factor/cAMP response element. J Biol Chem. 1998;273:10068–10077.
36. Murdoch C, Finn A. Chemokine receptors and their role in inflammation and infectious diseases. Blood. 2000;95:3032– 3043.
37. Denk A, Goebeler M, Schmid S, et al. Activation of NF-êB via theIKKcomplex isboth essential and sufficient for proinflammatory gene expression in primary ECs. J Biol Chem. 2001;276: 28451–28458.
38. Zoja C, Angioletti S, Donadelli R, et al. Shiga toxin-2 triggers endothelial leukocyte adhesion and transmigration via NF-êB dependent up-regulation of IL-8 and MCP-1. Kidney Int. 2002; 62:846–856.
39. Krishnaswamy G, Kelley J, Yerra L, et al. Human endothelium as a source of multifunctional cytokines: molecular regulation and possible role in human disease. J Interferon Cytokine Res. 1999;19:91–104.
40. Chandrasekar B, Marelli-Berg FM, Tone M, et al. â-adrenergic stimulation induces IL-18 expression via beta2-AR, PI3K, Akt, IKK and NF-êB. Biochem Biophys Res Commun. 2004;319:304– 311.
41. Kobayashi S, Nagino M, Komatsu S, et al. Stretch-induced IL-6 secretion from endothelial cells requires NF-êB activation. Biochem Biophys Res Commun. 2003;308:306–312.
42. Peng HB, Rajavashisth TB, Libby P, et al. Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells. J Biol Chem. 1995;270: 17050–17055.
43. Fan J, Frey RS, Malik AB. TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase. J Clin Invest. 2003;112:1234–1243.
44. Takahashi M, Kitagawa S, Masuyama JI, et al.Human monocyteendothelial cell interaction induces synthesis of GM-CSF. Circulation. 1996;93:1185–1193.
45. Beg AA, Baltimore D. An essential role for NF-êB in preventing TNFá-induced cell death. Science. 1996;274:782–784.
46. Brouard S, Berberat PO, Tobiasch E, et al. Heme oxygenase-1-derived carbonmonoxide requires the activation of transcription factor NF-êB to protect endothelial cells from TNFá-mediated apoptosis. J Biol Chem. 2002;277:17950–17961
47. Abid MR, Schoots IG, Spokes KC, et al. Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IêB/NF-êB. J Biol Chem. 2004;279:44030–44038.
48. Levkau B, Scatena M, Giachelli CM, et al. Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-êB loop. Nat Cell Biol. 1999;1:227–233.
49. Chandrasekar B, Vemula K, Surabhi RM, et al. Activation of intrinsic and extrinsic proapoptotic signaling pathways in IL-18-mediated human cardiac endothelial cell death. J Biol Chem. 2004;279:20221–20233.
50. Yoshida S, Ono M, Shono T, et al. Involvement of IL-8, vascular endothelial growth factor, and basic fibroblast growth factor in TNFá-dependent angiogenesis. Mol Cell Biol. 1997;17:4015– 4023.
51. DeBusk LM, Chen Y, Nishishita T, et al. Tie2 receptor tyrosine kinase, a major mediator of TNFá-induced angiogenesis in rheumatoid arthritis. Arthritis Rheum. 2003;48:2461–2471.
52. Yoshida A, Yoshida S, Ishibashi T, et al. Suppression of retinal neovascularization by theNF-êBinhibitorpyrrolidine dithiocarbamate in mice. Invest Ophthalmol Vis Sci. 1999;40:1624–1629.
53. Greten FR, Eckmann L, Greten TF, et al. IKKâ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 2004;118:285–296.
54. Pikarsky E, Porat RM, Stein I, et al. NF-êB functions as a tumor promoter in inflammation-associated cancer. Nature. 2004;431: 461–466.
55. Minhajuddin M, Fazal F, Bijli KM, et al. Inhibition of mTOR potentiates thrombin-induced ICAM-expression by accelerating and stabilizing NF-êB activation in ECs. J Immunol. 2005; 174:5823–5829.
56. Hajra L, Evans AI, Chen M, et al. The NF-kB signal transduction pathway in aortic endothelial cells is primed for activation in regionspredisposed toatherosclerotic lesion formation. ProcNatl Acad Sci USA. 2000;97:9052–9057.
57. Yamamoto Y, Gaynor RB. Therapeutic potential of inhibition of the NF-êBpathway in the treatment of inflammation and cancer. J Clin Invest. 2001;107:135–142.
58. Xu N, Gao XP, Minshall RD, et al. Time-dependent reversal of sepsis-induced PMN uptake and lung vascular injury by expressionofCD18antagonist. AmJPhysiolLungCellMolPhysiol. 2002; 282:L796–L802.
59. Beg AA, Sha WC, Bronson RT, et al. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-êB. Nature. 1995;376:167–170.
60. Kontgen F, Grumont RJ, Strasser A, et al. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 1995;9:1965–1977.
61. Weih F, Carrasco D, Durham SK, et al. Multiorgan inflammation and hematopoietic abnormalities in mice with targeted disruption of RelB, a member of the NF-êB/Rel family. Cell. 1995;80: 331–340.
62. Sha WC, Liou HC, Toumanen E, et al. Targeted disruption of the p50 subunit of NF-êB leads tomultifocal defects in immune responses. Cell. 1995;80:321–330.
63. Caamano JH, Rizzo CA, Durham SK, et al. NF-êB2 (p100/p52) is required for normal splenic microarchitecture and B cellmediated immune responses. J Exp Med. 1998;187:185–196.
64. Beg AA, Sha WC, Bronson RT, et al. Constitutive NF-êB activation, enhanced granulopoiesis, and neonatal lethality in IêBá-deficient mice. Genes Dev. 1995;9:2736–2746.
65. Memet S, Laouini D, Epinat JC, et al. IêBå-deficient mice: reduction of one T cell precursor subspecies and enhanced Ig isotype switching and cytokine synthesis. J Immunol. 1999;163:5994– 6005.
66. Franzoso G, Carlson L, Scharton-Kersten T, et al. Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Immunity. 1997;6:479–490.
67. Takeda K, Takeuchi O, Tsujimura T, et al. Limb and skin abnormalities in mice lacking IKKá. Science. 1999;284:313–316.
68. Rudolph D, Yeh WC, Wakeham A, et al. Severe liver degeneration and lack of NF-êB activation in NEMO/IKKã -deficient mice. Genes Dev. 2000;14:854–862.
69. Xiao G, Harhaj EW, Sun SC. NF-êB-inducing kinase regulates the processing of NF-êB2 p100. Mol Cell. 2001;7:401–409.
70. Miyawaki S, Nakamura Y, Suzuka H, et al. The new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol. 1994;24:429–434.